Network pharmacology study on the mechanism of berberine in Alzheimer’s disease model by Yaoyi Zhang, Shuai Lv, Pinyuan Huang, Lingmin Xiao, Nan Lin, En Huang

“…This study aimed to explore the target genes of BBR associated with AD therapy using a network pharmacology study. Through network pharmacology analysis, two main potential target genes, β-amyloid precursor protein (APP) and peroxisome proliferator-activated receptor gamma (PPARG), of BBR for AD therapy were screened out. …”
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Influence of Medication on Flare Up and Infection After Elective Orthopedic Surgery in Rheumatoid Arthritis Patient – A Narrative Review by Yaldi Rosadi, Yustin Marinta, Muthiah Nur Afifah

“…One retrospective study that the incidence of flares tends to be higher among the group of patients who received MTX therapy and stopped more than one week before surgery than the group who did not stop. …”
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Hepatic encephalopathy: pathogenesis, clinical presentation, diagnostics, treatment by Ch. S. Pavlov, I. V. Damulin, V. T. Ivashkin

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Interventions for Digital Addiction: Umbrella Review of Meta-Analyses by Peng Lu, Jiamin Qiu, Shiqi Huang, Xinman Wang, Shasha Han, Sui Zhu, Youjing Ning, Fang-fang Zeng, Yuan Yuan

“…These associations pertained to 8 interventions (group counseling, integrated internet addiction [IA] prevention programs, psychosocial interventions, reality therapy, self-control training programs, cognitive behavioral therapy, interventions to reduce screen time in children, and exercise) and 9 outcomes (self-control, self-esteem, internet gaming disorder symptoms, time spent gaming, IA scores, screen use time, interpersonal sensitivity longlines, anxiety, and depression). …”
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Influence of herbal medicine in periodontics by Vangara Aditya, Kharidhi Laxman Vandana

“…The use of herbs in the treatment of periodontitis is growing as an adjunct to nonsurgical modes of treatment, either in single herb or polyherbal therapy.…”
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Treatment of autonomous intestinal neuropathy in critical care by prucalopride and multistrain probiotic by A. L. Kovaleva, A. I. Ulyanin, O. Yu. Kiselyova, Ye. A. Poluektova, O. S. Shifrin, A. S. Tertychny, V. T. Ivashkin

“…Laboratory and instrumental investigation revealed obstructive right-sided abscessing pyelohephritis with development of sepsis; antibacterial therapy included meropenem in daily dose of 3.0 g along with correction of hypoalbuminemia and detoxication therapy. …”
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Impact of hepatic steatosis on the efficacy of antiviral treatment for chronic hepatitis B and the establishment of predictive model: a cohort study by Guanghui Ren, Kaining Jia, Shi Yin, Yunpeng Guan, Qingwei Cong, Ying Zhu

“…Methods A cohort of 320 CHB patients on antiviral therapy (including NAs and PEG IFNα) were included and categorized into CHB + MASLD (n = 125) and CHB group (n = 195). …”
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Clinical Practice Guidelines of the Russian Society for the Study of the Liver, the Russian Gastroenterological Association, the National Scientific Society of Infectious Disease S... by V. T. Ivashkin, V. P. Chulanov, N. A. Mamonova, M. V. Maevskaya, M. S. Zharkova, I. N. Tikhonov, P. O. Bogomolov, E. V. Volchkova, A. S. Dmitriev, O. O. Znojko, E. A. Klimova, K. V. Kozlov, I. E. Kravchenko, E. Yu. Malinnikova, R. V. Maslennikov, M. I. Mikhailov, K. E. Novak, I. G. Nikitin, V. E. Syutkin, E. V. Esaulenko, A. A. Sheptulin, E. N. Shirokova, N. D. Yushchuk

“…The spectrum of their effectiveness allows to achieve a sustained virological response in more than 90 % of cases, even in groups that were not previously considered even as candidates for therapy or were difficult to treat — patients receiving renal replacement therapy, after liver transplantation (or other organs), at the stage of decompensated liver cirrhosis, HIV co-infected, etc. …”
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Association of expedited review programmes with postmarketing safety events of new drugs approved by the US food and drug administration between 2007 and 2017 by Bao Liu, Xingyue Zhu

“…The raised risk for first safety event was found to associate with breakthrough therapy (adjusted HR 1.83; 95% CI 1.21 to 2.77; p=0.004), and with the combination of accelerated approval with orphan designation (adjusted HR 2.84; 95% CI 1.12 to 7.23; p=0.028). …”
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Patient with Jaundice, Dyspnea and Hyperferritinemia after COVID-19 by V. R. Grechishnikova, P. E. Tkachenko, M. S. Zharkova, T. P. Nekrasova, V. T. Ivashkin

“…Glucocorticosteroids therapy, transfusions of human immunoglobulin, albumin, and parenteral nutrition have led to patient's condition improvement.Conclusion. …”
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PROTACs: Mechanism and Bioavailability enhancement strategies by nanotechnology, RNA viral infections (vaccine strategy) and Prodrug development by Sanaul Mustafa, Md Sabir Hussain Siddiquee

“…This review also includes new progress, clinical applicability, and development trend of PROTAC for the change of disease therapy and drug delivery. …”
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Prevalence, Diagnostics and Treatment of Small Intestinal Bacterial Overgrowth in the Clinical Practice in Southern Federal District of the Russian Federation by N. V. Korochanskaya, I. L. Kliaritskaya, S. N. Serikova, A. V. Tkachev, M. V. Koroleva, M. A. Basenko

“…The widespread introduction of various versions of the breath test into the work of healthcare institutions will make it possible to overcome diagnostic difficulties in relation to verification of this diagnosis, substantiate and individualize the approach to prescribing antibacterial and probiotic therapy.…”
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Image Quality Assessment Based on Multi-Scale Representation and Shifting Transformer by Geng Fu, Ziyu Wang, Cuijuan Zhang, Zerong Qi, Mingzheng Hu, Shujun Fu, Yunfeng Zhang

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Physiotherapists’ perspectives on the implementation of direct access to physiotherapy services in Saudi Arabia: a cross-sectional study by Hosam Alzahrani, Razaz Shaheen, Osama Mohammed, Elaf Marouf

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SOCS2 inhibits the tumorigenesis of GISTs and increases the sensitivity of GISTs to imatinib by suppression of KIT activation by Liangying Zhang, Kun Xiao, Shaoting Zhang, Sien Zhao, Zimei Liu, Ming Wang, Kaiyue Qin, Yuanyuan Yu, Shujing Li, Lijun Ma, Jianmin Sun

“…In addition, the presence of SOCS2 increased the inhibition of KIT signaling and GIST cell survival and proliferation by imatinib in vitro, and imatinib treatment further reduced tumor growth in KITV558A/WT mice compared with that in KITV558A/WT/SOCS2-/- mice, indicating the key role of SOCS2 in the sensitivity of GISTs to the targeted therapy. Taken together, our data revealed the key role of SOCS2 in the tumorigenesis of GISTs and the sensitivity of GISTs to the targeted therapy, providing a better basis for the improved treatment strategy.…”
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Effects of Neoadjuvant Denosumab on Radiological and Histological Responses in Patients Undergoing En Bloc Resection for Giant Cell Tumor of Bone: A Systematic Review by Hendra Aditama, Yo Tendy Pratama, Dhanan Prastanika S, Dita Anggara K, Rhyan Dharma S

“…Denosumab, a monoclonal antibody, has emerged as a promising neoadjuvant therapy for GCTB, potentially facilitating surgical resection. …”
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Physical Activity and Gallstone Disease by I. N. Grigor’eva, T. E. Notova, T. I. Romanova

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Is Helicobacter pylori eradication required for non-steroidal anti-inflammatory drug-associated erosions and ulcers? by A. Ye. Karateyev, Ye. V. Moroz, Anastasia V. Tsurgan, N. V. Gontarenko

“…Available data allow to conclude that anti-H. pylori therapy requires differential approach in patients with indications for NSAID and LDA treatment. …”
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Differences in fatty infiltration in thigh muscles and physical function between people with and without knee osteoarthritis and similar body mass index: a cross-sectional study by Jessica B. Aily, Marcos de Noronha, Ricardo J. Ferrari, Stela M. Mattiello

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Efficacy and Safety of Bicyclol Treatment for Non-Alcoholic Fatty Liver Disease: Results of a Cohort Study by I. Yu. Pirogova, S. V. Yakovleva, T. V. Neuymina, S. P. Sinitsyn, V. S. Chulkov, T. N. Shamaeva

“…No significant changes were found in the group without drug therapy.Conclusions.  Bicyclol therapy in NAFLD is accompanied by positive dynamics of inflammation activity markers, insulin resistance and lipid spectrum, which suggests a positive dynamics of the stages of liver fibrosis and steatosis.…”
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