Unveiling the toxicity of JWH-018 and JWH-019: Insights from behavioral and molecular studies in vivo and vitro by Fenghua Zhou, Yan Shi, Sujun Tan, Xiaoli Wang, Weicheng Yuan, Shuqi Tao, Ping Xiang, Bin Cong, Chunling Ma, Di Wen

“…In the present study, we aimed to investigate the toxicity and underlying mechanisms of indole SCs JWH-018 and JWH-019 in mice (C57BL/6, male, 6–8 weeks old), zebrafish (AB strain, male, 4–5 months old) and modified human embryonic kidney (HEK) 293 T cells, using behavioral, pharmacokinetic, pharmacological approaches, and molecular docking. …”
Get full text

Effect of Water Treatment and Immersion in Calcium Salt Solutions on the Quality of Fruits of Peumo Pink Tomato ( Solanum lycopersicum L.) Stored under Cold Conditions by Julio Correa, Asuncion Amoros, Herman Patricio Silva, José Ignacio Covarrubias, Victor Hugo Escalona

“…In the break stage, it is perishable, and it has a postharvest life that does not exceed three weeks at 12 to 15°C. The aim of this study was to evaluate the effect of immersion in water and in calcium salt solutions on the metabolism and quality of tomato of traditional Peumo Pink cultivar stored for 28 days at 10ºC plus a simulated trading period of 2 days at 20ºC. …”
Get full text

Changes in grocery shopping behaviour among low-income households during the COVID-19 pandemic by Angela CB Trude, Caitlin M Lowery, Gabriela M Vedovato, Shahmir H Ali, Josephine M Dudzik

“…Families who purchased groceries in-store less frequently were less likely to report ever buying groceries online (rate ratio (RR): 0·66, 95 % CI 0·46, 0·93) compared with weekly grocery shoppers. Shoppers who intended to purchase more groceries online in the next 6 months were more likely to have online shopping experience, although this differed by timing of online grocery service adoption. …”
Get full text

Interaction effect between vitamin D and gestational diabetes mellitus in the second trimester by MA Ziwen, DING Xiaoying, CHU Liming, ZHANG Yan, ZHANG Aifeng, ZHU Yanjun, WANG Xun, XIE Zhenyu

“…The level of serum 25(OH)D at the time of OGTT were detected and other clinical indicators were followed up.ResultsThe age, systolic blood pressure in early pregnancy, pre-pregnancy BMI, FPG, OGTT 1-hour and 2-hour glucose, GHb, HOMA-IR, TG, AST, Cr, D-D, FDP and SF at 35 weeks’ gestation of the pregnant women were higher in the GDM group than that of the pregnant women in the normal group, while gestational weight gain and serum 25(OH)D level were significantly lower than that of the pregnant women in the normal group. …”
Get full text

The effects of Garcinia cambogia on glycaemic control and liver enzymes in adults: a systematic review and meta-analysis of randomised controlled trials by Sogand Tavakoli, Mohammad Reza Amini, Reyhaneh Rabiee, Marieh Salavatizadeh, Mostafa Afsharianfar, Moein Askarpour, Azita Hekmatdoost

“…Nevertheless, the administration of Garcinia cambogia for more than 8 weeks significantly decreased insulin levels. This meta-analysis showed that supplementation with Garcinia cambogia has no significant effect on FBS, insulin, ALT, or AST levels compared with control groups; however, it seems that increasing the duration of the intervention may have a decreasing effect on insulin levels.…”
Get full text

Biological and Molecular Characterization of Moroccan Isolates of <i>Spiroplasma citri</i> by Tourya Sagouti, Ikram Legrifi, Naima Rhallabi, Zineb Belabess, Moussa El Jarroudi, Said Amiri, Essaid Ait Barka, Abdessalem Tahiri, Rachid Lahlali

“…Biological indexing through reverse inoculation revealed that seven out of ten isolates caused moderate to intense symptoms within 8 to 10 weeks, with symptom severity varying across citrus cultivars and regions. …”
Get full text

Brief intervention to reduce fatigue impact in patients with inflammatory arthritis: design and outcomes of a single-arm feasibility study by Paul Ewings, Emma Dures, Sarah Hewlett, Joanna Thorn, Mwidimi Ndosi, Siobhan Creanor, Jo Adams, Lance M McCracken, Joe Lomax, Susan Bridgewater, Bryan Abbott, Alice Berry, Marie Urban

“…Baseline data were collected before the first session (T0) and outcomes at 6 weeks (T1) and 6 months (T2). The proposed primary outcome was fatigue impact (BRAF NRS Fatigue Effect). …”
Get full text

Altered thermal preference by preoptic estrogen receptor alpha neurons in postpartum females by Nan Zhang, Meng Yu, Qianru Zhao, Bing Feng, Yue Deng, Jonathan C. Bean, Qingzhuo Liu, Benjamin P. Eappen, Yang He, Kristine M. Conde, Hailan Liu, Yongjie Yang, Longlong Tu, Mengjie Wang, Yongxiang Li, Na Yin, Hesong Liu, Junying Han, Darah Ave Threat, Nathan Xu, Taylor Smiley, Pingwen Xu, Lulu Chen, Tianshu Zeng, Yanlin He, Chunmei Wang

“…Female mice with RE (>4 weeks post-weaning) displayed lower body temperature and a lower thermal preferred temperature, and lost preference for warm environments (30 °C) but preserved avoidance of cold environments (15 °C). …”
Get full text

Don’t mind the gap: reframing the Perren strain rule for fracture healing using insights from virtual mechanical testing by Maham Tanveer, Karina Klein, Brigitte von Rechenberg, Salim Darwiche, Hannah L. Dailey

“…Callus mineralization initiated outside the high-strain gap and was significantly lower within the fracture gap compared to around it at nine weeks. Conclusion: Ovine osteotomies can heal with high gap strains (> 10%) dominated by shear conditions. …”
Get full text

Influence of the Multifunctional Biological Product Phytop 26.82 on the Growth and Development of Seed Potatoes by Vladislava Maslennikova, Vera Tsvetkova, Andrey Petrov, Rinat Galeev, Maxim Shulga, Natalia Gavrilets, Sergey Ryumkin, Anastasia Shulga, Evgeniy Ryadskiy, Kristina Koloshina, Inga Ryumkina

“…Under the bioagent, Phytop 26.82, Rhizoctonia stem canker on the stems decreased by 45% overall counting weeks. The effectiveness of the bioagent Phytop 26.82 reached 100% in two aspects. …”
Get full text

Comparative evaluation of management practices among large-scale broiler farms of Punjab, Pakistan by Muhammad Tahir Amin, Muhammad Usman, Hafiz Muhammad Ishaq, Asad Ali, Muzamal Tariq, Mian Mubashar Saleem, Syed Ghulam Mohayud Din Hashmi, Kinza Saleem, Sohail Ahmad

“…The most commonly observed average downtime was 2–3 weeks plus washing with chlorinated water and detergent after dry cleaning at farms. …”
Get full text

Metformin reverts aortic calcifications and elastin loss induced by an experimental metabolic syndrome by Lucas Streckwall, Nancy Martini, Claudia Sedlinsky, León Schurman, María Virginia Gangoiti, Antonio Desmond McCarthy

“…After 14 days, and for another 4 weeks, MET (100 mg/kg per day) was added to half of each group’s drinking source, thus C (water), F (fructose), M (MET) and FM (fructose + MET). …”
Get full text

Gastroprotective Effects of Aqueous Extracts of Broccoli Stems on Acute Injury in Rats: A Comprehensive Evaluation of Gastric Function and Inflammatory Responses by Jihye Choi, Yuseong Jang, Hyeon-Gi Paik, Melissa Hyun-Joo Ha, Jungkee Kwon

“…Acute gastric injury was induced using 150 mM HCl/60% EtOH, and male SD rats (6-weeks old, <i>n</i> = 6/group) were administered BSE by oral gavage at concentrations of 50, 125, and 250 mg/kg. …”
Get full text

Application of photodynamic therapy with 5-aminolevulinic acid and fractional CO2 laser for the management of recalcitrant plantar warts by Jiaoquan Chen, Xinyi Xie, Yingxue Liu, Fengyi Chen, Yeqing Gong, Bihua Liang, Yiling Wu, Shiqi He, Yueming Li, Huilan Zhu, Shaoyin Ma

“…Patients then received He-Ne laser irradiation for 30 min at an energy density of 100 mW/cm², with treatments spaced 4 weeks apart. Results: The study included 10 participants aged 24 to 53 years (mean age: 33.4 ± 8.09 years). …”
Get full text

Formation of the Figge Maar Seafloor Crater During the 1964 B1 Blowout in the German North Sea by Jens Karstens, Jens Schneider von Deimling, Christian Berndt, Christoph Böttner, Michel Kühn, Benedict T. I. Reinardy, Axel Ehrhardt, Jonas Gros, Bettina Schramm, Dirk Klaeschen, Judith Elger, Matthias Haeckel, Mark Schmidt, Sven Heinrich, Philipp Müller, Frithjof Bense

“…The focused discharge of gas at the seafloor removed up to 4.8 Mt of sediments in the following weeks of vigorous venting. Eyewitness accounts document that the initial phase of crater formation was characterized by the eruptive expulsion of fluids and sediments cutting deep into the substrate. …”
Get full text

Experimental study of partially oxidized sodium alginate gel combined with myogenic stem cells to improve cardiac function in aged rats with myocardial infarction by Xinxin Ma, Xiaolu Hou, Peixin Dong, Jiayan Ye, Yangyang Gao, Ling Huang, Xiuping Bai

“…[Methods] The models of myocardial infarction in aged rats were established by ligating the coronary arteries and divided randomly into the group of saline control group, sodium alginate group, myogenic stem cells group and sodium alginate combined with myogenic stem cells group(joint group), each had 30 rats.The same amount of corresponding material was injected into the myocardial infarction area of rats in each group respectively.The cardiac structure and function of the rats were evaluated by echocardiography 8 weeks after the operation, and then the rats were executed.The hearts were removed to observe the differences in ventricular remodeling by histological analysis and the angiogenesis and collagen secretion of the ventricular slices were further analyzed. …”
Get full text

Combined surgical and interventional cardiology approach for central venous access salvage in children with intestinal failure: A case series by Emily Byrd, M. Jake Petersen, Minna M. Wieck, Frank Ing, Shinjiro Hirose

“…Results: Median age at the time of intervention was 1.4 years (range 2.5 weeks – 2.6 years) with a median weight of 10 kg (range 3.3–13.8 kg). …”
Get full text

Application of Laparoscopic Radical Resection for Type III and IV Hilar Cholangiocarcinoma Treatment by Sulai Liu, Xinyu Liu, Xuepeng Li, Ou Li, Weimin Yi, Junaid Khan, Pingzhou Yang, Chao Guo, Chuang Peng, Bo Jiang

“…One patient developed bile leakage after surgery, healed within 2 weeks after drainage. The postoperative hospital stay was 16 (13-24) days. …”
Get full text

Effects of non-contact electric fields on the kidneys and livers of tumour-bearing rats [version 6; peer review: 1 approved, 2 approved with reservations, 1 not approved] by Luthfi Nurhidayat, Ahmad Ghitha Fadhlurrahman, Firman Alamsyah, Warsito Purwo Taruno, Nisrina Firdausi, Subekti Evi Dwi Nugraheni, Rarastoeti Pratiwi

“…Animals were then exposed to electric fields (100 kHz, 50-60 V/m) for 10 hours a day for three weeks. Two kidney samples and two liver samples from different animals in each group were collected for observation of structural damage to the organs. …”
Get full text

Management of acute bacterial meningitis in a limited resource setting: an Egyptian consensus model by Samy Zaky, Mohamed Elbadry, Maysaa A. Saeed, Hanaa Fathelbab, Fatma Abdelsalam, Mohammed Gamal Abdel-Hamid, Alshaimaa Eid, Asmaa Bakr, Amira Maher, Mona Mohammed Abdelrahman, Mohamed A. Metwally, Mahmoud Saad Berengy, Enaam Ali AlMowafy, Hassan Goabar, Amin Abdel Baki, Ahmed Corie, Osama Hammad, Entesar Elsharkawy, Ahmed Saad, Fatma Ali-Eldin, Ahmed Mahdy, Ramadan Zaky, Reham Hammad, Gamal Essmat

“…Each statement was voted as strongly, moderately, or weekly recommended. Each statement should have a predefined score of 80% agreement to be accepted and reported in this consensus. …”
Get full text