Development of Duloxetine Hydrochloride Tablets for Delayed and Complete Release Using Eudragit L 100 by M. Yasmin Begum, Ali Alqahtani, Mohammed Ghazwani, Noura Abdullah Alhamood, Umme Hani, Avanthi Jajala, Mohamed Rahamathulla

“…Duloxetine HCl produces a toxic substance called alpha-naphthol when duloxetine HCl is in contact with gastric fluid. …”
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Effect of Food on the Steady-State Pharmacokinetics of Tenofovir and Emtricitabine plus Efavirenz in Ugandan Adults by Mohammed Lamorde, Pauline Byakika-Kibwika, William S. Tamale, Francis Kiweewa, Mairin Ryan, Alieu Amara, John Tjia, David Back, Saye Khoo, Marta Boffito, Cissy Kityo, Concepta Merry

“…The FDC should be taken without food by patients experiencing central nervous system toxicities.…”
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Two Birds With One Stone: A Novel Nanocomposite Combining Silicon Nanoparticles and Carbon‐Doped Titania as the Fluorescence Probe and Visible Light Photocatalyst for Simultaneous... by Liyun Ma, Zhi Li, Yiyi Shi, Yuchen Xie, Ming Jiang, Xu Yu, Li Xu

“…This process is driven by the superoxide radicals, holes and hydroxyl radicals produced by C‐TiO2/SiNPs under visible light irradiation. The total toxicities obviously reduce after OTC is degraded by C‐TiO2/SiNPs. …”
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Design of the Multi-Bioactive Graphene-Oxide/Gelatin/Alginate Scaffolds as Dual ECM-Mimetic and Specific Wound Healing Phase-Target Therapeutic Concept for Advanced Wound Healing by Marko Demenj, Martina Žabčić, Marija Vukomanović, Tatjana Ilić-Tomić, Dušan Milivojević, Simonida Tomić, Dubravka Živanović, Marija M. Babić Radić

“…No mortality was detected among the <i>Caenorhabditis elegans</i> throughout the incubation period, indicating that the scaffolds are not toxic. The results of in vitro release study of allantoin, quercetin, and caffeic acid confirm the scaffolds’ significant potential for simultaneous release. …”
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The abundance of microplastics in coral reef ecosystems in the waters of Krueng Raya, Aceh Besar by Ulfah Maria, Juliani Rika, Agustina Sri, Purnawan Syahrul, Malayana Intan, Muliari, Miswari Nur, Yusrizal, Irfannur

“…Microplastics have the potential to disrupt the balance of marine ecosystems due to their non-degradable and toxic nature to organisms. This study aims to analyze the abundance and types of microplastics in sediment from coral reef ecosystems at three locations in Krueng Raya waters (Inong Bale, Ahmad Rhang Manyang, and Lhok Mee) and evaluate the correlation between microplastic abundance and live coral conditions. …”
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Reduced Cardiovascular Capacity and Resting Metabolic Rate in Men with Prostate Cancer Undergoing Androgen Deprivation: A Comprehensive Cross-Sectional Investigation by Bradley A. Wall, Daniel A. Galvão, Naeem Fatehee, Dennis R. Taaffe, Nigel Spry, David Joseph, Robert U. Newton

“…To investigate if androgen deprivation therapy exposure is associated with additional risk factors for cardiovascular disease and metabolic treatment-related toxicities. Methods. One hundred and seven men (42–89 years) with prostate cancer undergoing androgen deprivation therapy completed a maximal graded objective exercise test to determine maximal oxygen uptake, assessments for resting metabolic rate, body composition, blood pressure and arterial stiffness, and blood biomarker analysis. …”
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Proteostasis Decline and Redox Imbalance in Age-Related Diseases: The Therapeutic Potential of NRF2 by Brigitta Buttari, Antonella Tramutola, Ana I. Rojo, Niki Chondrogianni, Sarmistha Saha, Alessandra Berry, Letizia Giona, Joana P. Miranda, Elisabetta Profumo, Sergio Davinelli, Andreas Daiber, Antonio Cuadrado, Fabio Di Domenico

“…This process facilitates the clearance of toxic protein aggregates, thereby actively maintaining cellular proteostasis. …”
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Evaluation of Bioactive Compounds and Chemical Elements in Herbs: Effectiveness of Choline Chloride-Based Deep Eutectic Solvents in Ultrasound-Assisted Extraction by Aleksandra Szydłowska-Czerniak, Agnieszka Kowaluk, Michał Strzelec, Tomasz Sawicki, Małgorzata Tańska

“…Additionally, macroelements (K, Na, Ca, Mg), micronutrients (Mn, Zn, Fe, Cu), and a toxic element (Cd) in four herbs were analyzed using inductively coupled plasma–mass spectrometry (ICP–MS). …”
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Protective Effect of Melatonin on Acute Pancreatitis by Jolanta Jaworek, Joanna Szklarczyk, Andrzej K. Jaworek, Katarzyna Nawrot-Porąbka, Anna Leja-Szpak, Joanna Bonior, Michalina Kot

“…The beneficial effect of melatonin on acute pancreatitis, which has been reported in many experimental studies and supported by clinical observations, is related to: (1) enhancement of antioxidant defense of the pancreatic tissue, through direct scavenging of toxic radical oxygen (ROS) and nitrogen (RNS) species, (2) preservation of the activity of antioxidant enzymes; such as superoxide dismutase (SOD), catalase (CAT), or glutathione peroxidase (GPx), (3) the decline of pro-inflammatory cytokine tumor necrosis α (TNFα) production, accompanied by stimulation of an anti-inflammatory IL-10, (4) improvement of pancreatic blood flow and decrease of neutrophil infiltration, (5) reduction of apoptosis and necrosis in the inflamed pancreatic tissue, (6) increased production of chaperon protein (HSP60), and (7) promotion of regenerative process in the pancreas. …”
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Li-doped C20 nanocage and its derivatives for gas sensing application: A density functional theory study by Poonam Parkar, Mohsen Doust Mohammadi, Ajay Chaudhari

“…The derivatives of C20 considered are either B-substituted, N-substituted or B and N co-substituted C20 Nanocages. Toxic gases H2S and NH3, were selected for evaluation. …”
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Silicon and Phosphorus Co-doping of Aluminium Nitride Nanotube (SiP-AlNNT) as Sensors for Polycyclic Aromatic Hydrocarbon Fuel Pollutants: A Computational Approach by Musa Runde, Uzairu Muhammad Sada, Friday Odey Izachi, Odey S. Eburu, Anthony M.S. Pembere

“…PAHs are mostly present in high concentrations in soils which are associated with industrial activities and are of concern due to their carcinogenic and toxic effects. With these growing industrial activities, developing alternative methods to mitigate the increasing negative effects caused by PAHs is considered a necessity. …”
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Use of Hybrid Flame Retardants in Chemically Foamed rPET Blends by Veronika Anna Szabó, Sándor Kálmán Jakab, András Kovács, Tamara Zsuzsanna Böcz, Gábor Dogossy

“…The utilization of halogen-free flame retardants is beneficial for better air quality, reducing toxic gas and smoke emissions.…”
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In Vitro Cadmium-Induced Alterations in Growth and Oxidative Metabolism of Upland Cotton (Gossypium hirsutum L.) by M. K. Daud, Lei Mei, Ullah Najeeb, Muhammad Azim Khan, Farah Deeba, Irum Raza, Aliya Batool, S. J. Zhu

“…Cadmium (Cd) is a toxic pollutant, which cause both dose- and time-dependent physiological and biochemical alterations in plants. …”
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An assessment of circulating biomarkers and germline genetic variants in predicting chemotherapy associated mucositis in Ewing sarcoma by Pawan Gulati, Vickyanne Carruthers, Claire Hutton, Chloe Cassidy, Edward B. Amankwatia, Séréna Pascual, Electra Florence, Tsegay G. Gebru, Andrea L. Jorgensen, Alastair Greystoke, Guy Makin, Martin G. McCabe, Daniel B. Hawcutt, Gareth J. Veal, David Jamieson

“…Background: Treatment of Ewing sarcoma is associated with severe toxicities including chemotherapy-induced mucositis. …”
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High throughput microwell spectrophotometric assay for olmesartan medoxomil in tablets based on its charge-transfer reaction with DDQ by Darwish Ibrahim A., Wani Tanveer A., Khalil Nasr Y., Abdel-Rahman Hamdy M.

“…It thus offers a reduction in the exposure of analysts to the toxic effects of organic solvents, as well as a reduction in the cost of analysis.…”
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Biological Characteristics of Fluorescent Superparamagnetic Iron Oxide Labeled Human Dental Pulp Stem Cells by Liang Ma, Ming-wei Li, Yu Bai, Hui-hui Guo, Sheng-chao Wang, Qing Yu

“…MTT showed that 12.5–50 μg/mL MIRB could promote cell proliferation and MIRB over 100 μg/mL exhibited toxic effect on hDPSCs. In vitro MRI showed that 1 × 106 cells labeled with various concentrations of MIRB (12.5–100 μg/mL) could be visualized. …”
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Artesunate, EDTA, and colistin work synergistically against MCR-negative and -positive colistin-resistant Salmonella by Yajun Zhai, Peiyi Liu, Xueqin Hu, Changjian Fan, Xiaodie Cui, Qibiao He, Dandan He, Xiaoyuan Ma, Gongzheng Hu

“…The excellent bacteriostatic effect was primarily related to the increased cell membrane damage, accumulation of toxic compounds and inhibition of MCR-1. The potential binding sites of AS to MCR-1 (THR283, SER284, and TYR287) were critical for its inhibition of MCR-1 activity. …”
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A Review on Complications and Management of Aluminium Phosphide (Rice Pill) and Zinc Phosphide Poisoning by Khadijeh Saravani, Anahita Alizadeh Ghamsari, Bita Dadpour, Alireza Ghassemi Toussi, Seyed Reza Mousavi, Farah Pouramiri

“…Results: According to the findings of most studies, aluminium  phosphide pills had the most adverse effects as toxic substances. Conclusion: Due to the prevalence of its consumption among young people with low education levels, there was a need for physicians to treat these patients as quickly as possible accurately. …”
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Rapid Screening Method for Detecting Ethinyl Estradiol in Natural Water Employing Voltammetry by Chalder Nogueira Nunes, Lucas Ely Pauluk, Maria Lurdes Felsner, Vanessa Egéa dos Anjos, Sueli Pércio Quináia

“…Current methods for the determination of this compound, such as chromatography, are expensive and lengthy and require large amounts of toxic organic solvents. In this work, a voltammetric procedure is developed and validated as a screening tool for detecting EE2 in water samples without prior extraction, clean-up, or derivatization steps. …”
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Surveillance of Aflatoxin and Microbiota Related to Brewer's Grain Destined for Swine Feed in Argentina by Gisela A. Gerbaldo, Carina M. Pereyra, Lilia R. Cavaglieri, Francisco Ruiz, Liliana Pascual, Ana M. Dalcero, Isabel L. Barberis

“…Regular monitoring of feeds is required in order to prevent chronic and acute toxic syndromes related to this kind of contamination.…”
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