Pyrrolizine-5-carboxamides: Exploring the impact of various substituents on anti-inflammatory and anticancer activities by Gouda Ahmed M., Abdelazeem Ahmed H., Abdalla Ashraf N., Ahmed Muhammad

“…Taken together, this study highlighted the significant impact of the substituents on the anti-inflammatory and anticancer activity of pyrrolizine-5-carboxamides, which could help in further optimization to discover good leads for the treatment of cancer and inflammation.…”
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A heteropolysaccharide from Rhodiola rosea L.: preparation, purification and anti-tumor activities in H22-bearing mice by Yaru Wu, Qing Wang, Huiping Liu, Lulu Niu, Mengyu Li, Qi Jia

“…Numerous polysaccharides isolated from plants have been used to augment traditional drugs in the treatment of cancer. In order to explore the influence to hepatocellular carcinoma, a novel cold water-soluble polysaccharide was separated from Rhodiola rosea L. root (RLP) and then its structure and anti-cancer activities were tested. …”
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Conjugates of Phthalocyanines With Oligonucleotides as Reagents for Sensitized or Catalytic DNA Modification

“…These results suggest the possible use of phthalocyanine-oligonucleotide conjugates as novel artificial regulators of gene expression and therapeutic agents for treatment of cancer.</p>…”
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Effects of Clinicopathological Characteristics on the Survival of Patients Treated with PD-1/PD-L1 Inhibitor Monotherapy or Combination Therapy for Advanced Cancer: A Systemic Revi... by Yuhan Wei, Yongfu Li, Qi Du, Xinyi Peng, Jiangtao Jin, Hong Guo, Yongyan Li, Qin Li

“…PD-1/PD-L1 inhibitors have made unprecedented progress in the treatment of cancer. Methods. A systemic search was conducted for randomized controlled trials that compared PD-1/PD-L1 inhibitor monotherapy or combination therapy with nonimmunotherapy. …”
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Assessment of the quality of life in metastatic colorectal cancer patients with KRAS gene mutant: a case-control study by Fahmideh Bagrezaei, Bahram Pourghassem Gargari, Reza Eghdam Zamiri, Abdolrasoul Safaiyan, Mohammad Alizadeh

“…The QOL was evaluated through validated questionnaires from the European Organization for Research and Treatment of Cancer (EORTC), including QLQ-C30 and the QLQ-CR29 questionnaire for colorectal cancer patients. …”
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Do non-mammary conditions influence patients’ cosmetic perception after breast conserving surgery? by Idam de Oliveira-Junior, Idam de Oliveira-Junior, Fabíola Cristina Brandini da Silva, Fabíola Cristina Brandini da Silva, Almir José Sarri, René Aloísio da Costa Vieira, René Aloísio da Costa Vieira

“…The patients answered the European Organization for Research and Treatment of Cancer Quality of Life questionnaire (EORTC QLQ) - C30, EORTC QLQ-BR23 and Breast Cancer Treatment Outcome Scale (BCTOS) questionnaires, underwent cosmetic breast self-assessment and had their breasts photographed. …”
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A multifunctional mesoporous silica drug delivery nanosystem that ameliorates tumor hypoxia and increases radiotherapy efficacy by Yanhong Chu, LiFeng Wang, Yaohua Ke, Xiaoyu Feng, Wenmei Rao, Wei Ren, Kai Xin, Yan Wang, Lixia Yu, Baorui Liu, Qin Liu

“…Safety assessments confirmed the absence of MSN@R837-Mn/ZnO2 toxicity, highlighting its potential as a promising approach with dual functionality for the diagnostic imaging and treatment of cancer.…”
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Identification of Breast Cancer Biomarkers by Constructing Protein-Protein Interaction and miRNAs-mRNAs Networks by Azizeh Asadzadeh, Bita Behboodian, Parsa Bernoos, Masoumeh Shojaei Barjouei

“…Background: In cancer-related diseases, early detection and control of disease progression are very important for successful treatment. Breast cancer is a significant problem due to its high mortality rate in the female population worldwide. …”
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Survival status of women with cervical cancer in Sub-Saharan Africa: a systematic review and meta-analysis, 2024 by Tadele Emagneneh, Chalie Mulugeta, Betelhem Ejigu, Abebaw Alamrew, Aynalem Yetwale Hiwot, Sefineh Fenta Feleke

“…BackgroundDespite the availability of vaccination and early treatment, cervical cancer remains a significant public health concern globally, particularly in Sub-Saharan Africa, where access to screening and treatment is often limited.MethodsIn this study, researchers conducted a survey of four international databases—Medline/PubMed, Scopus, Web of Science, and Henare—along with Google Scholar to search for gray literature. …”
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Implementation of support meetings for patients undergoing outpatient chemotherapy by a multidisciplinary cancer team by Miho Jinno, Misako Dai, Kaori Ito, Yosuke Ando, Seira Toyosato-Nishibe, Maki Akiyoshi, Sachie Noda, Hidezo Matsuda, Naho Tsujii, Miho Zennami, Masami Yamamura, Yoko Katagata, Akemi Ito, Aki Takai, Shigeki Yamada, Kenji Kawada, Junko Sugama, Keiko Mano

“…Background: Outpatient chemotherapy is a standard treatment for cancer. In nursing care for outpatients, it is important to enhance patients’ self-efficacy. …”
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Sulforaphane in alternative cancer chemotherapy: From carcinogenesis suppression to drug resistance reversal by Seyed Mohammad Doodmani, Payman Rahimzadeh, Najma Farahani, Seyedalireza Mirilavasani, Mina Alimohammadi, Noushin Nabavi, Elmira Alaei, Afshin Taheriazam, Maryam Abedi, Nadia Shafiee, Salman Daneshi, Mehrdad Hashemi

“…The management and treatment of cancer have posed significant challenges in recent years. …”
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Combination of Compound Kushen injection with first-line treatment versus first-line treatment alone for advanced colorectal cancer: a study protocol for a multicenter, openlabel,... by Jingyuan Wu, Yuansha Ge, Guanghui Zhu, Ruike Gao, Xiaoyu Zhu, Ying Zhang, Jie Li

“…Compound Kushen injection (CKI) is one of the representative drugs of anti-cancer Chinese herbal injection drugs, which has been widely used in the adjunct treatment of cancer in China. The aim of this trial is to evaluate the efficacy and safety of CKI combined with first-line treatment of advanced CRC. …”
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Discovery of a non‐nucleotide stimulator of interferon genes (STING) agonist with systemic antitumor effect by Xiyuan Wang, Zhengsheng Zhan, Zhen Wang, Yan Zhang, Kaiyan Zhao, Han Li, Xiaoqian Zhou, Yuting Guo, Fengying Fan, Jian Ding, Meiyu Geng, Xuekui Yu, Wenhu Duan, Zuoquan Xie

“…Abstract Agonists of the stimulator of interferon genes (STING) pathway are increasingly being recognized as a promising new approach in the treatment of cancer. Although progress in clinical trials for STING agonists in antitumor applications has been slow, there is still an urgent need for developing new potent STING agonists with versatile potential applications. …”
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Psychological factors affecting post-treatment follow-up care in breast cancer patients attending healthcare centers in western Mazandaran (2021-2022) by Zahra Fotokian, Sobhan Rahimi Esbo, Zahra Jannat Alipour, Ali Pourhabib, Fatemeh Ghaffari, Mojtaba Qanbari Qalesari, Shahrbanoo Keyhanian, Mohsen Vakili Sadeghi

“…Data were collected through personal information questionnaires, the Zigmond Hospital Anxiety and Depression Scale, the Psychological Distress Thermometer, the Fear of Cancer Recurrence Scale, and a post-treatment breast cancer follow-up care checklist. Data analysis was conducted using SPSS version 18, employing descriptive and inferential statistical methods. …”
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Remote Monitoring of Chemotherapy-Induced Peripheral Neuropathy by the NeuroDetect iOS App: Observational Cohort Study of Patients With Cancer by Ciao-Sin Chen, Michael P Dorsch, Sarah Alsomairy, Jennifer J Griggs, Reshma Jagsi, Michael Sabel, Amro Stino, Brian Callaghan, Daniel L Hertz

“…MethodsThe NeuroDetect app (Medable Inc) includes subjective EORTC (European Organization for Research and Treatment of Cancer) Quality of Life Questionnaire (QLQ)–20-item scale (CIPN20) and 6 objective functional assessments that use smartphone sensors to mimic neurological examinations, such as walking, standing, and manual dexterity tests. …”
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Impact of Additional Active Treatment for Prostate Cancer on Health-related Quality of Life of Men: Results from the EUPROMS 2.0 1-year Follow-up Survey by Lionne D.F. Venderbos, Sebastiaan Remmers, André Deschamps, John Dowling, Ernst-Günter Carl, Nuno Pereira-Azevedo, Monique J. Roobol

“…The EUPROMS 2.0 1yrFU survey included the validated European Quality of Life 5 Dimension 5 Level (EQ-5D-5L), European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire (EORTC-QLQ-C30), Expanded Prostate Cancer Index Composite Short Form (EPIC-26), and International Index of Erectile Function (IIEF)-15 overall satisfaction domains. …”
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Quality of life and its influencing factors in patients with gynecologic tumor (妇科肿瘤患者生存质量现状及影响因素调查研究) by CHEN Fan (陈帆), GUO Xiujing (郭秀静), CHEN Jing (陈静)

“…The general information questionnaire, EORTC Quality of Life Questionnaire (EORTC QLQ-30), Chinese version of the European Organization for Research and Treatment for Cancer Quality of Life Questionnaire-spiritual Well-being (EORTCQLQ-SWB32) and the Hospital Anxiety and Depression Scale(HAD) were used in the survey. …”
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High tumor mutational burden predicts favorable response to anti-PD-(L)1 therapy in patients with solid tumor: a real-world pan-tumor analysis by Sehhoon Park, Jaeyun Jung, You Jeong Heo

“…Background Tumor mutation burden (TMB) is an important biomarker to predict response to anti-PD-L1 treatment across cancer types. TruSight Oncology 500 (TSO500) is currently used globally as a routine assay for TMB.Methods Between 2019 and 2021, 1744 patients with cancer received TSO500 assay as part of a real-world clinical practice at the Samsung Medical Center, and 426 received anti-PD-(L)1 treatment. …”
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Multifunctional drug delivery nanoparticles for combined chemotherapy/chemodynamic/photothermal therapy against colorectal cancer through synergistic cuproptosis/ferroptosis/apopto... by Xiuzhang Yan, Heshi Liu, Lei Guo, Chang Liu, Shichen Zhang, Xue Wang, Yixin Tang, Rui Zhou, Xin Jiang, Erlei Wang, Shuohui Gao, Caina Xu

“…The use of combination therapies that employ a variety of cell death mechanisms has emerged as a promising avenue of research in the treatment of cancer. However, the optimization of therapeutic synergies when integrating different modes remains a significant challenge. …”
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Interleukin 15‐Presenting Nanovesicles with Doxorubicin‐Loaded Ferritin Cores for Cancer Immunochemotherapy by Yihui Zhai, Wen Zhang, Jinming Wang, Ying Kong, Rong Rong, Tianqun Lang, Chao Zheng, Yanke Wang, Yang Yu, Helen He Zhu, Ying Cai, Pengcheng Zhang, Yaping Li

“…The IL15‐displaying nanovesicle introduced here holds promise as a potential platform for immunochemotherapy in the treatment of cancer.…”
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