MET-PREVENT: metformin to improve physical performance in older people with sarcopenia and physical prefrailty/frailty – protocol for a double-blind, randomised controlled proof-of... by Andrew Clegg, James Wason, Miles Witham, Nina Wilson, Claire J Steves, Helen C Hancock, Avan A P Sayer, Leanne Marsay, Claire McDonald, Thomas von Zglinicki, Katherine J Rennie, Penny Bradley, Stephen Connolly, Shaun Hiu, Laura Robertson, Laura Simms, Alison J Steel, Bryony Storey

“…Eligible participants with low grip strength or prolonged sit-to-stand time together with slow walk speed will be randomised to either oral metformin hydrochloride 500 mg tablets or matched placebo, taken three times a day for 4 months. The recruitment target is 80 participants from two secondary care hospitals in Newcastle and Gateshead, UK. …”
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Dietary selenium peptide supplementation for increasing the growth of African catfish Clarias gariepinus by Muhammad Agus Suprayudi, Muhammad Roikhan Amanullah, Dedi Jusadi, Hasan Nasrullah, Ahmad Yazid Latif

“…A total of 15 catfish at an initial weight of 21.80 ± 0.29 g were reared in a 90×40×45 cm3 aquarium filled with water at a volume of 108 L, for 45 days. Fish were fed three times a day at satiation. Water quality management was carried out by the use of simple filtration in the container and water replacement to ensure optimum water quality values for catfish growth. …”
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Weight loss for overweight and obese patients with prostate cancer: a study protocol of a randomised trial comparing clinic-based versus Telehealth delivered EXercise and nutrition... by Robert U Newton, Daniel A Galvão, Dennis R Taaffe, Suzanne K Chambers, David Joseph, Amanda Devine, Colin I Tang, Nigel Spry, Emily Jeffery, Dickon Hayne, Pedro Lopez, P Lyons-Wall, Christine Kudiarasu

“…Exercise will consist of supervised resistance and aerobic exercise performed three times a week plus additional self-directed aerobic exercise performed 4 days/week for the first 6 months. …”
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Peptide-based vaccine targeting IL17A attenuates experimental spondyloarthritis in HLA-B27 transgenic rats by Tetsuya Tomita, Hiromi Rakugi, Hiroki Hayashi, Ryuichi Morishita, Jiao Sun, Yuka Yanagida, Shota Yoshida, Satoshi Baba, Akiko Tenma, Masayoshi Toyoura, Sotaro Kawabata, Takako Ehara, Ryoko Asaki, Makoto Sakaguchi, Hideki Tomioka, Munehisa Shimamura, Hironori Nakagami

“…This study aimed to assess the efficacy of an IL17A peptide-based vaccine on SpA manifestations in model rats.Methods HLA-B27/human β2-microglobulin (hβ2M) transgenic rats were immunised with heat-inactivated Mycobacterium tuberculosis (MT) to develop spondylitis and arthritis as an experimental SpA model after immunisation with a keyhole limpet hemocyanin-conjugated IL17A peptide-based vaccine with an alum adjuvant three times. The IL17A antibody titre was assessed using ELISA, and arthritis score and joint thickness were monitored two times a week. …”
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Production performance of eel Anguilla bicolor bicolor with the addition of calsium carbonat by Ardyen Saputra, Tatag Budiardi, Eddy Supriyono

“…The study was conducted with an experimental method with four treatments, the addition of dose CaCO3 on the culture media were (0, 50, 100, 150 mg/L) and repeated three times. Aquariums for fish maintenance were insulated form in the size of 100×50×40 cm3 and with recirculation system. …”
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Social context affects tissue-specific copper distribution and behaviour of threespine stickleback (Gasterosteus aculeatus) by Sienna L. Overduin, Shaun S. Killen, Alex M. Zimmer, Jenelle D. McCuaig, Lucy Cotgrove, Isabel Aragao, Kelly J. Rozanitis, Kurt O. Konhauser, Daniel S. Alessi, Tamzin A. Blewett

“…Isolated stickleback travelled three times less distance, took six times longer to consume food and exhibited moderately increased gill sodium-potassium ATPase activity than group exposed fish, with no effect of Cu. …”
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Development of an in vitro model to study muscle maladaptation to overtraining by Giuseppe Sirago, Clément Lanfranchi, Justin Carrard, Vincent Gremeaux, Nadège Zanou, Nicolas Place

“…For simulated overtraining (s-OT), the stimulation was applied three times per day for three consecutive days. Mitochondrial biogenesis biomarkers have been measured, alongside proteomics analysis and mitochondrial respiration. …”
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Addition of CaCO3 to culture media at the salinity of 3 g/L for freshwater tambaqui growth by Yuni Puji Hastuti, Chandra Yudistira, Kukuh Nirmala, Wildan Nurusallam, Kurnia Faturochman

“…Fishes were fed on bloodworms ad libitum or provided three times a day. The results showed that survival, daily growth rate, and absolute length growth of the CaCO3 treatments significantly higher (P<0.05) that that of control.  …”
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Time Interval for Diagnosis of Tuberculosis and Related Expenditure in Selected Health Centers in Addis Ababa, Ethiopia by Ezra Shimeles, Melaku Tilahun, Tsegaye Hailu, Fikre Enquselassie, Abraham Aseffa, Alemayehu Mekonnen, Getachew Wondimagegn

“…Patients who visited public hospitals were almost three times and those who visited private health facilities almost four times more likely to pay more than the median total expenditure, compared to those who visited health centre, AOR (95% CI) = 2.8 (1.53, 5.19) and AOR (CI) of 3.86 (1.06, 14.03), respectively. …”
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Effect of a high dose atorvastatin as adjuvant therapy to mesalamine in attenuating inflammation and symptoms in patients with ulcerative colitis: a randomized controlled pilot stu... by Sumaiah J. Alarfaj, Sahar M. El-Haggar, Sahar K. Hegazy, Sahar K. Hegazy, Maha M. Maher, Maha M. Maher, Monir M. Bahgat, Thanaa A. Elmasry, Sarah Alrubia, Amsha S. Alsegiani, Mostafa M. Bahaa

“…For 6 months, Group 1 (placebo group) received both a placebo and 1 g of mesalamine three times daily (t.i.d.). Group 2, (the atorvastatin group) received atorvastatin 80 mg once daily and 1 g of mesalamine t.i.d. …”
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The Improvement of Protein Retention through a Higher Utilization of Carbohydrate in the Diet with Chromium for Common Carp Cyprinus carpio Linn. by I. Mokoginta, F. Hapsyari, M. Agus Suprayudi

“…Fish fed upon the experimental diets three times daily, at satiation for 50 days. Results of this experiment showed that the protein retention could be improved by given Cr+3 in the diet. …”
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Potential public health impacts of gonorrhea vaccination programmes under declining incidences: A modeling study. by Lin Geng, Lilith K Whittles, Borame L Dickens, Martin T W Chio, Yihao Chen, Rayner Kay Jin Tan, Azra Ghani, Jue Tao Lim

“…VoD had a smaller impact (12.04% averted cases (95% CrI: 7.12%-15.00%)), but was three times more efficient than VoA in terms of averted cases per dose. …”
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Extract of seaweed Gracilaria verrucosa as immunostimulant to controlling white spot disease in Pacific white shrimp Litopenaeus vannamei by Aminatul Zahra, Sukenda Sukenda, Dinamella Wahjuningrum

“…Pacific white shrimp had been fed medicated feed three times daily 3% at satiation for 14 days. At 15th days, white shrimp were challenged with WSSV at 0.1 mL/shrimp intramuscularly. …”
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Sparse seagrass meadows are critical dugong habitat: A novel rapid assessment of habitat-wildlife associations using paired drone and in-water surveys by Nicole E. Said, Christophe Cleguer, Paul Lavery, Amanda J. Hodgson, Connor Gorham, Julian A. Tyne, Ankje Frouws, Simone Strydom, Johnny Lo, Holly C. Raudino, Kelly Waples, Kathryn McMahon

“…Paired assessment data was collected three times over two years. Benthic habitat (percent cover), seagrass nutritional quality and environmental parameters (temperature, water clarity, water current, water depth) were tested as predictor variables using generalised linear models, to examine drivers of both dugong presence/absence and abundance. …”
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Kappa-carrageenan as immunostimulant to control infectious myonecrosis (IMN) disease in white shrimp Litopenaeus vannamei by Dian Febriani, . Sukenda, Sri Nuryati

“…The parameters of observation consisted of immune parameters, clinical symptoms, growth, and survival. Shrimp were fed three times a day at feeding rate of 4–5% of body weight/day. …”
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Risk of Coronary Heart Disease among HIV-Infected Patients: A Multicenter Study in Brazil by Sandra C. Fuchs, Paulo R. Alencastro, Maria Letícia R. Ikeda, Nêmora T. Barcellos, Fernando H. Wolff, Ajácio B. M. Brandão, Ricardo A. A. Ximenes, Demócrito de B. Miranda-Filho, Heloísa Ramos Lacerda, Maria de Fátima P. M. de Albuquerque, Ulisses Ramos Montarroyos, Max W. Nery, Marilia D. Turchi

“…The Framingham score ≥10 was similar between regions for males, patients aged ≥60 years, with obesity, central obesity, hypertension, and diabetes mellitus. Women were three times more likely to have coronary heart disease in 10 years than men. …”
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Growth performance of pearl goldfish juvenile carassius auratus cultured in 3 ppt salinity with different exposure time of electric field by Kukuh Nirmala, Rizky Armansyah, Agus Priyadi

“…Exposure time of electric field were zero, two, four, and six minutes before the fish are fed, performed every day as much as three times i.e. morning, afternoon, and evening. The research design used was completely randomized design with four treatments, namely 0, 2, 4, and 6 (time for exposure is zero/control, two, four, and six minute) with three replications. …”
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Projeto de extensão universitária ‘SaúHDe renal’: Efeitos na qualidade de vida e na aptidão física by Jordana Letícia Buratti, Thaís Severo Dutra, Moane Marchesan Krug, Clara Suemi da Costa Rosa, Paulo Ricardo Moreira, Robelius De-Bortoli, Rodrigo de Rosso Krug

“…The TF consisted of resistance exercises three times/week during HD for 32 weeks. A six-minute walk assessed physical fitness, sit and stand test, forearm flexion, flexibility, and dynamometry. …”
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Sex-specific analysis of individual and ski geometry-related risk factors for ACL injuries in recreational alpine skiing: A case-control study by Gerhard Ruedl, Martin Faulhaber, Markus Posch

“… Introduction In recreational alpine skiing, female skiers experience knee injuries at twice the rate of male skiers, with the risk of anterior cruciate ligament (ACL) injuries being three times higher in women (Posch et al. 2021). In addition to individual factors such as, e.g., age or skill level, ski geometry parameters may also influence the risk of ACL injuries (Ruedl et al., 2022). …”
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Inorganic constituents in cassava derivatives: Total concentration, dietary intake and bioaccessibility by Leilane R. Santos, Filipe B. Santana, Hilária F.A. Silveira, Wellington C. de Carvalho, Laís A. Souza, Rennan Geovanny O. Araujo, Maria Graças A. Korn, Daniele Cristina M.B. Santos

“…For Pb, the concentrations were three times higher than the legislated values in Brazil. …”
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