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3581
The Effect of Lipotoxicity on Renal Dysfunction in a Nonobese Rat Model of Metabolic Syndrome: A Urinary Proteomic Approach
Published 2019-01-01“…The development of metabolic syndrome-associated renal dysfunction is exacerbated by a number of factors including dyslipidemia, ectopic deposition of lipids and their toxic metabolites, impairment of lipid metabolism, and insulin resistance. …”
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3582
Nucleotide receptor P2X7/STAT6 pathway regulates macrophage M2 polarization and its application in CAR-T immunotherapy
Published 2025-01-01“…Furthermore, M2 macrophage suppresses the toxic effect of CAR-T cells on OC cells, while silencing the P2X7 receptor nullifies the immunosuppressive effect of M2 macrophages on CAR-T cells. …”
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3583
Cadmium and lead uptake by wild swamp eel in the populous river
Published 2023-07-01“…BACKGROUND AND OBJECTIVES: For enhanced environmental management of the Ciliwung River, toxic pollutions such as cadmium dan lead data are required. …”
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3584
A STUDY OF THE INFLUENCE OF EXTRACELLULAR VESICLES ON THE MORPHOFUNCTIONAL STATE OF THE ENDOMETRIUM IN VITRO
Published 2024-11-01“…It was noted that extracellular vesicles do not have a toxic effect on cell culture. Under the influence of vesicles, the number of cell nuclei increases. …”
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3585
Rapamycin-resistant polyclonal Th1/Tc1 cell therapy (RAPA-201) safely induces disease remissions in relapsed, refractory multiple myeloma
Published 2025-01-01“…Median progression-free survival was 6.0 months (range, 2.1 to>16.8 months). There were no toxicities of any grade attributable to RAPA-201, including no cytokine release syndrome and no immune effector cell-associated neurotoxicity syndrome. …”
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3586
Photochemical oxidation and landfarming as remediation techniques for oil-contaminated soil
Published 2024-01-01“…Natural attenuation takes too long to produce positive results, whereas landfarming can produce toxic intermediates due to the organisms’ inability to degrade other oil components. …”
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3587
The effect of endosulfan bioaccumulation on the growth of carp, Cyprinus carpio LINN.
Published 2009-01-01“…This study resulted that endosulfan was very toxic to the carp with LC50-96h value was 2.42 (2.206-2.652) mg/l. …”
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3588
Primary Terminal Haemochromatosis in a 50 Year-Old Patient
Published 2021-04-01“…The patient had a history of long-term alcohol consumption at toxic doses, putative cirrhosis, paroxysmal atrial fibrillation, type 2 diabetes mellitus. …”
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Buffalo milk quality in southern Italy: trace elements & endocrine disruptors. A One Health analysis
Published 2023-11-01“…Regarding the presence of metals, of the twenty trace elements analysed, only lead is regulated in the EU and no sample exceeded the maximum limit (LM = 0.02 mg/kg). Potentially toxic elements such as chromium (< 0.141 mg/kg), cobalt (< 0.008 mg/kg), manganese (< 0.035 mg/kg), selenium (< 0.044 mg/kg), vanadium (< 0.016 mg/kg), zinc (<4.31 mg/kg) and strontium (< 0.947 mg/kg) have been found in milk at levels that do not constitute a health risk; furthermore their presence could be related to the geographical origin. …”
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3590
Phase 1, open-label, dose-escalation study on the safety, pharmacokinetics, and preliminary efficacy of intravenous Coxsackievirus A21 (V937), with or without pembrolizumab, in pat...
Published 2023-01-01“…Dose-escalation proceeded if no dose-limiting toxicities (DLTs) occurred in cycle 1 of the previous cohort. …”
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3591
Systematic preclinical evaluation of CD33-directed chimeric antigen receptor T cell immunotherapy for acute myeloid leukemia defines optimized construct design
Published 2021-09-01“…Gemtuzumab-based CD33CARTs were unexpectedly toxic in vivo in animal models despite observed in vitro anti-leukemia activity. …”
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3592
Neuroprotective role of epigallocatechin-3-gallate, albeginin and melanoxetin in alzheimer's disease
Published 2025-02-01“…Melanoxetin, a phenolic molecule, chelates toxic metals, lowers ROS, and protects neurons at 15–40 mg/kg/day in animal models and 50–150 mg/day in humans. …”
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3593
Ligilactobacillus salivarius LZZAY01 accelerated autophagy and apoptosis in colon cancer cells and improved gut microbiota in CAC mice
Published 2025-02-01“…However, these treatments are associated with a high recurrence rate, poor prognosis, and highly toxic side effects. The probiotics have the potential to prevent CRC, and they display a favorable safety performance. …”
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3594
Ibrutinib disrupts blood-tumor barrier integrity and prolongs survival in rodent glioma model
Published 2024-04-01“…Our results motivate the need to identify other BTB modifiers, all with the intent of improving survival and reducing systemic toxicities.…”
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3595
A New CYP2E1 Inhibitor, 12-Imidazolyl-1-dodecanol, Represents a Potential Treatment for Hepatocellular Carcinoma
Published 2021-01-01“…This antitumour effect was not associated with tumour cachexia. I-ol was not toxic to healthy tissues or organs. This study demonstrates for the first time the therapeutic effect of the specific CYP2E1 inhibitor I-ol on the tumorigenesis of HCC. …”
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3596
First-in-human phase 1 dose-escalation results with livmoniplimab, an antibody targeting the GARP:TGF-ß1 complex, as monotherapy and in combination with the anti–PD-1 antibody budi...
Published 2024-10-01“…Secondary objectives were to assess safety and pharmacokinetics (PK), and exploratory objectives included evaluating preliminary efficacy.ResultsFifty-seven patients enrolled in the dose escalation: 23 in monotherapy cohorts and 34 in combination therapy cohorts. Dose-limiting toxicities were limited, no maximum tolerated dose was reached, and the maximum administered dose of 1500mg was selected for dose expansion. …”
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3597
Potential impact and mechanism of aged polyethylene microplastics on nitrogen assimilation of Lactuca sativa L.
Published 2025-02-01“…Possible mechanisms included inhibition of carbon assimilation, photosynthesis, and Ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco). The toxic effect of aged MNPs on growth and N assimilation in lettuce was much greater than that of the particle size, which was attributed to the carbonyl and hydroxyl groups caused by aging. …”
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Green synthesis of titanium dioxide photocatalyst using Lactobacillus bulgaricus for processing palm oil mill effluent
Published 2024-01-01“…Testing the titanium dioxide photocatalyst to treat palm oil mill secondary effluent yielded in elimination efficiency of 16.16-27.27 percent for chemical oxygen demand and 11.05-21.95 percent for biological oxygen demand. Phenol, which is toxic and difficult to degrade biologically, could eliminated significantly (up to 81.12 percent) using a photocatalyst dose of 1 gram per liter at a time irradiation of 2.5 hour.CONCLUSION: The biological synthesis of nano titanium dioxide photocatalysts is affected by temperatures and metal oxide concentrations. …”
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