Randomised controlled trial of topical kanuka honey for the treatment of rosacea by James Fingleton, Mark Weatherall, Richard Beasley, Irene Braithwaite, Janwillem Kocks, Mark Holliday, Andrew Corin, Colin Helm, Davitt Sheahan, Barney Montgomery, Judith Riley, Anna Hunt, Christopher Tofield

“…The change in IGA-RSS for Honevo compared to control at week 2 minus baseline was −1 (Hodges-Lehman estimate, 95% CI −1 to 0, p=0.03), and at week 8 minus baseline was −1 (Hodges-Lehman estimate, 95% CI −1 to 0, p=0.005). …”
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Safety and efficacy of switching from adalimumab to sarilumab in patients with rheumatoid arthritis in the ongoing MONARCH open-label extension by Gerd R Burmester, Mark C Genovese, Vibeke Strand, Gregory St John, Andrea Rubbert-Roth, Howard Amital, Tatiana Raskina, Antonio Gómez-Centeno, Claudia Pena-Rossi, Leon Gervitz, Karthinathan Thangavelu, Susan Boklage

“…Objective Evaluate open-label sarilumab monotherapy in patients with rheumatoid arthritis switching from adalimumab monotherapy in MONARCH (NCT02332590); assess long-term safety and efficacy in patients continuing sarilumab during open-label extension (OLE).Methods During the 48-week OLE, patients received sarilumab 200 mg subcutaneously once every 2 weeks. …”
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Blood glucose response to kratom tea (Mitragyna speciosa Korth.) by Fadly Dzul

“…Methods: This evaluation was executed using an experimental design with ten subjects, which included pure standard glucose in week 1 and standard glucose mixed with 1% kratom tea in week 2, with a 1-week wash-out period. …”
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Loss of Appetite in Adult Patients: Effectiveness and Safety of an Appetite Stimulating Medication in an Open-Label, Investigator-Initiated Study in India by S. Nagaraj

“…Majority of the patients had CNAQ appetite scores of 17–28 at baseline (94%), week 1 (66%), and week 2 (78%) of treatment. For patients with acute and chronic illness, a statistically significant improvement was observed in the mean CNAQ score at week 1 (26.75 (3.69), P = 0.0256; 25.24 (5.33), P = 0.0004) and at week 2 (26.63 (3.46), P = 0.0027; 25.26 (4.43), P ≤ 0.0001) from baseline (21.88 (3.31) and 22.12 (2.69), respectively). …”
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Effect of Motorized Elephant-Assisted Therapy Program on Balance Control of Children with Autism Spectrum Disorder by Satiansukpong Nuntanee, Sasat Daranee

“…Pretests were administered one week before participation in the METP, and then, posttests were administered one week after completing the METP. …”
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Polyethylene Glycol 3350 in the Treatment of Chronic Idiopathic Constipation: Post hoc Analysis Using FDA Endpoints by Stacy B. Menees, Anthony J. Lembo, William D. Chey

“…This multicenter, double-blind, placebo-controlled, parallel-group trial included adults with chronic idiopathic constipation randomized to polyethylene glycol 3350 17 g (n = 204) or placebo (n = 100) once daily for 24 weeks. Post hoc analyses were performed using the US Food and Drug Administration endpoint (≥3 complete spontaneous bowel movements/week and an increase of ≥1 complete spontaneous bowel movement/week from baseline for ≥9/12 weeks, including 3 of the last 4 weeks) along with additional efficacy and safety outcomes. …”
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Serum Activins and Follistatin during the Treatment of Chronic Hepatitis C Genotypes 1 and 4 and Their Correlations with Viral Load and Liver Enzymes: A Preliminary Report by Bassem Refaat, Adel Galal El-Shemi, Ahmed Mohamed Ashshi, Adnan AlZanbagi

“…This study was cross-sectional and sera were collected from 165 participants classified into 7 groups: 40 healthy negative control, 33 treatment naïve patients as positive control, 19 patients at week 4, 22 at week 12, and 19 at week 24 of treatment initiation and 21 responders and 11 nonresponders at the end of 48-week treatment protocol. …”
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The prognostic value of ferritinemia level in patients with chronic hepatitis C by N. C. Sargsyants, E. H. Grigoryan

“…The average level of ferritin in the patients included in PEGIFN α-2a and RBV group, prior to onset of treatment was normal (241,4±33,1), on the 12th week of treatment it turn to be elevated in 90% of patients with average level of 703,5±133,4 ng/dl (p=0,009 at comparison to initial level), and after the end of treatment course elevation was observed in 66,6% of patients at average value of 473,6±96,3 ng/dl (p=0,044 at to starting point, p=0,07 at comparison to the 12-th week data). …”
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MEASUREMENT OF RADIATION EXPOSURE IN FACILITIES FOR RADIOLOGY DIAGNOSTIC AT THE COVID-19 EMERGENCY HOSPITAL IN WISMA ATLET JAKARTA by Muhammad Irsal, Firdha Adlia Syuhada, Yolanda Pangestu Ananda, Andre Galih Pratama Putra, Muhammad Rizky Syahputera, Syahputera Wibowo

“…Results: The assessment for the area 1 was 1 = 22.38 mR /week, in the area was 2 = 5.23 mR /week, in the area 3 = 7.32 mR / week, in the area 4 = 8.67 mR /week. …”
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The Impact of Exercise Play on the Biomechanical Characteristics of Single-Leg Jumping in 5- to 6-Year-Old Preschool Children by Zhanbing Song, Bojie Hou, Zhongqiu Ji, Guiping Jiang

“…Objective: This study aimed to investigate the effects of a 12-week self-designed exercise game intervention on the kinematic and kinetic data of the supporting leg in preschool children during the single-leg jump. …”
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Natural fermentation of bitter gourd (Momordica charantia) and noni fruit (Morinda citrifolia) in honey increases total phenol, total flavonoid, and antioxidant activity by Guardiola Esther Natalia, Sumitro Sutiman Bambang, Widyarti Sri

“…Total phenol (TPC), total flavonoid content (TFC), and antioxidant activity were measured every two weeks. TPC in fermented NF increased from 56.62 mg GAE/gr to 156.59 GAE in the 6-week. …”
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Double-blind, randomized, placebo-controlled pilot clinical trial with gamma-band transcranial alternating current stimulation for the treatment of schizophrenia refractory auditor... by Xiaojuan Wang, Xiaochen Zhang, Yuan Chang, Jingmeng Liao, Shuang Liu, Dong Ming

“…Auditory hallucination symptom scores and 64-channel electroencephalograms were measured at baseline, week2, week4 and follow-up. For clinical symptom score, we observed a significant interaction between group and time for auditory hallucinations symptoms (F(3,90) = 26.964, p < 0.001), and subsequent analysis showed that the 40Hz-tACS group had a higher symptom reduction rate than the sham group at week4 (p = 0.036) and follow-up (p = 0.047). …”
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Optimal dose and type of exercise improve walking velocity in adults with Parkinson’s disease: a systematic review and Bayesian network meta-analysis by Shaoqing Xie, Yuan Yuan, Junyu Wang, Ying Bai, Tao Wang, Bopeng Qiu, Yong Yang, Shu-Cheng Lin

“…Aerobic Exercise (AE) demonstrated the greatest improvement at an optimal dose of 1,400 METs-min/week (SMD:1.215, 95% Crl: 0.113 to 2.306). Both Multicomponent Exercise (Mul) (SMD: 1.202, 95% Crl: 0.193 to 2.231) and Sensory Exercise (SE) (SMD: 0.649, 95% Crl: 0.139 to 1.183) showed optimal outcomes at a dose of 1,000 METs-min/week. …”
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Nocturnal sweating—a common symptom of obstructive sleep apnoea: the Icelandic sleep apnoea cohort by Thorarinn Gislason, Christer Janson, Erla Bjornsdottir, Bryndis Benediktsdottir, Erna Sif Arnardottir, Sigurdur Juliusson, Samuel T Kuna, Allan I Pack

“…The control group consisted of 703 randomly selected subjects from the general population.Intervention PAP therapy in the OSA cohort.Main outcome measures Subjective reporting of nocturnal sweating on a frequency scale of 1–5: (1) never or very seldom, (2) less than once a week, (3) once to twice a week, (4) 3–5 times a week and (5) every night or almost every night. …”
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Comparison of Social Physique Anxiety of Fitness and Pilates Exercise in Women by Yeliz Doğru

“…The FG performed the 8-week fitness exercise for three days eight week. …”
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Vibration therapy as an intervention for trochanteric hip fractures – A randomized double-blinded, placebo-controlled trial by Ronald Man Yeung Wong, Pui Yan Wong, Chaoran Liu, Chun Sing Chui, Wing Hong Liu, Ning Tang, James Griffith, Ning Zhang, Wing Hoi Cheung

“…The balancing ability test could not be performed in most of the subjects at the baseline measurement. However, from week 6 to week 26, LMHFV group had significantly improved balancing compared to placebo group for overall stability index (week 26: 1.6 ± 1.1 vs. 3.4 ± 2.6; p = 0.006), anteroposterior stability index (week 26: 1.1 ± 0.7 vs. 2.1 ± 1.9; p = 0.048) and medial-lateral stability index (week 26: 0.9 ± 0.7 vs. 2.2 ± 2.2; p = 0.008). …”
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Preliminary investigation on the establishment of a new meibomian gland obstruction model and gene expression by Ming Sun, Huanmin Cheng, Zheng Yang, Jiangqin Tang, Shengshu Sun, Zhanglin Liu, Shaozhen Zhao, Lijie Dong, Yue Huang

“…MG acini was smaller at 8-week and 16-week MGO rats in HE staining. Oil Red O staining showed less condensed staining in the 8- and 16-week MGO groups, while more condensed staining in the 4-week MGO group. …”
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Efficacy and Safety of Risankizumab in Patients with Psoriasis Showing Suboptimal Response to Secukinumab or Ixekizumab: Results from a Phase 3b, Open-Label, Single-Arm (aIMM) Stud... by Richard B. Warren, Lev Pavlovsky, Antonio Costanzo, Michael Bukhalo, Neil J. Korman, Yu-Huei Huang, Georgios Kokolakis, Andreas Pinter, Nadia Ibrahim, Yanbing Zheng, Leonidas Drogaris, Vassilis Stakias, Ahmed M. Soliman, Simone Rubant, Diamant Thaçi

“…The primary endpoint was the proportion of patients achieving sPGA of 0/1 at week 16. Secondary endpoints included sPGA 0/1 at week 52, sPGA 0, Dermatology Life Quality Index (DLQI) 0/1, and Psoriasis Symptoms Scale (PSS) 0 at weeks 16 and 52. …”
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Establishment and Maintenance of a Digital Therapeutic Alliance in People Living With Negative Symptoms of Schizophrenia: Two Exploratory Single-Arm Studies by Cassandra Snipes, Cornelia Dorner‑Ciossek, Brendan D Hare, Olya Besedina, Tim Campellone, Mariya Petrova, Shaheen E Lakhan, Abhishek Pratap

“…In study 2, the 3-week orientation phase was followed by an abbreviated active 4-week phase. …”
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Apoptosis in the liver of male <em>db/db</em> mice during the development of obesity and type 2 diabetes by S. V. Michurina, I. Yu. Ishchenko, S. A. Arkhipov, M. A. Cherepanova, D. V. Vasendin, E. L. Zavjalov

“…Homozygous males of BKS.Cg-Dock7mLeprdb/+/+/J mice (db/db mice) are characterized by progressive obesity and the development of type 2 diabetes mellitus (DM2) with severe hyperglycemia at 4–8 weeks and organ lesions at 8–10 weeks of age. The aim of this research was to study the expression of molecular cell regulators of apoptosis in liver cells of db/db mice males at different stages of obesity and diabetes development (at the age of 10 and 18 weeks). …”
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