Resolving tumor microenvironment heterogeneity to forecast immunotherapy response in triple-negative breast cancer through multi-scale analysis by Shihao Sun, Shuang Chen, Kaiyuan Li, Ge Zhang, Ge Zhang, Ge Zhang, Nan Wang, Yijia Xu, Xinxing Wang, Jiangrui Chi, Lin Li, Yi Sun

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An immune responsive tumor microenvironment imprints into PBMCs and predicts outcome in advanced pancreatic cancer: lessons from the PREDICT trial by Anton Lahusen, Manfred P. Lutz, Rui Fang, Martina Kirchner, Sarah Albus, Klaus Kluck, Meinolf Karthaus, Andreas Schwarzer, Gabriele Siegler, Alexander Kleger, Thomas J. Ettrich, Alexander Becher, Sabine Höfling, Jens T. Siveke, Jan Budczies, Andrea Tannapfel, Albrecht Stenzinger, Phyllis Fung-Yi Cheung, Tim Eiseler, Thomas Seufferlein

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Changes in the tumor microenvironment in recurrent head and neck squamous cell carcinoma and its implication on efficacy of immune checkpoint inhibitors by Dong Hyun Kim, Mingu Kang, Gahee Park, Mohammad Mostafavi, Yoojoo Lim, Chan-Young Ock, Jiwon Koh, Yoon Kyung Jeon, Kyeong Cheon Jung, Soon-Hyun Ahn, Eun-Jae Chung, Seong-Keun Kwon, Bhumsuk Keam

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The correlation of HLA-A in Thai EGFR-mutated advanced non-small cell lung cancer, outcome, and tumor microenvironment by Nicha Zungsontiporn, Korakot Srianuwattipong, Sakun Santisukwongchote, Piyada Sitthideatphaiboon, Poonchavist Chantranuwat, Chatchawit Aporntewan, Chanida Vinayanuwattikun

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Elucidating the dynamic tumor microenvironment through deep transcriptomic analysis and therapeutic implication of MRE11 expression patterns in hepatocellular carcinoma by Ruiqiu Chen, Chaohui Xiao, Zizheng Wang, Guineng Zeng, Shaoming Song, Gong Zhang, Lin Zhu, Penghui Yang, Rong Liu

“…Abstract Aim This study aims to explore the dynamic tumor microenvironment of hepatocellular carcinoma (HCC) through deep transcriptomic analysis and to identify key regulatory genes, among which MRE11 was further validated for its immunomodulatory and prognostic significance. …”
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Petiveria alliacea and Caesalpinia spinosa extracts reduce the generation of cancer-associated fibroblasts in a 3D platform representative of the tumor microenvironment by María Camila Jimenez, Paola Lasso, Susana Fiorentino, Alfonso Barreto

Subjects: “…Tumor microenvironment…”
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Synergistic therapy for pancreatic cancer by deactivating cancer-associated fibroblasts and driving T-cell migration into tumor microenvironment using nanochaperone delivery system by Jiajing Chen, Feihe Ma, Yujie Chen, Mengchen Xu, Yongxin Zhang, Shuyu Wang, Hongyun Liu, Linlin Xu, Yang Liu, Rujiang Ma, Jinpu Yu, Linqi Shi

“…The success of immunotherapy in pancreatic ductal adenocarcinoma (PDAC) is greatly limited by the scarcity of cytotoxic T lymphocytes (CTLs) in tumor microenvironment, which is mainly due to the physical barrier formed by a dense extracellular matrix (ECM). …”
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Precision-cut tumor tissue slices, a novel tool to study the tumor microenvironment interactions with chimeric antigen receptor (CAR) T cells. by Valeria Durante, Alina Wittwer, Benjamin Theek, Manuel Martinez-Osuna, Emmanuel Donnadieu, Olaf Hardt, Dominik Eckardt, Andreas Bosio, Sonja Schallenberg, Christoph Herbel

“…Therefore, understanding the features of the tumor microenvironment (TME), is key to improve efficacy of adoptive cell therapies (ACTs) against solid tumors. …”
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Coordinating oncogenesis and immune evasion: KPNA2, GOLM1, and TK1 as novel CAR T-cell targets in lung adenocarcinoma by Wangrui Liu, Hui Zou, Lei Guo, Zhonghua Zhou, Yahui Xie, Huaqi Guo, Gang Wei, Kai Zhang, Hui Yin, Shiyin Wei, Jiachang Chi

Subjects: “…Tumor microenvironment…”
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Coordinated changes in midkine expression and midkine-associated multiomic profile in glioma microenvironment by Mieszko Lachota, Katarzyna Zielniok, Agata Góźdź, Patrycja Szpak, Ilona Kalaszczyńska, Radosław Zagożdżon

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Correction: myCAF-derived Exosomal PWAR6 accelerates CRC liver metastasis via altering glutamine availability and NK cell function in the tumor microenvironment by Hongsheng Fang, Weixing Dai, Ruiqi Gu, Yanbo Zhang, Jin Li, Wenqin Luo, Shanyou Tong, Lingyu Han, Yichao Wang, Chengyao Jiang, Xue Wang, Renjie Wang, Guoxiang Cai

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Single‐Cell RNA Sequencing Reveals the Critical Role of SEC16B in Lung Metastasis of Osteosarcoma by Shangyu Liu, Haijun Tang, Shanhang Li, Jian Guan, Yangjie Cai, Hening Li, Weijie Yan, Wei Dai, Danting Xiao, Zhuan Zou, Wenyu Feng, Xinli Zhan, Yun Liu, Juliang He

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Global research landscape of retinoblastoma biomarkers: a multidisciplinary bibliometric analysis based on multiple databases (2005–2025) by Zhixin Peng, Qi Hu, Xiangdong Chen

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A paracrine activin A–mDia2 axis promotes squamous carcinogenesis via fibroblast reprogramming by Michael Cangkrama, Mateusz Wietecha, Nicolas Mathis, Rin Okumura, Luca Ferrarese, Dunja Al‐Nuaimi, Maria Antsiferova, Reinhard Dummer, Metello Innocenti, Sabine Werner

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Metabolic reprogramming and immunosenescence in colorectal cancer: mechanisms and therapeutic implications by Jun Zhu, Kuan Shen, Kuan Shen, Qiang Su, Guozhong Yao, Xiaochen Chen

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PANoptosis-Relevant Subgroups Predicts Prognosis and Characterizes the Tumour Microenvironment in Ovarian Cancer by Chen Y, Deng Z, Chen J, Lin J, Zou J, Li S, Sun Y

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Neutrophils in cancer: At the crucial crossroads of anti‐tumor and pro‐tumor by Wenpeng Cai, Tao Fan, Chu Xiao, Ziqin Deng, Yixiao Liu, Chunxiang Li, Jie He

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Aquaglyceroporin-7 ameliorates sorafenib resistance and immune evasion in hepatocellular carcinoma through inhibition of lipid accumulation by Guangsi He, Wenzhu Shao, Weifei Wang, Lu Sun, Beibei Gao, Jie Wei

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Stereotactic body radiation therapy or conventional fractionated radiotherapy combined with immune checkpoint inhibitors? From biological perspectives by Yanmei Liu, Ganghui Ye, Weijun Chen, Yan Ding, Shenpeng Ying, Shixiu Wu

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The molecular biology of peritoneal metastatic disease by Sanne Bootsma, Maarten F Bijlsma, Louis Vermeulen

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