Recurrent Thymic Carcinoma Treated With Median Sternotomy, Innominate Vein Replacement for Superior Vena Cava, and Iodide Implantation: A Case Report and Review of the Literature by Zhong‐zheng Chen, Wen‐dong Qu, Xing‐shu Zhang, Yong‐xiang Song

“…It emphasizes the importance of early diagnosis, complete surgical resection, and tailored adjuvant therapies, including chemotherapy, radiotherapy, and immunotherapy, to improve survival outcomes. …”
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NF-κB-Inducing Kinase Is Essential for Effective c-Rel Transactivation and Binding to the <i>Il12b</i> Promoter in Macrophages by Natalia Cuesta, Anna D. Staniszewska, Cristóbal Moreno, Carmen Punzón, Manuel Fresno

“…NIK dysfunction could lead to weakened immune responses, and targeting this pathway may help in developing therapies for immune-related conditions.…”
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Development and characterization of orthotopic patient-derived xenograft models of peritoneal metastatic mucinous appendiceal adenocarcinoma by I. Ito, V.K. Pattalachinti, A.M.G. Yousef, S. Chowdhury, M.M. Fanaeian, E. Haque, B.B. Gunes, M. Yousef, E.R. Salle, M.A. Zeineddine, S. Ji, R. Li, W. Wang, B.A. Helmink, M.W. Taggart, M.G. White, K.F. Fournier, N.W. Fowlkes, J.P. Shen

“…Conclusions: These molecularly profiled, orthotopic PDX models of metastatic AAs represent a unique resource for future exploration to identify novel therapies for this orphan disease.…”
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Evaluation of the Antitumor Effects of Platinum-Based [Pt(η1-C2H4-OR)(DMSO)(phen)]+ (R = Me, Et) Cationic Organometallic Complexes on Chemoresistant Pancreatic Cancer Cell Lines... by Erika Stefàno, Luca Giulio Cossa, Federica De Castro, Erik De Luca, Viviana Vergaro, Giulia My, Gianluca Rovito, Danilo Migoni, Antonella Muscella, Santo Marsigliante, Michele Benedetti, Francesco Paolo Fanizzi

“…Pancreatic cancer is one of the most lethal malignancies with an increasing incidence and a high mortality rate, due to its rapid progression, invasiveness, and resistance to anticancer therapies. In this work, we evaluated the antiproliferative and antimigratory activities of the two organometallic compounds, [Pt(η1-C2H4-OMe)(DMSO)(phen)]Cl (1) and [Pt(η1-C2H4-OEt)(DMSO)(phen)]Cl (2), on three human pancreatic ductal adenocarcinoma cell lines with different sensitivity to cisplatin (Mia PaCa-2, PANC-1, and YAPC). …”
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The Incidence of Nosocomial Bloodstream Infections in Children With Congenital Heart Disease Undergoing Cardiac Surgery: A Retrospective Study by Mohammad Mehdi Rajabi, Behdad Gharib, Mohammad Reza Mirzaaghayan

“…Our results highlight the need for stronger infection control measures and targeted antibiotic therapies to effectively manage BSIs. Further research is recommended to validate these results and improve preventive measures in pediatric cardiac units. …”
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Cancer Stem Cells from Tumor Cell Lines Activate the DNA Damage Response Pathway after Ionizing Radiation More Efficiently Than Noncancer Stem Cells by Heriberto Abraham Valencia-González, Graciela Ruíz, Elizabeth Ortiz-Sánchez, Alejandro García-Carrancá

“…Understanding the DNA damage response pathway may provide therapeutic targets to sensitize CSC to cytotoxic therapies to improve current cancer treatments.…”
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Public knowledge of early stroke symptoms in the Vilnius region by A. Atkočiūnas, M. Mačionytė, R. Mameniškienė

“…The evident decline in disabling outcomes can be attributed to the increasing use of reperfusion therapies. Stroke recognition and urgent admission of patients to specialized stroke centres after the onset of first stroke symptoms are essential for treatment outcomes. …”
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Immunotherapies to Nano-Immunotherapies: Advances in Immune Targeting in Bladder Cancer by Beatriz Ramos, Dakota Rogers

“…Furthermore, natural killer cell-based therapies and novel immune targets like TIGIT and CD155 are under investigation to enhance anti-tumor immunity. …”
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Health Canada's use of its priority review process for new drugs: a cohort study by Joel Lexchin

“…The purpose of this study is to compare Health Canada's use of priority reviews to therapeutic ratings from two independent organisations, the Patented Medicine Prices Review Board (PMPRB) and the French drug bulletin Prescrire International, over the period 1 January 1997–31 December 2012.Design Cohort study.Data sources Annual reports of the Therapeutic Products Directorate, and the Biologics and Genetic Therapies Directorate; evaluations of therapeutic innovation from PMPRB and Prescrire International; WHO Collaborating Centre for Drug Statistics Methodology.Interventions Assessments by PMPRB and Prescrire International treated as a gold standard for postmarket therapeutic value.Primary and secondary outcome measures Drug-by-drug comparison between the review status from Health Canada and the therapeutic status from PMPRB/Prescrire using κ values, and positive and negative predictive values. …”
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Exploring the Mechanisms of Zhenbao Pills in the Treatment of Stroke through Network Pharmacology Combined with Mendelian Randomization by Yanhong Liu, Yunqi Hua, Xiaoe Jia

“…Research on stroke biomarkers can aid in the development of targeted therapies, while Zhenbao Pills (ZBP) from traditional Chinese medicine may enhance recovery from neurological disorders. …”
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A Systematic Literature Review of the Epidemiology, Health-Related Quality of Life Impact, and Economic Burden of Immunoglobulin A Nephropathy by Christina Soeun Kwon, Patrick Daniele, Anna Forsythe, Christopher Ngai

“…IgAN is a rare disease where disease progression causes increasing patient burden, underscoring the need for therapies that prevent kidney function decline and HRQoL deterioration while reducing mortality.…”
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The Role of Intraarterial Chemotherapy in the Management of Retinoblastoma by Aleksandra Pekacka

“…Future work should focus on conducting larger prospective studies with longer follow-up. Multiple novel therapies for the management of retinoblastoma are currently being tested, including angiogenic inhibitors and targeted agents. …”
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Prevalence and Associated Factors of Depressive Symptoms in Patients with Myasthenia Gravis: A Cross-Sectional Study of Two Tertiary Hospitals in Riyadh, Saudi Arabia by Mohammed H. Alanazy

“…Data were collected with a two-part standardized questionnaire: the first part included data on sociodemographic and clinical features of MG including disease type and duration, therapies, prednisolone dose, time of the last relapse, previous critical care unit admissions, MG status (controlled, partially controlled, or uncontrolled), and comorbid diseases; the second part included items from the previously validated Arabic version of the Patient Health Questionnaire-9 (PHQ-9). …”
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Intravenous thrombolysis prevents neurological deterioration in patients with acute pontine infarction by Zhenxiao Chai, Weili Chen, Yichan Ye, Mengwan Song, Lingling Lin, Dongdong Lin, Xuerong Huang, Lifen Chi, Ruyue Huang

“…Patients' clinical characteristics, laboratory findings, and outcomes were analyzed to determine the efficacy and safety of IVT.ResultsOf 211 study patients (median age, 67 years [interquartile range, 57–75 years]; 132 [62.6%] men), 74 received IVT; 137 patients did not receive IVT, but accepted other antithrombotic therapies, including antiplatelet or anticoagulant drugs. …”
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Outcome of spine surgery in the context of spinal metastatic disease: The National Surgical Quality Improvement Program by Salim M. Yakdan, Maya Herrera, Nour Wehbe, Monifa Al Akoum, Muhammad Irfan Kaleem, Miguel A. Ruiz-Cardozo, Karan Joseph, Nada Assaf, Hani Dimassi

“…Despite poor overall survival, recent advances in targeted therapies and minimally invasive surgical techniques have made surgery a more viable option for managing metastatic spine disease. …”
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A scoping review of the contralateral effects of unilateral peripheral stimulation on neuromuscular function. by Shi Zhou, Shuang-Shuang Zhang, Zachary J Crowley-McHattan

“…The findings suggest a need to enhance the awareness of cross-education caused by peripheral stimulation, to help improve the translation of theoretical concepts to clinical practice, and aid in developing well-designed clinical trials to determine the efficacy of cross-education therapies.…”
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High immunoproteasome and low constitutive proteasome subunit levels correlate with sensitivity to bortezomib-containing chemotherapy: update from the Children’s Oncology Group AAL... by Margot S. F. Roeten, Johan van Meerloo, Suzanne N. van Dijk, Zinia Kwidama, Gaye Jenkins, David T. Teachey, Meenakshi Devidas, Mignon L. Loh, Gertjan J. L. Kaspers, Sonja Zweegman, Gerrit Jansen, Terzah M. Horton, Jacqueline Cloos

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Viral and Nonviral Engineering of Natural Killer Cells as Emerging Adoptive Cancer Immunotherapies by Sandro Matosevic

“…As effectors of cancer immunotherapy, NK cells are attractive as they do not attack healthy self-tissues nor do they induce T cell-driven inflammatory cytokine storm, enabling their use as allogeneic adoptive cellular therapies. Clinical responses to adoptive NK-based immunotherapy have been thwarted, however, by the profound immunosuppression induced by the tumor microenvironment, particularly severe in the context of solid tumors. …”
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Growth Characteristics of Sheep-Derived <i>Bacteroides fragilis</i> and Preliminary Research on Effects in Mice and Lambs by Cheng Cheng, Jinye Du, Jianping Tao, Darong Cheng

“…Traditional antibiotic treatments often disrupt the Intestinal microbiota, induce antibiotic resistance, and cause adverse side effects, highlighting the urgent need to develop alternative therapies. <i>Bacteroides fragilis</i>, a candidate next-generation probiotic, has been closely associated with intestinal health. …”
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A Predicted Helix-Turn-Helix Core Is Critical for Bacteriophage Kil Peptide to Disrupt <i>Escherichia coli</i> Cell Division by Arindam Naha, Todd A. Cameron, William Margolin

“…<b>Conclusions</b>: Understanding the structure and function of Kil and similar peptides can potentially reveal additional ways to target FtsZ for antimicrobial therapies and elucidate how FtsZ functions in bacterial cell division.…”
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