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16101
The Ability of Combined Flavonol and Trihydroxyorganic Acid to Suppress SARS-CoV-2 Reproduction
Published 2024-12-01“…As the global fight against SARS-CoV-2 continues, plant-based therapies like this complex could complement existing treatments and provide new options for managing and treating the disease.…”
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16102
Heterogeneity of cancer-associated fibroblast subpopulations in prostate cancer: Implications for prognosis and immunotherapy
Published 2025-02-01“…Our findings contribute to a deeper understanding of the TME's complexity, advocating for further exploration into CAF-targeted therapies aimed at enhancing treatment responses and ultimately improving patient outcomes.…”
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16103
Comparison of the efficacy and safety of bupropion versus aripiprazole augmentation in adults with treatment-resistant depression: a nationwide cohort study in South Korea
Published 2025-01-01“…This study aimed to compare the efficacy and safety of bupropion and aripiprazole as augmentation therapies for TRD. Methods This population-based, retrospective cohort study included adults aged ≥18 years with a diagnosis of depressive disorder who met the criteria for TRD. …”
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16104
Citrullinated Autoantigen–Specific T and B Lymphocytes in Rheumatoid Arthritis: Focus on Follicular T Helper Cells and Expansion by Coculture
Published 2025-01-01“…This technology will serve as a platform to identify therapies that modulate disease‐specific immune cells.…”
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16105
Safety and Effectiveness of BPaL-Based Regimens to Treat Multidrug-Resistant TB: First Experience of an Italian Tuberculosis Referral Hospital
Published 2024-12-01“…<b>Background/Objectives</b>: Tuberculosis (TB) is preventable and curable, but multidrug-resistant TB (MDR-TB) and extensively drug-resistant TB (XDR-TB) pose significant challenges worldwide due to the limited treatment options, lengths of therapies, and high rates of treatment failure. The management of MDR-TB has been revolutionized by all oral anti-TB drug regimens that are likely to improve adherence and treatment outcomes. …”
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16106
Mast Cells Exert Anti-Inflammatory Effects in an IL10−/− Model of Spontaneous Colitis
Published 2018-01-01“…Further investigation of the mechanism of the anti-inflammatory role of the mast cells may elucidate novel therapies.…”
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16107
Quo vadis autoimmune hepatitis? - Summary of the 5th international autoimmune hepatitis group research workshop 2024Keypoints
Published 2025-02-01“…Although standard treatment with corticosteroids and thiopurines improves the life expectancy of patients with AIH, remission rates and tolerability are generally overestimated and the development of alternative first-line and salvage therapies has been disappointingly slow compared to in rheumatological diseases or inflammatory bowel disease. …”
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16108
QUIET WARRIOR – Rationale and design: An ancillary study to the Women's IschemiA TRial to Reduce Events in Nonobstructive CAD (WARRIOR)
Published 2025-03-01“…There is a notable deficiency in therapies tailored for IHD in women, who often present with variable symptoms that delay diagnosis and treatment. …”
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16109
Enhanced penetration and biofilm eradication by sophorolipid micelles encapsulating Honokiol: a comprehensive solution for biofilm-associated lung infections
Published 2025-02-01“…Abstract Background Biofilm-associated lung infections, particularly those caused by Staphylococcus aureus (S. aureus), pose significant clinical challenges to conventional therapies. S. aureus Biofilm infections are refractory to treatment due to the presence of persister bacterial cells and the barrier effect of unique extracellular polymeric substances (EPS). …”
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16110
Joint Group and Multi Institutional Position Opinion: Cirrhotic Cardiomyopathy—From Fundamentals to Applied Tactics
Published 2024-12-01“…However, our group still advocates them as essential tools in optimizing the neurohumoral pathologic axis that perpetuates CCM. Other targeted therapies with direct anti-inflammatory and antioxidative effects still lack sufficient evidence for wide approval. …”
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16111
High-definition transcranial infraslow pink noise stimulation for chronic low back pain: protocol for a pilot, safety and feasibility randomised placebo-controlled trial
Published 2022-06-01“…Current treatments demonstrate modest effects, warranting newer therapies. Brain imaging demonstrates altered electrical activities in cortical areas responsible for pain modulation, emotional and sensory components of pain experience. …”
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16112
Transcriptional analysis of murine biliary atresia identifies macrophage heterogeneity and subset-specific macrophage functions
Published 2025-01-01“…Transcriptional similarities between murine BA and human cholestatic macrophages may enable translation of future mechanistic studies to new macrophage subset-specific therapies.…”
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16113
Dual Mechanisms of Action: Anti-Candida and Anti-Inflammatory Potential of <i>Lactobacillus</i> Fermentation Broth in Treating Vulvovaginal Candidiasis
Published 2024-12-01“…By promoting a healthy vaginal microbiome, reducing inflammation, and maintaining tissue health, this probiotic-based approach presents a novel strategy for addressing VVC, particularly in cases of drug resistance or adverse reactions to standard therapies. This study underscores the potential of microbiome-modulating strategies in managing vaginal infections, paving the way for more targeted and side-effect-free VVC treatments.…”
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16114
Creation of new anastomosis for management of obstructive symptoms related to gastrojejunal anastomosis in patients who undergo gastric bypass: a case series
Published 2025-01-01“…Surgical revision of the GJ anastomosis is technically challenging and carries significant morbidity, making endoscopic therapies such as endoscopic balloon dilation (EBD) and stent placement the preferred approach. …”
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16115
Development and validation of a machine learning-based prediction model for hepatorenal syndrome in liver cirrhosis patients using MIMIC-IV and eICU databases
Published 2025-01-01“…From two sizable public databases, we retrieved pertinent information about the cirrhosis patients’ therapies, comorbidities, laboratory results, and demographics. …”
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16116
Case report: an unusual long-term evolution of a diffuse midline glioma, H3K27 altered
Published 2025-02-01“…Better understanding this molecular cascade might help to identify novel targets for individualized therapies.…”
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16117
Mitral Valve Transcatheter Edge-to-Edge Repair Volumes and Trends
Published 2023-01-01“…Further studies are needed to understand the clinical impact of variability in utilization and the optimal procedural volumes to ensure high efficacy outcomes and maintain critical access to MTEER therapies.…”
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16118
Gastroenteropancreatic Neuroendocrine Neoplasia Characterization in Portugal: Results from the NETs Study Group of the Portuguese Society of Endocrinology, Diabetes and Metabolism
Published 2019-01-01“…Surgery (79.6%) and somatostatin analogues (30.7%) were the most frequently used therapies of GEP-NENs with reported grading. Conclusion. …”
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16119
Mapping existing research on flushing peripheral vascular catheters: a scoping review protocol
Published 2025-01-01“…Introduction The peripheral vascular catheter (PVC) is the most common intravenous medical device used in hospitals, given it is crucial for the delivery of intravenous therapies. Despite its widespread use, PVC complications such as occlusion, infiltration, extravasation, phlebitis, thrombophlebitis, catheter-related thrombosis and catheter-related bloodstream infection significantly affect patient safety, leading to increased morbidity and healthcare costs. …”
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16120
The role of CXCL12/CXCR4/CXCR7 axis in cognitive impairment associated with neurodegenerative diseases
Published 2025-02-01“…This review explores the role of this axis in the pathogenesis of CI across these neurodegenerative diseases, synthesizing current evidence and its implications for targeted therapies. In AD, dysregulation of this axis contributes to amyloid-β accumulation and tau hyperphosphorylation, leading to synaptic dysfunction and cognitive decline. …”
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