Real-World Persistence and Effectiveness of Upadacitinib versus Other Janus Kinase Inhibitors and Tumor Necrosis Factor Inhibitors in Australian Patients with Rheumatoid Arthritis by Peter Youssef, Sabina Ciciriello, Talib Tahir, Joanna Leadbetter, Belinda Butcher, Miriam Calao, Nicole Walsh, Catherine O’Sullivan, Tegan Smith, Geoffrey Littlejohn

“…The DAS28CRP(3) remission rate was 73% at 3 months, with improvements observed across lines of therapy. UPA monotherapy and combination therapy had similar persistence (27.8 [23.5, 33.4] versus 30.4 months [22.1, 35.3], p = 0.84) and effectiveness. …”
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Reciprocal regulation between DNMT3A/3B and microRNAs miRs-299-3p/-30e is a causal factor for the downregulation of microRNAs targeting androgen receptor in prostate cancer by Kavya Ganapathy, Christian F. Harrs, Samuel Harris, Stephen J. Staklinski, Ayman Khatib, Jong Y. Park, Ratna Chakrabarti

“…We performed DNMT activity assays and ectopic expression of miRNAs to study their effects. Results: We observed higher promoter methylation of these miRNA genes in cells derived from an AA patient compared to cells of CA origin, which can be reversed through AzaC treatment. …”
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Large-scale evidence generation and evaluation across a network of databases for type 2 diabetes mellitus (LEGEND-T2DM): a protocol for a series of multinational, real-world compar... by Rohan Khera, Yuan Lu, Harlan M Krumholz, Martijn J Schuemie, Ruijun Chen, George Hripcsak, Marc A Suchard, Patrick B Ryan, Anna Ostropolets

“…LEGEND-T2DM will leverage the Observational Health Data Sciences and Informatics (OHDSI) community that provides access to a global network of administrative claims and electronic health record data sources, representing 190 million patients in the USA and about 50 million internationally. …”
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Radiogenomics and machine learning predict oncogenic signaling pathways in glioblastoma by Abdul Basit Ahanger, Syed Wajid Aalam, Tariq Ahmad Masoodi, Asma Shah, Meraj Alam Khan, Ajaz A. Bhat, Assif Assad, Muzafar Ahmad Macha, Muzafar Rasool Bhat

“…Disruptions in various oncogenic signaling pathways, such as Receptor Tyrosine Kinase (RTK)-Ras-Extracellular signal-regulated kinase (ERK) signaling, Phosphoinositide 3- Kinases (PI3Ks), tumor protein p53 (TP53), and Neurogenic locus notch homolog protein (NOTCH), contribute to the development of different tumor types, each exhibiting distinct morphological and phenotypic features that can be observed at a microscopic level. However, identifying genetic abnormalities for targeted therapy often requires invasive procedures, prompting exploration into non-invasive approaches like radiogenomics. …”
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Effect of temporal water restrictions on drinking behavior and time budget in lactating dairy cows according to their position in the social hierarchy within the herd by E. Nizzi, O. Dhumez, C. Hurtaud, A. Boudon

“…Hourly lying time decreased at the end of the water restriction periods, that is, at 1000 h in HL, at 1100 h in D2H, and at 1200 and 1300 h in D4H, which was not observed in CTRL, which could be interpreted as a sign of cow discomfort. …”
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A green forage diet enhances microbial diversity in buffalo rumen by Angela Salzano, Giovanna Bifulco, Alfio Calanni Macchio, Valentina Longobardi, Francesca Aragona, Giovan Maria Pacelli, Giuseppe Campanile

“…Al though the abundant microbial taxa of the rumen are not affected by the experimental diet, we observed a significant increase in rare species and an overall increase in total biodiversity in the Green group. …”
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The Degree of Cervical Intervertebral Disc Degeneration Is Associated With Denser Bone Quality of the Cervical Sub‐endplate and Vertebral Body by Jia‐Yu Chen, Jia‐Chen Yang, Ruo‐Yao Li, Zu‐Cheng Huang, Zhi‐Ping Huang, Xiu‐Hua Wu, Qing‐An Zhu, Yin Ding

“…Negative correlations were observed between both cranial and caudal VBQ and EBQ scores and Pfirrmann grades. …”
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Hubungan Tingkat Kemandirian dalam Melakukan Aktivitas Kehidupan Sehari-Hari dan Status Gizi pada Usia Lanjut di Panti Sosial Tresna Werdha Sabai Nan Aluih Sicincin by Afifah Alfyanita, Rose Dinda Martini, Husnil Kadri

“…The objective of this study was to determine the relationship between the level of independence in performing ADL and nutritional status of elderly.This research was an observational analytical study which designed as cross-sectional study. …”
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A PEDAGOGIA DA ALTERNÂNCIA COMO PROPOSTA DE EDUCAÇÃO NO CAMPO: UM ESTUDO NA ESCOLA FAMÍLIA AGRÍCOLA ITAPIREMA EM RONDÔNIA, BRASIL by Claudineia Ferreira dos Santos, Charles Carminati de Lima, Yanet Reimondo Barrios, Daniete Fernandes Rocha

“…From the results, it was possible to observe the predominant option in studying at the Agricultural Family School (EFA Itapirema) because the school has a technical course of professional preparation. …”
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Safety profile of sacituzumab govitecan in patients with breast cancer: A systematic review and meta-analysis by Maria Inez Dacoregio, Isabella Michelon, Caio Ernesto do Rego Castro, Francisco Cezar Aquino de Moraes, Guilherme Rossato de Almeida, Lis Victória Ravani, Maysa Vilbert, Ricardo Lima Barros Costa

“…Compared to TPC, we observed a higher risk of neutropenia (OR 3.11, 95 % CI 1.62–5.99, I2 = 81 %; p < 0.001), diarrhea (OR 6.82, 95 % CI 3.99–11.66, I2 = 64 %; p < 0.001) and anemia (OR 2.26, 95 % CI 1.20–4.27, I2 = 78 %; p = 0.012) for those on SG. …”
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Long-Term Real-World Outcomes of Tenofovir Alafenamide in Chronic Hepatitis B: Detailed Analysis of Treatment-Naive and Experienced Patients by Yu-Xuan Song, Guang-Jun Song, Hui Ma, Bo Feng, Yan-Di Xie

“…A significant decrease in the HBsAg levels from the baseline was observed at 144 and 192 weeks in the treatment-naive patients (p=0.01). …”
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Development and Validation of the Systemic Inflammatory Response Index-Based Nomogram for Predicting Short-Term Adverse Events in Patients With Acute Uncomplicated Type B Aortic In... by Wang Y, Wu X, Wang Y, Zhang Z, Liu X, Sun D, Liu X, Zhou T, Wang X

“…Patients were categorized into the stable group (N=225) and the exacerbation group (N=107) based on the occurrence of ARAEs within 30-day observation period. SIRI was calculated using neutrophil, monocyte, and lymphocyte counts. …”
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Cancer mortality and sectors of employment: a cohort study in Italy by Stefania Massari, Lisa Bauleo, Claudio Gariazzo, Paola Michelozzi, Luca Dei Bardi, Nicolas Zengarini, Sara Maio, Massimo Stafoggia, Marina Davoli, Giovanni Viegi, Giulia Cesaroni, Alessandro Marinaccio, on behalf of the BIGEPI Collaborative Group

“…The outcomes confirmed some well-known associations (e.g. lung and pleura in construction, pleura in paper and printing, and lung in wood and leather) and suggested possible high-risk sectors that have not yet been thoroughly investigated. In men we observed an increased mortality risk for stomach cancer in the printing and paper industry (HR = 1.69, 95% CI:1.11–2.57) as well as for stomach and lung cancer in cleaning activities (HR = 1.98, 95% CI:1.13–3.49 and HR = 1.55, 95% CI:1.22–1.98, respectively). …”
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Exploration of Degradation Mechanism of Chlorogenic Acids in Stevia Based on UPLC-QTOF MS/MS by Juan-juan WU, Zi-xuan WANG, Yun-he LIAN, Li-juan HOU, Zhi-ping NIU, Wen-chang WANG, Di WU

“…In acidic or alkaline conditions, hydrolysis and structural transformations are common degradation pathways observed. In summary, dehydration, degradation, hydrolysis, and isomerization are four potential pathways of loss for stevia-derived chlorogenic acids subjected to environmental fluctuations. …”
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Patient satisfaction with radio-frequency identification (RFID) tag localization compared with wire localization for nonpalpable breast lesions: the RFID trial by Raphaël Pete, Céleste Pinard, Fanny Sirodot, Ioana Molnar, Margot Dressaire, Angeline Ginzac, Catherine Abrial, Xavier Durando, Marielle Tekath

“…A reduction in pain between device insertion and surgery was observed in the RFID group (p = 0.009). The median placement time was shorter in the RFID group (15 min, IQR = 6) than in the wire group (20 min, IQR = 30) (p = 0.01). …”
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Examining differences in exposure to digital marketing of unhealthy foods reported by Canadian children and adolescents in two policy environments by Laura Vergeer, Carolina Soto, Mariangela Bagnato, Elise Pauzé, Ashley Amson, Tim Ramsay, Dana Lee Olstad, Vivian Welch, Monique Potvin Kent

“…This study examined differences in self-reported exposure to digital food marketing between children and adolescents in different policy environments: Ontario (where food marketing is self-regulated) and Quebec (where advertising is government regulated). Methods An observational cross-sectional online survey was conducted in April 2023 among children (aged 10–12 years) and adolescents (13–17 years) from Ontario and Quebec, recruited by Leger Marketing. …”
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Effect of Whole Wheat Noodles on Biochemical Indexes and Histopathology of Type 2 Diabetic Rats by Li WU, Yuan ZHANG, Chunhong TANG, Huan YOU, Haijun CHANG, Shuai ZHANG

“…Section staining was performed, followed by biomicroscopic observation of organ histopathological changes. Results: Compared with the model group, whole wheat noodles intervention significantly slowed down the symptoms of weight loss in diabetic rats (P<0.05), reduced dietary and water intake in diabetic rats (P<0.01), and lowered blood glucose values in diabetic rats (P<0.01), with the best effect in the high-dose group, with a reduction of blood glucose values by 44.87%. …”
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Immune response and growth performance of crayfish Cherax quadricarinatus fed with supplementary diet of synbiotic by Amrullah Amrullah, Wahidah Wahidah

“…During 40 days of rearing, immune responses observations were conducted every 10 days, while the crayfish weight were recorded on day 40. …”
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Antibacterial and Antifungal Activities of Linear and Cyclic Peptides Containing Arginine, Tryptophan, and Diphenylalanine by David Salehi, Eman H. M. Mohammed, Naiera M. Helmy, Keykavous Parang

“…The highest activity was observed against <i>S. pneumoniae</i> with MIC values of 0.39–0.78 µM among tested compounds. …”
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Construction and characterization of chimeric FcγR T cells for universal T cell therapy by Juanjuan Zhao, Manling Chen, Xudong Li, Zhaoqi Chen, Wei Li, Rongqun Guo, Min Wang, Zhongxing Jiang, Yongping Song, Jianxiang Wang, Delong Liu

“…The cytotoxicity of 64-8a CFR T cells was significantly inhibited by free human IgG at a physiological dose (P < 0.001), which was not observed in 16s3, 32-8a CFR T cells. Compared to 32-8a CFR T cells, 16s3 CFR T cells exhibited more prolonged cytotoxicity than 32-8a CFR T cells (P < 0.01). …”
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