Immunosenescence and cancer: molecular hallmarks, tumor microenvironment remodeling, and age-specific immunotherapy challenges by Qianwen Liu, Jingfeng Li, Xiuqiao Sun, Jiayu Lin, Zhengwei Yu, Yue Xiao, Dan Li, Baofa Sun, Haili Bao, Yihao Liu

“…Aging reshapes the tumor microenvironment (TME) through recruitment of immunosuppressive cells, senescence-associated secretory phenotypes (SASP), and metabolic reprogramming, contributing to therapy resistance and poor prognosis in elderly patients. …”
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Collagen gene signature in the tumor microenvironment predicts survival and guides prognosis in bladder cancer by Yi Huang, Shuogui Fang, Weibin Xie, Yitong Zou, Hui Zhuo, Gang Shen, Hua Zhou, ChunPing Mao, Cong Lai, Jianqiu Kong, Xinxiang Fan

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TP53-mutated MDS and AML: immune dysregulation, tumor microenvironment, and emerging therapeutic strategies by Marwah M. Albakri, Marwah M. Albakri

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Targeting autophagy and plasminogen activator inhibitor-1 increases survival and remodels the tumor microenvironment in glioblastoma by Sophie G. Shifman, Jennifer L. O’Connor, Daniel P. Radin, Aryan Sharma, Laura Infante, Francesca Ferraresso, Christian J. Kastrup, Daniel A. Lawrence, Stella E. Tsirka

“…A critical factor for GBM survival is communication with the tumor microenvironment (TME), which can be programmed by glioma cells to support growth and immunosuppression. …”
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GTSE1-expressed osteoblastic cells facilitate formation of pro-metastatic tumor microenvironment in osteosarcoma by Linzhu Wang, Wenyue Li, Weihang Ji, Danyang Bing, Mingyue Liu, Kaidong Liu, Bo Chen, Zhangxiang Zhao, Yunyan Gu, Xuelian Li, Xiaoqiang E, Lei Yang

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Heterogeneity of the liver cancer tumor microenvironment: mitochondrial metabolism and causal inference through Mendelian randomization by Xiaping Liu, Zhang Jing, Jian Chen, Linhong Su, Jun Lin, Xiaoqu Zhu, Xiaodan Ye

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From tumor microenvironment to ocular hypertension: unraveling the pathogenesis and therapeutic strategies of cancer-related glaucoma by Bin Lin, Bin Lin, Bin Lin, Bin Lin, Bin Lin, Bin Lin, Dong-kan Li, Dong-kan Li, Dong-kan Li, Dong-kan Li, Dong-kan Li, Dong-kan Li

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PROS1‐MERTK Axis Drives Tumor Microenvironment Crosstalk and Progression in Papillary Thyroid Microcarcinoma by Wenqian Zhang, Ye Zhang, Zhu Liu, Zhiyuan Wang, Huaqin Wang, Xiaoyu Ji, Hongyue Su, Fan Yang, Lirong Yan, Ying Xu, Hao Zhang, Wei Sun

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Tumor microenvironment-preserving gliosarcoma organoids as an in vitro preclinical platform: a comparative analysis with glioblastoma models by Junseong Park, Dokyeong Kim, Hyeon-Chun Park, Minyoung Park, Songzi Zhang, Okcho Na, Youn Soo Lee, Minho Lee, Stephen Ahn, Yeun-Jun Chung

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Regulatory B cells drive immune evasion in the tumor microenvironment and are involved peritoneal metastasis in gastric cancer by Yuta Fujiwara, Jun Kinoshita, Mari Shimada, Hiroto Saito, Toshikatsu Tsuji, Daisuke Yamamoto, Hideki Moriyama, Motoki Horii, Sachiyo Nomura, Takashi Matsushita, Yasuhiko Yamamoto, Noriyuki Inaki

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Single-cell RNA sequencing reveals the effects of mental stress on mouse mammary tumors and the tumor microenvironment by Pengfei Liu, Wenjing Ma, Tao Wang, Jinhui Lü, Weizhong Wang, Yixing Wang, Qifan Tang, Jing Di, Evelyne Bischof, Qian Zhao, Zuoren Yu

“…However, its effects on the tumor microenvironment (TME) remain unclear. In this study, we applied single-cell sequencing analysis to tumor tissues from MMTV-PyMT transgenic mice with mammary gland tumors with or without exposure to mental stress. …”
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Cancer-associated fibroblast-mediated immune evasion: molecular mechanisms of stromal-immune crosstalk in the tumor microenvironment by Junling Luo, Junling Luo, Xuehua Xiang, Xuehua Xiang, Guangyuan Gong, Guangyuan Gong, Lang Jiang, Lang Jiang

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Preconditioning of the tumor microenvironment with oncolytic reovirus converts CD3-bispecific antibody treatment into effective immunotherapy by Rob C Hoeben, Sjoerd H van der Burg, Thorbald van Hall, Christianne Groeneveldt, Priscilla Kinderman, Diana J M van den Wollenberg, Ruben L van den Oever, Jim Middelburg, Dana A M Mustafa, Nadine van Montfoort

“…Immune-competent KPC3 tumor-bearing mice were intratumorally injected with reovirus type 3 Dearing strain and the reovirus-induced changes in the tumor microenvironment and spleen were analyzed over time by NanoString analysis, quantitative RT-PCR and multicolor flow cytometry. …”
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A Transcriptomic Biomarker for Predicting the Response to TACE Correlates with the Tumor Microenvironment and Radiomics Features in Hepatocellular Carcinoma by Wang C, Leng B, You R, Yu Z, Lu Y, Diao L, Jiang H, Cheng Y, Yin G, Xu Q

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CTSS in the tumor microenvironment links immune escape and immunotherapy sensitivity in kidney renal clear cell carcinoma by Hanjing Zhou, Jun Ying, Xuchun Xu, Jian Huang

“…Abstract The tumor microenvironment (TME) of kidney renal clear cell carcinoma (KIRC) exhibits complex dynamics among immune, stromal, and malignant cells that drive immune escape (IE) mechanisms and influence clinical outcomes. …”
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P03 | THE ROLE OF FILAMIN A IN REGULATING BREAST CANCER CELL BEHAVIOR AND TUMOR MICROENVIRONMENT INTERACTIONS

“…However, due to the cell line-specific effects and conflicting reports in the literature, further research is required to clarify the context-dependent functions of FLNa within diverse tumor microenvironments. …”
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Identification of epithelial-mesenchymal transition prognostic signature associated with prognosis, tumor microenvironment, and therapeutic effect in prostate cancer by Yiyuan Li, Yiyuan Li, Ke Li, Hua Wang, Jianguang Qiu, Jianguang Qiu, Chutian Xiao, Chutian Xiao

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Identification of anoikis-related genes to develop a risk model and predict the prognosis and tumor microenvironment in rectal adenocarcinoma by Bing Zhao, Xuegui Tang

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Dynamic changes in the tumor microenvironment under the effect of estradiol as a diagnostic tool and target for targeted cancer therapy by A. I. Stukan, A. Yu. Goryainova, A. A. Meshcheryakov, V. A. Porkhanov, R. A. Murashko, S. V. Sharov, V. N. Bodnya

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A high stroma-tumor ratio is associated with an immunosuppressive tumor microenvironment and a poor prognosis in bladder cancer by Yiqiang Da, Zirong Lu, Zirong Lu, Zijian Zhu, Hongrui Tai, Yuan Liu, Yichao Zhu, Yichao Zhu

“…The stroma of the tumor microenvironment (TME) largely affects the progression of BLCA. …”
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