Phase II clinical trial assessing the addition of hyperthermia to salvage concurrent chemoradiotherapy for unresectable recurrent head and neck cancer in previously irradiated pati... by Kai-Lin Yang, Mau-Shin Chi, Chung-Yu Hao, Hui-Ling Ko, Yi-Ying Huang, Ren-Hong Wu, Hung-Chih Lai, Ying-Chu Lin, Sheng-Po Hao, Kwan-Hwa Chi

“…No grade 5 toxicity was observed. Conclusions Adding hyperthermia to salvage CCRT greatly enhances tumor response and survival rates compared to historical re-irradiation outcomes for previously irradiated unresectable recurrent head and neck cancer, with manageable toxicities. …”
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Longitudinal assessment of diffusion-weighted imaging during magnetic resonance-guided radiotherapy in head and neck cancer by Simon Boeke, Jonas Habrich, Sarah Kübler, Jessica Boldt, Fritz Schick, Konstantin Nikolaou, Jens Kübler, Cihan Gani, Maximilian Niyazi, Daniel Zips, Daniela Thorwarth

“…Significant differences from 0 for mean ADC were observed starting from week 1, for tumor volumes from week 2 for GTV-P and week 1 for GTV-N and for HRS in week 1 for GTV-P and week 2 for GTV-N. …”
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Clinical Study of Sentinel Lymph Node Detection to Evaluate Pelvic Lymph Node Metastasis to Determine the Prognosis of Patients with Early Cervical Cancer by Peipei Li, Shuai Feng, Guodong Zhou, Lu Zhang, Xiugui Sheng, Dapeng Li

“…The detection rates, accuracy, sensitivity, coincidence rate, false negative rate, and negative predictive values of these cases were estimated, and the follow-up outcomes were carefully observed. Chi squared test or Fisher’s exact test was employed for a comparison of the categorical variables. …”
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Lenvatinib Therapy in Patients with Unresectable Hepatocellular Carcinoma in Real Clinical Practice by V. V. Petkau, A. V. Sultanbaev, K. V. Menshikov, A. S. Antipin, M. V. Volkonsky, V. M. Filippova, Yu. V. Vasilyeva, A. A. Tarkhanov, M. R. Mukhitova, M. Zh. Murzalina, A. R. Safarova

“…A multicenter retrospective observational study included 58 patients with a confirmed uHCC diagnosis receiving lenvatinib. …”
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Sinensetin attenuates hepatic ischemia-reperfusion injury through suppressing GRP78/CHOP-mediated endoplasmic reticulum (ER) stress in mice by Yihong Yang, Guanghua Xiong, Huangqi Shi, Yulin Peng, Jinghong Liu, Yaxuan Jiang, Min Lu, Hongbo Liu, Yong Liu

“…We also evaluated the protective effect of sinensetin in mice liver I/R injury through histopathological observation, enzyme activity, immunofluorescence, Western blot, molecular docking, and molecular pharmacology experiments.ResultsIn our study, we have successfully established the mouse HIRI injury model, and the liver function indicators such as ALT, AST and LDH were significantly increased in the HIRI model group, while SEN pretreatment could lead to a significant decrease in these enzymatic activities, especially perfusion at 6 h. …”
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Reinforcing cancer immunotherapy with engineered porous hollow mycobacterium tuberculosis loaded with tumor neoantigens by Jie Jiang, Feng-Ying Huang, Shu-Zhen Dai, Guang-Hong Tan, Ming-Hui Chen, Hengyu Chen, Wu-Ping Zheng, Ri-Hong Wu, Weijing Xie

“…Fluorescence microscopy was used to detect PAMPs and adhesion molecules on phMTb as well as to observe its role in aiding dendritic cells (DCs) in antigen uptake into endosomes or lysosomes. …”
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Regional climatic changes and their impact on the level of avalanche hazard in East Kazakhstan by Olga Petrova, Natalya Denissova, Gulzhan Daumova, Yelena Ivashchenko, Evgeny Sergazinov

“…To identify regional climate changes and its connection with the avalanche-prone situation in the region, the study analyzed meteorological data from weather stations located directly near avalanche prone locations over the past 23 years since 2001, as well as data from observations of avalanche-prone areas since 2005 and information on registered spontaneous avalanches from 2013 to the present. …”
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Baska Mask versus I-gel in Spontaneously Breathing Anaesthetised Patients: A Randomised Clinical Study by Bhagyavardhan Botta, Yogarajan Ramalingam, Grishma Robba, Tanya Elizabeth, Kala Balasubramanian, Selvamani Subramanian, Senthil Kumar Vannivedu Santhnam, Kavyasri Morampudi

“…The outcomes were analysed using statistical software Statistical Package for Social Sciences (SPSS) version 23.0 and repeated measures Analysis of Variance (ANOVA) was applied to find the relationship between the two groups. Results: It was observed that the I-gel mask was easier to insert compared to the Baska mask (p=0.03). …”
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Qualitative application of the diffusion of innovation theory to maternity waiting homes in rural Zambia by Jeanette L. Kaiser, Rachel M. Fiorillo, Taryn Vian, Thandiwe Ngoma, Kayla J. Kuhfeldt, Michelle L. Munro-Kramer, Davidson H. Hamer, Misheck Bwalya, Viviane R. Sakanga, Jody R. Lori, Eden Ahmed Mdluli, Peter C. Rockers, Godfrey Biemba, Nancy A. Scott

“…., relative advantage, compatibility, observability, complexity, etc.) affected MWH use after implementation of an improved quality MWH model in rural Zambia compared to standard of care. …”
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Long-term outcomes of robot-assisted versus minimally invasive esophagectomy in patients with thoracic esophageal cancer: a propensity score-matched study by Toru Sakurai, Akihiro Hoshino, Kenta Miyoshi, Erika Yamada, Masaya Enomoto, Junichi Mazaki, Hiroshi Kuwabara, Kenichi Iwasaki, Yoshihiro Ota, Shingo Tachibana, Yutaka Hayashi, Tetsuo Ishizaki, Yuichi Nagakawa

“…Blood loss volume was significantly smaller (P = 0.012), postoperative complications (Clavien–Dindo ≥ 2) were significantly lower (P = 0.021), and postoperative hospital stay was significantly shorter (P < 0.001) in the RAMIE group than those in the MIE group. The median observation period was 63 months. The 5-year OS rates were 73.1% and 80.8% in the RAMIE and MIE groups, respectively (P = 0.360); the 5-year DFS rates were 76.9% and 76.9% in the RAMIE and MIE groups, respectively (P = 0.749). …”
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Biochemical study of striped catfish Pangasianodon hypophthalmus broodstock induced by PMSG hormone + anti‒dopamine and turmeric addition by Harton Arfah, Agus Oman Sudrajat, Muhammad Agus Suprayudi, Muhammad Zairin Junior

“…ABSTRACT   This study aimed to evaluate biochemical changes (cholesterol, triglyceride, HDL, LDL, glucose, and plasma protein) on striped catfish Pangasianodon hypophthalmus broodstock induced with PMSG hormone and turmeric addition. An observation was also done to blood glycogen content. …”
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Phenotypic and Genotypic Characterization of Extended Spectrum Beta-Lactamase-Producing Clinical Isolates of Escherichia coli and Klebsiella pneumoniae in Two Kenyan Facilities: A... by Sylvia M. Maveke, Gabriel O. Aboge, Laetitia W. Kanja, Alfred O. Mainga, Naftaly Gachau, Beatrice W. Muchira, Gervason A. Moriasi

“…Notably, the FOX-CRO-FEP-AMC-TZP-AZM-LVX-MI phenotype was observed in ESBL-positive and ESBL-negative K. pneumoniae isolates. …”
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Modeling regional aboveground carbon stock dynamics affected by land use and land cover changes by A.D. Malik, M.C.W. Arief, S. Withaningsih, P. Parikesit

“…The bare land and built-up expansion related to the observed land clearing for the Cisumdawu Highway mainly came from the conversion of mixed gardens, paddy fields, and drylands. …”
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Evaluation of primary HPV-based cervical screening among older women: Long-term follow-up of a randomized healthcare policy trial in Sweden. by Qingyun Yao, Jiangrong Wang, K Miriam Elfström, Björn Strander, Joakim Dillner, Karin Sundström

“…<h4>Conclusions</h4>In this study, we observed that women over 55 years of age who received a primary negative HPV test result had substantially lower risk of CIN2+, and ICC, compared to women who received a primary negative cytology result. …”
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Application of fuzzy logic in decision-making process for relocation of floating net cages in river fish farming by R. Pramana, B.Y. Suprapto, Z. Nawawi

“…Meanwhile, the three remaining locations were recommended to "Move" as they exhibited poor water quality, with potential of hydrogen values below 6. Field observations indicated that these locations were situated near residential areas, factories/industries, and tributaries, which are highly susceptible to waste and pollution. …”
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Les vestiges fauniques de la rue Lecointre à Reims/Durocortorum : une carrière utilisée comme dépotoir by Frédéric Poupon

“…These deposits are clearly different from the collective management of equine corpses previously observed in Reims, and characterized by the mass disposal of carcasses in one place and resulting in an exclusive and impressive dumping site for these remains.…”
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A visual walkthrough of robotic partial mesorectal excision using the Versius surgical system by Amro Mureb

“…A recent systematic review on distal mesorectal spread and PME showed that for partial mesorectal excision, substantial overtreatment is present if a distal margin of more than 5 cm is routinely utilized; in addition, PME has good oncological results and leads to the best-fitted functional results possible for the patient's condition.1,2 Regarding the morbidity and oncological outcomes after PME, Kanso et al. showed that PME can be performed safely, with a low risk of definitive stoma and local recurrence and the survival rate that was observed, indicates that the prognosis is not altered compared with TME in the treatment of upper and some middle rectal tumour.3 Another study evaluating the oncological outcomes of PME in patients with upper and middle rectal cancer showed that PME and shorter resection margins do not jeopardize the oncological outcomes.4 Robotic colorectal surgery has gained popularity in the last few years as it overcomes most of the limitations of conventional laparoscopic surgery, especially when working in a confined, narrow pelvis. …”
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Systematic review of multidrug-resistant Klebsiella pneumoniae in the Arabian Peninsula: molecular epidemiology and resistance patterns by Enaam K. Idrees, Enaam K. Idrees, Marwh G. Aldriwesh, Marwh G. Aldriwesh, Marwh G. Aldriwesh, Manal M. Alkhulaifi, Majed F. Alghoribi, Majed F. Alghoribi, Majed F. Alghoribi

“…Various resistance mechanisms and patterns were observed between countries and across different years within the same country. …”
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Unravelling the role of secretory Immnuoglobulin-A in COVID-19: a multicentre study in nursing homes during the first wave by Rafael Bielza, Patricia Pérez, Nuria García, Laura Ballesteros-Sanabria, Rosa María Martínez, Azam Ghazi, Clara Hernando, María Victoria Rodríguez, Israel J. Thuissard, Cristina Andreu-Vázquez, José Manuel Bautista

“…No significant differences were observed in age, sex, CGA, duration of symptoms, disease severity, overall 30-day-mortality, or reinfection between “induced” and “non-induced” residents. …”
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Influence of diet nutrient density and a multicarbohydrase containing α-galactosidase on performance, carcass characteristics, breast myopathies, and nutrient utilization of broile... by J.P. Gulizia, J.I. Vargas, S.M. Bonilla, J.R. Hernandez, L.M. Almeida, P. Soster, S. Thuekeaw, B. Hutson, S. Llamas-Moya, T. Duong, W.J. Pacheco

“…Nutrient density x CAG interactions were observed for multiple measurements including feed conversion ratio (FCR; d 1 to 42), CP digestibility, and apparent ileal digestible energy (AIDE). …”
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