Tofacitinib Efficacy/Safety in Patients with Ankylosing Spondylitis by Baseline Body Mass Index: A Post Hoc Analysis of Phase 2/3 Trials by Hillary Norton, Paula Sliwinska-Stanczyk, Tomas Hala, Bassel El-Zorkany, Lori Stockert, Rajiv Mundayat, Lisy Wang, Christopher T. Ritchlin

“…Conclusions Regardless of baseline BMI category, efficacy was greater with tofacitinib versus placebo in patients with AS, and no treatment effect differences between categories were observed, with exceptions for BMI ≥ 30 kg/m2 (more active/treatment-refractory disease and a smaller sample size). …”
Get full text

Crystal structures of zinc(II) coordination complexes with isoquinoline N-oxide by Erin N. Groneck, Nathan Peek, Will E. Lynch, Clifford W. Padgett

“…The X—Zn—X bond angles are approximately 15–17° larger than the O—Zn—O bond angles resulting in the observed tetrahedral distortion. In complex (IV), hexakis(isoquinoline N-oxide-κO)zinc(II) bis(perchlorate), [Zn(C9H7NO)6](ClO4)2, the zinc(II) ion occupies a special position with 3 site symmetry and is octahedrally coordinated by six iQNO ligands, albeit with slight distortions evidenced by a spread of cis bond angles from 85.82 (4) to 94.18 (4)°. …”
Get full text

Developing a comprehensive inventory to define harm reduction housing by Sofia Zaragoza, Joseph Silcox, Sabrina Rapisarda, Charlie Summers, Patricia Case, Clara To, Avik Chatterjee, Alexander Y. Walley, Miriam Komaromy, Traci C Green

“…Methods We collected data between June and September 2023 and included semi-structured qualitative interviews with HRH staff (n = 19), ethnographic observations and photos at six HRH sites. Candidate inventory components were derived through triangulation of the data. …”
Get full text

Efficacy of non-invasive brain stimulation interventions on cognitive impairment: an umbrella review of meta-analyses of randomized controlled trials by Minmin Wu, Wenjing Song, Xue Wang, Lili Teng, Jinting Li, Jiongliang Zhang, Xinyue Li, Donghui Yu, Huanhuan Jia, Binhan Wang, Qiang Tang, Luwen Zhu

“…Significant improvements were observed in global cognition, language, executive function, and memory. …”
Get full text

Whether the Indications for Reverse Shoulder Arthroplasty Should Continue to Be Expanded? A Systematic Review and Meta‐Analysis by Huankun Li, Hangsheng Bao, Zhidong Yang, Baijun Hu, Yaocheng Pan, Yi Wang, Jiayi Chen, Hongjun Chen, Bisheng Shen, Yonggen Zou

“…In terms of complication and revision rates, RTSA had lower rates compared to HA and ATSA, except for the complication rate, where there was no significant difference between RTSA and ATSA (p = 0.521), but statistically significant differences were observed in other measures. Conclusion RTSA demonstrates better clinical efficacy compared to HA but is inferior to ATSA. …”
Get full text

The Opportunity of Using Diode Laser with the Length of 1940 nm in the Treatment of Hemorrhoids by S. A. Frolov, A. M. Kuzminov, D. V. Vyshegorodtsev, O. A. Mainovskaya, Yu. L. Trubacheva, O. Yu. Fomenko, V. Yu. Korolik, I. S. Bogormistrov, I. A. Mukhin, A. M. Battalova, E. M. Bogdanova

“…All had no complaints characteristic of hemorrhoidal disease, no relapse of the disease was detected in any observation. Transrectal ultrasound with Dopplerography was performed, which made it possible to diagnose a 2–3-fold decrease in blood flow along the terminal branches of the upper rectal artery, and internal hemorrhoids determined earlier, before surgery, were not visualized already 1 month after surgery. …”
Get full text

Outcome and Management of Sepsis at RozhHalat Emergency Hospital in Erbil –Kurdistan region of Iraq by Samir Qader Ahmad, Shakawan Muhamad Ismaeel, Dara Ahmed Mohammed Ahmed Mohammed, Halgurd Fathulla Ahmed

“…Sepsis is a complex condition characterized by activation of inflammatory process and coagulation system in response to microbial insult. An observational prospective study was carried out at RozhHalat emergency hospital in Erbil-Kurdistan region of Iraq between February 2017 to January 2018.The study was approved by the scientific and ethical committee of Kurdistan board of medical specialties. 50 patients aged between (10 - 80) years old presented to this hospital with sign and symptoms of infection were recruited to this study. 50 patients with signs and symptoms of sepsis were recorded in this study. …”
Get full text

Biotechnological Phytocomplex of <i>Zanthoxylum piperitum</i> (L.) DC. Enhances Collagen Biosynthesis In Vitro and Improves Skin Elasticity In Vivo by Giovanna Rigillo, Giovanna Pressi, Oriana Bertaiola, Chiara Guarnerio, Matilde Merlin, Roberto Zambonin, Stefano Pandolfo, Angela Golosio, Francesca Masin, Fabio Tascedda, Marco Biagi, Giulia Baini

“…ZPP upregulated lysyl oxidase (LOX) protein levels, critical for collagen cross-linking and ECM stability, with protective effects observed under oxidative/inflammatory conditions. Additionally, ZPP selectively inhibited collagenase, attenuating collagen breakdown, though antioxidant activity was modest. …”
Get full text

Antimicrobial Resistance Genes in Clinical <i>Escherichia coli</i> Strains from Livestock and Poultry in Shandong Province, China During 2015–2020 by Miaoli Wang, Shaopeng Wu, Yao Wang, Feng Chen, Zhangqi Shen, Zouran Lan

“…Through the correlation analysis, <i>mcr</i> genes were observed to have certain relationships with ARGS such as <i>bla_TEM</i>, <i>floR</i>, <i>catA/B</i>, and <i>oqx</i>. …”
Get full text

Durable responders in advanced NSCLC with elevated TMB and treated with 1L immune checkpoint inhibitor: a real-world outcomes analysis by David P Carbone, David Spigel, Jeffrey S Ross, Karthikeyan Murugesan, Gerald Li, Richard S P Huang, Ryon P Graf, Geoffrey R Oxnard, Alexa Schrock, Liangliang Zhang, Khaled Tolba, Jacob Sands

“…Comparing low TMB (&lt;10 muts/Mb), high TMB (10–19 muts/Mb), and very high TMB (≥20 muts/Mb) receiving ICPI alone, we observed a stepwise increase in median rwPFS (real world-progression free survival) (6.5, 7.5, 17.2 months) and rwOS (real world-overall survival) (10.1, 11.8, 26.9 months) as TMB increased. …”
Get full text

Blastic plasmacytoid dendritic cell neoplasm: a Swiss case series of a very rare disease and a structured review of the literature by Ramona Meier-Lienhard, Cosima Suter, Thomas Pabst, Felicitas Hitz, Jakob R. Passweg, Olivier Spertini, Nathan Cantoni, Daniel Betticher, Lucas Simeon, Michael Medinger, Stefanie Hayoz, Adrian Schmidt

“…Most of them had very small sample sizes (only ten papers with more than ten patients) and all but one were retrospective or observational respectively. Most included patients were Europeans (n = 385, 64%) and Asians (n = 120, 20%), followed by Americans (n = 90, 15%) and patients from Australia/New Zealand (n = 3) and Africa (n = 2). …”
Get full text

Investigating the dual causative pathways linking immune cells and venous thromboembolism via Mendelian randomization analysis by Ning Qi, Zhuochen Lyu, Lu Huang, Yun Zhao, Wan Zhang, Xinfeng Zhou, Yang Zhang, Jiasen Cui

“…Results From a strictly statistical perspective, no significant associations were observed after FDR correction. However, our exploratory analysis suggested potential trends between immune cell traits and VTE. …”
Get full text

Age-related differences in long-term potentiation-like plasticity and short-latency afferent inhibition and their association with cognitive function by Tong Wang, Ying Shen, Tianjiao Zhang, Chuan He, Qian Lu, Jie Song, Manyu Dong, Yilun Qian, Sisi Huang, Jing Teng

“…In individuals over 60 years of age, there is a reduction in LTP-like plasticity, while a decline in cholinergic system function is observed in those over 70. Thus, the cholinergic system may play a vital role in preventing cognitive decline during normal ageing. …”
Get full text

External beam radiation therapy versus radical prostatectomy for high-risk prostate cancer: protocol of the RECOVER study by Caroline M. van der Starre, Chris H. Bangma, Maarten J. Bijlsma, Alfons C.M. van den Bergh, Lambertus A.L.M. Kiemeney, Wietske Kievit, Kees Vos, Diederik M. Somford, Sally M. Wildeman, Katja K.H. Aben, Igle J. de Jong, Floris J. Pos, Berdine L. Heesterman

“…Secondary endpoints PFS and DMFS are evaluated using a competing risk analysis and cost-utility and budget-impact analyses will be performed to determine cost and cost-effectiveness. Discussion An observational prospective design was chosen since a randomized controlled trial comparing surgery and radiotherapy was not deemed feasible. …”
Get full text

Efficacy and safety of various drug combinations in treating plaque Psoriasis: A meta-analysis [version 2; peer review: 2 approved] by Nayak Snehasis, Karshe Haji Ali, Pendyala Siri, Ngabo Herve, Sayed Zafar

“…A significant PASI 75- response was observed in the pioglitazone combination subgroup as compared to placebo (OR=4.92,95% CI 2.19-11.05, P = 0.0001); methotrexate combination subgroup as compared to placebo (OR=2.56, 95% CI 1.67-3.94, P< 0.0001) test of subgroup differences showed P= 0.14, I2= 34%. …”
Get full text

L’officier de police, le checkpoint et l’interrogatoire : les spatialités des performances sécuritaires dans le centre-ville du Caire by Laura Monfleur

“…In turn, security performance constructs downtown Cairo as a sensitive zone where police presence, checkpoints and interrogations are all reminders of the social order, a way of telling everyone their place and who has coercive power, but also of a spatial order, a way of signifying to whom downtown belongs.This research is based on various field surveys conducted in Cairo in 2015 and then between 2019 and 2021. Observations of urban spaces in Wast al-Balad enabled systematic surveys to be carried out and a map of security infrastructures and law enforcement agencies to be produced. …”
Get full text

Spatiotemporal variation in biomass abundance of different algal species in Lake Hulun using machine learning and Sentinel-3 images by Zhaojiang Yan, Chong Fang, Kaishan Song, Xiangyu Wang, Zhidan Wen, Yingxin Shang, Hui Tao, Yunfeng Lyu

“…Significant annual variations in the biomass abundance of Cyanophyta and Bacillariophyta were observed, whereas those of Chlorophyta remained stable. …”
Get full text

A cohort study of serum 25-hydroxyvitamin D levels and the risk of hyperlipidaemia in adults by Zi-yue Liu, Sha Liu, Xue Yao, Chun-yang Wang, Yunhao Song, Yan-ming Bi, Jin-Xiu Wang, Yang Li, Ta-la Shi, Wei Mi, Caiyun Chen, Zhi-Yong Hu

“…A significant difference in the proportion of vitamin D deficiency was observed between males and females (22.06% vs. 10.94%, p &lt; 0.001). …”
Get full text

miR-26a-5p Attenuates Oxidative Stress and Inflammation in Diabetic Retinopathy through the USP14/NF-κB Signaling Pathway by Jie Bian, Weizhong Ge, Zhengmei Jiang

“…Müller cells were identified via morphology observation under phase contrast microscope and fluorescence staining for glutamine synthetase. …”
Get full text

Entre espaces domestiques et « espaces domestiqués » : « L’autonomisation intime » des étudiantes en Turquie by Tuğba Gökduman

“…These interviews were accompanied by observations and informal conversations which took place in different spaces of student socialization, such as university campuses, cafes, bars, or nightclubs.…”
Get full text