Anthelmintic activity of 1,10-phenanthroline-5,6-dione-based metallodrugs by Maria E. Cirino, Thainá R. Teixeira, Alessandro M. H. Silva, Ana C. C. Borges, Lucas Fukui-Silva, Luis G. Wagner, Christiane Fernandes, Malachy McCann, André L. S. Santos, Josué de Moraes

“…Given the promising biological properties of phendione and its metal complexes, these findings contribute to the growing body of research seeking to address the urgent need for new anthelmintic therapies.…”
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Antiarrhythmic Effects of Carvedilol and Flecainide in Cardiomyocytes Derived from Catecholaminergic Polymorphic Ventricular Tachycardia Patients by R. P. Pölönen, K. Penttinen, H. Swan, K. Aalto-Setälä

“…CPVT cardiomyocytes carrying the exon 3 deletion had the most severe Ca2+ abnormalities, but they had the best response to drug therapies. According to this study, the arrhythmia-abolishing effect of neither of the drugs is optimal. iPSC-CMs provide a unique platform for testing drugs for CPVT.…”
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Alpha-defensins increase NTHi binding but not engulfment by the macrophages enhancing airway inflammation in Alpha-1 antitrypsin deficiency by Jungnam Lee, Naweed Mohammad, Kyudong Han, Kyudong Han, Tammy Flagg-Dowie, Maria Magallon, Mark L. Brantly, Karina A. Serban, Karina A. Serban

“…Dampening the downstream effects of a high concentration of α-defensins may render AAT and TLR4 inhibitors as potential therapies to decrease NTHi colonization and increase its clearance by phagocytosis in AATD individuals.…”
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Mindfulness influences the psycho-social dimension of chronic pain: A randomized controlled clinical trial in Indian context by Anirban Pal, Purnava Mukhopadhyay, Rajasree Biswas, Dipasri Bhattacharya

“…The research with community-based group therapies (like mindfulness) to address the psycho-social aspects in chronic pain patients remains limited. …”
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Japanese Patients’ and Physicians’ Preferences for Anticoagulant Use in Atrial Fibrillation: Results from a Discrete-choice Experiment by Ken Okumura, Hiroshi Inoue, Masahiro Yasaka, Juan Marcos Gonzalez, A. Brett Hauber, Bennett Levitan, Zhong Yuan, Jean Baptiste Briere

“…The findings demonstrate the importance of physician-patient communication in treatment decisions involving stroke preventative therapies.…”
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A Cytokine That Is Involved in Immune Responses in Chronic Hepatitis B Virus Patients by Noor R. Abady, Zeana Shakir Al-Al Hindi

“…Gaining insight into the function of IL-17 may help develop more effective therapies for CHB and LC patients. It is crucial to conduct further research in this area to develop tailored therapeutics.…”
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Effects and Mechanisms of Silibinin on Influenza A/H1N1 Pathogenesis in a Mouse Model by Mohsen Keshavarz, Mohsen Ghorbani, Forough Shamsizadeh, Haideh Namdari, Vahid Salimi, Farhad Rezaei

“…These results support the idea that therapies aimed at moderating immune and inflammatory responses are essential to decrease the mortality rate caused by IAV infection. …”
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Synthetic embryology of the human heart by Maria Belen Paredes-Espinosa, Janet L. Paluh

“…The evolution of stem cell-based heart models from cells and tissues to organoids and assembloids and recently synthetic embryology gastruloids, is poised to revolutionize our understanding of cardiac development, congenital to adult diseases, and patient customized therapies. Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have already been integrated into transplantable patches and are in preclinical efforts to reverse fibrotic scarring from myocardial infarctions. …”
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Natural products as anticancer agents and enhancing their efficacy by a mechanism-based precision approach by Stephen Safe

“…A mechanism-based precision medicine approach should enhance the clinical efficacy of dietary and related natural products as anticancer agents and decrease toxic side effects for some combination therapies.…”
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Drivers of innovation value: simulation for new drug pricing evaluation based on system dynamics modelling by Qian Xing, Wendi Cheng, Wei Wang, Chunlin Jin, Haiyin Wang

“…Sensitivity analysis highlights that factors like combination therapies, faster mechanisms of action, and novel therapeutic parts notably influence the value dimension. …”
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Gut Microbiota Variations between Henoch-Schonlein Purpura and Henoch-Schonlein Purpura Nephritis by Fang Zhou, Qimin Shao, Lihong Jia, Chunyan Cai

“…This study provides valuable insights that will benefit the development of future microbe-based therapies to improve clinical outcomes or prevent the incidence of HSP or HSPN in children.…”
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Triphenylmethane derivatives have high in vitro and in vivo activity against the main causative agents of cutaneous leishmaniasis. by Renata Celi Carvalho de Souza Pietra, Lucas Fonseca Rodrigues, Eliane Teixeira, Levi Fried, Benjamin Lefkove, Ana Rabello, Jack Arbiser, Lucas Antônio Miranda Ferreira, Ana Paula Fernandes

“…Thus, there is an urgent need for the development of new and inexpensive therapies for the treatment of CL. In this study, we evaluate the activity of the triphenylmethane (TPM) class of compounds against three species of Leishmania which are pathogenic in humans. …”
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Integrative analysis of SEPN1 in glioma: Prognostic roles, functional implications, and potential therapeutic interventions. by Zisong Wang, Danwen Wang, Xuanyu Wang, Yihang Xu, Yunhe Yuan, Yuxin Chen, Zhiqiang Li, Xiaoping Liu

“…<h4>Conclusions</h4>SEPN1 emerges as a novel biomarker and therapeutic target in glioma, providing a basis for future development of targeted therapies.…”
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Unravelling the impact of SARS-CoV-2 on hemostatic and complement systems: a systems immunology perspective by Didar Murad, Rehan Zafar Paracha, Maryum Nisar

“…The knowledge that we have acquired could contribute to designing therapies that target the hemostatic and complement systems.…”
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Meta-Analysis and Systematic Review of the Role of Appendectomy in the Pathogenesis of Colorectal Cancer by M.I. A. Nezhad, N. P. Yabandeh

“…Nevertheless, it is advisable for physicians to weigh the potential benefits of alternative therapies and consider the future complications that may arise from an unnecessary appendectomy.…”
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3 years survival of patients with multiple myeloma. by Julio Dámaso Fernández Águila, Alexander García Blay, Luis Alberto Corona Martínez, Maritza Cabrera Zamora, Leovaldo Prieto Jiménez., Tamara Guerra Alfonso

“…Frequently we don’t identify the patients that could be cured with advanced therapies, nor even recognize those, in which we expect a long survival with the classic treatment measures. …”
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Generation of a human induced pluripotent stem cell line (UNIFEi001-A) from a patient with Spinocerebellar ataxia type 1 (SCA1) by Mariangela Pappadà, Sara Melija, Martina Facchini, Mara Martino, Sofia Minarini, Anna Caproni, Chiara Nordi, Paola Rimessi, Rita Selvatici, Peggy Marconi

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Effect of non-pharmacological interventions for overweight/obese women with polycystic ovary syndrome on ovulation and pregnancy outcomes: a protocol for a systematic review and ne... by Juan Li, Jie Yang, Fan-rong Liang, Jun Zhou, Gui-Xing Xu, Han Yang, Yan-qun Xiao, Jia-jia Liu, Zhi-yong Xiao, Xiao-yan Zheng, Li-ying Liu, Zheng Yu

“…Non-pharmacological interventions used for the management of infertility include lifestyle interventions, acupuncture therapies and nutritional supplements. These interventions have been reported to be beneficial in alleviating infertility among overweight women with PCOS. …”
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Incidence, Characteristics, and Management of Patients with Recurrent Myocardial Infarctions: Insights from the EYESHOT POST-MI by Leonardo De Luca, Furio Colivicchi, Domenico Gabrielli, Donata Lucci, Gabriele Grippo, Francesco Piemonte, Bruno Villari, Andrea Di Lenarda, Fabrizio Oliva, Michele Massimo Gulizia

“…Our data suggest that patients with multiple MIs managed by cardiologists in routine clinical practice present an incremental clinical risk, more frequently undergo coronary angiography, and are more intensively managed with pharmacological therapies compared to patients at their first MI episode.…”
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Residual β-Cell Function in Type 1 Diabetes Followed for 2 Years after 3C Study by Kun Lin, Xiaoping Yang, Yixi Wu, Shuru Chen, Qiong Zeng

“…Therefore, intervention therapies of β-cells should start from the early stage, and the recommended target goal of stimulated C-peptide is 0.615 pmol/mL or above.…”
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