Algorithm of management of patients with acute cholestatic hepatitis (Clinical case presentation) by T. A. Deyeva, Ye. N. German, M. V. Mayevskaya, V. T. Ivashkin

“…As a result of the carried out therapy (desintoxication preparations, ursodeoxycholic acid) and cancellation of all possible hepatotoxic agents symptoms of disease gradually regressed and improvement of laboratory parameters was marked.Conclusion. …”
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Current and future therapeutic options for chronic hepatitis D virus infection by Mariantonietta Pisaturo, Antonio Russo, Pierantonio Grimaldi, Salvatore Martini, Nicola Coppola

“…In the last few years there have been innovations in HDV therapy which have brought new excitement in the scientific community also considering the few therapeutic opportunities. …”
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Comprehensive synthesis of mHealth interventions in psychiatry: insights from systematic, scoping, narrative reviews and content analysis by Zaakira Shahul Hameed Mahreen, Noor Azziah Zainuldin, Melvyn Weibin Zhang

“…These studies highlight the effectiveness of mHealth interventions in reducing symptoms through cognitive–behavioural therapy, mindfulness and psychoeducation, benefitting adolescents, perinatal women and marginalised groups. …”
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Chronic pancreatitis: issues remain unresolved by V. T. Ivashkin, K. V. Ivashkin, A. V. Okhlobystin

“…Thus, in practical situation it is reasonable to control both severity of disorders of pancreatic secretion, and efficacy of enzyme replacement therapy according to scores of trophological status of the patient both clinical (BMI), and laboratory (serum levels of prealbumin, retinol-binding protein, cholesterol, magnesium). …”
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Antenatal corticosteroids in Singapore: a clinical and scientific assessment by Arundhati Gosavi, Zubair Amin, Sean William David Carter, Mahesh Arjandas Choolani, Erin Lesley Fee, Mark Amir Milad, Alan Hall Jobe, Matthew Warren Kemp

“…Drawing on clinical and experimental data, we reviewed the pharmacokinetic profile and pharmacodynamic effects of dexamethasone treatment regimen in Singapore, with a view to creating a development pipeline for optimising this critically important antenatal therapy.…”
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INTESTINAL MICROBIOME - A LEADING FACTOR IN HUMAN HEALTH AND DISEASES by E. Blum Hubert

“…Summary: Major advances in molecular and cell biology significantly improved our understanding of disease pathogenesis as well as in novel strategies for the diagnosis, therapy and prevention of human diseases. Based on modern molecular, genetic, epigenetic microbiologic and biochemical studies it is, on the one hand, possible to identify disease-related point mutations and single nucleotide polymorphisms within genome-wide association analyses (GWAS). …”
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Efficacy of esomeprazole at treatment of patients with gastroesophageal reflux disease by Yu. V. Yevsyutina

“…Results of multiple studies prove that esomeprazole is a highly effective antisecretory drug which can be used as for treatment of patients with erosive esophagitis and non-erosive reflux disease and as a maintenance therapy. Conclusion. Esomeprazole, in particular generic drug Emanera, is one of the most effective and safe antisecretory drugs. …”
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Acetylcholine in irritable bowel syndrome pathogenesis and the role of cholineblockers by Yu. O. Shulpekova

“…The agents, influencing cholinergic receptors, are one of basic resources of modern pharmaceutical therapy of irritable bowel syndrome.…”
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A rare case of renal cystic oncocytoma: Case report by Mohamed Lameir, Ahmed Mustafa, Jouhar Kolleri, Akram Twair, Mohammed Akhtar, Sali Alatasi

“…Renal oncocytomas are relatively benign renal tumours, accounting for approximately 5 % of primary adult epithelial kidney neoplasms that are surgically removed.The Bosniak classification is used to assist in estimating the probability of cancer and make recommendations for therapy or subsequent studies. We report a 52-year-old male who presented with a left renal cyst with an enhancing nodular component which showed interval increase in the size after one year (Bosniak IV). …”
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Processing of Red Ginger Powder Drink to Improve the Immune System During the Covid-19 Pandemic by Hasni Yaturramadhan, Anwar Syahdat

“…Introduction: Covid-19 is a disease that must be watched out for because of its relatively fast transmission and has a mortality rate that cannot be ignored and there is no definitive therapy. The body's immune system is important for maintained in this covid-19 era, in addition to consuming adequate nutrition, regular rest, supplements that contain lots of vitamin C and good sources of antioxidants for consumption. …”
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The perspectives of autologous hepatocytes generation for the treatment of liver failure by M. N. Evseeva, A. F. Sheptulina, Yu. P. Rubtsov

“…This review presents alternative approaches for liver failure treatment: inhibition of epithelial-mesenchymal transformation, e.g. by induction of proliferation (gene therapy with HGF), and by influence on immune imbalance (T-regulatory lymphocytes application).Conclusion. …”
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Diagnostics and Treatment of Esophageal Achalasia (Clinical Guidelines of the Russian Gastroenterological Association, Russian Scientific Medical Society of Internal Medicine, Russ... by V. T. Ivashkin, A. S. Trukhmanov, I. V. Maev, O. M. Drapkina, A. I. Martynov, O. A. Storonova, E. A. Godgello, M. P. Korolev, T. L. Lapina, P. V. Pavlov, A. V. Paraskevova, I. A. Tarasova, E. D. Fedorov, A. T. Tskhovrebov, M. P. Shapka, A. L. Shestakov, A. V. Yurasov

“…To analyse the obtained data, the Chicago classification is recommended — it allows to ascertain the type of achalasia, which determines the choice of treatment method and the assessment of the prognosis of the therapy effectiveness. Treatment of achalasia can be pharmacological, endoscopic (pneumatic balloon dilation, peroral endoscopic myotomy, botulinum toxin injection), aimed at regulating the tone and motility of the esophagus and cardia while preserving all anatomical structures, and surgical (laparoscopic esophagocardiomyotomy, esophagectomy), in which the muscle fibers of the esophagus and esophagogastric junction are intersected or the altered esophagus is completely removed with simultaneous formation of an artificial esophagus from the stomach or colon (esophagoplasty).Conclusion. …”
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Incidence, prevalence, and predictors of osteoporotic fracture in adult lung transplant recipients by Elisabeth Ng, Shanal Kumar, Eldho Paul, Daniel Bennett, Luisa Rosi, Louise Fuller, Lauren Chiu, Shoshana Sztal-Mazer, Steven Ivulich, Greg Snell, Leon A. Bach, Kathryn L. Hackman

“…Our institution offers LT recipients protocolized antiresorptive therapy, with zoledronic acid (ZA) used first line. …”
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Prognostic value of body adipose tissue parameters in cancer patients treated with immune checkpoint inhibitors by Yan Li, Yean Yu, Kun Lv, Rongjuan Ge, Xie Xie

“…ObjectiveThis study aims to explore the relationship between body adipose tissue characteristics and clinical outcomes in cancer patients receiving immune checkpoint inhibitor (ICI) therapy.MethodsWe conducted an extensive literature search across three major online databases—Embase, PubMed, and the Cochrane Library—to identify studies examining the link between body adipose tissue and treatment outcomes in cancer patients undergoing ICI therapy, from the inception of each database until February 20, 2024. …”
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Dysplasia of stomach epithelium at chronic <i>H. pylori</i>-associated gastritis: is everything quite so simple? by T. L. Lapina, A. S. Tertychny, S. S. Pirogov, V. V. Sokolov, I. M. Kartavenko, E. R. Nasretdinova, A. A. Paraskevova, O. A. Storonova, O. S. Lyashenko, Ye. Yu. Yur'yeva, A. S. Trukhmanov, V. T. Ivashkin

“…At low grade (mild) dysplasia complex endoscopic investigation is recommended to identify local premalignant lesions of the stomach mucosa, and at ruling them out — to determine adequate therapy. So, in presented clinical case H. pylori eradication therapy in 45-year old patient has led to disappearance of changes suspicious to epithelial dysplasia. …”
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OLIG2 mediates a rare targetable stem cell fate transition in sonic hedgehog medulloblastoma by Kinjal Desai, Siyi Wanggou, Erika Luis, Heather Whetstone, Chunying Yu, Robert J. Vanner, Hayden J. Selvadurai, Lilian Lee, Jinchu Vijay, Julia E. Jaramillo, Jerry Fan, Paul Guilhamon, Michelle Kushida, Xuejun Li, Gregory Stein, Santosh Kesari, Benjamin D. Simons, Xi Huang, Peter B. Dirks

“…Targeting this rare OLIG2-driven proliferative programme with a small molecule inhibitor, CT-179, dramatically attenuates early tumour formation and tumour regrowth post-therapy, and significantly increases median survival in vivo. …”
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TOPBP1 as a potential predictive biomarker for enhanced combinatorial efficacy of olaparib and AZD6738 in PDAC by Xiao-Mei Tang, Min-Min Shi, Jia-Cheng Wang, Yi-Jin Gu, Yu-Ting Dai, Qin-Xin Yang, Jia Liu, Ling-Jie Ren, Xin-Yun Liu, Chun Yang, Fang-Fang Ma, Ji-Bing Liu, Hong Yu, Da Fu, Yun-Feng Wang

“…Notably, this combination therapy was more effective in PDAC cell lines exhibiting high TOPBP1 expression, indicating that TOPBP1 may serve as a useful predictive biomarker. …”
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Energy management education for persons living with long COVID-related fatigue (EMERGE): protocol of a two-parallel arms target trial emulation study in a multicentre outpatient in... by Emilia Riggi, Marco Barbero, Gian Luca Di Tanna, Ruth Hersche, Andrea Weise

“…The ‘standard of care’ of the CG will include any intervention, except occupational therapy-based EME in peer groups. The causal contrast of interest will be the per-protocol effect. …”
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Exploring and detecting predictors associated with survival and mortality of cervical cancer patients: a 10-year retrospective study by Shaba Muneeha, Raushan Kumar Chaudhary, Vijith Vittal Shetty, Soumya Patil, Uday Venkat Mateti

“…Using cox regression analysis, advanced age (age > 50 years: hazard ratio (HR): 1.82), underweight (BMI < 18.5: HR:1), postmenopause (HR:1), advanced stage of cervical cancer (Stage I, Stage II, Stage III, Stage IV: HR:1, HR:2.78, HR:10.08, HR:20.81), poorly differentiated cervical cancer (HR:1.70), radiation therapy (HR:4.86), chemotherapy (HR:6.55) or chemoradiation therapy (HR:3.31) and surgery plus chemotherapy (HR: 4.55) were identified to be significant predictors of mortality among cervical cancer patients. …”
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A Nomogram Based on Circulating Inflammatory Factors for Predicting Prognosis of Newly Diagnosed Multiple Myeloma Patients by Wang M, Yue X, Ding Y, Cai Z, Xiao H, Huang H, He J

“…Mowang Wang,1– 4,&ast; Xiaoyan Yue,5,&ast; Yingying Ding,5,&ast; Zhen Cai,1,4 Haowen Xiao,5 He Huang,1– 4 Jingsong He1,4 1Bone Marrow Transplantation Center, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, People’s Republic of China; 2Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, Zhejiang Province, People’s Republic of China; 3Institute of Hematology, Zhejiang University, Hangzhou, Zhejiang Province, People’s Republic of China; 4Zhejiang Province Engineering Laboratory for Stem Cell and Immunity Therapy, Hangzhou, Zhejiang Province, People’s Republic of China; 5Department of Hematology and Cell Therapy, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: He Huang; Jingsong He, Bone Marrow Transplantation Center, the First Affiliated Hospital, Zhejiang University School of Medicine, No. 79 Qingchun Road, Hangzhou, Zhejiang Province, 310006, People’s Republic of China, Email huanghe@zju.edu.cn; hejingsong@zju.edu.cnPurpose: The growth and survival of multiple myeloma (MM) cells depend heavily on bone marrow microenvironment, where inflammation emerges as a significant feature and is commonly associated with unfavorable prognosis in MM. …”
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