SARS-CoV-2 infections in pediatric and young adult recipients of chimeric antigen receptor T-cell therapy: an international registry report by Hongyan Liu, Colleen Callahan, Shannon L Maude, Kevin Owen McNerney, Rebecca M Richards, Paibel Aguayo-Hiraldo, Friso G Calkoen, Julie-An Talano, Amy Moskop, Adriana Balduzzi, Jennifer Krajewski, Hema Dave, Anant Vatsayan, Yimei Li, Kara Lynn Davis

“…While SARS-CoV-2 mortality rates of 33%–40% are reported in adult CAR T-cell recipients, outcomes in pediatric and young adult CAR T-cell recipients are limited.Methods We created an international retrospective registry of CAR T recipients aged 0–30 years infected with SARS-CoV-2 within 2 months prior to or any time after CAR T infusion. SARS-CoV-2-associated illness was graded as asymptomatic, mild, moderate, or severe COVID-19, or multisystem inflammatory syndrome in children (MIS-C). …”
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Outcomes of endometrial cancer prevention strategies in patients with Lynch syndrome: a nationwide cohort study in the NetherlandsResearch in context by Ellis L. Eikenboom, Lotte van Leeuwen, Floris Groenendijk, Jorien M. Woolderink, Anne M. Van Altena, Monique E. Van Leerdam, Manon C.W. Spaander, Helena C. van Doorn, Anja Wagner, M.C. Breijer, A.S. Tjalsma, F. Vork, H.P.M. Smedts, J. van der Velden, M.M.A. Brood-van Zanten, J.E. van de Riet, A.L.M. Oei, H. Kessel, P.M.L.H. Vencken, M.P.L.M. Snijders, R.H.M. Hermans, A. Bouman, H.W. Ünsalan, A.M.G. van de Swaluw, G.M. Plaisier, H.C. van Doorn, K. van den Berg, W. Hofhuis, Y.A.J.M. Dabekausen, P.R. Kolk, H.T.C. Nagel, A.M.L.D. van Haaften-de Jong, A.C. van Hof, M. van den Hende, J. Kaijser, H.H. de Haan, R.A. Smit, M.W.G. Moonen-Delarue, J.J. Beltman, J.E. Martens, R. Kruitwagen, J.M. van der Ploeg, J.M. Woolderink, S.F.P.J. Coppus, M.J. Duk, M.J.A. Apperloo, C.M. Koopmans, C.C.M. Buis, H. van Meurs, E.C. Dul, B.B.J. Hermsen, A.M. van Altena, A. Baalbergen, A.A. van Ginkel-Terng, M. Baas, P. van Greunen, C.M.W.H. Smeets, H. Knipscheer, J.E. Martens, C. Schmeink, M.D. van der Laan, E.J.M. van Es, J.E.W. van Dijk, F.M.F. Rosier-van Dunné, H. Nijman, C.G. Gerestein, D. Boskamp, E.C.A.H. Scheers, M. Verbruggen, L.R. Bartelink, C.B.M. Kruijdenberg, J.M. Briët, B. Visschers, M. Engelen

“…Overall survival after endometrial carcinoma diagnosis was analyzed using Kaplan Meier time to event analyses, cumulative incidence was calculated after adjusting for competing risks (death and prophylactic hysterectomy). …”
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A randomized, placebo-controlled trial of the BTK inhibitor zanubrutinib in hospitalized patients with COVID-19 respiratory distress: immune biomarker and clinical findings by Steven P. Treon, Camille N. Kotton, David J. Park, Giorgia Moranzoni, Camilla K. Lemvigh, Joseph C. Gathe, Tilly A. Varughese, Christopher F. Barnett, Johnny M. Belenchia, Nina M. Clark, Charles M. Farber, Muhammad Bilal Abid, Gulrayz Ahmed, Christopher J. Patterson, Maria L. Guerrera, Jacob D. Soumerai, Vipheaviny A. Chea, Isabel P. Carulli, Jackson Southard, Shuqiang Li, Catherine J. Wu, Kenneth J. Livak, Eric Holmgren, Pil Kim, Carrie Shi, Holly Lin, Vanitha Ramakrishnan, Ying Ou, Scott Olszewski, Lars Rønn Olsen, Derin B. Keskin, Derin B. Keskin, Zachary R. Hunter, Christopher Tankersley, Todd Zimmerman, Binod Dhakal

“…Co-primary endpoints were respiratory failure-free survival rate and time to return to breathing room air at 28 days. …”
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The role of OCO-3 XCO₂ retrievals in estimating global terrestrial net ecosystem exchanges by X. Wang, F. Jiang, F. Jiang, F. Jiang, H. Wang, Z. Zhang, M. Wu, J. Wang, W. He, W. Ju, W. Ju, J. M. Chen, J. M. Chen

“…The reasons for the poor performance of assimilating OCO-3 XCO<span class="inline-formula">₂</span> alone include the lack of observations beyond 52° S and 52° N, the large fluctuations in the number of data, and the varied observation time. Our study indicates that assimilating OCO-3 XCO<span class="inline-formula">₂</span> retrievals alone leads to an underestimation of land sinks at high latitudes and that a joint assimilation of OCO-2 XCO<span class="inline-formula">₂</span> and the OCO-3 XCO<span class="inline-formula">₂</span> retrievals observed in the afternoon is required for a better estimation of global terrestrial NEE.…”
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Histopathologic Progression and Metastatic Relapse Outcomes in Small Cell Neuroendocrine Carcinomas of the Urinary Tract by Mohammad Jad Moussa, Georges C. Tabet, Arlene O. Siefker‐Radtke, Lianchun Xiao, Nathaniel R. Wilson, Jianjun Gao, Christopher J. Logothetis, Petros Grivas, Byron Lee, Amishi Y. Shah, Pavlos Msaouel, Roger Li, Leticia Campos Clemente, Jianping Zhao, Nizar M. Tannir, Ashish M. Kamat, Donna E. Hansel, Charles C. Guo, Matthew T. Campbell, Omar Alhalabi

“…Relapse event was the time‐to‐event outcome, and relapse probabilities were estimated using a competing risk method with cumulative incidence functions (CIFs). …”
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Efficacy and safety of SHR8554 on postoperative pain in subjects with moderate to severe acute pain following orthopedic surgery: A multicenter, randomized, double-blind, dose-expl... by Yanhua Zhao, Zhisheng Lu, Xuesong Song, Haihui Xie, Xungang Xiao, Guonian Wang, Qi Zhou, Qingmei Zhang, Liang Liu, Zhijian Lan, Ning Bai, Haiyan Wang, Zhihao Pan, Liang Dong, Xianzhong Lin, Gang Chen, Qinghui Wang, Jiangtao Dong, Jia Deng, Yongshan Nan, Jiaqiang Zhang, Xiaohua Zhou, Yanjuan Huang, Yongquan Chen, Huanzhong He, Ye Yang, Dengpan Yao, Jintai Jia, Shuan Jin, Yafeng Zhang, Zhonghui Luo, Jiangang Li, Linzhong Zhang, Fang Wang, Juehua Jing, Jiang Zhu, Lin Li, Guangda Wang, Huajing Guo, Qiang Wang, Diansan Su, Weifeng Yu, Xiyao Gu

“…Secondary outcomes included rSPID and active-SPID (aSPID) at other time points, rescue analgesia received, cumulative dose of analgesics, and satisfaction scores. …”
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Factors associated with physical fitness and disparities in population segments among older adults: A cross-sectional study by Yuqin Rao, Jingjing Wang, Kai Li, Fanhui Zheng, Ying Chen, Bo Zhai, Jintao Hong, Chen Wang, Bao Liu, Dao Wang

“…Participants completed physical fitness assessments encompassing body fat percentage, lung capacity, high leg raise in place, grip strength, seated forward bending, 30-s sit-to-stand test, single-leg standing with eyes closed, and choice reaction time. A profile analysis model was constructed by feature extraction, label design and clustering using principal component analysis and k-prototypes. …”
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The Nature of Gradualness for Changes in Place of Articulation Features of Vowels in Serial Optimality Theory: Evidence from Three Iranian Languages by Mehdi Fattahi

“…In the first case scenario, the only logical path to have one feature change each time in Kalhori would be eàiàyàu. Each of these vowels in this chain is different in only one feature to its adjacent step. …”
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Application of lacrimal gland ultrasonography in the evaluation of chronic ocular graft-versus-host-disease by Mingxia Zhong, Siyuan Liu, Jinghan Luo, Qin Zhang, Zhou Yang, Shanshan Zhang

“…The disease activity of oGVHD and the severity of ocular surface involvement were assessed using various parameters such as Ocular Surface Disease Index (OSDI), Schirmer test, tear film break-up time (BUT), tear meniscus height, corneal/conjunctival staining and meibomian gland dropout. …”
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A Study on the Yield Stability of Oilseed Sunflower Genotypes under Drought Stress by Nasrin Akbari, Reza Darvishzadeh

“…Therefore, taking into account the quantitative control, and the effects of the environment and the interaction of the genotype × environment, selection for this trait is complex, costly, and time-consuming. Therefore, understanding the genotype × environment interaction is essential for the development of high-yielding and stable genotypes. …”
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Changes of Narrative: Osvald Sirén’s Photographic Modeling of Modern Research on Chinese Garden by Jiuwen GU, Yuanfeng SHI, Shan JIA

“…He applied a concept very similar to the area exposure method, generating images with personal characteristics. At the same time, these images of gardens with great detail content have formed a strong set of garden narratives, which in turn influence the perspective of garden research — a spatially compressed perspective with multiple details superimposed on each other, and a perspective that transforms spatial protagonists and garden narratives, which has begun to subconsciously influence the direction of garden research. …”
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Age-related changes in brain signal variability in autism spectrum disorder by Priyanka Sigar, Nicholas Kathrein, Elijah Gragas, Lauren Kupis, Lucina Q. Uddin, Jason S. Nomi

“…BSV was quantified using the root-mean-square successive difference (rMSSD) of the resting-state fMRI time series. We examined categorical group differences in rMSSD between ASD and TD groups, controlling for both linear and quadratic age. …”
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ZC3H15 suppression ameliorates bone cancer pain through inhibiting neuronal oxidative stress and microglial inflammation by Li-Quan Huang, Ting-Xuan Yan, Bao-Sheng Wang, Hao Li, Nai-Bao Zhou

“…Methods: To evaluate the expression of ZC3H15 in cancer-induced pain, we used microcomputed tomography (MicroCT), immunoblotting, co-immunoprecipitation (Co-IP), behavior tests, quantitative real-time polymerase chain reaction (qRT-PCR), and immunofluorescence assays in this investigation. …”
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Applicazione del Workload Indicators of Staffing Need (WISN) per la stima del fabbisogno di Tecnici Sanitari di Radiologia Medica in una Struttura di Diagnostica per Immagini itali... by Domenico Riccardo Cammisa, Francesca Fortunato, Antonio Alemanno, Rosetta D'Andria, Federica Guglielmi

“…L’indagine tra i dirigenti delle professioni sanitarie ha confermato la necessità di un metodo più preciso ed efficace, basato sull’effettivo carico di lavoro. L’Available Working Time (AWT) rilevato di 1369 ore/anno è risultato simile a quello previsto dalla Conferenza Stato-Regioni di 1480 ore/anno evidenziando che, nonostante i TSRM in organico siano 13, il volume di ore di servizio svolte corrisponde a quello di 10 unità. …”
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Heart failure with mildly reduced ejection fraction: retrospective study of ejection fraction trajectory risk by Robert J.H. Miller, Majid Nabipoor, Erik Youngson, Gynter Kotrri, Nowell M. Fine, Jonathan G. Howlett, Ian D. Paterson, Justin Ezekowitz, Finlay A. McAlister

“…The primary outcome was all‐cause mortality or cardiovascular hospitalization after the second echocardiogram. Associations with time to first event were assessed with multivariable Cox analyses adjusted for age, co‐morbidities, and medications. …”
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SERT-Deficient Mice Fed Western Diet Reveal Altered Metabolic and Pro-Inflammatory Responses of the Liver: A Link to Abnormal Behaviors by Raymond Cespuglio, Anna Gorlova, Konstantin Zabegalov, Kirill Chaprov, Evgeniy Svirin, Kseniia Sitdikova, Alisa Burova, Boris Shulgin, Ksenia Lebedeva, Alexei V. Deikin, Sergey Morozov, Tatyana Strekalova

“…Hepatic pro-inflammatory and metabolism-related gene expression and markers of nitrosative stress, were analyzed utilizing real-time polymerase chain reaction (RT-PCR) and correlated with behavioral and histological outcomes. …”
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Soybean oil, a linoleic acid source, in lamb diets: metabolic, feeding behavior, and ruminal parameters by V. G. O. Lima, L. O. da Silva, J. E. de Freitas Jr., H. D. R. Alba, V. M. Leite, W. P. Silva, D. D. S. Pina, L. C. Leite, C. S. Rodrigues, S. A. Santos, G. G. P. de Carvalho

“…The data were analyzed using linear and quadratic polynomial contrasts, except for the ruminal fermentation parameters and plasma glucose, which were analyzed using repeated measures over time. There was a linear reduction in DM (<span class="inline-formula"><i>P</i></span> <span class="inline-formula">=</span> 0.019) and crude protein (<span class="inline-formula"><i>P</i></span> <span class="inline-formula">=</span> 0.007) intake as well as a linear decrease in non-fibrous carbohydrate intake (<span class="inline-formula"><i>P</i></span> <span class="inline-formula">&lt;</span> 0.001) and digestibility (<span class="inline-formula"><i>P</i></span> <span class="inline-formula">=</span> 0.039) due to increased SO inclusion levels. …”
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Human Capital, Economic Growth and Environmental Quality with Special Emphasis on Public Education Expenditures: An Application of DSGE Models by Yahya Mohaghegh, hashem zare, Mehrzad Ebrahimi

“…For this reason, countries are trying to address environmental crises and economic growth at the same time. Basically, it is believed that the destruction of ecosystems in many countries is the result of human actions, including rapid industrialization, population growth, expansion of economic activities, urbanization, and widespread consumption of fossil fuels. …”
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Household transmission of SARS-CoV-2 in a rural area in South Africa by G Maimela, C E Martin, M Chersich, B Bello, J Mauti, T Bäernighausen, S Kohler, A Almuedo-Riera, S Luchters, S Sawry

“…We found a high SARS‐CoV‐2 infection rate among HCs in a rural setting, with 48% of households having a co‐primary case at the time of enrolment. Households with co‐primary cases were associated with a higher seroprevalence and incidence of SARS‐CoV‐2. …”
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FTO rs17817449 Variant Increases the Risk of Severe Obesity in a Brazilian Cohort: A Case-Control Study by Salum KCR, Assis ISS, Kopke ÚA, Palhinha L, Abreu GM, Gouvêa LW, Teixeira MR, Mattos FCC, Nogueira Neto JF, Felício RFM, Rosado EL, Zembrzuski VM, Campos Junior M, Maya-Monteiro CM, Cabello PH, Carneiro JRI, Bozza PT, Kohlrausch FB, da Fonseca ACP

“…We collected demographic, body composition, biochemical, and genotyping data by real-time PCR, and performed logistic and linear regression analyses to investigate the association of polymorphisms with severe obesity status and obesity-related quantitative parameters.Results: Individuals with severe obesity had significantly higher anthropometric measures, blood pressure, and biochemical levels. …”
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