TIGIT inhibitor M6223 as monotherapy or in combination with bintrafusp alfa in patients with advanced solid tumors: a first-in-human, phase 1, dose-escalation trial by Wei Gao, Ping Hu, Aung Naing, Meredith McKean, Anthony Tolcher, Lillian L Siu, Keyvan Tadjalli-Mehr, Anja Victor, Emilia Richter, Marco A F Nogueira Filho, Thomas Kitzing, Stephan Gleicher, Daniel Holland

“…Additional objectives included pharmacokinetics, pharmacodynamics and clinical activity (NCT04457778).Results Two dose-limiting toxicities were observed: grade 3 adrenal insufficiency (Part 1A: M6223 900 mg every 2 weeks) and grade 3 anemia (Part 1B: M6223 300 mg, only BA related). …”
Get full text

Exposure to Subclinical Doses of Fumonisins, Deoxynivalenol, and Zearalenone Affects Immune Response, Amino Acid Digestibility, and Intestinal Morphology in Broiler Chickens by Revathi Shanmugasundaram, Laharika Kappari, Mohammad Pilewar, Matthew K. Jones, Oluyinka A. Olukosi, Anthony Pokoo-Aikins, Todd J. Applegate, Anthony E. Glenn

“…The study was conducted to evaluate the least toxic effects of combined mycotoxins fumonisins (FUM), deoxynivalenol (DON), and zearalenone (ZEA) on the production performance, immune response, intestinal morphology, and nutrient digestibility of broiler chickens. …”
Get full text

MT2A promotes angiogenesis in chronically ischemic brains through a copper–mitochondria regulatory mechanism by Ni Mo, Chuyang Tai, Yang Yang, Cong Ling, Baoyu Zhang, Lei Wei, Cian Yao, Hui Wang, Chuan Chen

“…Metallothionein 2 A (MT2A) has a high affinity for metal ions and is potentially capable of chelating toxic copper ions to alleviate the impairment of angiogenesis. …”
Get full text

Ketamine Infusion as an Adjunct to Opioid Analgesia in Pediatric Patients with High-Risk Neuroblastoma Undergoing Treatment with Dinutuximab: Adverse Effects and Safety in a Non-IC... by Streby KA, Tobias JD, McPhaden E, Downie S, Stanek J, Roth C, Patel PO

“…In addition, the secondary objective is to describe the toxicities of pain management with opioids versus opioid plus ketamine.Methods: A retrospective chart review of 40 hRNBL patients receiving dinutuximab at Nationwide Children’s Hospital, from 2010 to 2022, was conducted. …”
Get full text

Biofloc technology significantly reshapes water microbiome and improves survival rates in Japanese eel (Anguilla japonica) by Jiho Yang, Hyunjun Choi, Jun Seong Park, Yehyeon Cha, Ju-Ae Hwang, Seung-Yoon Oh

“…Biofloc technology (BFT) systems offer the potential to reduce water consumption and eliminate waste products by using beneficial microorganisms to convert waste into usable nutrients or non-toxic molecules. Unlike flow-through systems (FTS), which depend on continuous water exchange and result in higher operational costs as well as limited microbiome stability, BFT operates without the need for constant water exchange. …”
Get full text

Effects of Climatic Conditions and Agronomic Practices on Health, Tuber Yield, and Mineral Composition of Two Contrasting Potato Varieties Developed for High and Low Input Producti... by Gultekin Hasanaliyeva, Ourania Giannakopoulou, Juan Wang, Marcin Barański, Enas Khalid Sufar, Daryl Knutt, Jenny Gilroy, Peter Shotton, Halima Leifert, Dominika Średnicka-Tober, Ismail Cakmak, Levent Ozturk, Bingqiang Zhao, Per Ole Iversen, Nikolaos Volakakis, Paul Bilsborrow, Carlo Leifert, Leonidas Rempelos

“…In contrast, the effect of climatic and agronomic drivers on tuber mineral and toxic metal concentrations in the two varieties was found to be similar. …”
Get full text

Oncolytic virus OH2 extends survival in patients with PD-1 pretreated melanoma: phase Ia/Ib trial results and biomarker insights by Juan Li, Xuan Wang, Li Zhou, Jun Guo, Lu Si, Bixia Tang, Chuanliang Cui, Xiaoting Wei, Xinan Sheng, Siming Li, Zhihong Chi, Lili Mao, Bin Lian, Xieqiao Yan, Yan Kong, Caili Li, Xiangyong Gu, Binlei Liu, Hui Tian, Han Hu

“…A phase III clinical trial is ongoing in China (NCT05868707).Conclusions OH2 oncolytic virotherapy exhibited a favorable safety profile without dose-limiting toxicities (DLTs) and demonstrated durable antitumor efficacy in patients with melanoma, especially in those who had progressed on anti-PD-1 treatment.Trial registration number ClinicalTrials.gov identifier NCT04386967.…”
Get full text

Tannin alleviated reproductive dysfunction in pregnant ewes infected with Haemonchus contortus by Xin Li, Xin Li, Hai Xiang, Hai Xiang, Rong Liang, Rong Liang, Xinyu Han, Xinyu Han, Rongzhen Zhong, Rongzhen Zhong, Hongyu Liu, Hongyu Liu, Yi Fang, Yi Fang

“…IntroductionHaemonchus contortus (H. contortus) infection has a significant impact on the health of pregnant ewes and adversely affects fetal development, highlighting the critical need for a non-toxic feed additive as an alternative and sustainable control strategy. …”
Get full text

Preclinical pharmaco-toxicological screening of biomimetic melanin-like nanoparticles as a potential therapeutic strategy for cutaneous melanoma by Iasmina Marcovici, Iasmina Marcovici, Raul Chioibas, Raul Chioibas, Istvan Zupko, Iulia Pinzaru, Iulia Pinzaru, Alina Moaca, Alina Moaca, Adriana Ledeti, Adriana Ledeti, Lucian Barbu-Tudoran, Lucian Barbu-Tudoran, Andreea Geamantan, Andreea Geamantan, Iasmina Predescu, Iasmina Predescu, Cristina Adriana Dehelean, Cristina Adriana Dehelean

“…In ovo, MEL-NPs lacked irritant and vascular toxic effects, while exerting an angio-suppressive activity.ConclusionMEL-NPs demonstrated promising anti-melanoma properties, showing a selective cytotoxicity, a strong anti-invasive effect and a pro-apoptotic activity in CM cells, while inhibiting CAM angiogenesis, these novel findings contributing to future research on the potential application of this nanoplatform in CM therapy.…”
Get full text

Marine sponge symbiotic bacterial bioremediation against heavy metal pollutants in tiger prawns; Penaeus monodon culture medium by I. Marzuki, I. Pratama, R. Asaf, A. Athirah, K. Nisaa, N. Nurbaya, M. Muslimin, N. Nurhidayah, S. Suwardi, A. Sahrijanna, K. Kamaruddin

“…These symptoms included necrosis, myopathy, and infiltration, which are indicative of decreased cell function due to the presence of toxic agents.CONCLUSION: Bioremediation with Bacillus pumilus and Pseudomonas stutzeri bacteria helped reduce the accumulation of heavy metal pollutants. …”
Get full text

Discontinuation of immune checkpoint inhibitors for reasons other than disease progression and the impact on relapse and survival of advanced melanoma patients. A systematic review... by Konstantinos Lallas, Eftychia Chatziioannou, Derya Durak, Georg Frey, Lina Maria Serna-Higuita, Marie-Lena Rasch, Athanassios Kyrgidis, Eleni Timotheadou, Zoe Apalla, Ulrike Leiter, Lukas Flatz, Lukas Flatz, Aimilios Lallas, Teresa Amaral, Teresa Amaral

“…Studies referring to melanoma patients who ceased ICIs electively (i.e. due to complete response (CR), protocol completion or patient/physician’s wish) or due to treatment-limiting toxicities (TLTs) were selected. Relapse rates (RRs) post cessation, time to PD, rechallenge and disease control rate (DCR) after 2nd course were the main outcomes. …”
Get full text

The First Large Identification of 3ANX and NX Producing Isolates of <i>Fusarium graminearum</i> in Manitoba, Western Canada by Maria Antonia Henriquez, Srinivas Sura, Sean Walkowiak, David Kaminski, Anne Kirk, Mark W. Sumarah, Parthasarathy Santhanam, Nina Kepeshchuk, Jules Carlson, E. RoTimi Ojo, Pam de Rocquigny, Holly Derksen

“…<i>F. graminearum</i> produces toxic secondary metabolites that include trichothecene type A and type B mycotoxins. …”
Get full text

Human health risk assessment of drinking water using heavy metal pollution index: a GIS-based investigation in mega city by Maria Latif, Iqra Nasim, Mubeen Ahmad, Rab Nawaz, Arifa Tahir, Muhammad Atif Irshad, Aamal A. Al-Mutairi, Ali Irfan, Sami A. Al-Hussain, Magdi E. A. Zaki

“…A total of 25 samples were collected by random sampling from hand pumps during 4 months (March–June, 2021) for determining various physiochemical attributes (pH, electric conductivity, turbidity, total hardness, chloride, and phosphate) and potentially toxic elements (arsenic, cadmium, and lead) using standard protocols. …”
Get full text

Sistem Akuaponik untuk Peternakan Lele dan Tanaman Kangkung Hidroponik Berbasis IoT dan Sistem Inferensi Fuzzy by Fachrul Rozie, Iwan Syarif, Muhammad Udin Harun Al Rasyid, Edi Satriyanto

“…Catfish feces and food scraps accumulate in water and can be toxic to catfish because they contain high levels of anomia so it is very dangerous if not disposed of. …”
Get full text

Chemical Synthesis, Efficacy, and Safety of Antimalarial Hybrid Drug Comprising of Sarcosine and Aniline Pharmacophores as Scaffolds by Jean Baptiste Niyibizi, Peter G. Kirira, Francis T. Kimani, Fiona Oyatsi, Joseph K. Ng’ang’a

“…Sarcosine-aniline hybrid was significantly less toxic compared with artesunate, chloroquine, and doxorubicin. …”
Get full text

Paracrine activity of Smurf1-silenced mesenchymal stem cells enhances bone regeneration and reduces bone loss in postmenopausal osteoporosis by Alberto González-González, Itziar Álvarez-Iglesias, Daniel García-Sánchez, Monica Dotta, Ricardo Reyes, Ana Alfonso-Fernández, Alfonso Bolado-Carrancio, Patricia Díaz-Rodríguez, María Isabel Pérez-Núñez, José Carlos Rodríguez-Rey, Jesús Delgado-Calle, Flor M. Pérez-Campo

“…This study provides compelling evidence for the therapeutic potential of Smurf1-silenced MSC-derived secretome as a non-toxic and targeted treatment for osteoporosis. These findings warrant further in vivo studies and clinical trials to validate its therapeutic efficacy and safety.…”
Get full text

Occurrence of Alternaria Toxins, Ochratoxin A and Aflatoxins B1 in Green Arabic Coffee (Coffea arabica) in Saudi Arabia: Risk Assessment on HepG-2 Cell Line and Male Albino Rats by Ahmed Hashim Almusallam, Ahmed Mahmoud Ismail

“…This indicates that the mixture of AFB1, ALT-Ts and OTA had an enhanced toxic consequence against treated HepG-2 cell line and rats. …”
Get full text

Neuroprotective Actions of Cannabinoids in the Bovine Isolated Retina: Role of Hydrogen Sulfide by Leah Bush, Anthonia Okolie, Jenaye Robinson, Fatima Muili, Catherine A. Opere, Sunny E. Ohia, Ya Fatou Njie Mbye

“…Both hydrogen sulfide and endocannabinoids can protect the neural retina from toxic insults under in vitro and in vivo conditions. …”
Get full text

Chemical Composition and Larvicidal Activity of Flower Extracts from Clitoria ternatea against Aedes (Diptera: Culicidae) by Darvin R. Ravindran, Madhuri Bharathithasan, Patmani Ramaiah, Mohd Sukhairi Mat Rasat, Dinesh Rajendran, Shakila Srikumar, Intan H. Ishak, Abd Rahman Said, Rajiv Ravi, Mohamad Faiz Mohd Amin

“…Moreover, the results for nontarget organism test on guppy fish, Poecilia reticulata, showed no mortalities with flower extracts at 2500 mg/L, hence posing no toxic effects on fish. In this study, we have found a total of 16 chemical compounds and 6 chemical compounds have been reported to possess direct insecticidal, larvicidal, and pupicidal effects. …”
Get full text

Natural Product Identification and Molecular Docking Studies of Leishmania Major Pteridine Reductase Inhibitors by Moses N. Arthur, George Hanson, Emmanuel Broni, Patrick O. Sakyi, Henrietta Mensah-Brown, Whelton A. Miller, Samuel K. Kwofie

“…Crucial to the drug development, the compounds were physiochemically and pharmacologically profiled, narrowing the selection to eight compounds, excluding those with potential toxicities. The five selected compounds ZINC000095486253, ZINC000095486221, ZINC000095486249, 8alpha-hydroxy-13-epi-pimar-16-en-6,18-olide, and pachycladin D were predicted to be antiprotozoal (<i>Leishmania</i>) with Pa values of 0.642, 0.297, 0.543, 0.431, and 0.350, respectively. …”
Get full text