The greenhouse gas observation mission with Global Observing SATellite for Greenhouse gases and Water cycle (GOSAT-GW): objectives, conceptual framework and scientific contribution... by Hiroshi Tanimoto, Tsuneo Matsunaga, Yu Someya, Tamaki Fujinawa, Hirofumi Ohyama, Isamu Morino, Hisashi Yashiro, Takafumi Sugita, Satoshi Inomata, Astrid Müller, Tazu Saeki, Yukio Yoshida, Yosuke Niwa, Makoto Saito, Hibiki Noda, Yousuke Yamashita, Kohei Ikeda, Nobuko Saigusa, Toshinobu Machida, Matthias Max Frey, Hyunkwang Lim, Priyanka Srivastava, Yoshitaka Jin, Atsushi Shimizu, Tomoaki Nishizawa, Yugo Kanaya, Takashi Sekiya, Prabir Patra, Masayuki Takigawa, Jagat Bisht, Yasko Kasai, Tomohiro O. Sato

“…GOSAT-GW will fly in a sun-synchronous orbit with a local overpass time of approximately 13:30 and a 3-day ground-track repeat cycle. …”
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First-year dynamics of the anaerobic microbiome and archaeome in infants’ oral and gastrointestinal systems by Charlotte J. Neumann, Rokhsareh Mohammadzadeh, Pei Yee Woh, Tanja Kobal, Manuela-Raluca Pausan, Tejus Shinde, Victoria Haid, Polona Mertelj, Eva-Christine Weiss, Vassiliki Kolovetsiou-Kreiner, Alexander Mahnert, Christina Kumpitsch, Evelyn Jantscher-Krenn, Christine Moissl-Eichinger

“…In contrast to this, we could track specific bacterial strains transitioning from oral to gut or persisting in the gut over time.…”
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IL-6/GATA2/SERPINE1 pathway is implicated in regulating cellular senescence after acute kidney injury by Hongshuang Su, Xiaoxi Lin, Ayinuer Paredong, Ayinuer Paredong, Congcong Yao, Yan Zhang, Mengke Geng, Yuqian Guan, Lichao Gong, Feng Jiang, Qi Lv, Songtao Shou, Heng Jin

“…The expression levels of SERPINE1, GATA2, p53, and p21 were determined by real-time quantitative PCR and Western blot. Additionally, a dual-luciferase reporter gene assay was conducted to validate the binding effect of SERPINE1 and GATA2.ResultsTranscriptome Analysis revealed that genes including GATA2 and SERPINE1 were downregulated in HK-2 cells following tocilizumab treatment. …”
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Neuropilin1-dependent paracrine signaling of cancer cells mediated by miRNA exosomal cargo by Claudia Palazzo, Roberta Mastrantonio, Noemi Gioelli, Erika Testa, Francesco Recco, Donatella Lucchetti, Giulia Villari, Alessio D’Alessio, Alessandro Sgambato, Flavio Mignone, Guido Serini, Maria Teresa Viscomi, Luca Tamagnone

“…Wound healing, transwell, and digital real-time migration assays were carried out to assess the activity of cancer cell-derived exosomes in the regulation of endothelial cells. …”
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Using Human-Centered Design to Bridge Zero-Dose Vaccine Gap: A Case Study of Ilala District in Tanzania by Simon Martin Nzilibili, Hellen Maziku, Awet Araya, Ruthbetha Kateule, Millenium Anthony Malamla, Suna Salum, Furaha Kyesi, Lotalis Gadau, Tumaini Menson Haonga, Florian Tinuga, Rashid Mfaume, Zaitun Hamza, Georgina Joachim, Alice Geofrey Mwiru, Alex Benson, Oscar Kapela, Ona Machangu, Norman Jonas, Ntuli Kapologwe

“…., the inadequate support of local community leaders in under-five vaccination sensitization and surveillance; poor infrastructure to new settlement areas; hesitancy and unwillingness of parents/guardians; absence of house numbers; limited/time-constrained availability of resources to facilitate mobile immunization services, etc. …”
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Elucidating the pharmacological foundations and mechanisms of the Sihai Shuyu formula in treating Graves’ disease through integrated serum metabolomics and network pharmacology wit... by Xiaoju Liu, Xingjia Li, Wenbin Huang, Yifan Cui, Fengyun Cheng, Guofang Chen, Guofang Chen, Xiaodong Mao, Chao Liu, Chao Liu, Shuhang Xu

“…Ultra-High Performance Liquid Chromatography with Quadrupole Time-of-Flight Mass Spectrometry (UPLC-Q-TOF-MS) was used in conjunction with network pharmacology and molecular docking to identify and predict SHSY’s active chemical components and targets. …”
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Rehospitalization burden and morbidity risk in patients with heart failure with mid‐range ejection fraction by Enrique Santas, Rafael de laEspriella, Patricia Palau, Gema Miñana, Martina Amiguet, Juan Sanchis, Josep Lupón, Antoni Bayes‐Genís, Francisco Javier Chorro, Julio Núñez Villota

“…Abstract Aims Heart failure with mid‐range ejection fraction (HFmrEF) has been proposed as a distinct HF phenotype, but whether patients on this category fare worse, similarly, or better than those with HF with reduced EF (HFrEF) or preserved EF (HFpEF) in terms of rehospitalization risks over time remains unclear. Methods and results We prospectively included 2961 consecutive patients admitted for acute HF (AHF) in our institution. …”
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Effectiveness of ertugliflozin during Ramadan fasting in patients with type 2 diabetes mellitus: a real-world study (ErtuRamadan study) by Md Faruque Pathan, Nazma Akter, Marufa Mustari, M. Saifuddin, Mirza Sharifuzzaman, Mohammad Motiur Rahman, Mohammed Ripon, S. M. Mohiuddin, A. B. M. Kamrul-Hasan, Mohammad Abdul Hannan, Muhammad Shah Alam, Samira Mahjabeen, Faria Afsana, Muhammed Abu Bakar, Tahniyah Haq, Afsar Ahammed, Samir Kumar Talukder, Sourav Sarkar, Shahjada Selim

“…BackgroundManagement of type 2 diabetes mellitus (T2DM) during Ramadan fasting presents unique challenges due to prolonged fasting periods, irregular meal schedules, and altered medication timing, potentially impacting glycemic control. Ertugliflozin, a sodium-glucose co-transporter 2 (SGLT2) inhibitor, has been shown to improve glycemic control in T2DM effectively. …”
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The impact of war on people with type 2 diabetes in Ukraine: a survey studyResearch in context by Oksana Sulaieva, Viktoriia Yerokhovych, Sergii Zemskov, Iuliia Komisarenko, Vitalii Gurianov, Volodymyr Pankiv, Oleksandr Tovkai, Tetyana Yuzvenko, Violetta Yuzvenko, Andrii Tovkai, Zlatoslava Shaienko, Tetyana Falalyeyeva, Nadiya Skrypnyk, Taras Romaniv, Nadiya Pasyechko, Taras Krytskyy, Solomiia Danyliuk, Andrii Klantsa, Dmytro Krasnienkov, Oleksandr Gurbych, Nazarii Kobyliak

“…HbA1c levels demonstrated a time-dependent pattern of growth, reflecting the cumulative effect of war-related factors on T2D patients’ health. …”
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Evaluating the differences in healthy lifestyle behaviors between Chinese urban and rural residency after the termination of social distancing: analysis based on propensity score m... by Yudong Miao, Dongfang Zhu, Zhanlei Shen, Yi Li, Wanliang Zhang, Junwen Bai, Ruizhe Ren, Jingbao Zhang, Dan Guo, Clifford Silver Tarimo, Wenyong Dong, Rongmei Liu, Qiuping Zhao, Xue Zhou, Jianping Hu

“…China ended social distancing on January 8, 2023, and the healthy lifestyle behaviors of residents after this time are unclear. The goal of this study was to evaluate the differences in healthy lifestyle behaviors between Chinese urban and rural residency after the termination of social distancing. …”
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Engaging the private sector as part of HIV pre-exposure prophylaxis service delivery in Vietnam: a comparative analysis of uptake, persistence and HIV seroconversion from 2018 to 2... by Bao Ngoc Vu, Kimberly Green, Huong Phan, Long Tran, Phuong Phan, Tham Tran, Linh Doan, Yen Vu, Chau Pham, Dao Nguyen, Anh Doan, Trang Ngo, Phuong Tran, Vuong Nguyen, Bieu Nguyen, Thai Phan, Ha Nguyen

“…We used the Kaplan-Meier time-to-event approach to estimate PrEP persistence and mixed-effects logistic regression analysis to assess factors associated with the PrEP persistence.ResultsFrom October 2017 to September 2023, 29,944 individuals initiated PrEP, and among these, 79.3% started PrEP at a private sector clinic while 20.7% initiated in a public sector clinic. …”
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Construction and Pathogenicity Analysis of a GFPuv-labeled Peanut Ralstonia solanacearum Strain by Jinling HUANG, Yushuang WU, Huiquan TANG, Minyi HUANG, Ruixue YANG, Qiang WANG, Yong YANG, Xiaodan TAN

“…【Objective】The study aimed to construct a GFPuv-labeled peanut Ralstonia solanacearum, which was used to observe the infection pathway in host plants in real-time. Meanwhile, genomic integration sites suitable for exogenous gene were identified.…”
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Systematic bias between blinded independent central review and local assessment: literature review and analyses of 76 phase III randomised controlled trials in 45 688 patients with... by Jianrong Zhang, Yu Huang, Hengrui Liang, Wenhua Liang, Jianxing He, Yiyin Zhang, Jiaxi He, Jieyu Wu, Long Jiang, Shiyan Tang, Qihua He, Lindsey Tristine Hamblin, Zhiheng Xu, Yaoqi Chen, Difei Chen, Xinyu Wang, Kexin Deng, Shuhan Jiang, Jiaqing Zhou, Jiaxuan Xu, Xuanzuo Chen

“…Additionally, the articles should report objective response rate (ORR), disease control rate (DCR), progression-free survival (PFS) or time to progression (TTP); the treatment effect of these endpoints, OR or HR, should be based on central and local assessments.Results Of 76 included trials involving 45 688 patients, 17 (22%) trials reported their endpoints with statistically inconsistent inferences (p value lower/higher than the probability of type I error) between central and local assessments; among them, 9 (53%) trials had statistically significant inference based on central assessment. …”
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Derivation and validation of a clinical predictive model for longer duration diarrhea among pediatric patients in Kenya using machine learning algorithms by Billy Ogwel, Vincent H. Mzazi, Alex O. Awuor, Caleb Okonji, Raphael O. Anyango, Caren Oreso, John B. Ochieng, Stephen Munga, Dilruba Nasrin, Kirkby D. Tickell, Patricia B. Pavlinac, Karen L. Kotloff, Richard Omore

“…Abstract Background Despite the adverse health outcomes associated with longer duration diarrhea (LDD), there are currently no clinical decision tools for timely identification and better management of children with increased risk. …”
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Evidence construction of Silibinin capsules against alcoholic liver disease based on a meta-analysis and systematic review by Yan Wang, Yan Wang, Wenmin Yang, Wenmin Yang, Yuan Yang, Yuan Yang, Xingning Liu, Xingning Liu, Lanfen Peng, Lanfen Peng, Qi Huang, Qi Huang, Qi Huang, Kongli Fan, Kongli Fan, Rui Hu, Rui Hu, Jinyu Yi, Jinyu Yi, Xin Zhong, Xin Zhong, Jing Li, Jialing Sun, Xiaozhou Zhou, Xiaozhou Zhou

“…Primary outcomes included liver function indicators such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyl transferase (GGT), total bilirubin (TBIL), lipid indicators including triglycerides (TG) and total cholesterol (TC), coagulation indicators including prothrombin time (PT), liver fibrosis indicator (PC-III), and Effective Rate. …”
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Basic Molecular Biology, Metabolic and Immunological Mechanisms of Fecal Microbiota Transplantation by O. V. Goloshchapov, A. V. Beynarovich, A. B. Chukhlovin, R. V. Klementeva, A. A. Shcherbakov, E. A. Bakin, I. K. Golubovskaya, N. D. Ventslovayte, O. S. Yudintseva, M. V. Gorchakova, V. E. Karev, M. A. Kucher, M. A. Suvorova, E. V. Svetkina, G. G. Rodionov, V. V. Gostev, S. V. Sidorenko, I. S. Moiseev, A. D. Kulagin

“…To monitor the basic effects of FMT, we performed targeted DNA sequencing of 16S rRNA gene (V3–V4) using MiSeq platform as well as multiplex real-time PCR, MS/gas chromatography technique, immunophenotyping of blood lymphocytes, histological and immunohistochemical techniques.Clinical case. …”
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Longitudinal Changes in Body Weight of Breastfeeding Mothers in the First Year after Delivery and its Relationship with Human Milk Composition: a Combined Longitudinal and Cross-se... by Huijuan Ruan, Yajie Zhang, Qingya Tang, Xuan Zhao, Xuelin Zhao, Yi Xiang, Wei Geng, Yi Feng, Wei Cai

“…The human milk, maternal weight, and dietary surveys were collected in the longitudinal cohort at different follow-up time points (1−14 days postpartum, 2−4 months postpartum, 5−7 months postpartum, and 12−17 months postpartum). …”
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High-resolution 4D electrical resistivity tomography and below-ground point sensor monitoring of High Arctic deglaciated sediments capture zero-curtain effects, freeze–thaw transit... by M. O. Cimpoiasu, O. Kuras, H. Harrison, P. B. Wilkinson, P. Meldrum, J. E. Chambers, D. Liljestrand, C. Oroza, S. K. Schmidt, P. Sommers, L. Vimercati, T. P. Irons, Z. Lyu, A. Solon, J. A. Bradley, J. A. Bradley

“…Geoelectrical monitoring using electrical resistivity tomography (ERT) has proven to be an effective method to capture soil moisture distribution in time and space. ERT instrumentation has been adapted for year-round operation in high-latitude weather conditions. …”
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Benefits, limits, and risks of ChatGPT in medicine by Jonathan A. Tangsrivimol, Jonathan A. Tangsrivimol, Erfan Darzidehkalani, Hafeez Ul Hassan Virk, Zhen Wang, Zhen Wang, Jan Egger, Michelle Wang, Sean Hacking, Benjamin S. Glicksberg, Markus Strauss, Markus Strauss, Chayakrit Krittanawong, Chayakrit Krittanawong

“…Studies show significant efficiency gains, including 70% reduction in administrative time for discharge summaries and achievement of medical professional-level performance on standardized tests (60% accuracy on USMLE, 78.2% on PubMedQA). …”
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Effects of macitentan and selexipag across prognostic age groups in patients with pulmonary arterial hypertension by Richard Channick, MD, Sarah Medrek, MD, Marion Delcroix, MD, Sean Gaine, MD, Pavel Jansa, MD, PhD, Irene Lang, MD, Vallerie McLaughlin, MD, Sanjay Mehta, MD, Tomas Pulido, MD, Bhagavatula Sastry, MD, Rogerio Souza, MD, PhD, Adam Torbicki, MD, Carol Zhao, MS, Paul Strachan, MD, Peter Agron, PhD, Joseph Yen, PhD, Olivier Sitbon, MD, PhD

“…METHODS: Randomized trials evaluated macitentan (SERAPHIN; NCT00660179) and selexipag (GRIPHON; NCT01106014) versus placebo (primary endpoint: time to morbidity/mortality [M/M]). This analysis defined age thresholds differentiating M/M risk in patients randomized to placebo (Cox regression determining treatment effect by age). …”
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