Modern Approaches to the Diagnosis and treatment of <i>Clostridioides difficile (C. difficile)</i>-associated Disease in Adults (literature Review and Expert Council Resolution) by V. T. Ivashkin, I. V. Maev, D. N. Andreev, O. V. Goloshchapov, A. A. Derinov, O. Yu. Zolnikova, K. V. Ivashkin, O. Yu. Kiseleva, A. P. Kiryukhin, O. S. Lyashenko, E. A. Poluektova, A. S. Tertychnyy, A. S. Trukhmanov, A. I. Ulyanin, A. A. Sheptulin, O. S. Shifrin

“…Addition of the probiotic strain Saccharomyces boulardii CNCM I-745 to antibacterial therapy promotes both primary and secondary prevention of C. difficile-associated disease.…”
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Achilles Tendon Rupture In Recreational Athletes - Hobby-Ending Incident or Easily Treatable Injury? Current Insight Into Risk Factors, Treatment Options and Recovery Strategies by Jakub Kędzia, Joanna Duda, Kinga Racisz, Paweł Racisz, Alicja Obcowska, Aleksandra Walendzik, Łukasz Sencerek

“…Conclusion: Optimal outcomes for ATR treatment are achieved through operative intervention, particularly minimally invasive surgery, paired with early rehabilitation. Physical therapy, blood-flow restriction training, and stretching can aid return to sport. …”
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Square-Stepping HIIT Combined With 'Phyllanthus amarus' Supplementation Alleviates Fasting Blood Glucose and Oxidative Stress in Overweight and Obese Individuals by Surachat Buddhisa, Nattaphol Prakobkaew, Piyapong Prasertsri, Sudarat Boonpitak, Puttipong Poncumhak, Orachorn Boonla

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The effect of bacterial overgrowth syndrome and bacterial translocation on the course of liver cirrhosis by M. S. Zharkova, M. V. Mayevskaya, V. T. Ivashkin

“…Ascitis, resistant to diuretic therapy was more frequent in patients with bacterial translocation (66,7%) in comparison to patients without it (14,3%) [OR 4,667; 95%CI: 0,717–30,353; р=0,036]. …”
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The Role of Platelet-Rich Plasma (PRP) in Enhancing IVF Success in Women With Ovarian Insufficiency: A Cohort Study by Zahra Mohammad Alipour, Farahnazsadat Ahmadi, Sina Mohajernoei, Roghaye Gharaei, Nazanin Hojjati, Elham Shirali, Firouzeh Akbari Asbagh

“…The findings suggest that with longer follow-up and larger sample sizes, PRP could be validated as a promising adjunctive therapy for women with ovarian insufficiency undergoing IVF. …”
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Socio-Demographic and Lifestyle Factors Influencing Adherence to AntiHypertensive Treatment in a Rural Area of Ludhiana, India by Sangeeta Girdhar, ,Mahesh Satija, Daljit Kaur, .Anurag Chaudhary

“…Non-adherence to drug therapy among anti-hypertensives is a matter worth concern. …”
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Homologous recombination deficiency test validation in patients with high-grade advanced ovarian cancer by Angelica Nogueira Rodrigues, Andreza Karine de Barros Almeida Souto, Diocésio Alves Pinto de Andrade, Larissa Müller Gomes, Sandra Satie Koide, Renata de Godoy e Silva, Bruno Batista de Souza, Juliana Doblas Massaro, Andréia Cristina de Melo, Andrea Morais Borges, Camila Giro, Carlos Augusto Vasconcelos de Andrade, Cesar Martins da Costa, Daniel Luiz Gimenes, Eduardo Caminha Bandeira de Mello, Fernanda Cesar de Oliveira, Frederico Müller de Toledo Lima, Gabriel Lima Lopes, Gustavo de Oliveira Bretas, Gustavo Guerra Jacob, Herika Lucia da Costa Silva, Juliana Ferrari Notaro, Lara Ladislau Alves, Marcos Veloso Moitinho, Mirian Cristina da Silva, Roberto Abramoff, Thais Amaral da Cunha Rauber, Rodrigo Dienstmann, Fernanda Christtanini Koyama

“…BackgroundAlong with BRCA mutation status, homologous recombination deficiency (HRD) testing is a prognostic and predictive biomarker for poly-ADP-ribose polymerase (PARP) inhibitor therapy indication in high-grade epithelial ovarian, fallopian tube, or peritoneal cancer. …”
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Therapeutic effects of reduced glutathione on liver function, fibrosis, and HBV DNA clearance in chronic hepatitis B patients by Qiyao Wei, Jing Zhao

“…The control group received standard entecavir treatment (0.5 mg/time, once a day, continuous treatment for 3 months), while the observation group received a combination therapy of reduced glutathione and the standard entecavir treatment. …”
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Most oncological pancreas resections must consider the mesopancreas by S. A. Safi, S. David, L. Haeberle, S. Vaghiri, T. Luedde, C. Roderburg, I. Esposito, G. Fluegen, W. T. Knoefel

“…Borderline resectable PDAC patients who retain an increased risk of infiltration to the portomesenteric system and/or arterial vasculate are candidates for neoadjuvant therapy. However, redefined pathological analysis revealed the dorsal resection margin to be similar at risk for R1 resection. …”
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Variability and performance of NHS England’s ‘reason to reside’ criteria in predicting hospital discharge in acute hospitals in England: a retrospective, observational cohort study... by Elizabeth Sapey, Simon Ball, David McNulty, Felicity Evison, Suzy Gallier, Katherine Reeves

“…In those remaining in hospital without eR2R, 61.2% met eR2R criteria on subsequent days (76% within 24 hours), most commonly due to increased NEWS2 (21.9%) or intravenous therapy administration (32.8%).Conclusions Reported R2R metrics are highly variable between and within acute Trusts in England. …”
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Derivation of a simple risk calculator for predicting clinical worsening in patients with pulmonary hypertension due to interstitial lung disease by K. El-Kersh, R. Bag, N. Bhatt, C. King, A. Waxman, F. Rischard, H. Kim, D. Cella, E. Shen, SD Nathan

“…Moreover, the calculators can provide clinicians with important prognostic information which can be used to reinforce the benefits of therapy. The risk calculators may also find utility as part of the composite allocation score of ILD-PH patients listed for lung transplant. …”
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Cost drivers associated with autologous stem-cell transplant (ASCT) in patients with relapsed/refractory diffuse large B-cell lymphoma in a Japanese real-world setting: A structura... by Saaya Tsutsué, Shinichi Makita, Hiroya Asou, Shingo Wada, Wen Shi Lee, Dilinuer Ainiwaer, Koki Idehara, Sona-Sanae Aoyagi, Seok-Won Kim, Todd Taylor

“…A total of 15 patients (13.89%) received subsequent therapies. The most frequent subsequent therapy was GDP-based with or without rituximab (n = 8, 7.41%). …”
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Adverse health effects after breast cancer up to 14 years after diagnosis by Marianne J. Heins, Kelly M. de Ligt, Janneke Verloop, Sabine Siesling, Joke C. Korevaar, Annette Berendsen, Daan Brandenbarg, Anneriet Dassen, Agnes Jager, Jacqueline Hugtenburg, Gerda van der Weele

“…Osteoporosis and chest symptoms were associated with hormone therapy; osteoporosis and skin infections with chemotherapy and lymphedema and skin infections with axillary dissection. …”
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Efficacy of Esophageal Protector in Treating Gastroesophageal Reflux Disease with Extraesophageal Symptoms: a Multicenter, Open-Label, Observational Study by Yu. A. Kucheryavy, D. N. Andreyev, E. Yu. Eryomina, A. A. Gilmanov, O. V. Nazarova, Ye. A. Sidneva, Yu. G. Topalova

“…This prospective observational multicenter study demonstrated that the addition of Alfasoxx to standard GERD therapy contributes to a significant regression of both esophageal and extraesophageal symptoms, as well as a decrease in the need for antacid medications.…”
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Effects of low, moderate, and high-intensity aquatic exercise on joint edema in induced rat knee arthritis by Alline Mardegan Mioto, Daniel Fernando dos Reis, Thiago Alves Garcia, Guilherme Akio Tamura Ozaki, Iara Buriola Trevisan, Rodrigo Metzker Pereira Ribeiro, Robson Chacon Castoldi, José Carlos Silva Camargo Filho

“… Introduction: Arthritis has prompted interest in using physical exercise as therapy. This study assesses the effects of low-, moderate-, and high-intensity exercise on induced arthritis in male Wistar rats. …”
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GP73-mediated secretion of PKM2 and GP73 promotes angiogenesis and M2-like macrophage polarization in hepatocellular carcinoma by Shujie Wang, Tongjia Zhang, Yue Zhou, Zitao Jiao, Kejia Lu, Xinyi Liu, Wei Jiang, Zhe Yang, Hui Li, Xiaowei Zhang

“…This study reveals the role of GP73 in enhancing PKM2 and GP73 secretion in promoting HCC progression, providing a theoretical basis and drug targets for HCC therapy.…”
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Identification of a distinctive immunogenomic gene signature in stage-matched colorectal cancer by Pankaj Ahluwalia, Ashis K. Mondal, Ashutosh Vashisht, Harmanpreet Singh, Ahmet Alptekin, Kalyani Ballur, Nivin Omar, Meenakshi Ahluwalia, Kimya Jones, Amanda Barrett, Vamsi Kota, Ravindra Kolhe

“…Further research using similar methods could identify therapy-specific gene signatures to strengthen the development of personalized medicine for CRC patients.…”
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Comparisons of adverse events associated with immune checkpoint inhibitors in the treatment of non-small cell lung cancer: a real-world disproportionality analysis based on the FDA... by Ruichen Gao, Wenjun Liang, Jintao Chen, Mingxia Yang, Xiaowei Yu, Xiaohua Wang

“…Abstract Background Immune checkpoint inhibitor (ICI) therapy is increasingly used to treat non-small cell lung cancer (NSCLC). …”
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Effects of exercise training on the nigrostriatal glutamatergic pathway and receptor interactions in Parkinson’s disease: a systematic review by Shahid Ishaq, Iqbal Ali Shah, Shin-Da Lee, Shin-Da Lee, Bor-Tsang Wu

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Relationship between sleep disorders and depressive symptoms among young women in Japan: a web-based cross-sectional study by Yuta Suzuki, Yukio Urabe, Noriaki Maeda, Satoshi Arima, Tsubasa Tashiro, Rami Mizuta, Takeru Abekura, Sakura Oda, Satoshi Onoue

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