Real-World Data for Lenvatinib in Radioiodine-Refractory Differentiated Thyroid Cancer (RELEVANT): A Retrospective Multicentric Analysis of Clinical Practice in Austria by G. Rendl, B. Sipos, A. Becherer, S. Sorko, C. Trummer, M. Raderer, W. Hitzl, M. Ardelt, H. J. Gallowitsch, C. Pirich

“…Dose reduction was noted in 39 patients (91%). Grade ≥3 toxicities (hypertension, diarrhea, weight loss, and palmar-plantar erythrodysesthesia syndrome) were most common leading to discontinuation of lenvatinib in 7 patients (16%). …”
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Hepatic Stellate Cell-Derived Microvesicles Prevent Hepatocytes from Injury Induced by APAP/H2O2 by Renwei Huang, Qunwen Pan, Xiaotang Ma, Yan Wang, Yaolong Liang, Bingyan Dai, Xiaorong Liao, Mingyi Li, Huilai Miao

“…Our results demonstrate that HSC-derived MVs protect hepatocytes from toxicant-induced injury.…”
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A Cell-Based Evaluation of the Tyrosinase-Mediated Metabolic Activation of Leukoderma-Inducing Phenols, II: The Depletion of <i>Nrf2</i> Augments the Cytotoxic Effect Evoked by Tyr... by Tomoko Nishimaki-Mogami, Shosuke Ito, Kazumasa Wakamatsu, Takumi Akiyama, Norimasa Tamehiro, Norihito Shibata

“…These compounds possess a <i>p</i>-substituted phenol moiety and undergo oxidation into highly reactive and toxic <i>o</i>-quinone metabolites by tyrosinase. …”
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Lymphocyte Oxidative Stress/Genotoxic Effects Are Related to Serum IgG and IgA Levels in Coke Oven Workers by Meili Gao, Yongfei Li, Aqun Zheng, Xiaochang Xue, Lan Chen, Yu Kong

“…These data suggest that oxidative stress/DNA damage induced by PAHs may play a role in toxic responses for PAHs in immunological functions.…”
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The Fungi-specific histone Acetyltransferase Rtt109 mediates morphogenesis, Aflatoxin synthesis and pathogenicity in Aspergillus flavus by acetylating H3K9 by Ruilin Sun, Meifang Wen, Lianghuan Wu, Huahui Lan, Jun Yuan, Shihua Wang

“…Abstract Aspergillus flavus is a common saprophytic filamentous fungus that produces the highly toxic natural compound aflatoxin during its growth process. …”
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Development of Collagen-Based 3D Matrix for Gastrointestinal Tract-Derived Organoid Culture by Joo Hyun Jee, Dong Hyeon Lee, Jisu Ko, Soojung Hahn, Sang Yun Jeong, Han Kyung Kim, Enoch Park, Seon Young Choi, Sukin Jeong, Joong Woon Lee, Han-Jun Cho, Min-Soo Kwon, Jongman Yoo

“…On the other hand, natural characteristics of collagen emphasize toxic-free friendly niche to both organoid and normal tissue. …”
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Effectiveness of purple leaves (Graptophyllum pictum L. Griff) and hydroxyapatite as socket preservation biomaterials by Ratri Maya Sitalaksmi, Rizkipriyanto Azharpratomo, Shafira Ninditya Irsan, Primanda Nur Rahmania, Sisca Meida Wati, Syafira Salsabila Adam, Kavanila Bilbalqish, Khairul Anuar bin Shariff, Harry Laksono, Agus Dahlan, Devi Rianti

“…Purple leaves contains flavonoids, steroids, tannins, saponins,and non-toxic alkaloids. These compounds play roles as antimicrobials, immunomodulators, antioxidants, anti-inflammatories, analgesics. …”
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Significant role of anionic behavior of cocoyl glutamate on lead(II) ion adsorption towards activated carbon adsorbent from cigarette butts by Moh Zeinur Ridho, Retno Pertiwi, Eldo Delta Bagaskara, Raya Rambu Rambani, Chika Synthia Pitaloka, Fanta Mei Wahyuni, Istiqomah Rahmawati, Muhammad Reza

“…Cigarette butts are one of the most abundant waste in the world, being dangerous due to non-biodegradable behavior and highly toxic. Cigarette butts can be converted to activated carbon (CA) which can be used as an adsorbent. …”
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Switch of phosphorylation to O-GlcNAcylation of AhR contributes to vascular oxidative stress induced by benzo[a]pyrene by Rong Wang, Yun Huang, Xiaoruo Gan, Chenghao Fu, Yuemin Li, Ning Chen, Hao Xi, Huishan Guo, Wei Zhang, Yuhong Lü, Yan Zhang, Pin Lü

“…Benzo[a]pyrene (B[a]P) is a food contaminant toxic for cardiovascular diseases. The nuclear translocation of Arylhydrocarbon receptor (AhR) plays an important role in B[a]P-induced oxidative stress and vascular diseases. …”
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Sun-Drying and Melatonin Treatment Effects on Apricot Color, Phytochemical, and Antioxidant Properties by Rukiye Zengin, Yılmaz Uğur, Yasemin Levent, Selim Erdoğan, Harlene Hatterman-Valenti, Ozkan Kaya

“…These findings suggest promising applications for commercial-scale implementation through either dipping or spraying methods. The non-toxic nature of melatonin and its demonstrated efficacy in preserving fruit quality parameters position it as a valuable post-harvest treatment option in the fruit supply chain. …”
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Combined exposure to mixed brominated flame retardants on obstructive sleep apnea syndrome in US adults by Junping Liu, Zhaoyue Liu, Xinru Liu, Nan Wang, Lin Wu, Xiaoxue Xu, Wei Liu, Yajie Feng, Huanyu Zhang, Yue Zhou, Xinle Yin, Yaping Liu, Qunhong Wu, Ning Ning, Libo Liang

“…Results Serum BFRs, including PBDE28, PBDE47, PBDE99, PBDE100, and PBB153, showed positive correlations with the OSAS risk. The toxic effect of serum BFRs co-exposure on OSAS risk was consistently demonstrated through the results of WQS regression, QGC and BKMR models. …”
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Species-specific mercury speciation in billfishes and its implications for food safety monitoring and dietary advice by Anaïs Médieu, David Point, Valérie Allain, Nathalie Bodin, Mélanie Lemire, Pierre Ayotte, Zahirah Dhurmeea, Matthieu Waeles, Laure Laffont, Antoine Le Gohalen, François Roupsard, Anne Lorrain

“…Humans are exposed to toxic methylmercury mainly by consuming marine fish, in particular top predator species like billfishes or tunas. …”
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TMEM45A enhances palbociclib resistance and cellular glycolysis by activating AKT/mTOR signaling pathway in HR+ breast cancer by Cui Chen, Zehong Chen, Jinze Zhao, Xinyun Wen, Hanming Yao, Zijin Weng, Huiping Xiong, Zongheng Zheng, Juekun Wu

“…Additionally, the use of engineered exosomes loaded with siRNA targeting TMEM45A presents a promising strategy for enhancing CDK4/6 inhibitor sensitivity without observable toxic side effects in a patient-derived xenograft (PDX) model. …”
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Selection of an optimal method for screening the collection of narrow-leaved lupine held by the Vavilov Institute for the qualitative and quantitative composition of seed alkaloids by A. V. Kushnareva, Т. V. Shelengа, I. N. Perchuk, G. P. Egorova, L. L. Malyshev, Yu. A. Kerv, A. L. Shavarda, M. A. Vishnyakova

“…However, the presence of secondary metabolites – alkaloids – in lupine seeds considerably affects the quality of raw produce, reducing its nutritive value; in addition, high concentrations of alkaloids are toxic to humans and animals. Therefore, plant breeders working with lupine need to gain knowledge about the variability of alkaloid content in seeds of different genotypes and search for the sources of their low concentrations in the crop’s gene pool. …”
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Omega-3 fatty acids: molecular weapons against chemoresistance in breast cancer by Vittoria Marchio, Giuseppina Augimeri, Catia Morelli, Adele Vivacqua, Cinzia Giordano, Stefania Catalano, Diego Sisci, Ines Barone, Daniela Bonofiglio

“…Omega-3 (ω-3) polyunsaturated fatty acids (PUFAs), including docosahexaenoic and eicosapentaenoic acids, have drawn attention for their antitumoral properties and their preventive activities against chemotherapy-induced toxicities in breast cancer. A literature review was conducted on PubMed using keywords related to breast cancer, omega-3, chemoresistance, and chemotherapy. …”
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Mercury Vapour Long-Lasting Exposure: Lymphocyte Muscarinic Receptors as Neurochemical Markers of Accidental Intoxication by E. Roda, A. Giampreti, S. Vecchio, P. Apostoli, T. Coccini

“…A 72-year-old man with polyneuropathy of suspected toxic origin. At hospitalization, toxicological clinical evaluations confirmed the altered neurological picture documented across the last decade. …”
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Targeting transforming growth factor-β1 by methylseleninic acid/seleno-L-methionine in clear cell renal cell carcinoma: Mechanisms and therapeutic potential by Aseel O. Rataan, Yan Xu, Sean M. Geary, Yousef Zakharia, Eman S. Kamel, Youcef M. Rustum, Aliasger K. Salem

“…Seleno-L-methionine (SLM) treatment in a nude mouse xenograft model showed a significant tumor growth inhibition and TGF-β1 downregulation at non-toxic doses. These findings suggest that selenium-mediated downregulation of TGF-β1, PD-L1, and VEGF could be a viable therapeutic strategy for ccRCC.…”
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Cigarette and e-cigarette reversely regulated autophagy via distinct level of ROS in vitro by Yao Wang, Jialing Zhong, Zuyi Jin, An Luo, Zehong Wu, Xingtao Jiang, Jianwen Chen, Peiqing Liu, Min Li

“…This study aimed to compare the cytotoxicity of conventional cigarettes and e-cigarettes, identify the toxic components of e-cigarettes, and explore the mechanisms of cellular injury. …”
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Comparative anti-methanogenic ability of green algae (C. reinhardtii) with/without nanoparticles: in vitro gas and methane production by Valiollah Palangi, Adem Kaya, Muhlis Macit, Hayrunnisa Nadaroglu, Hayrullah Bora Ünlü, Ali Kaya, Ashkan Fekri, Ayaz Mammadov, Maximilian Lackner

“…The green algal plant (C. reinhardtii), which has many non-toxic antioxidants, was used as a carbon source to produce carbon quantum dots (CQD). …”
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Effect of fungicides on soil respiration, microbial community, and enzyme activity: A global meta-analysis (1975–2024) by Zikai Wang, Shourong Yun, Yuli An, Liulingqian Shu, Shunjin Li, Kai Sun, Wei Zhang

“…Overall, fungicides inhibit the abundance, diversity, and enzyme activity of soil microorganisms; however, precise control of fungicide dosage is essential to minimize their toxic effects on soil.…”
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