Clinical Results after High-Dose Intensity-Modulated Radiotherapy for High-Risk Prostate Cancer by Valérie Fonteyne, Nicolaas Lumen, Geert Villeirs, Piet Ost, Gert De Meerleer

“…In this paper we report on (i) late toxicity and (ii) biochemical (bRFS) and clinical relapse-free survival (cRFS) of this combined treatment. …”
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Fragment optimized chalcone derivatives targeting OmpA protein as a therapeutic approach against multidrug resistant Acinetobacter baumannii by Muhammad Naveed, Amina Abid, Tariq Aziz, Ayesha Saleem, Arooj Arshad, Khushbakht Javed, Hafiz Muzzammel Rehman, Ghulam Nabi, Mitub Al-harbi, Abdullah F. Alasmari

“…Furthermore, for a more potent compound, fragment optimization was performed and led to a new lead compound fragment optimized isobavachalcone (FOI) which shows increased binding energy −6 kcal/mol. ADMET and toxicity analysis was performed of both the compounds isobavachalcone and FOI which revealed favorable pharmacokinetic profiles for both compounds, but toxicity analysis showed discrepancies, with the isobavachalcone exhibiting toxicity but FOI compound showing no detectable toxicity. …”
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Attempted Suicide by Massive Warfarin Ingestion Conservatively Managed Using Phytonadione by Katherine L. March, Kruti S. Patel, Jennifer D. Twilla

“…Treatment strategies for acute toxicity following massive ingestion of warfarin are not well described in the literature. …”
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Euodiae Fructus: a review of botany, application, processing, phytochemistry, quality control, pharmacology, and toxicology by Yule Hao, Jiawen Qi, Xinggui Huang, Chenhao Liu, Yi Liu

“…Further in-depth research is necessary to explore the mechanisms underlying EF’s pharmacological and toxicological mechanisms and to develop strategies for quality control and toxicity mitigation. The toxicity of EF can be reduced by processing, but this aspect is rarely discussed, and the quality control needs to be further standardized. …”
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Toxicological Evaluation and Protective Effects of Ethanolic Leaf Extract of Cassia spectabilis DC on Liver and Kidney Function of Plasmodium berghei-Infected Mice by Wiwied Ekasari, Anisah Mahardiani, Nindya T. Putri, Tutik S. Wahyuni, Heny Arwati

“…The acute and subacute toxicity tests were carried out on healthy mice that were given EECS at a dose of 150 mg/kg BW. …”
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Therapeutic Implications of a Polymethoxylated Flavone, Tangeretin, in the Management of Cancer via Modulation of Different Molecular Pathways by El-Shaimaa A. Arafa, Noura T. Shurrab, Manal A. Buabeid

“…In addition, tangeretin is known to exhibit considerable selective toxicity to many types of cancer cell proliferation such as ovarian, brain, blood, and skin cancer. …”
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Preparation and In Vitro Evaluation of Alginate Microparticles Containing Amphotericin B for the Treatment of Candida Infections by Merlis P. Alvarez-Berrios, Lisa M. Aponte-Reyes, Lourdes Diaz-Figueroa, Juan Vivero-Escoto, Alexis Johnston, David Sanchez-Rodriguez

“…Our results demonstrated that the platform developed in this work was able to induce antifungal toxicity against Candida albicans yeast cells at the same level of free AmB with minimal toxicity to lung cells, which is one of the main side effects induced by commercial drug delivery systems containing AmB. …”
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Real‐World Study of EGFR‐TKI Rechallenge With Another TKI After First‐Line Osimertinib Discontinuation in Patients With EGFR‐Mutated Non‐Small Cell Lung Cancer: A Subset Analysis o... by Kei Sonehara, Kazunari Tateishi, Kiyotaka Yoh, Kazuhiro Usui, Yukio Hosomi, Kazuma Kishi, Go Naka, Kageaki Watanabe, Shu Tamano, Kohei Uemura, Hideo Kunitoh

“…In clinical practice, rechallenge therapy with another EGFR‐tyrosine kinase inhibitor (TKI) is often performed after first‐line TKI discontinuation owing to resistance or toxicity; however, the efficacy and toxicity of EGFR‐TKI rechallenge after first‐line osimertinib have not been adequately investigated. …”
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Hypercapnea and Acidemia despite Hyperventilation following Endotracheal Intubation in a Case of Unknown Severe Salicylate Poisoning by Shannon M. Fernando, Valérie Charbonneau, Hans Rosenberg

“…Salicylates are common substances for deliberate self-harm. Acute salicylate toxicity is classically associated with an initial respiratory alkalosis, followed by an anion gap metabolic acidosis. …”
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Nano–bio surface interactions, cellular internalisation in cancer cells and e‐data portals of nanomaterials: A review by Ram Dhan Yadav, Abha Chaudhary

“…The increased activity of NPs may also result in toxicity on health and environment, thus emphasis should be given to assess the toxicity of NMs in the medical field. …”
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Overview of (1→3)-β-D-glucan immunobiology by David L. Williams

“…Here we review the chemistry, immunobiology and toxicity of (1→3)-β-D-glucans and how it may relate to effects caused by inhalation.…”
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Acute Liver and Renal Failure: A Rare Adverse Effect Exclusive to Intravenous form of Amiodarone by Robin Paudel, Prerna Dogra, Saurav Suman, Saurav Acharya, Jyoti Matta

“…The mechanism of acute liver and renal toxicity is not clearly known but is believed to be secondary to amiodarone induced (relative) hypotension, idiosyncratic reaction to the drug, and toxicity of the vector that carries the medication, polysorbate-80. …”
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Combined BPA and DIBP Exposure Induced Intestinal Mucosal Barrier Impairment Through the Notch Pathway and Gut Microbiota Dysbiosis in Mice by Mengge Duan, Yuting Wang, Shiyu Chen, Jiawen Lu, Ruihong Dong, Qiang Yu, Jianhua Xie, Yi Chen

“…However, little research has investigated the combined toxicity of BPA and DIBP, particularly their intestinal toxicity. …”
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Cardiac Transplantation following Cobalt Cardiomyopathy from Bilateral Metal-on-Metal Hip Replacements by Peter Szedlak, Amrik Virdi, Paul Cacciottolo, Stephen Shepherd, Stephen Pettit, Florian Falter

“…Following a prolonged period of deterioration without a clear cause, the diagnosis of cobalt toxicity-related cardiomyopathy due to cobalt-chromium alloy hip prostheses was eventually made. …”
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High on Cannabis and Calcineurin Inhibitors: A Word of Warning in an Era of Legalized Marijuana by Naomi Hauser, Tanmay Sahai, Rocco Richards, Todd Roberts

“…Tacrolimus toxicity can be severe and may include multiorgan damage. …”
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Effect of spirulina supplementation on growth, immunity, antioxidant status and pathomorphological perspectives in broilers exposed to dietary aflatoxin B1 by Ayman S. Salah, Antonia Lestingi, Mahmoud S. El-Tarabany, Marwa Mostafa, Rania Samir Zaki, Mahmoud M. Azzam, Alessandro Di Cerbo, Mahmoud Alagawany, Ahmed Fotouh

“…AFB1 toxicity reduced the activity of SOD and GPx (P < 0.05). …”
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Acute enteritis with pelvic SBRT: Influence of bowel delineation methods by Akshay Dinesan, Maneesh Singh, Prachi Mehta, Priyamvada Maitre, Vedang Murthy

“…Patients with acute bowel toxicity (CTCAE v5.0) were included as cases while those without were controls. …”
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Bioassays and virtual screening to identify potent natural antifouling compounds from the brown macroalga Dictyota dichotoma by Ba-akdah Mohammad Abdulaziz, Satheesh Sathianeson

“…The metabolites also showed positive for crustacean and fish toxicity in toxicity prediction using an in silico method.…”
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Outcome differences by sex in oncology clinical trials by Ashwin V. Kammula, Alejandro A. Schäffer, Padma Sheila Rajagopal, Razelle Kurzrock, Eytan Ruppin

“…Abstract Identifying sex differences in outcomes and toxicity between males and females in oncology clinical trials is important and has also been mandated by National Institutes of Health policies. …”
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Plants with known antagonistic properties against pests: how they influence non-target free-living soil fauna? by Kassimira Ilieva-Makulec, Michał Bielecki, Grzegorz Makulec

“…The toxicity of the hemp extract showed a clear dependence on its concentration. …”
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