Mechanistic insights toward progress in alogliptin beyond glycemic control: translational perspective by Faraha Ahmed, Syed Sufian Ahmad, M. Mumtaz Alam, M. Shaqiquzzaman, Abul Kalam Najmi, Mohammad Ahmed Khan

“…It is administered orally and efficacious as monotherapy as well as combined therapy with other T2DM drugs, such as pioglitazone and metformin. …”
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Impact of developmental state, p53 status, and interferon signaling on glioblastoma cell response to radiation and temozolomide treatment. by Artem Berezovsky, Oluwademilade Nuga, Indrani Datta, Kimberly Bergman, Thais Sabedot, Katherine Gurdziel, Susan Irtenkauf, Laura Hasselbach, Yuling Meng, Claudius Mueller, Emanuel F Petricoin, Stephen Brown, Neeraja Purandare, Sidhesh Aras, Tom Mikkelsen, Laila Poisson, Houtan Noushmehr, Douglas Ruden, Ana C deCarvalho

“…Both mutant and wt p53 models exhibited significant activation of the DNA-damage associated interferon (IFN) response in CSCs and differentiated cells, implicating this pathway in the GBM response to therapy. We observed that activation of NF-κB was positively correlated with the levels of O-6-methylguanine-DNA methyltransferase (MGMT) protein, a direct DNA repair enzyme leading to TMZ resistance, regardless of MGMT promoter methylation status, further supporting the clinical potential for inhibition of NF-kB signaling in GBM treatment. …”
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Evaluation of Inhaler Technique in Patients with Asthma and Chronic Obstructive Pulmonary Disease in Andaman and Nicobar Islands – An Observational Study by M. Natraj, Vishal Singh, T. Anbarasan

“…The mainstay treatment for both diseases includes inhalational therapy. A high percentage of patients have symptoms that are not well controlled in spite of using effective medications. …”
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MRI-based hip cartilage measures in osteoarthritic and non-osteoarthritic individuals: a systematic review by Jacob L Jaremko, Hector N Aguilar, Michele C Battié

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Benign mature teratoma of the conus medullaris in a 57-year-old-female: case report and literature review by Daniel Yamba Yamba, Dramane Cissé, Oualid Mohammed Hmamouche, Faycal Lakhdar, Mohammed Benzagmout, Khalid Chakour, Mohammed El Faiz Chaoui

“…Furthermore, the paucity of literature on the Adjuvant therapy for spinal teratoma is a challenge for neurosurgery for aiming of total resection.…”
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Targeting ceramide transfer protein sensitizes AML to FLT3 inhibitors via a GRP78-ATF6-CHOP axis by Xiaofan Sun, Yue Li, Juan Du, Fangshu Liu, Caiping Wu, Weihao Xiao, Guopan Yu, Xiaowei Chen, Robert Peter Gale, Hui Zeng

“…However, whether targeting CERT to induce ceramide accumulation thereby improving AML therapy efficiency remains elusive. Here, we show that knocking down CERT inhibits the growth and promotes the apoptosis of AML cells carrying FLT3-ITD mutation. …”
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PET imaging of AAV9 and AAVBR1 trafficking in normal mice by Aditya Bansal, Shalini Sharma, Manasa Kethamreddy, Mukesh K. Pandey

“…Abstract Adeno-associated virus (AAV) mediated gene therapy is advancing and needs a noninvasive imaging tool to evaluate its effective targeting, biodistribution and clearance for precise use in humans. …”
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The prognostic value of ferritinemia level in patients with chronic hepatitis C by N. C. Sargsyants, E. H. Grigoryan

“…In 32 patients, who received PEG-IFN α-2a and RBV, it was determined on starting point, on the 12th week and after termination of therapy. Logistical regression has been applied to study effect of ferritin and other variables on frequency of sustained virologic response (SVR). …”
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Fixation of A Closed Displaced Midshaft Clavicle Fracture by Intramedullary K-Wire: A Case Report by Devuandre Naziat, David Haryadi

“…On the other hand, conservative therapy of Robinson type 2B clavicle fracture has been linked to a higher rate of nonunion and a decrease in strength and endurance of the shoulder. …”
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Bioanthropological and Biomechanical Perspectives on Skeletal Senescence Variation by Sayf Muhammad Alaydrus, Muhamad Andri Jauhari

“…Dietary change, estrogen replacement therapy, and calcitonin consumption are effective measures in reducing the effects of osteoporosis. …”
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Preventive aspects and patient satisfaction with laser aided gingivectomy versus conventional method. An in-vivo comparative study by Aras Maruf Rauf, Ara Omer Fattah

“…Methods: This in vivo comparative study was designed to include 64 patients, divided into 2 groups of patients treated with either Laser therapy (34 Patients) or conventional method (30 Patients) of gingivectomy. …”
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Brd7 loss reawakens dormant metastasis initiating cells in lung by forging an immunosuppressive niche by Jayanta Mondal, Junfeng Zhang, Feng Qing, Shunping Li, Dhiraj Kumar, Jason T. Huse, Filippo G. Giancotti

“…Finally, attenuating this immunosuppressive milieu by neutrophil depletion, neutrophil extracellular trap (NET) inhibition, or immune checkpoint therapy abrogates metastatic outgrowth. These findings implicate Brd7 and PBAF in triggering metastatic outgrowth in cancer, pointing to targetable underlying mechanisms involving specific immune cell compartments.…”
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Treatment approaches for idiopathic retroperitoneal fibrosis: a systematic review with meta-analysis by Annik Steimer, Mike O. Becker

“…Abstract Background Currently, there is no standard therapy for idiopathic retroperitoneal fibrosis, so a systematic review was undertaken to assess the effectiveness of different treatment approaches. …”
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Prolotherapy Perineural Injection in Carpal Tunnel Syndrome with Bifid Median Nerve: A Case Report by Tresna Angga Basunanda, Arfano Januar Sangkai

“…Perineural injection therapy with 5% dextrose or prolotherapy becoming a common method for treating carpal tunnel syndrome. …”
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The impact of PD-L1 polymorphisms on the efficacy of immune checkpoint inhibitors depends on the tumor proportion score: a retrospective study by Keiichiro Suminaga, Takashi Nomizo, Hironori Yoshida, Hiroaki Ozasa

“…Conclusion The rs2282055 genotype may help in selecting cases from the TPS-negative patient population that may benefit from ICI therapy.…”
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A single-centre experience of His bundle pacing without electrophysiological mapping system: implant success rate, safety, pacing characteristics and one-year follow up by Swee Leng Kui, Colin Yeo, Lisa Teo, Ai Ling Him, Sherida Binte Syed Hamid, Kelvin Wong, Vern Hsen Tan

“…The indications for HBP were atrioventricular block (n = 13, 61.9%), sinus node dysfunction (n = 7, 33.3%) and upgrade from implantable cardioverter-defibrillator to His-cardiac resynchronisation therapy (n = 1, 4.8%). No significant difference was observed in baseline characteristics between Timeframe 1 and Timeframe 2. …”
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Unravelling anti-cancer properties of solanaceous extracts using GC–MS and HPLC by Iqra Riaz, Yamin Bibi, Muhammad Arshad, Muhammad Sheeraz Ahmad, Manzer H. Siddiqui, Yawen Zeng, Abdul Qayyum

“…Because of the adverse effects of the majority of the medications used in its therapy, managing it remains a major concern despite the availability of numerous remedies. …”
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Advances in regenerative medicine-based approaches for skin regeneration and rejuvenation by Nathalia Silva Dutra Alves, Gustavo Roncoli Reigado, Mayara Santos, Izabela Daniel Sardinha Caldeira, Henrique dos Santos Hernandes, Bruna Leticia Freitas-Marchi, Elina Zhivov, Felipe Santiago Chambergo, Viviane Abreu Nunes

“…This review examines core technologies including stem cell therapy, bioengineered skin substitutes, platelet-rich plasma (PRP), exosome-based therapies, and gene editing techniques like CRISPR. …”
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Comparison of Real-world Outcomes Between Patients Treated with Tapentadol ER or Oxycodone CR by Mike Durkin, Jacqueline Pesa, Jessica Lopatto, Rachel Halpern, Damon Van Voorhis, Stephanie Korrer

“…Patients had continuous health plan enrollment for 6 months before and after the index date, ≥ 90 days supply of opioid therapy, and no index drug claims in the preindex period. …”
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A Health Economic Analysis Exploring the Cost Consequence of Using a Surgical Site Infection Prevention Bundle for Hip and Knee Arthroplasty in Germany by Rhodri Saunders, Rafael Torrejon Torres, Henning Reuter, Scott Gibson

“…The SPB includes antimicrobial incision drapes, patient warming, and negative pressure wound therapy in high-risk patients. SSI reduction associated with these interventions was sourced from published meta-analyses. …”
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