Showing 3,581 - 3,600 results of 3,629 for search '"Toxicity"', query time: 0.07s Refine Results
  1. 3581

    The Effect of Lipotoxicity on Renal Dysfunction in a Nonobese Rat Model of Metabolic Syndrome: A Urinary Proteomic Approach by Irena Markova, Denisa Miklankova, Martina Hüttl, Petr Kacer, Jelena Skibova, Jan Kucera, Radislav Sedlacek, Tereza Kacerova, Ludmila Kazdova, Hana Malinska

    Published 2019-01-01
    “…The development of metabolic syndrome-associated renal dysfunction is exacerbated by a number of factors including dyslipidemia, ectopic deposition of lipids and their toxic metabolites, impairment of lipid metabolism, and insulin resistance. …”
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  2. 3582

    Nucleotide receptor P2X7/STAT6 pathway regulates macrophage M2 polarization and its application in CAR-T immunotherapy by Qin Si, Lu Yang, Jie Liu, Hui Liu, Ruifang Bu, Na Cui

    Published 2025-01-01
    “…Furthermore, M2 macrophage suppresses the toxic effect of CAR-T cells on OC cells, while silencing the P2X7 receptor nullifies the immunosuppressive effect of M2 macrophages on CAR-T cells. …”
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  3. 3583

    Cadmium and lead uptake by wild swamp eel in the populous river by N. Nurhasanah, L. Sulistyowati, E. Riani, M. Cordova

    Published 2023-07-01
    “…BACKGROUND AND OBJECTIVES: For enhanced environmental management of the Ciliwung River, toxic pollutions such as cadmium dan lead data are required. …”
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  4. 3584
  5. 3585

    Rapamycin-resistant polyclonal Th1/Tc1 cell therapy (RAPA-201) safely induces disease remissions in relapsed, refractory multiple myeloma by Lawrence G Lum, Parameswaran Hari, Aniko Szabo, Michele Donato, Jee Hyun Park, Daniel H Fowler, Binod Dhakal, Saurabh Chhabra, Deborah D Glass, David S Siegel, Tania C Felizardo

    Published 2025-01-01
    “…Median progression-free survival was 6.0 months (range, 2.1 to>16.8 months). There were no toxicities of any grade attributable to RAPA-201, including no cytokine release syndrome and no immune effector cell-associated neurotoxicity syndrome. …”
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  6. 3586

    Photochemical oxidation and landfarming as remediation techniques for oil-contaminated soil by M. Mambwe, K.K. Kalebaila, T. Johnson

    Published 2024-01-01
    “…Natural attenuation takes too long to produce positive results, whereas landfarming can produce toxic intermediates due to the organisms’ inability to degrade other oil components. …”
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  7. 3587

    The effect of endosulfan bioaccumulation on the growth of carp, Cyprinus carpio LINN. by Imam Taufik, E. Supriyono, K. Nirmala

    Published 2009-01-01
    “…This study resulted that endosulfan was very toxic to the carp with LC50-96h value was 2.42 (2.206-2.652) mg/l. …”
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  8. 3588

    Primary Terminal Haemochromatosis in a 50 Year-Old Patient by M. I. Gonik, M. S. Zharkova, O. Yu. Kiseleva, E. V. Berezina, Sh. A. Ondos, Yu. V. Lerner, E. A. Kogan, V. T. Ivashkin

    Published 2021-04-01
    “…The patient had a history of long-term alcohol consumption at toxic doses, putative cirrhosis, paroxysmal atrial fibrillation, type 2 diabetes mellitus. …”
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  9. 3589

    Buffalo milk quality in southern Italy: trace elements & endocrine disruptors. A One Health analysis by Luigi Jacopo D’Auria

    Published 2023-11-01
    “…Regarding the presence of metals, of the twenty trace elements analysed, only lead is regulated in the EU and no sample exceeded the maximum limit (LM = 0.02 mg/kg). Potentially toxic elements such as chromium (< 0.141 mg/kg), cobalt (< 0.008 mg/kg), manganese (< 0.035 mg/kg), selenium (< 0.044 mg/kg), vanadium (< 0.016 mg/kg), zinc (<4.31 mg/kg) and strontium (< 0.947 mg/kg) have been found in milk at levels that do not constitute a health risk; furthermore their presence could be related to the geographical origin. …”
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  10. 3590
  11. 3591
  12. 3592

    Neuroprotective role of epigallocatechin-3-gallate, albeginin and melanoxetin in alzheimer's disease by Arif Malik, Mehreen Hassan, Sulayman Waquar, Muhammad Wasim, Anam Naz, Faryal M. Awan, Muhammad T. Khan, Ali I. Khawaja, Sumera Zaib, Jamshed Iqbal, Ayesha Zahid, Marvi Marvi, Javeid Iqbal, Heng Wang, Dong-Qing Wei

    Published 2025-02-01
    “…Melanoxetin, a phenolic molecule, chelates toxic metals, lowers ROS, and protects neurons at 15–40 mg/kg/day in animal models and 50–150 mg/day in humans. …”
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  13. 3593

    Ligilactobacillus salivarius LZZAY01 accelerated autophagy and apoptosis in colon cancer cells and improved gut microbiota in CAC mice by Wenhong Yang, Tao Li, Shixiang An, Rong Chen, Yuxin Zhao, Jiaxian Cui, Mingyu Zhang, Jingkun Lu, Yunpeng Tian, Lili Bao, Pengwei Zhao

    Published 2025-02-01
    “…However, these treatments are associated with a high recurrence rate, poor prognosis, and highly toxic side effects. The probiotics have the potential to prevent CRC, and they display a favorable safety performance. …”
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  14. 3594
  15. 3595

    A New CYP2E1 Inhibitor, 12-Imidazolyl-1-dodecanol, Represents a Potential Treatment for Hepatocellular Carcinoma by Torsten Diesinger, Alfred Lautwein, Sebastian Bergler, Dominik Buckert, Christian Renz, Radovan Dvorsky, Vyacheslav Buko, Siarhei Kirko, Edith Schneider, Florian Kuchenbauer, Mukesh Kumar, Cagatay Günes, Felicitas Genze, Berthold Büchele, Thomas Simmet, Martin Haslbeck, Kai Masur, Thomas Barth, Dieter Müller-Enoch, Thomas Wirth, Thomas Haehner

    Published 2021-01-01
    “…This antitumour effect was not associated with tumour cachexia. I-ol was not toxic to healthy tissues or organs. This study demonstrates for the first time the therapeutic effect of the specific CYP2E1 inhibitor I-ol on the tumorigenesis of HCC. …”
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  16. 3596

    First-in-human phase 1 dose-escalation results with livmoniplimab, an antibody targeting the GARP:TGF-ß1 complex, as monotherapy and in combination with the anti–PD-1 antibody budi... by Toshio Shimizu, Toshio Shimizu, John Powderly, Albiruni Abdul Razak, Patricia LoRusso, Kathy D. Miller, Steven Kao, Sarah Kongpachith, Catherine Tribouley, Michelle Graham, Brian Stoll, Maulik Patel, Mohammad Sahtout, Martha Blaney, Rachel Leibman, Talia Golan, Talia Golan, Anthony Tolcher

    Published 2024-10-01
    “…Secondary objectives were to assess safety and pharmacokinetics (PK), and exploratory objectives included evaluating preliminary efficacy.ResultsFifty-seven patients enrolled in the dose escalation: 23 in monotherapy cohorts and 34 in combination therapy cohorts. Dose-limiting toxicities were limited, no maximum tolerated dose was reached, and the maximum administered dose of 1500mg was selected for dose expansion. …”
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  17. 3597

    Potential impact and mechanism of aged polyethylene microplastics on nitrogen assimilation of Lactuca sativa L. by Xiaoli Mou, Hedong Zhu, Renrui Dai, Li Lu, Shengqi Qi, Min Zhu, Yuyang Long, Nan Ma, Chao Chen, Jiali Shentu

    Published 2025-02-01
    “…Possible mechanisms included inhibition of carbon assimilation, photosynthesis, and Ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco). The toxic effect of aged MNPs on growth and N assimilation in lettuce was much greater than that of the particle size, which was attributed to the carbonyl and hydroxyl groups caused by aging. …”
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  18. 3598

    Social problems and the quality of life / by Lauer, Robert H., Lauer, Jeanette C.

    Published 2023
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  19. 3599

    Social problems and the quality of life / by Lauer, Robert H., Lauer, Jeanette C.

    Published 2023
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  20. 3600

    Green synthesis of titanium dioxide photocatalyst using Lactobacillus bulgaricus for processing palm oil mill effluent by L. Agustina, M. Romli, P. Suryadarma, S. Suprihatin

    Published 2024-01-01
    “…Testing the titanium dioxide photocatalyst to treat palm oil mill secondary effluent yielded in elimination efficiency of 16.16-27.27 percent for chemical oxygen demand and 11.05-21.95 percent for biological oxygen demand. Phenol, which is toxic and difficult to degrade biologically, could eliminated significantly (up to 81.12 percent) using a photocatalyst dose of 1 gram per liter at a time irradiation of 2.5 hour.CONCLUSION: The biological synthesis of nano titanium dioxide photocatalysts is affected by temperatures and metal oxide concentrations. …”
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