ANTIBODY-TO-IMAGING PIPELINE TO MONITOR DRUG-TARGET ENGAGEMENT IN BREAST TUMORS

“…However, therapeutic efficacy is often compromised by tumor microenvironment (TME) features, such as dense extracellular matrix and poor vascularization, that limit antibody access and binding. …”
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Overexpression of the ferroptosis-related gene, NFS1, corresponds to gastric cancer growth and tumor immune infiltration by Mao Zhiyun, Shi Zhongmei, Cui Ming, Ma Xiaohong, Wang Yan, Zhang Xiaojie, Jing Rongrong, Wang Jingchun

“…Based on functional enrichment analysis, NFS1 may have a role in ferroptosis and the tumor microenvironment (TME), such as epithelial–mesenchymal transition control, and the stromal and immunologic responses. …”
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A Needle‐Like H2S‐Releasing and H2O2 Self‐Replenishing Nanoplatform for Enhanced Chemodynamic Tumor Immunotherapy by Xiaoxiao Sun, Xia Zhang, Haiyan Qin, Lingling Li

“…Abstract The tumor microenvironment (TME) significantly restricts chemodynamic therapy (CDT) efficacy through hypoxia and antioxidant defenses. …”
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Crosstalk between the tumor immune microenvironment and metabolic reprogramming in pancreatic cancer: new frontiers in immunotherapy by Taijin Shi, Xiaoyan Cui, Junlin Wang, Guangqia Liu, Jiayin Meng, Yingjie Zhang

“…With the rapid development of sequencing technology, the complex components in the tumor microenvironment (TME) of PC have been gradually revealed. …”
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Analysis and Functional Significance of TRAP1 in Glioblastoma by I. F. Gareev, O.A. Beylerli, Zhang Hongli, S. A. Roumiantsev

“…Exosomal TRAP1 likely participates in intercellular communication, promoting tumor adaptation to stress and the formation of a pro-tumor microenvironment. Conclusion. These findings support the pivotal role of TRAP1 in regulating metabolic status and maintaining aggressive phenotypes in glioblastoma. …”
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ATG7-deficient fibroblast promotes breast cancer progression via exosome-mediated downregulation of SCARB1 by Kangdi Li, Ting Liu, Zhihong Luo, You Yu, Yi Liu, Zhaoqing Zhang, Wenhua Li

“…Thus, our results indicate that ATG7 expression in fibroblasts plays a vital role in regulating breast cancer tumorigenesis and progression by modifying stromal–epithelial crosstalk and remodeling the tumor microenvironment (TME). These results suggest that ATG7 can function as a tumor suppressor and represent a new candidate for prognosis and targeted therapy.…”
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Repurposed Antipsychotics as Potential Anticancer Agents: Clozapine Efficacy and Dopaminergic Pathways in Neuroblastoma and Glioblastoma by Catarina Moura, Maria João Gouveia, Nuno Vale

“…Emerging evidence suggests that dopamine (DA), a neurotransmitter crucial for cognitive and emotional processes, and its receptors may influence tumor growth and the tumor microenvironment. This study aimed to evaluate the potential anticancer effects of repurposed antipsychotic dopamine-targeting drugs (Clozapine, CLZ; Pimozide, PIM; Olanzapine, OLZ; and Risperidone, RIS) and antiemetic drugs (Domperidone, DOM; Droperidol, DRO) on neuroblastoma (SH-SY5Y) and glioblastoma (A172) cell lines, and to assess whether their efficacy is modulated by oxidative stress and DA synthesis. …”
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Assessing the predictive role of platelet-lymphocyte ratio in EGFR-mutated non-small cell lung cancer patients treated with tyrosine kinase inhibitors: an analysis across TKI gener... by Ryan Cooper, Dhruv Ramaswami, Jacob S. Thomas, Jorge J. Nieva, Robert Hsu

“…The significant changes in peripheral cell counts suggest variable tumor microenvironment changes dependent on the generation of TKI received.…”
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Mechanistic Foundations of KRAS‐Driven Tumor Ecosystems: Integrating Crosstalk among Immune, Metabolic, Microbial, and Stromal Microenvironment by Jiayao Ma, Shenao Fu, Jun Tan, Ying Han, Yihong Chen, Xiangying Deng, Hong Shen, Shan Zeng, Yinghui Peng, Changjing Cai

“…It affects about one‐fifth of cancer cases. The tumor microenvironment (TME) is a multifaceted network of immune cells, metabolites, microbiota, stromal components, and extracellular matrix. …”
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Macrophages and macrophage extracellular vesicles confer cancer ferroptosis resistance via PRDX6-mediated mitophagy inhibition by Naisheng Zheng, Fuli Li, Qing Huang, Xian Huang, Tomasz Maj

“…Ferroptosis has emerged as a promising therapeutic target in cancer therapy, with the tumor microenvironment (TME) playing a pivotal role in regulating ferroptosis. …”
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An oxidative stress related gene signature predicts prognosis in cholangiocarcinoma by Han Fan, Peng Qiu, Yun Lu, Zhengdong Deng, Li Tian

“…Model performance was assessed with Kaplan-Meier survival, ROC curve, PCA, and t-SNE analyses. Tumor microenvironment (TME) features, immune cell infiltration, and chemosensitivity to cisplatin and 5-fluorouracil were also evaluated. …”
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Viral-Track integrated single-cell RNA-sequencing reveals HBV lymphotropism and immunosuppressive microenvironment in HBV-associated hepatocellular carcinoma by Zhepeng Liu, Wajeeha Naz, Tanzeel Yousaf, Junwei Sun, Qijia Wu, Mingxiong Guo, Geng Tian, Guihong Sun

“…Abstract The tumor microenvironment (TME) is a crucial mediator of tumor progression and treatment response. …”
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MARCO expression on myeloid-derived suppressor cells is essential for their differentiation and immunosuppression by Sijia Liu, Binle Tian, Na Wang, Zhilong Wang, Wen Zhang, Qi Li, JianFei Wang, Guo-Huang Fan, Caicun Zhou

“…Abstract Myeloid-derived suppressor cells (MDSCs) significantly contribute to the immunosuppressive tumor microenvironment (TME), and targeted inhibition of MDSCs is a potential therapeutic strategy against cancer. …”
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Bibliometric analysis of programmed cell death and immunogenic cell death in hepatocellular carcinoma immunotherapy: global trends and future directions by Shan-Peng Chen, Jie Tian

“…Future studies are expected to focus on immune evasion, tumor microenvironment regulation, novel cell death mechanisms, and personalized immunotherapy. …”
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Targeting the Tumor Microbiota in Cancer Therapy Basing on Nanomaterials by Yanan Niu, Junya Feng, Jie Ma, Tixian Xiao, Wei Yuan

“…ABSTRACT Intra‐tumoral microbiota, which is a potential component of the tumor microenvironment (TME), has been emerging as a key participant and driving factor in cancer. …”
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Machine Learning‐Enhanced Nanoparticle Design for Precision Cancer Drug Delivery by Qingquan Wang, Yujian Liu, Chenchen Li, Bin Xu, Shidang Xu, Bin Liu

“…Next, they delve into nano–bio interactions in drug delivery, including NP–protein interactions, blood circulation, NP extravasation into the tumor microenvironment (TME), tumor penetration and distribution, as well as cellular internalization. …”
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Palmitoylation prevents B7-H4 lysosomal degradation sustaining tumor immune evasion by Yijian Yan, Jiali Yu, Weichao Wang, Ying Xu, Kole Tison, Rongxin Xiao, Sara Grove, Shuang Wei, Linda Vatan, Max Wicha, Ilona Kryczek, Weiping Zou

“…Abstract B7-H4 functions as an immune checkpoint in the tumor microenvironment (TME). However, the post-translational modification (PTM) of B7-H4 and its translational potential in cancer remains incompletely understood. …”
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Strategies for in situ reprogramming of tumor cells into antigen-presenting cells by LIN Yongfang, WU Lichuan, JIE Xiaoliang, ZHOU Guangbiao

“…To address this challenge, researchers have explored strategies to reprogram tumor cells in situ within the tumor microenvironment into immune cells, so as to fully activate anti-tumor immune responses and overcome the limitations of conventional cell therapies that rely on in vitro cell expansion. …”
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Coexistence of bullous pemphigoid, intrahepatic cholangiocarcinoma, and alopecia areata: a case report of multifactorial autoimmunity in a surgical context by Shanlin Li, Shanlin Li, Ying Wang, Dingquan Yang

“…Malignant tumors can exacerbate immune disorders through a variety of potential pathways, including pro-inflammatory responses in the tumor microenvironment, cross-immune responses induced by tumor-associated antigens, and the lifting of immunosuppressive states and activation of underlying autoimmune responses after surgery. …”
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Dual inhibition of FAS and HAS2/3 by 4-MU in Realgar-Coptis chinensis unveils a metabolic checkpoint for liver cancer therapy by Songtao Wu, Yingying Wang, Denghui Deng, Guohua Zheng, Hanxiang Mei, Cong Wang, Xiang Zheng, Chun Gui, Fei Liao, Meixian Xiang

“…In addition, as a hyaluronan synthase (HAS2/3) inhibitor, 4-MU interfered with the HA-dependent tumor microenvironment and fibrosis process by inhibiting HAS2/3. …”
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