Digital twin-enhanced three-organ microphysiological system for studying drug pharmacokinetics in pregnant women by Katja Graf, José Martin Murrieta-Coxca, Tobias Vogt, Sophie Besser, Daria Geilen, Tim Kaden, Tim Kaden, Anne-Katrin Bothe, Diana Maria Morales-Prieto, Behnam Amiri, Behnam Amiri, Stephan Schaller, Ligaya Kaufmann, Martin Raasch, Ramy M. Ammar, Ramy M. Ammar, Christian Maass, Christian Maass

“…Long-term exposure simulations confirmed the value of this integrated system for predicting the non-toxic metabolization of prednisone.ConclusionThis approach may provide a potential non-animal alternative that could contribute to our understanding of drug behavior during pregnancy and may support early-stage drug safety assessment for vulnerable populations.…”
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In vitro investigating of anticancer activity of focuxanthin from marine brown seaweed species by M. Karkhane Yousefi, M. Seyed Hashtroudi, A. Mashinchian Moradi, A.R. Ghasempour

“…The results showed that fucoxanthin extract from Dictyota. indica at 24-hour treatment and 50 µg/ml concentration has the most effective anticancer activity on the breast cancer cells line, without toxic effects to the normal cells. According to the obtained results, it seems that Dictyota. …”
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Multi-targeted nanogel drug delivery system alleviates neuroinflammation and promotes spinal cord injury repair by Penghui Wang, Zaifeng Chen, Ping Li, Abdullah Al Mamun, Shaoxia Ning, Jinjing Zhang, Chonghui Tang, Tianmiao Sun, Jian Xiao, Xiaojie Wei, Fenzan Wu

“…Our results demonstrate that encapsulating Que in LipTC (QLipTC) enhances solubility, minimizes toxic side effects, facilitates lesion targeting, and aids in crossing the blood-spinal cord barrier. …”
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Determination of Pendimethalin Dynamic Residual Distribution in Crucian Carp Tissues and Associated Risk Assessment by Lu Qiao, Na Yuan, Gang Han, Bo Cheng, Defu Zhang, Jinlong Song, Yingchun Mu

“…Pendimethalin has been considered a moderately to extremely toxic compound for fish and aquatic organism. This study developed the determination of dynamic residual distribution for pendimethalin in crucian carp tissues (muscle, liver, kidney, gill, and blood) under semistatic exposure system by high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method. …”
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Linking Endotoxins, African Dust PM10 and Asthma in an Urban and Rural Environment of Puerto Rico by Mario G. Ortiz-Martínez, Rosa I. Rodríguez-Cotto, Mónica A. Ortiz-Rivera, Cedric W. Pluguez-Turull, Braulio D. Jiménez-Vélez

“…Urban extracts were highly toxic, proinflammatory (IL-6/IL-8 secretion), and induced higher TLR4 expression and NF-κB activation compared to rural extracts. …”
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Customizing the optical, electronic and transport attributes of lead-free hybrid FASnBr3 perovskites triggered by spin-orbit coupling and strains by Nusrat Jahan, Farah B.H. Pritu, Md Rasidul Islam, Budrun Neher, M Mahbubur Rahman, Farid Ahmed

“…However, the commonly studied MAPbI3 and FAPbI3 are toxic and less stable, prompting the necessity for safer replacements. …”
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OsHMA3 overexpression works more efficiently in generating low-Cd rice grain than OsNramp5 knockout mutation by Yuejing Gui, Joanne Teo, Dongsheng Tian, Raji Mohan, Zhongchao Yin

“…Abstract Objective Cadmium (Cd) is a highly toxic metal element and a carcinogen to humans. Rice is prone to taking up Cd from paddy fields and accumulating it in grain, which raises health concerns for rice consumers. …”
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How do serum cytokine levels change in myocarditis and inflammatory dilated cardiomyopathy relative to healthy individuals? A protocol for a systematic review and meta-analysis by Romuald Wojnicz, Piotr Lewandowski, Maciej Baron, Marcin A Rojek, Marcin Goławski, Karol Krystek, Magdalena Żegleń, Pascal Zytkiewicz, Jakub Kancerek, Klaudia Gabriela Lis, Jakub Warecki, Jakub Kufel, Kamila Kuśpiel

“…Introduction Myocarditis is an inflammatory heart disease resulting from infections, toxic exposures or autoimmune reactions. Irrespective of the factors responsible for this disease, cytokines play an important role in regulating the immunological response involved in its development and progression. …”
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Nanoemulsified Butenafine for Enhanced Performance against Experimental Cutaneous Leishmaniasis by Adriana Bezerra-Souza, Jéssica A. Jesus, Márcia D. Laurenti, Aikaterini Lalatsa, Dolores R. Serrano, Luiz Felipe D. Passero

“…Increased steady-state flux was reported for nanoenabled butenafine formulations with reduced lag time in Franz cell diffusion assays across Strat-M membranes. No toxic or inflammatory reactions were detected in animals treated with BUT-SNEDDS, BUT-SNEDDS gel, or butenafine. …”
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A review on bioremediation by microbial immobilization-an effective alternative for wastewater treatment by Frank Abimbola Ogundolie, Olorunfemi Oyewole Babalola, Charles Oluwaseun Adetunji, Christiana Eleojo Aruwa, Jacqueline Njikam Manjia, Taoheed Kolawole Muftaudeen

“…Furthermore, our work stands out by highlighting emerging state-of-the-art tools that are bioinspired [enzymes, reactive permeable barriers linked to electrokinetic, magnetic cross-linked enzyme aggregates (CLEAs), bio-coated films, microbiocenosis], as well as the use of nanosized biochar and engineered cells or their bioproducts targeted at enhancing the removal efficiency of metals, carbonates, organic matter, and other toxicants and pollutants. The potential integration of 'omics' technologies for enhancing and revealing new insights into bioremediation via cell immobilization is also discussed.…”
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The oncolytic adenovirus TILT-123 with pembrolizumab in platinum resistant or refractory ovarian cancer: the phase 1a PROTA trial by Matthew Stephen Block, James Hugo Armstrong Clubb, Johanna Mäenpää, Santeri Pakola, Dafne Carolina Alves Quixabeira, Tatiana Kudling, Elise Jirovec, Lyna Haybout, Mirte van der Heijden, Sanae Zahraoui, Susanna Grönberg-Vähä-Koskela, Sini Raatikainen, Victor Arias, Saru Basnet, Nea Ojala, Teijo Pellinen, Annabrita Hemmes, Katja Välimäki, Annukka Pasanen, Tuomo Alanko, Daniel Adamo, Susan Ramadan, Jorma Sormunen, Juha Kononen, Julia Wanda Cohen, Michael Jon Chisamore, John Goldfinch, Suvi Sorsa, Riikka Havunen, Claudia Kistler, Aino Kalervo, Víctor Cervera-Carrascon, João Manuel dos Santos, Akseli Hemminki

“…Treatment was well tolerated, and no dose-limiting toxicities were observed. The most frequent adverse events were fever (40%), fatigue (40%) and nausea (40%). …”
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Understanding retinal tau pathology through functional 2D and 3D iPSC-derived in vitro retinal models by Lorenza Mautone, Federica Cordella, Alessandro Soloperto, Silvia Ghirga, Giorgia Di Gennaro, Ylenia Gigante, Silvia Di Angelantonio

“…These changes are associated with impaired synaptic development, reduced neuronal connectivity, and enhanced cellular stress responses, including the increased formation of stress granules, markers of apoptosis and autophagy, and the presence of intracellular toxic tau aggregates. This study highlights the value of retinal models derived from human induced pluripotent stem cells in exploring the mechanisms underlying retinal pathology associated with tau mutations. …”
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High-resolution observation per 1.5 h revealed prominent time-dependent daily contamination variations of p-phenylenediamine (PPD) antioxidants and their quinone derivatives PPDQs... by Zifang Peng, Shijiao Hou, Qingyun He, Fangcheng Su, Lishun Ren, Congcong Pei, Dan Yin, Yanhao Zhang, Yanjie Huang, Shusheng Zhang, Zongwei Cai

“…Current study builds the relationship between pollution status of such novel pollutants and human activities, and possibly guides people in central China to take precautions to protect themselves from environmental toxicants at special daily time.…”
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Less cytotoxic phthalocyanine derivative promotes in vitro wound healing compared to chlorhexidine by Caique Andrade Santos, Adriano de Souza Pessoa, Fabiano Vieira Vilhena, Rodrigo Cardoso de Oliveira, Paulo Sérgio da Silva Santos, Carla Andreotti Damante, Mariana Schutzer Ragghianti Zangrando

“…In a comparative analysis, PHY showed less cytotoxicity than CHX and PHY concentrations of 0.0075% and 0.015% was non-toxic even after 48 h of contact with the cells. …”
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Towards the Sustainable Removal of Heavy Metals from Wastewater Using <i>Arthrospira platensis</i>: A Laboratory-Scale Approach in the Context of a Green Circular Economy by Lamprini Malletzidou, Eleni Kyratzopoulou, Nikoletta Kyzaki, Evangelos Nerantzis, Nikolaos A. Kazakis

“…The use of living <i>Arthrospira platensis</i> (<i>A. platensis</i>) cultures emerges as a promising green solution for the bioremediation of water contaminated by toxic metal waste. The scope of the present study is to evaluate the microalga’s potential in heavy metal remediation, in the case of multi-metal-treated (multi-MT) systems. …”
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Canagliflozin attenuates kidney injury, gut-derived toxins, and gut microbiota imbalance in high-salt diet-fed Dahl salt-sensitive rats by Lili He, Qingjuan Zuo, Sai Ma, Guorui Zhang, Zhongli Wang, Tingting Zhang, Jianlong Zhai, Yifang Guo

“…This study employed 16S rRNA sequencing technology and liquid chromatography–tandem mass spectrometry (LC–MS/MS)-based metabolic profiling combined with advanced differential and association analyses to investigate the correlation between the microbiome and the metabolome in male DSS rats.Results A high-salt diet disrupted the balance of the intestinal flora and increased toxic metabolites (methyhistidines, creatinine, homocitrulline, and indoxyl sulfate), resulting in severe kidney damage. …”
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Monitoring N : P Ratio and Cd, Cu, Pb, and Zn Contents in Different Types of Anaerobic Digestates: A Six-Year Study Case by Christina-Luise Roß, Kerstin Nielsen, Jorita Krieger, Marieke Hoffmann, Karen Sensel-Gunke, Frank Ellmer, Timo Kautz

“…Depending on the quality of the input substrates, process parameters, and postfermentation treatments, digestates may contain a broad spectrum of potentially toxic elements. We suspected that these contents may vary on a broad scale even under seemingly stable process conditions at the biogas plant. …”
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Performance enhancement of full inorganic Sb2S3 solar cells with MnS hole transport layers by Minghong Rui, Hangyu Li, Yuan Li, Wenqi Li, Sumei Wang

“…However, the issue of high cost, poor environmental stability and toxic benzene-based solvents for preparation represent significant challenges for the efficient organic HTLs. …”
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Evaluation of cellular and physiological alterations of cells from Mytilus galloprovincialis exposed to benzisothiazolinone by Federica Impellitteri, Kristian Riolo, Giorgia Zicarelli, Miriam Porretti, Cristiana Roberta Multisanti, Giuseppe Piccione, Alessia Giannetto, Caterina Faggio

“…This extensive use is reflected in a vast amount of this compound in the environment, which may cause toxic effects in organisms that come in contact with it. …”
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Multimodal lung cancer theranostics via manganese phosphate/quercetin particle by Chong Qiu, Fei Xia, Qingchao Tu, Huan Tang, Yinan Liu, Hongda Liu, Chen Wang, HaiLu Yao, Linying Zhong, Yuanfeng Fu, Pengbo Guo, Weiqi Chen, Xinyu Zhou, Li Zou, Licheng Gan, Jiawei Yan, Yichong Hou, Junzhe Zhang, Huanhuan Pang, Yuqing Meng, Qiaoli Shi, Guang Han, Xijun Wang, Jigang Wang

“…Mechanistic studies indicated that QCT and Mn2+ exhibited excellent peroxidase-like (POD-like) activity, catalysing the conversion of endogenous hydrogen peroxide into highly toxic hydroxyl radicals through a Fenton-like reaction, depleting glutathione (GSH), promoting reactive oxygen species (ROS) generation in mitochondria and endoplasmic reticulum, and inducing ferroptosis. …”
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