The steps that young people and suicide prevention professionals think the social media industry and policymakers should take to improve online safety. A nested cross-sectional stu... by Jo Robinson, Jo Robinson, Pinar Thorn, Pinar Thorn, Samuel McKay, Samuel McKay, Hannah Richards, Hannah Richards, Rikki Battersby-Coulter, Rikki Battersby-Coulter, Michelle Lamblin, Michelle Lamblin, Laura Hemming, Laura Hemming, Laura Hemming, Louise La Sala, Louise La Sala

“…Two expert panels were developed to participate in the overarching Delphi study, one of young people and one of suicide prevention experts; of them 43 young people and 23 professionals participated in the current study. …”
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Аssessment of the prospects for growing forest crops of European larch in the Eastern Forest-Steppe of Ukraine by Svitlana Raspopina, Maksim Didenko

“…The name of the soil was identified by laying soil profiles and describing them according to the morphological characteristics of the genetic horizons. …”
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Nucleotide receptor P2X7/STAT6 pathway regulates macrophage M2 polarization and its application in CAR-T immunotherapy by Qin Si, Lu Yang, Jie Liu, Hui Liu, Ruifang Bu, Na Cui

“…We engineered CAR-T cells targeting the non-functional P2X7 (nfP2X7) receptor, and co-cultured them with macrophages silencing P2X7 receptor along with OC cells. …”
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Ruthenium(II) Lipid‐Mimics Drive Lipid Phase Separation to Arouse Autophagy‐Ferroptosis Cascade for Photoimmunotherapy by Yue Zheng, Wen‐Jin Wang, Jing‐Xin Chen, Kun Peng, Xiao‐Xiao Chen, Qing‐Hua Shen, Bing‐Bing Liang, Zong‐Wan Mao, Cai‐Ping Tan

“…Herein, a series of Ru(II) lipid‐mimics based on short chains or midchain lipids are developed. Among them, Ru‐LipM with two dodecyl chains significantly induces natural lipid phase separation via hydrocarbon chain‐melting phase transitions. …”
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Testing an Electronic Patient-Reported Outcome Platform in the Context of Traumatic Brain Injury: PRiORiTy Usability Study by Christel McMullan, Grace Turner, Ameeta Retzer, Antonio Belli, Elin Haf Davies, Laura Nice, Luke Flavell, Jackie Flavell, Melanie Calvert

“…Each participant took part in cognitive interviews using with the “Think Aloud” method, encouraging them to verbalize their thoughts and experiences while using the platform. …”
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Development and Implementation of a Registry of Patients Attending Multidisciplinary Pain Treatment Clinics: The Quebec Pain Registry by M. Choinière, M. A. Ware, M. G. Pagé, A. Lacasse, H. Lanctôt, N. Beaudet, A. Boulanger, P. Bourgault, C. Cloutier, L. Coupal, Y. De Koninck, D. Dion, P. Dolbec, L. Germain, V. Martin, P. Sarret, Y. Shir, M.-C. Taillefer, B. Tousignant, A. Trépanier, R. Truchon

“…Between 2008 and 2013, 6902 patients were enrolled in the QPR, and data were collected prior to their first visit at the pain clinic and six months later. More than 90% of them (mean age ± SD: 52.76 ± 4.60, females: 59.1%) consented that their QPR data be used for research purposes. …”
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Super-enhancers in tumors: unraveling recent advances in their role in Oncogenesis and the emergence of targeted therapies by Yumeng Ji, Baixue Li, Rongjin Lin, Jing Yuan, Yang Han, Yuping Du, Yang Zhao

“…Abstract Super enhancers are a unique class of enhancers that possess a distinct structure and mechanism, which enable them to exhibit stronger gene transcription regulatory function than classical enhancers, thereby regulating cellular activities. …”
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Memory B cells and their transcriptomic profiles associated with belimumab resistance in systemic lupus erythematosus in the maintenance phase by Takeshi Iwasaki, Takeshi Iwasaki, Hajime Yoshifuji, Koji Kitagori, Shuji Sumitomo, Shuji Akizuki, Ran Nakashima, Hideaki Tsuji, Ryosuke Hiwa, Mirei Shirakashi, Kosaku Murakami, Akira Onishi, Hideo Onizawa, Masao Tanaka, Fumihiko Matsuda, Akio Morinobu, Koichiro Ohmura, Koichiro Ohmura

“…Memory B cells and high Ig expression in them were identified as a treatment-resistant factor of belimumab in SLE patients. …”
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Identification and validation of glycolysis-related diagnostic signatures in diabetic nephropathy: a study based on integrative machine learning and single-cell sequence by Xiaoyin Wu, Xiaoyin Wu, Buyu Guo, Buyu Guo, Xingyu Chang, Xingyu Chang, Yuxuan Yang, Yuxuan Yang, Qianqian Liu, Qianqian Liu, Jiahui Liu, Jiahui Liu, Yichen Yang, Yichen Yang, Kang Zhang, Yumei Ma, Songbo Fu, Songbo Fu, Songbo Fu

“…The expression levels of diagnostic signatures were verified in vitro.ResultsThrough the 108 combinations of machine learning algorithms, we selected 12 diagnostic signatures, including CD163, CYBB, ELF3, FCN1, PROM1, GPR65, LCN2, LTF, S100A4, SOX4, TGFB1 and TNFAIP8. Based on them, an integrative model named GScore was established for predicting DN onset and stratifying clinical risk. …”
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Enterotype Bacteroides Is Associated with a High Risk in Patients with Diabetes: A Pilot Study by Jiajia Wang, Wenjuan Li, Chuan Wang, Lingshu Wang, Tianyi He, Huiqing Hu, Jia Song, Chen Cui, Jingting Qiao, Li Qing, Lili Li, Nan Zang, Kewei Wang, Chuanlong Wu, Lin Qi, Aixia Ma, Huizhen Zheng, Xinguo Hou, Fuqiang Liu, Li Chen

“…More and more studies focus on the relationship between the gastrointestinal microbiome and type 2 diabetes, but few of them have actually explored the relationship between enterotypes and type 2 diabetes. …”
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Deciphering the Differences Between Epstein–Barr Virus‐Associated and Negative Gastric Cancer in the Prospect of CDKN2A Genomic Alterations and Lymphoid Infiltration by Fuda Xie, Bonan Chen, Yang Lyu, Peiyao Yu, Canbin Fang, Kam Tong Leung, Shouyu Wang, Dazhi Xu, Jun Yu, Kwok Wai Lo, Ka Fai To, Wei Kang

“…Furthermore, EBV infection was positively correlated with CD8+T cell infiltration, and both of them predicted better prognosis. Conclusion This study highlighted the comprehensive impact of EBV infection in GC formation and proposed a thought‐provoking observation for further investigation into the roles of CDKN2A and EBV infection in gastric tumorigenesis.…”
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Classification of risk for transmission of vaccine-preventable diseases in Brazilian municipalities: comparative analysis before and after the national movement for vaccination and... by Ana Catarina de Melo Araújo, Thales Philipe Rodrigues da Silva, Janaina Fonseca Almeida Souza, Krishna Mara Rodrigues Freire, Fernanda Penido Matozinhos, Eder Gatti Fernandes

“…In 2023, 34.90% of municipalities were classified as adequate (≥ 70%), and among them, 582 (10.46%) achieved 100% HCV for all vaccines. …”
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Digital technologies for water use and management in agriculture: Recent applications and future outlook by Carlos Parra-López, Saker Ben Abdallah, Guillermo Garcia-Garcia, Abdo Hassoun, Hana Trollman, Sandeep Jagtap, Sumit Gupta, Abderrahmane Aït-Kaddour, Sureerat Makmuang, Carmen Carmona-Torres

“…It examines key water-related challenges - scarcity, pollution, inefficient use and climate change - and shows how various digital technologies such as Remote Sensing, Artificial Intelligence, the Internet of Things, Big Data, Robotics, Smart Sensors and Blockchain can help address them. The review finds that these technologies offer significant potential for improving water management practices, with Remote Sensing and Artificial Intelligence emerging as the most versatile and widely adopted. …”
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The effect of nursing care provided to coronary intensive care patients according to their circadian rhythms on sleep quality, pain, anxiety, and delirium: a randomised controlled... by Meryem Pelin, Havva Sert

“…Melatonin increased and cortisol decreased in both groups without statistically significant differences between them (melatonin and cortisol levels: p > 0.05). Considering the sound levels in the environment, the first-night decibel mean was significantly higher in the intervention group than in the control group (first-night decibel mean: intervention group 56.58 ± 2.43 dB vs. control group 54.51 ± 2.41 dB, p < 0.05). …”
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Forest Fire Clustering: A Novel Tool for Identifying Star Members of Clusters by Xingyin Wei, Jing Chen, Su Zhang, Feilong He, Yunbo Zhao, Xuran He, Yongjie Fang, Xinhao Chen, Hao Yang

“…We compare the performance of FFC with that of DBSCAN and HDBSCAN on this data set by configuring them into the same processing pipeline for identifying star members. …”
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Studying and enhancing the methods for distance teaching of computer science in Kazakh secondary school students during the pandemic by M. M. Zhamankarin, A. M. Sivinskiy, M. K. Aitkenova, M. B. Zhanibekov

“…The analysis of the data obtained at the concluding stage of the experiment allowed to compare them with the reference values calculated at the preliminary stage of the research in question. …”
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Successful Achievement of Demanding Outcomes in Upadacitinib-Treated Atopic Dermatitis Patients: A Real-World, 96-Week Single-Centre Study by Stamatios Gregoriou, Ioannis-Alexios Koumprentziotis, Ileana Afroditi Kleidona, Michail Bakakis, Eleni Hatzidimitriou, Theodora Douvali, Aikaterini Tsiogka, Styliani Mastraftsi, Aristeidis Vaiopoulos, Alexander Stratigos

“…Six (16.7%) patients experienced AEs with four of them discontinuing medication; no patient discontinued because of upadacitinib inefficacy. …”
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Adherence to stand-by emergency treatment and mosquito protection measures in short-term travellers to moderate malaria risk areas by Daniel Julien Franken, Vita Willemijn Jongen, Anna Rooyakkers, Martin Peter Grobusch, Jelte Elsinga, Margarita Boering, Maria Prins, Brigitte Antonia Geertruida Lucía van Cleef

“…Of these travellers 44 % received a pre-travel SBET prescription, although presumably only a small fraction of them actually travelled remotely. None of the 25 travellers who reported fever used the prescribed SBET and five sought medical care. …”
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Exploring the Diversity of Some Microorganisms from Lake Al-Asfar, KSA: The Good, the Bad, and the Pathogenic by Fatimah Al Tammar, Nermin El Semary, Munirah F. Aldayel, Duaa Althumairy, Gowhara Alfayad

“…Some pose serious health risks, but some of them also contribute to reducing some of the pollution levels. …”
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Recombinant Anti-PF4 Antibodies Derived from Patients with Vaccine-Induced Immune Thrombocytopenia and Thrombosis (VITT) Facilitate Research and Laboratory Diagnosis of VITT by Luisa Müller, Venkata A. S. Dabbiru, Lucy Rutten, Rinke Bos, Roland Zahn, Stefan Handtke, Thomas Thiele, Marta Palicio, Olga Esteban, Marta Broto, Tom Paul Gordon, Andreas Greinacher, Jing Jing Wang, Linda Schönborn

“…Chemiluminescence assays and both anti-PF4 IgG and anti-PF4 IgG/heparin ELISA showed concentration-dependent PF4 binding of all six rAbs, however, with different reactivities among them. PIPA showed a similar, concentration-dependent platelet activation pattern. rAbs varied in their reactivity and the majority of the tested rAbs were able to induce procoagulant platelets. …”
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