The development and evaluation of a tublysine-based antibody-drug conjugate with enhanced tumor therapeutic efficacy by Huihui Guo, Hongsheng Xie, Yuanyuan Huang, Junxiang Jia, Xiangfei Kong, Qingliang Yang, Shun Gai, Wenjun Li, Lu Bai, Lingli Zhang, Xiaoxiao Chen, Zhicang Ye, Hangbo Ye, Linyao Zhao, Yifang Xu, Yong Du, Xiuzhen Zhang, Miaomiao Chen, Xiaomai Zhou, Robert Y. Zhao

“…Antibody-drug conjugates (ADCs) offer targeted cancer therapy by delivering cytotoxic agents directly to tumor cells. …”
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Skin autofluorescence as part of the comprehensive assessment of clinical and metabolic status of patients with end-stage chronic kidney disease by Darya Yu. Konovalova, Peter A. Lebedev, Olga V. Ushakova, Elena E. Potyakina, Dmitriy V. Kornilin, Vladimir N. Grishanov, Marina V. Komarova

“…These high-cost technologies of renal replacement therapy have significantly improved over recent decades, but the quality of life remains low and mortality is still high, especially in patients receiving PHD. …”
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Application of glycyrrhizinic acid in treatment of patients with alcoholic liver disease by I. G. Nikitin, I. Ye. Baykova, V. M. Volynkina, L. M. Gogova, G. I. Storozhakov, M. P. Prushkovskaya

“…Application of phosphogliv along with abstinence increases efficacy of therapy of alcoholinduced liver disease. The further studying of this agent is necessary at various clinical variants of disease with dynamic evaluation of basic clinical and laboratory parameters and effects of treatment on liver morphology.…”
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Real-World Health Care Outcomes and Costs Among Patients With Juvenile Idiopathic Arthritis in Spain by Jordi Antón, Estefania Moreno Ruzafa, Mireia Lopez Corbeto, Rosa Bou, Judith Sánchez Manubens, Sonia Carriquí Arenas, Joan Calzada Hernández, Violetta Bittermann, Carolina Estepa Guillén, Juan Mosquera Angarita, Lucía Rodríguez Díez, Estíbaliz Iglesias, Miguel Marti Masanet, Berta Lopez Montesinos, Maria I. González Fernández, Alfonso de Lossada, Carmen Peral, Mónica Valderrama, Noelia Llevat, María Montoro Álvarez, Immaculada Calvo Penadés

“…Identifying and implementing early and adequate therapy are critical for improving clinical outcomes. …”
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Physical activity and depression by Monika Wojtasik, Katarzyna Żak, Adam Załóg, Maria Nowak, Edyta Pietryszak, Wojciech Kulej, Paulina Szołtek, Rafał Pardela, Marcel Paruzel, Martyna Łęcka

“… This article aims to present the significance of physical activity as a key element in the prevention and therapy of depressive disorders. Through a review of the latest scientific research findings, the article focuses on the role of regular physical activity in reducing the risk of depressive disorders and its effectiveness in the therapeutic process. …”
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Efficacy and safety of the first domestic pegilated interferon alpha-2b «Pegaltevir» at chronic hepatitis C: pilot data of phase III clinical study by V. T. Ivashkin, Ye. N. Bessonova, P. O. Bogomolov, N. I. Geyvandova, K. V. Zhdanov, M. V. Mayevskaya, V. G. Morozov, V. D. Pasechnikov, I. Yu. Khomenko, A. V. Yagoda

“…Overall 140 patients with chronic hepatitis C, who received no antiviral therapy previously were included in original study. …”
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A remarkable and durable response to tislelizumab treatment of an anaplastic thyroid carcinoma without targetable genomic alterations: a case report by Jingjing Chai, Jiaqi Lv, Jian Xiong, Xiuwen Chen, Senyuan Luo, Zhiguo Luo, Zhiguo Luo, Ming Luo

“…However, none of these mutations have corresponding targeted therapies. Consequently, we administered tislelizumab as an immunotherapeutic intervention. …”
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Genomic characterization of chronic lymphocytic leukemia in patients of African ancestry by Cecilia Bonolo de Campos, Chantal E. McCabe, Laura A. Bruins, Daniel R. O’Brien, Sochilt Brown, Renee C. Tschumper, Cristine Allmer, Yuan Xiao Zhu, Kari G. Rabe, Sameer A. Parikh, Neil E. Kay, Huihuang Yan, James R. Cerhan, John N. Allan, Richard R. Furman, J. Brice Weinberg, Danielle M. Brander, Diane F. Jelinek, Marta Chesi, Susan L. Slager, Esteban Braggio

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Staphylococcus aureus susceptibilities from wounds of patients who use illicit fentanyl by Drew T. Dickinson, Stephen Saw, Lauren Dutcher, Christina Maguire, Adrienne Terico, Margaret Lowenstein, Sonal Patel

“…Conclusion: High nonsusceptibility to clindamycin and tetracycline suggests these agents should not be prescribed as empiric therapy for acute S. aureus SSTI in PWUF in Philadelphia. …”
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Inducers of Autophagy and Cell Death: Focus on Copper Metabolism by Weikang Ling, Shuo Li, Yang Zhu, Xin Wang, Dongmei Jiang, Bo Kang

“…Meanwhile, the application of copper-induced cell death in cancer therapy is discussed, aiming to provide new insights and guiding future research toward advancing cancer therapy.…”
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Weizmannia coagulans BC99 modulate gut microbiota after Helicobacter pylori eradication: A randomized double-blind placebo-controlled trial by Ying Wu, Shirui Zhai, Caie Wang, Zhouya Bai, Pingping Tian, Shanshan Tie, Yao Wang, Yingjian Zhang, Lina Zhao, Shaobin Gu

“…Both groups were received bismuth quadruple therapy for 4 weeks and took either BC99 or placebo for 6 weeks. …”
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Enucleated bone marrow-derived mesenchymal stromal cells regulate immune microenvironment and promote testosterone production through efferocytosis by Lu Sun, Jiayu Huang, Xuezi Wang, Peng Huang, Baolin Dong, Zehang Liang, Jiahong Wu, Jiancheng Wang

“…Testosterone replacement therapy (TRT) is widely used to treat TD, but this regimen can lead to a series of side effects. …”
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The Effectiveness of Add-on Treatment with Nutraceutical by V. T. Ivashkin, M. A. Morozova, E. A. Poluektova, O. S. Shifrin, A. G. Beniashvili, G. E. Rupchev, A. A. Alekseev, Yu. M. Poluektov, Z. A. Mamieva, A. L. Kovaleva, A. I. Ulyanin, E. A. Trush

“…Add-on of nutraceutical “SZ Gastro” to basic treatment is safe and significantly increases effectiveness of the therapy in the patients with IBS and IBS in combination with PD.…”
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Follicular Occlusion Syndrome — a Possible Option of Follicular-Retension Origin of Pilonidal Sinus by D. D. Shlyk, M. N. Pikuza, Yu. E. Kitsenko, A. S. Pirogova, N. B. Paramonova, R. T. Rzaev, N. P. Teplyuk, P. V. Tsarkov

“…All patients with confirmed FOS have received pathogenetic local and conservative therapy. After the therapy remission of combined diseases is noted.Conclusion. …”
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Interdisciplinary collaboration across secondary and primary care to improve medication safety in the elderly (IMMENSE study): study protocol for a randomised controlled trial by Liv Mathiesen, Jeanette Schultz Johansen, Kjerstin Havnes, Kjell H. Halvorsen, Stine Haustreis, Lillann Wilsgård Skaue, Elena Kamycheva, Kirsten K. Viktil, Anne Gerd Granås, Beate H. Garcia

“…Introduction Drug-related problems (DRPs) are common in the elderly, leading to suboptimal therapy, hospitalisations and increased mortality. …”
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Evaluation of the impact of PEPFAR transition on retention in care in South Africa’s Western Cape Province by J Chiliza, R Laing, F G Feeley, A T Brennan

“…The main outcome was RIC 12 months after antiretroviral therapy initiation for two periods – during PEPFAR and post PEPFAR. …”
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A protocol to optimize non-invasive brain stimulation for post-stroke rehabilitation by Ayesha Juhi, Manul Das, Dinesh Bhatia, Suman Dhaka, Rajesh Kumar, Deepak Kumar, Shreya Sharma, Pritam Kumar Chaudhary, Chanchal Goyal, Md Asif Khan, Himel Mondal

“…Along with this, there is a standard therapy group (n = 30) as control. Participants receive 20 min sessions, five days a week, over six weeks. …”
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Efficacy and safety of once-weekly semaglutide monotherapy in a young subject with Prader-Willi syndrome, obesity, and type 2 diabetes: a case report by Elisa Dinoi, Giuseppe Daniele, Giuseppe Daniele, Angela Michelucci, Fulvia Baldinotti, Fabrizio Campi, Piero Marchetti, Stefano Del Prato, Angela Dardano, Angela Dardano

“…The patient was discharged on a basal-bolus insulin therapy managed by his parents due to his cognitive impairment. …”
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The cultural and historical significance of malopo ritual: a Pedi perspective by M. E. K. Lebaka

“… Indeed, the implicit hypothesis that “there is little possibility, if any, for the Pedi traditional healers to experience the supernatural form of healing without performing music and dancing to it” raises the issue of “What makes the dance potent as a healing therapy?” or ‘What is the role of music in such healing processes?’. …”
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Common Green Bottle Fly or Sheep Blow Fly Lucilia sericata (Meigen) (Insecta: Diptera: Calliphoridae) by Matthew Anderson, Phillip E. Kaufman

“…Medical treatment using maggot therapy can help to heal infections that are otherwise incurable. …”
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