Cancer and neurotransmitter receptors by Xiaoqiang Wang, Muyan Shi, Jie Tian, Weifeng Yu, Jing Ni

“…In addition, NRs also regulate cellular metabolic processes and tumor microenvironment (TME) remodeling. More importantly, numerous basic and clinical studies have suggested that NRs may be potential targets for cancer treatments, and corresponding agonists or antagonists have been identified effectively in controlling tumor growth and metastasis. …”
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Neuropilin-2 upregulation by stromal TGFβ1 induces lung disseminated tumor cells dormancy escape and promotes metastasis outgrowth by L Recalde-Percaz, I de la Guia-Lopez, P Linzoain-Agos, A Noguera-Castells, M Rodrigo-Faus, P Jauregui, A Lopez-Plana, P Fernández-Nogueira, M Iniesta-González, M Cueto-Remacha, S Manzano, R Alonso, N Moragas, C Baquero, N Palao, E Dalla, FX Avilés-Jurado, I Vilaseca, X León-Vintró, M Camacho, G Fuster, J Alcaraz, J Aguirre-Ghiso, P Gascón, A Porras, A Gutiérrez-Uzquiza, N Carbó, P Bragado

“…Therefore, identifying the mechanisms that govern metastatic growth poses a major biomedical challenge. Tumor microenvironment signals regulate the fate and survival of disseminated tumor cells (DTCs) in secondary organs. …”
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Sphingosine 1-phosphate derived from tumor-educated hepatic stellate cells combining with S1PR4 promotes tumor associated macrophages differentiation through FAO modulation by Rui Feng, Zilin Cui, Long Yang, Zirong Liu

“…Macrophages, making great contributes to TIME, develop into tumor-associated macrophages (TAM) under the influence of the tumor microenvironment (TME), resulting in altered metabolic pathways. …”
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A Two-eRNA-Based Signature Can Impact the Immune Status and Predict the Prognosis and Drug Sensitivity of Lung Adenocarcinoma by Li Wang, Shao-quan Zhou, Yu Zhou, Jia-xi Lu

“…Immune infiltration of the tumor microenvironment was positively associated with overall survival (OS) in lung adenocarcinoma (LUAD). …”
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Dual Nature of Neutrophil Extracellular Traps (NETs)—From Cancer’s Ally to Therapeutic Target by Karolina Buszka, Claudia Dompe, Kinga Derwich, Izabela Pieścikowska, Michał Nowicki, Joanna Budna-Tukan

“…This review examines the role of NETs in the tumor microenvironment, their contribution to cancer progression and metastasis, and their potential use in liquid biopsy and cancer therapy.…”
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Necroptosis-Related Prognostic Signature and Nomogram Model for Predicting the Overall Survival of Patients with Lung Cancer by Yunpeng Xuan, Xiangfeng Jin, Mingzhao Wang, Zizong Wang

“…The correlation between RS model and tumor microenvironment, mutation status, or drug susceptibility was analyzed. …”
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Cancer-Associated Fibroblast Risk Model for Prediction of Colorectal Carcinoma Prognosis and Therapeutic Responses by Yan Wang, Zhengbo Chen, Gang Zhao, Qiang Li

“…Cancer-associated fibroblasts (CAFs) are important cellular elements in the tumor microenvironment of CRC, which contribute to CRC progression and immune escape. …”
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Hypoxia Induced Downregulation of Na+/H+ Exchanger-1 Activity Decreases Tumor Cell Proliferation by Gül Şimşek, Hilmi Burak Kandilci

“…Objectives: Hypoxia and acidosis are the hallmarks of proliferative tumor microenvironment which can modulate the expression and function of Na+/H+ exchanger-1 (NHE1) via hypoxia inducible factor 1 (Hif). …”
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Asporin increases the extracellular matrix cross-links and inhibits the cancer cell migration by Kimberly Hernandez, Caitlin H Nguyen, Girdhari Rijal

“…Background Migrating strategies of the triple-negative breast cancer (TNBC) together with its role in the establishment of tumor microenvironment (TME), supporting metastasis, have been extensively studied. …”
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Mitophagy related gene signature for prognosis and therapeutic evaluation in KIRC by Dengyi Duan, Yangyang Guo, Jianmin Li, Zhengyang Li, Guoping Xu, Yuanjie Niu, Yang Zhao

“…We subsequently constructed a clinically applicable nomogram by integrating the risk score with established prognostic indicators and relevant clinical parameters, thereby enabling multidimensional risk evaluation. Notably, tumor microenvironment characterization revealed enhanced immunotherapeutic responsiveness in high-risk patients, highlighting potential clinical utility for treatment selection. …”
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Targeted screening and single-cell analysis of genetic variants in melanoma using Mendelian randomization by Shi Li, Kaijiong Zhang, Guiji Zhang, Min Shi, Xing Yin, Bo Wang

“…Single-cell analysis revealed cellular heterogeneity in the tumor microenvironment, with HLA-E, ZNF578, CDK4, SRPK2, and TSPAN31 identified as potentially significant genes. …”
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Spatial transcriptomics and scRNA-seq: decoding tumor complexity and constructing prognostic models in colorectal cancer by Wei Song, Yatao Wang, Min Zhou, Fengqin Guo, Yanliang Liu

“…Abstract Introduction Recent advancements in transcriptomic analysis, combined with single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics, have deepened our understanding of the tumor microenvironment and cellular heterogeneity, laying the groundwork for personalized therapies. …”
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Metabolic reprogramming in colorectal cancer: a review of aerobic glycolysis and its therapeutic implications for targeted treatment strategies by Boran Pang, Hao Wu

“…Driven by the tumor microenvironment (TME), this adaptation enhances cancer cell proliferation through accelerated ATP generation, biosynthesis support, and redox balance. …”
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Transcriptional downregulation of MHC class I and melanoma de- differentiation in resistance to PD-1 inhibition by Jenny H. Lee, Elena Shklovskaya, Su Yin Lim, Matteo S. Carlino, Alexander M. Menzies, Ashleigh Stewart, Bernadette Pedersen, Malama Irvine, Sara Alavi, Jean Y. H. Yang, Dario Strbenac, Robyn P. M. Saw, John F. Thompson, James S. Wilmott, Richard A. Scolyer, Georgina V. Long, Richard F. Kefford, Helen Rizos

“…We reasoned that resistance mechanisms will reflect the tumor microenvironment, and thus we examined PD-1 inhibitor resistance relative to T-cell activity in 94 melanoma tumors collected at baseline and at time of PD-1 inhibitor progression. …”
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Causal relationships between immune cell traits and HER2 subtypes in breast cancer: a Mendelian randomization study by Fenfen Gu, Chuling Hu, Chao Li

“…Immune cells are critical components of the tumor microenvironment, influencing breast cancer progression. …”
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Nanotechnology and natural killer cell immunotherapy: synergistic approaches for precise immune system adjustment and targeted cancer treatment in gastrointestinal tumors by Xiwen Kang, Danyang Li, Rui Sun

“…Nonetheless, their effectiveness against gastrointestinal tumors is constrained by issues such as insufficient tumor penetration, brief survival in the body, and suppression by the immunosuppressive tumor microenvironment (TME). Meanwhile, nanotechnology has transformed cancer treatment by offering methods for precise drug delivery, immune system modulation, and improved bioavailability. …”
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Reticulon 4 in Breast Cancer: A Comprehensive Analysis of its Biomarker Potential for Prognosis, Immunology, and Drug Sensitivity by Tuğcan Korak, Murat Kasap

“…Analysis of the tumor microenvironment (TME) revealed significant correlations between RTN4 and immune cell infiltration, immune and molecular subtypes, and stromal components (p<0.05). …”
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Nanoengineered hydrogels disrupt tumor antioxidant defense via photothermal-chemodynamic synergy and oxidative stress boosts by Leiguang Ye, Yang Qiao, Peisan Wang, Wei Li, Xianwen Wang, Yiqun Zhang, Zhennan Yuan

“…Simultaneously, Ru-PC exhibited tumor microenvironment-responsive catalytic activity, catalyzing the conversion of hydrogen peroxide (H2O2) into highly toxic hydroxyl radicals (·OH) via Fenton-like reactions. …”
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A mitochondrial-related gene signature predicts prognosis and immunotherapy response in hepatocellular carcinoma by Hongli Shu, Rui Li, Xiaolong Tang, Qiongfang Zhang

“…MRGs-based nomogram exhibited superior predictive accuracy, highlighting their clinical potential for personalized risk assessment. Within the tumor microenvironment, high-MRGs tumors demonstrated significant enrichment of immunosuppressive components, including regulatory T cells, tumor-associated macrophages, and checkpoint molecules PD-1 and CTLA-4. …”
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m5C RNA modification in colorectal cancer: mechanisms and therapeutic targets by Jiawei Wang, Cenyi Qi, Ran Wang, Yuepeng Cao, Yuping Zhou, Guoliang Ye

“…Future research should focus on revealing the specific role of m5C modification in the tumor microenvironment and drug resistance mechanisms and promote its clinical translation in diagnosis and treatment.…”
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