Therapeutic role of miR-26a on cardiorenal injury in a mice model of angiotensin-II induced chronic kidney disease through inhibition of LIMS1/ILK pathway by Weijie Ni, Yajie Zhao, Jinxin Shen, Qing Yin, Yao Wang, Zuolin Li, Taotao Tang, Yi Wen, Yilin Zhang, Wei Jiang, Liangyunzi Jiang, Jinxuan Wei, Weihua Gan, Aiqing Zhang, Xiaoyu Zhou, Bin Wang, Bi-Cheng Liu, Yuanyuan Ji

“…Histological staining, immunohistochemistry, quantitative real-time polymerase chain reaction (PCR), and Western blotting were applied to study the regulation of miR-26a on Ang-II-induced cardiac and renal injury. …”
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Identification of strengths and weaknesses of the healthcare system for persons living with rare diseases in Catalonia (Spain), and recommendations to improve its comprehensive att... by José Hernández-Rodríguez, Fernando Martínez-Valle, Xènia Acebes, Carmen Alerany, Jordi Antón, Gonzalo Calvo, Marian Corral, Jordi Cruz, M. Antònia Mangues-Bafalluy, José Mateo, Josefa Rivera, Albert Salazar, Roser Francisco, Cristina Mallol, Rita Reig-Viader, Ariadna Tigri-Santiña, Assumpta Ricart, Francesc Palau

“…Abstract Background Rare diseases (RDs) are a heterogeneous group of complex and low-prevalence conditions in which the time to establish a definitive diagnosis is often too long. …”
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Determinants of the Continuum of Maternal Healthcare Services in Northwest Ethiopia: Findings from the Primary Health Care Project by Asmamaw Atnafu, Adane Kebede, Bisrat Misganaw, Destaw Fetene Teshome, Gashaw Andargie Biks, Getu Debalkie Demissie, Haileab Fekadu Wolde, Kassahun Alemu Gelaye, Mezgebu Yitayal, Tadesse Awoke Ayele, Telake Azale, Terefe Derso, Tsegaye Gebremedhin, Endalkachew Dellie

“…Women who were able to read and write (AOR: 2.70, 95% CI: 1.22, 6.04), using car/motorcycle as a means of transportation to get the health facility (AOR: 5.59, 95% CI: 2.29, 9.50), travel time less than an hour to get the health facility (AOR: 4.98, 95% CI: 2.97, 8.38), being satisfied with the service delivery (AOR: 1.89, 95% CI: 1.15, 3.11), and getting health education on maternal healthcare services in the last 6 months (AOR: 2.77, 95% CI: 1.52, 5.05) were factors associated with the completion of the continuum of maternal healthcare services. …”
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Steatohepatitis-induced vascular niche alterations promote melanoma metastasis by Johannes Hoffmann, Julia Schüler, Bianca Dietsch, Sina Wietje Kürschner-Zacharias, Carsten Sticht, Felix A. Trogisch, Maren Schreitmüller, Tinja Baljkas, Kai Schledzewski, Manuel Reinhart, Sebastian A. Wohlfeil, Manuel Winkler, Christian David Schmid, Joerg Heineke, Cyrill Géraud, Sergij Goerdt, Philipp-Sebastian Reiners-Koch, Victor Olsavszky

“…Methods Mice were fed a choline-deficient L-amino acid-defined (CDAA) diet for ten weeks to induce MASH-associated liver fibrosis, or a CDAA diet or a high fat diet (HFD) for shorter periods of time to induce early steatosis-associated alterations. …”
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Inter-rater reliability and prognostic value of baseline Radiographic Assessment of Lung Edema (RALE) scores in observational cohort studies of inpatients with COVID-19 by Andrew I Kim, William Bain, Alison Morris, Barbara Methe, Bryan J McVerry, Georgios D Kitsios, Daniel Kotok, Janet S Lee, Nameer Al-Yousif, Christine E Girard, Jana J Jacobs, Konstantin Golubykh, Hafiz Qurashi, Michael Lu, Saketram Komanduri, Anatoliy Korzhuk, Halimat O Lawal, Nicholas Abourizk, Caitlin Schaefer, Kevin J Mitchell, Catherine M Dietz, Ellen K Hughes, Clara S Brandt, Georgia M Fitzgerald, Robin Joyce, Asmaa S Chaudhry, Jose D Rivera, Shruti Shettigar, Allen Lavina, Samantha R Gillenwater, Anas Hadeh, Faraaz A Shah, Matthew Bittner, Niall Prendergast, John Evankovich, Navitha Ramesh, Cathy Kessinger

“…In the discovery cohort, the required level of respiratory support at the time of CXR acquisition (supplemental oxygen or non-invasive ventilation (n=178); invasive-mechanical ventilation (n=234), extracorporeal membrane oxygenation (n=13)) was significantly associated with RALE scores (median (IQR): 20.0 (14.1–26.7), 26.0 (20.5–34.0) and 44.5 (34.5–48.0), respectively, p<0.0001). …”
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Metabolomics, network pharmacology, and microbiome analyses uncover the mechanisms of the Chinese herbal formula for the improvement of meat quality in spent hens by Zhihua Li, Md. Abul Kalam Azad, Chengwen Meng, Xiangfeng Kong, Jue Gui, Wenchao Lin, Yadong Cui, Wei Lan, Qinghua He

“…Chinese herbs have been widely used as medicine for a long time to prevent diseases and as nutrient supplements to improve the product quality. …”
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Knowledge, attitude, and perception of Pakistani populations toward monkeypox: a cross-section study by Humayun Yousaf, Abdul Qadeer, Muhammad Sohail, Maqbool Khan, Muhammad Farooq, Zakir Khan, Dalia Fouad, Yu-Chia Liu, Chien-Chin Chen, Chien-Chin Chen, Chien-Chin Chen, Chien-Chin Chen

“…About 83.95% (2909) answered that during interaction with the Mpox patient, they’d dress in the appropriate personal protective clothing, like masks, gloves, and gowns. At the same time, 77.66% (2691) responded that they would perform hand hygiene after touching the patients’ surroundings, like beds, tables, doors, etc.ConclusionsMaximum research participants showed good attitudes and knowledge about Mpox. …”
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Biochemical, Histological, and Multi-Omics Analyses Reveal the Molecular and Metabolic Mechanisms of Cold Stress Response in the Chinese Soft-Shelled Turtle (<i>Pelodiscus sinensis... by Liqin Ji, Qing Shi, Chen Chen, Xiaoli Liu, Junxian Zhu, Xiaoyou Hong, Chengqing Wei, Xinping Zhu, Wei Li

“…Histological and TUNEL detection in the liver demonstrated that the 14 °C and 7 °C cold stress caused severe morphological damage and cell apoptosis in a time-dependent manner. DEGs in the biosynthesis of fatty acids (<i>Acsbg2, Acsl3, Acsl4, Acsl5, Mcat,</i> and <i>Acacb</i>), as well as unsaturated fatty acids (<i>Hsd17b12</i>, <i>Elovl7</i>, <i>Scd</i>, and <i>Baat</i>), starch and sucrose metabolism (<i>Pgm1</i>, <i>Pgm2</i>, and <i>Treh</i>), and apoptosis (<i>Ddit3</i>, <i>Gadd45a</i>, <i>Lmnb1</i>, <i>Tuba1c</i>, <i>Tnf</i>, <i>Tnfsf10</i>, <i>Fos</i>, <i>Itpr1</i>, and <i>Ctso</i>) were discovered in the transcriptome under cold stress. …”
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Noninferiority trial in veal calves on the efficacy of oxytetracycline and florfenicol treatment for pneumonia guided by quick thoracic ultrasound by Stan Jourquin, Florian Debruyne, Laurens Chantillon, Thomas Lowie, Randy Boone, Jade Bokma, Bart Pardon

“…After d 1, only calves with consolidations ≥1cm were given further treatment. On each time point, maximum consolidation depth was used to categorize calves into 4 qTUS categories: healthy (no consolidation), mild pneumonia (consolidation <1 cm), moderate pneumonia (consolidation 1–3 cm) and severe pneumonia (consolidation ≥3 cm). …”
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The Use of Zeolit and Activated Carbon on Packing System of Corydoras aenus by E. Supriyono, E. Supendi, K. Nirmala

“…Suitable and efficient packing technology is very needed to send live fish for long time transportation.  Two third of packing plastic volume was filled by oxygen, and Corydoras aenus 20 fish/pack.  …”
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GIS-based modeling and analytical approaches for groundwater quality suitability for different purposes in the Egyptian Nile Valley, a case study in Wadi Qena by Hanaa A. Megahed, Abd El-Hay A. Farrag, Amira A. Mohamed, Mahmoud H. Darwish, Mohamed A. E. AbdelRahman, Heba El-Bagoury, Paola D’Antonio, Antonio Scopa, Mansour A. A. Saad

“…Availability in Egypt is minimal due to a real restriction on the quantity and quality of acceptable water; it is also increasingly in demand, particularly since the reduction in the share in the Nile following the construction of the Renaissance Dam in Ethiopia. At the same time, the need for water increases due to population growth, industrial development and the cultivation of desert land. …”
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Pengembangan Aplikasi Sistem Informasi Pendataan Bangunan (SIPBANG) pada Dinas Pekerjaan Umum dan Penataan Ruang (DPUPR) Kota Malang Menggunakan Framework Scrum by Muhamad Rifky, Yusi Tyroni Mursityo, Bondan Sapta Prakoso

“…Scrum was used as the main method for system development because of three-month time limit from DPUPR. Besides, management project was used as the method that would ease the arrangement of general project planning from initialization, planning, implementation, evaluation, and closing. …”
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Can invasive interventions be avoided with a holistic swallowing therapy program in older patients in intensive care units: percutaneous endoscopic gastrostomy tubes or oral intake... by Çağla Eliküçük, Fatma Esen Aydinli, Nazan Has Selmi, Cansu Uzunoğlu, Murathan Köksal, Volkan Öter, Belgin Akan, Erdal Birol Bostanci, Güldeniz Argun

“…The bedside water swallowing test results demonstrated statistically significant differences in therapy timings among older patients (p &lt; 0.001). There were significant improvements in swallowing physiology, as represented by the improved oral and pharyngeal composite scores of the Modified Barium Swallow Impairment Profile (MBSImP) and Penetration-Aspiration Scala (PAS) levels. …”
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Multiple ovulation was positively associated with milk yield independently of circulating progesterone concentrations in multiparous high-producing Holstein cows submitted to Doubl... by T.J. Valdés-Arciniega, E. Anta-Galván, I.M.R. Leão, T.O. Cunha, M.S. El Azzi, N.B. Cook, J.P.N. Martins

“…The study used first-service multiparous cows submitted to a Double-Ovsynch program (GnRH; 7 d later, PGF2α; 3 d later, GnRH; 7 d later, GnRH [G1]; 7 d later, PGF2α [PG1]; 1 d later, PGF2α; ∼32 h later, GnRH [G2]; ∼16 h later, timed AI [TAI]). To assess ovulatory response and proportion of MOV, ovarian ultrasonography examinations were performed at G1 (n = 1,215) and G2 (n = 1,345) and from 40 to 48 h after each GnRH. …”
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Measurement report: Analysis of aerosol optical depth variation at Zhongshan Station in Antarctica by L. Chen, L. Chen, L. Zhang, Y. She, Z. Zeng, Y. Zheng, B. Tian, W. Zhang, Z. Liu, H. Che, M. Ding

“…We observed a peak in AOD (<span class="inline-formula">∼</span> 0.06) at 14:00 local time (LT) at Zhongshan Station, possibly associated with a slight decrease in boundary layer height (BLH). …”
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Emergence of mcr-8.1-bearing MDR-hypervirulent Klebsiella pneumoniae ST307 by Jie Sheng, Rory Cave, Mary M. Ter-Stepanyan, Siyu Lu, Yingxiong Wang, Taihang Liu, Hermine V. Mkrtchyan

“…ABSTRACT We report for the first time whole-genome sequencing of four multidrug-resistant sequence type (ST) 307 Klebsiella pneumoniae recovered from patients in two hospitals in Armenia. …”
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Studying the Beneficial Indicators of Intercropping of Safflower (Carthamus tinctorius L.) with Chickpea (Cicer arietinum L.), Lentil (Lens culinaris Medik), and Bitter Vetch (Lath... by Amin Yari, Farzad Mondani, Alireza Bagheri, Hamid Reza Chaghazardi

“…Introduction[1] Intercropping is an agroecological technique in which two or more species are grown in the same area for a certain period of time. These species should be complementary to each other regarding the use of productive resources. …”
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Ethnic and racial discrimination in maternal health care in Mexico: a neglected challenge in the search for universal health coverage by Edson Serván-Mori, Sergio Meneses-Navarro, Rocío García-Díaz, Diego Cerecero-García, David Contreras-Loya, Octavio Gómez-Dantés, Arachu Castro

“…We defined ECMH as adequate antenatal care (ANC), skilled and/or institutional delivery care, timely postpartum care, and complication-free postpartum/puerperium. …”
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Designing a Model for Credit Risk Assessment of Customers for Guarantees Issued by the Export Guarantee Fund of Iran via Artificial Neural Network Model by Farshid Ahmadi Sartakhti, Kambiz Hojabr Kiani, Seyed Shamsoddin Hoseini, Abbas Memarnejad

“…ObjectiveOne of the most important risks faced by financial institutions is credit risk, which is formed by the possibility of the receiver's default in repaying the loan or repaying the loan on time. One of the pivotal financial institutions in Iran's economy is the Export Guarantee Fund of Iran. …”
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Long-Term Safety of Ixekizumab Treatment in Patients with Psoriasis, Psoriatic Arthritis, or Axial Spondyloarthritis: a Post Hoc Analysis of Cerebro-Cardiovascular Events by Mark Lebwohl, Atul Deodhar, Sergio Schwartzman, Carlo Salvarani, Meghan Feely McDonald, Natalia Bello, Elsie L. Grace, Elsa Inman, Andris Kronbergs, Marcus Ngantcha, Proton Rahman, Kim A. Papp, Joseph F. Merola, Alice B. Gottlieb, Andrew Blauvelt

“…Patients with these conditions are often exposed for extended time periods to biologics, such as ixekizumab (IXE). …”
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