A review on intrathecal administration of medications for leptomeningeal metastases in solid tumors by Xuemei Wang, Chi Yao, Li Quan, Junxiang Zhou

“…It is hoped that future research will focus on exploring more potentially effective anti-tumor drugs for IT treatment, conducting in-depth pharmacokinetic studies, and developing long-acting and low-toxic IT administration regimens for the treatment of meningeal metastases.…”
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Effect Of Zinc And Ingredients Of Protein Supplement On Sperm Parameters And Male Reproductive Hormones- An RCT Study by Saira Safdar, Irfan Afzal Mughal, Noor Ul Ain, Sidra Jabeen, Muhammad Hassaan Farooq, Asma Irfan

“… Objective: The purpose of this study was to assess the protective effects of zinc against injury to sperm parameters and male reproductive hormones brought on by toxic protein supplement constituents. Methods: 30 male Sprague Dawley rats were used in the study, of which 10 were in Group 1 (given standard laboratory food), 10 were in Group 2, fed standard laboratory food nutritional supplement powder and 10 were in Group 3, fed standard laboratory food, nutritional supplement powder and zinc. …”
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Optimization of the DNA isolation procedure for assessing the genetic diversity of essential oil roses (<i>Rosa</i> L.) by S. B. Seitadzhieva, S. Z. Guchetl, S. V. Didovich, E. V. Gorodnyaya

“…High content of organic compounds that worsen nucleic acid purification in aromatic plants, as well as the use of such toxic substances as phenol and mercaptoethanol in many protocols for plant DNA isolation, make it advisable to take the above disadvantages into account when optimizing the DNA extraction technique for the work with essential oil rose plants. …”
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Preparation of ZnAl layered double hydroxides supported by silica for the treatment of Cr(VI) and Cu(II) in aqueous solution by Fengrong Zhang, Luxing Liu, Cuilan Zhang, Dawei Shang, Lishun Wu

“…The adsorption properties of ZA/SiO2 for the removal of toxic metal ions (Cu(II) and Cr(VI)) from water were evaluated. …”
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The Protective Effect of Naringin against Bleomycin-Induced Pulmonary Fibrosis in Wistar Rats by Nergiz H. Turgut, Haki Kara, Sahende Elagoz, Koksal Deveci, Huseyin Gungor, Emre Arslanbas

“…These results show that naringin has the potential of reducing the toxic effects of bleomycin and may provide supportive therapy for conventional treatment methods for idiopathic pulmonary fibrosis.…”
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Respirable Particles and Gas Contaminants Emissions from a Desktop Laser Cutter and Engraver by Kevin O’Neill, Xinyi Niu, Jun Wang, Runcheng Fang

“…These contaminants include respirable particulates, volatile organic compounds (VOCs), and other toxic substances that pose health risks to humans. …”
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Structural, Optical, Antibacterial, and Anticancer Properties of Cerium Oxide Nanoparticles Prepared by Green Synthesis Using Morinda citrifolia Leaves Extract by Abozer Y. Elderdery, Badr Alzahrani, Abdulrahim A. Alabdulsalam, Siddiqa M. A. Hamza, Ahmed M. E. Elkhalifa, Abdulaziz H. Alhamidi, Fehaid Alanazi, A. Mohamedain, Suresh Kumar Subbiah, Pooi Ling Mok

“…Green synthesis of nanoparticles is preferred to make it more economical, eco-friendly, and less toxic. The aim of our study here is to formulate the CeO2 NPs (CeO2 NPs) using Morinda citrifolia (Noni) leaf extract and study its optical, structural, antibacterial, and anticancer abilities. …”
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A Rare Case of Large-Vessel Vasculitis following Checkpoint Inhibitor Therapy and Pegfilgrastim by Joseph Mort, Shipra Maheshwari, Nayanika Basu, Patrick Dillon, Kevin Brady, Harry Bear, Trish Millard

“…Immune-related adverse events (irAEs) such as colitis and pneumonitis are well-established toxicities associated with CPI therapy. However, large-vessel vasculitis secondary to CPI utilization is reported only in rare case reports and case series. …”
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Hiper IgE dengan Nekrolisis Epidermal Toksik by Adrian Ramdhany, Raveinal Raveinal

“…Akibatnya, istilah-istilah seperti ‘staphylococcal-induced toxic epidermal necrolysis’ dan ‘drug-induced scalded skin syndrome’ menang selama beberapa dekade, tetapi sekarang dipisahkan karena terapi dan prognosisnya berbeda. …”
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Safety, Tolerability, and Pharmacokinetics of NIM‐1324 an Oral LANCL2 Agonist in a Randomized, Double‐Blind, Placebo‐Controlled Phase I Clinical Trial by Andrew Leber, Raquel Hontecillas, Nuria Tubau‐Juni, Josep Bassaganya‐Riera

“…In conclusion, NIM‐1324 treatment is well‐tolerated up to daily oral doses of at least 1500 mg (nominal), a ≥ six‐fold margin over the anticipated therapeutic dose, and 1000 mg (maximum observed exposure), at least a four‐fold margin over the anticipated therapeutic dose with no dose limiting toxicities.…”
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Characterization of Patients with Acute Myocardial Infarction Treated at the General University Hospital Dr. Gustavo Aldereguía Lima by Edislaimy Suárez Rosales, Rodolfo Javier Rivero Morey, Lourdes María Roca Surí, Francisco de Jesús Valladares Carvajal, Evelyn Delgado Rodríguez, Lourdes María Fernández García

“…Variables such as: age, sex, skin color, origin, comorbidities, toxic habits, clinical manifestations, thrombolysis, place where they were thrombolyzed, causes of non-thrombolysis, topography of acute myocardial infarction, discharge status, infarction complications and of thrombolytic treatment. …”
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Modeling of genetic processes underlying the development of resistance to fipronil in the Colorado potato beetle (Leptinotarsa decemlineata Say) by K. A. Kitaev, I. S. Mardanshin, E. V. Surina, T. I. Leontieva, M. B. Udalov, G. V. Benkovskaya

“…Calculations of the survival rates of Colorado potato beetle individuals were carried out taking into account the statistical regularities of the distribution of the toxic substance after treatment by insecticides. …”
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Re‐evaluation of butane (E 943a), isobutane (E 943b) and propane (E 944) as food additives by EFSA Panel on Food Additives and Flavourings (FAF), Laurence Castle, Monica Andreassen, Gabriele Aquilina, Maria Bastos, Polly Boon, Biagio Fallico, Reginald Fitzgerald, Maria Jose Frutos Fernandez, Bettina Grasl‐Kraupp, Ursula Gundert‐Remy, Rainer Gürtler, Eric Houdeau, Marcin Kurek, Henriqueta Louro, Patricia Morales, Sabina Passamonti, Gabriele Gagliardi, Salvatore Multari, Josef Daniel Rasinger, Ana Maria Rincon, Camilla Smeraldi

“…Existing EU specifications for the three food additives already contain limits for the toxic impurity 1,3‐butadiene (1,3‐BD), however due to a lack of information on the manufacturing processes used, uncertainties do remain regarding the potential presence of other impurities not listed in the current EU specifications for food additives. …”
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Screening of Active Components and Key Targets of Radix Codonopsis in the Treatment of Gastric Cancer by Lijun Tang, Jinhui Chen, Jin Yin, Mingli Fang

“…However, chemotherapy drugs will cause serious toxic and side effects on other normal tissues and cells. …”
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Transgenic plants as genetic models for studying functions of plant genes by A. V. Kochetov, V. K. Shumny

“…It was also found that these plants were more tolerant to various abiotic stresses (drought, NaCl, cold, toxic heavy metals), which may result from the protective proline effect early in exposure to stress, preventing the cellular gene expression machinery from damage by stress-generated free radicals.…”
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Dynamics of REL, RELA and IRF1 transcription factor expression in U937 macrophages after dioxin exposure by E. V. Kashina, D. Y. Oshchepkov, E. V. Antontseva, M. Y. Shamanina, D. P. Furman, V. A. Mordvinov

“…The aryl hydrocarbon receptor (AhR), a ligand- activated transcription factor, participates in a wide range of critical cellular events in response to endogenous signals or xenobiotic chemicals. 2,3,7,8-tetrachlorodibenzo-para-dioxin (TCDD) is one of the AhR ligands with a very high binding affinity for the AhR. TCDD is the most toxic among the dioxin xenobiotics and induces a broad spectrum of biological responses, including immunotoxicity and cancer. …”
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Molecular identification and phylogenetic relationship of Bangladeshi pufferfish based on mitochondrial COI and 16S rRNA genes by Md Sagir Ahmed, Nafisa Islam, Durjoy Raha Antu, Mysha Mahjabin, Sujan Kumar Datta, Osamu Arakawa

“…Pufferfish poisoning sporadically occurs due to the consumption of toxic pufferfish throughout the country. Identification of pufferfish is challenging and/or misleading, based on only morphometric characteristics. …”
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A parallel bioreactor strategy to rapidly determine growth-coupling relationships for bioproduction: a mevalonate case study by Alec Banner, Joseph Webb, Nigel Scrutton

“…However, this process also led to the formation of the toxic byproduct acetate, which can slow growth and cause problems during downstream processing. …”
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Synthesis, in vitro safety and antioxidant activity of new pyrrole hydrazones by Tzankova Diana, Vladimirova Stanislava, Aluani Denitsa, Yordanov Yordan, Peikova Lily, Georgieva Maya

“…The initial in vitro safety screening for cytotoxicity (on HepG2 cells) and hemocompatibility (hemolysis assay) showed good safety of the new compounds, where ethyl 5-(4-bromophenyl)-1-(1-(2-(4-hydroxy-3-methoxybenzylidene)-hydrazineyl)-1-oxo-3-phenylpropan-2-yl)-2-methyl-1H-pyr-role-3-carboxylate (4d) and ethyl 5-(4-bromophenyl)-1-(1-(2-(2-hydroxybenzylidene)hydrazineyl)-1-oxo-3-phenylpropan--2-yl)-2-methyl-1H-pyrrole-3-carboxylate (4a) were the least toxic. The antioxidant activity in terms of radical scavenging activity (DPPH test) and reducing ability (ABTS) was also evaluated. …”
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Histopathological and Biochemical Assessment of Neuroprotective Effects of Sodium Valproate and Lutein on the Pilocarpine Albino Rat Model of Epilepsy by Aziza Rashed Al-Rafiah, Khlood Mohammed Mehdar

“…Sodium valproate (SVP) is a commonly used antiepileptic drug (AED); however, it has toxic effects. Lutein (L), a carotenoid, has potent antioxidant and anti-inflammatory properties. …”
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