Pas de Deux: Active Ulcerative Colitis in an HIV-Positive Patient by David C Pearson, Lloyd R Sutherland, Stephan Urbanski

“…This case raises questions about immune regulation in ulcerative colitis because the patient has active disease in addition to a reduced number of T helper cells. It also presents a difficult management problem because the patient has a limited life expectancy and is reluctant to accept colectomy, and further immunosuppressive therapy may be dangerous.…”
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12/15-Lipoxygenase Is an Interleukin-13 and Interferon-γ Counterregulated-Mediator of Allergic Airway Inflammation by Alexa R. Lindley, Margaret Crapster-Pregont, Yanjun Liu, Douglas A. Kuperman

“…Interleukin-13 and interferon-γ are important effectors of T-helper cells. Interleukin-13 increases expression of the arachidonic acid-metabolizing enzyme, 15-lipoxygenase-1, in a variety of cell types. 15-lipoxygenase-1 is dramatically elevated in the airways of subjects with asthma. …”
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The Role of Th17 Cells and IL-17 in Th2 Immune Responses of Allergic Conjunctivitis by Xiang-Tian Meng, Yun-Yue Shi, Hong Zhang, Hong-Yan Zhou

“…It has been found that new subpopulations of T-helper cells, Th17 cells that produce interleukin-17 (IL-17), play an important role in the Th2-mediated pathogenesis of conjunctivitis. …”
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Colitis in spondyloarthritis by Muhammed Hafis, Vikas Agarwal

“…Mucosal inflammation leads to disruption of the epithelial barrier and activation of antigen-presenting cells and T-helper cells, which then home to synovium to cause inflammation maintaining the gut synovial axis. …”
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The Role of the IL-12 Cytokine Family in Directing T-Cell Responses in Oral Candidosis by Xiao-Qing Wei, Helen Rogers, Michael A. O. Lewis, David W. Williams

“…In this regard, the role of Th1/2, helper cells, together with the recently identified Th17 and Treg cells in candidosis will be discussed. …”
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Role of T-Cell Polarization and Inflammation and Their Modulation by n-3 Fatty Acids in Gestational Diabetes and Macrosomia by A. Hichami, O. Grissa, I. Mrizak, C. Benammar, N. A. Khan

“…Th (T helper) cells are differentiated into either Th1 or Th2 phenotype. …”
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Pneumocystis carinii: A Review of an Important Opportunistic Pathogen in AIDS by M John Gill, Ron Read

“…Individuals with damaged T helper cells secondary to malignancies (eg, Hodgkin’s lymphoma), drugs (eg, cyclosporine, steroids), or certain infections (eg, human immunodeficiency virus) are at particular risk. …”
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The Immunogenicity of HLA Class II Mismatches: The Predicted Presentation of Nonself Allo-HLA-Derived Peptide by the HLA-DR Phenotype of the Recipient Is Associated with the Format... by Vadim Jucaud

“…The HLA-DR phenotype of recipients contributes to DSA formation by presenting allo-HLA-derived peptides to T-helper cells, which induces the differentiation of B cells into plasma cells. …”
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In silico data mining of large-scale databases for the virtual screening of human interleukin-2 inhibitors by Halim Sobia Ahsan, Zaheer-Ul-Haq, Khan Ajmal, Al-Rawahi Ahmed, Al-Harrasi Ahmed

“…Interleukin-2 (IL-2) is involved in the activation and differentiation of T-helper cells. Uncontrolled activated T cells play a key role in the pathophysiology by stimulating inflammation and autoimmune diseases like arthritis, psoriasis and Crohn’s disease. …”
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Decreased Regulatory T Cells in Vulnerable Atherosclerotic Lesions: Imbalance between Pro- and Anti-Inflammatory Cells in Atherosclerosis by Ilonka Rohm, Yevgeniya Atiskova, Stefanie Drobnik, Michael Fritzenwanger, Daniel Kretzschmar, Rudin Pistulli, Jürgen Zanow, Thomas Krönert, Gita Mall, Hans Reiner Figulla, Atilla Yilmaz

“…The following results were observed: in unstable lesions, significantly higher numbers of proinflammatory cells like DCs, T helper cells, cytotoxic T cells, and natural killer cells were detected compared to stable plaques. …”
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Increased Peripheral Proinflammatory T Helper Subsets Contribute to Cardiovascular Complications in Diabetic Patients by Ru-xing Zhao, Wen-juan Li, Yi-ran Lu, Jun Qin, Chuan-long Wu, Meng Tian, Tian-yi He, Shou-nan Yi, Dong-qi Tang, Lei Sun, Li Chen

“…The frequencies of peripheral total CD4+ T helper cells, proinflammatory Th1, Th17, and Th22 subsets were determined by flow cytometry in diabetic patients with or without CHD (n=42 and 67, resp.). …”
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Deep immunophenotypic dissection and clinical impact of T cells in the follicular lymphoma microenvironment by Sary El Daker, David Qualls, Andriy Derkach, Samida Beqaj, Leonardo Boiocchi, Venkatraman Seshan, Jeeyeon Baik, Menglei Zhu, Gilles Salles, Ahmet Dogan, Mikhail Roshal, Pallavi Galera

“…FL-UT cases with either increased T-reg TC or increased T follicular helper cells (TFH) showed reduced time to first treatment (…”
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CD4+CD25highCD127low Regulatory T Cells in Peripheral Blood Are Not an Independent Factor for Chronic Graft-versus-Host Disease after Allogeneic Stem Cell Transplantation by Jolanta B. Perz, Selma Gürel, Stefan O. Schonland, Ute Hegenbart, Anthony D. Ho, Peter Dreger

“…Regulatory T cells (Treg) are a subset of CD4+ T-helper cells believed to maintain tolerance after HSCT. …”
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Correction of cellular and humoral links immunity in piglets under the weaning condition by Nataliia Ohorodnyk, Vitalii Tkachuk, Nataliia Motko, Andriy Boyko, Serhii Pavkovych

“…The findings revealed that weaning from sows caused a reduction in the number of T-cells of varying degrees of avidity, a decrease in the relative number of T-suppressors in piglets’ blood, and an increase in the number of certain subpopulations of T-helper cells. Conversely, the administration of the liposomal preparation to piglets enhanced the number of various subpopulations of total and active T-lymphocytes and B-lymphocytes in their blood after weaning and increased the activity of lymphoid cells in the blast transformation reaction with phytohaemagglutinin. …”
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Impact of Extracellular Matrix-Related Genes on the Tumor Microenvironment and Prognostic Indicators in Esophageal Cancer: A Comprehensive Analytical Study by Yinghong Wu, Wenjie Hu, Zhihong Jia, Qiying Zhu, Jinghui Xu, Liang Peng, Renjie Wang

“…Focusing on the TENM1 gene, we found it significantly impacts immune response, showing a positive correlation with T helper cells, NK cells, and CD8+ T cells, but a negative correlation with neutrophils and Th17 cells. …”
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Immunomodulatory Effects of Taiwanese Neolitsea Species on Th1 and Th2 Functionality by Yin-Hua Cheng, Ying-Chi Lin, Ih-Sheng Chen, Sian-De Liu, Jih-Heng Li, Chia-Chi Wang

“…N. aciculata var. variabillima significantly suppressed IFN-γ, IL-10, and IL-17, demonstrating the broad suppressive effects on T helper cells; N. konishii significantly suppressed IFN-γ and IL-10 production, while the production of IL-17 was not altered. …”
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NF-κB-94ins/del ATTG Genotype Contributes to the Susceptibility and Imbalanced Th17 Cells in Patients with Immune Thrombocytopenia by Jie Yu, Mingqiang Hua, Xueyun Zhao, Rui Wang, Chaoqing Zhong, Chen Zhang, Ruiqing Wang, Guosheng Li, Na He, Ming Hou, Daoxin Ma

“…RT-PCR was used to examine the polymorphism and expression of genes involved in the NLRP3 inflammasome in ITP patients. T helper cells and apoptosis of PBMC from ITP patients were analyzed by flow cytometry. …”
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Transcriptional profiles analysis of effects of Toxoplasma gondii rhoptry protein 16 on THP-1 macrophages by Ningai Yang, Ningai Yang, Ningai Yang, Mingyang Li, Hong Yang, Jiaming Li, Tiantian Dang, Guangqi Li, Zhijun Zhao, Zhijun Zhao, Zhijun Zhao

“…Immuno-featured differential analysis showed that type 17 T helper cells were more strongly correlated with GPR158 and STRA13, while CD8 T-cell was most strongly correlated with STOML1.DiscussionTherefore, we conclude that the ROP16 protein plays a pivotal role in THP-1 macrophage infection and these five differentially expressed genes may serve as promising molecular targets for the prevention or control of toxoplasmosis. …”
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The Mechanisms of the Regulation of Immune Response in Patients with Comorbidity of Chronic Obstructive Pulmonary Disease and Asthma by Elena P. Kalinina, Yulia K. Denisenko, Tatyana I. Vitkina, Elena G. Lobanova, Tatyana P. Novgorodtseva, Marina V. Antonyuk, Tatyana A. Gvozdenko, Vera V. Knyshova, Anna V. Nazarenko

“…The specific features in comorbid COPD and asthma were lymphocytosis, increased absolute count of T-helper cells, increased cytotoxic T-lymphocytes in relative and absolute count, increased relative and absolute numbers of B-lymphocytes, and high levels of total IgE. …”
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Microbial dysbiosis in periodontitis and peri-implantitis: pathogenesis, immune responses, and therapeutic by Ziwei Cui, Peng Wang, Weiyue Gao

“…Regional immunity of periodontium involving neutrophils, T helper cells-17, and immune-related cytokines is crucial for maintaining periodontal homeostasis and responding to microbial imbalances. …”
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