Interaction of Herbal Compounds with Biological Targets: A Case Study with Berberine by Xiao-Wu Chen, Yuan Ming Di, Jian Zhang, Zhi-Wei Zhou, Chun Guang Li, Shu-Feng Zhou

“…Further studies are warranted to elucidate the mechanisms of action of berberine using systems biology approach.…”
Get full text

Multi-target and natural product-based multi-drug approach for anti-VEGF resistance in glioblastoma by Sasikumar Jalajakumari Soumya, Kesavan Rathi Arya, Chandran Sheela Abhinand, Padmanabhan Sunitha, Ajitha Prabhakaran Athira, Achuthsankar Sukumaran Nair, Oommen V. Oommen, Perumana R. Sudhakaran

Get full text

Understanding integrative approach of translational bioinformatics on cardiovascular disease: Myocardial Ischemia by Yeswanth Ranganathan, Saayaa Nazar, Ravi Shankar Krishnan, Yuvaraj Dinakarkumar, Vijayalakshmi Varadarajan, Lenita Sebastian, Brindha Rethinam

“…Additionally, it examines the application of systems biology and network analysis to understand biological networks, and the use of clinical decision support systems to enhance patient care. …”
Get full text

The histone methyltransferase DOT1B is dispensable for stage differentiation and macrophage infection of Leishmania mexicana by Nicole Eisenhuth, Elisa Theres Rauh, Melina Mitnacht, Andrea Debus, Ulrike Schleicher, Falk Butter, Katerina Pruzinova, Petr Volf, Christian J. Janzen

Get full text

Identification of Biomarkers of Arrhythmogenic Cardiomyopathy (ACM) by Plasma Proteomics by Sinda Zarrouk, Houda Ben-Miled, Nadia Rahali, Josef Finsterer, Fatma Ouarda

“…High-throughput plasma proteomic profiling, a powerful tool for gaining insights into disease pathophysiology at the systems biology level, has not been used to study ACM. …”
Get full text

Penicillium psychrofluorescens sp. nov., a naturally autofluorescent Antarctic fungus by Alinta Furnell, Nicole Benaud, Xabier Vázquez-Campos, Edward C.Y. Liew, Allison Mertin, Jordan A. Vink, Kate Montgomery, Marc R. Wilkins, Brett A. Summerell, Belinda C. Ferrari

Get full text

Candidate Genes Associated with Delayed Neuropsychomotor Development and Seizures in a Patient with Ring Chromosome 20 by Thiago Corrêa, Amanda Cristina Venâncio, Marcial Francis Galera, Mariluce Riegel

“…Chromosomal microarray analysis (CMA) enabled us to restrict a chromosomal segment and thus integrate clinical and molecular data with systems biology. With this approach, we were able to identify candidate genes that may help to explain the consequences of deletions in 20q13.33. …”
Get full text

Digital twins as global learning health and disease models for preventive and personalized medicine by Xinxiu Li, Joseph Loscalzo, A. K. M. Firoj Mahmud, Dina Mansour Aly, Andrey Rzhetsky, Marinka Zitnik, Mikael Benson

Get full text

Analysis of Benzene-Induced Effects on Rhodococcus sp. 33 Reveals that Constitutive Processes Play a Major Role in Conferring Tolerance by Tony Gutiérrez, Robert Learmonth, Iain Couperwhite

Get full text

Development and validation of the Chinese Rural Middle-aged and Elderly Health Literacy Scale by Rui Li, Fei Wang, Jie Huang, Zhengyu Wu, Wenjuan Gong, Yoshida Koki, Yi-Chen Chiang, Maoming Jiang, Jiannan Ma, Zhengkui Liu, Dewen Wang

Get full text

ANALYSIS OF THE INTERACTIONS OF NEURONAL APOPTOSIS GENES IN THE ASSOCIATIVE GENE NETWORK OF PARKINSON’S DISEASE by M. A. Yankina, O. V. Saik, P. S. Demenkov, E. K. Khusnutdinova, E. I. Rogaev, I. N. Lavrik, V. А. Ivanisenko

“…Analysis of gene networks is one of the key approaches in systems biology. We previously developed the ANDSystem tool, designed to automatically extract knowledge from scientific publications and reconstruct on this basis associative gene networks describing the molecular genetic mechanisms of biological processes. …”
Get full text

Determining correct tracheal tube insertion depth by measuring distance between endotracheal tube cuff and vocal cords by ultrasound in Chinese adults: a prospective case-control s... by Xuanling Chen, Wenwen Zhai, Zhuoying Yu, Jiao Geng, Min Li

Get full text

Integrative transcriptome profiling for identifying ALS potential treatment using the drug repurposing approach by Navid Kashani, Amir Sabbaghian, Fatemeh EmamiPari, Mohammad Khalili Gorjimahalleh, Mahdi Aalikhani

“…Thus, we here attempted to identify crucial genetic biomarkers through transcriptome profiling and systems biology methodologies to advance our knowledge of the diagnosis and pathogenesis of ALS. …”
Get full text

A ribosome-associating chaperone mediates GTP-driven vectorial folding of nascent eEF1A by Ibrahim M. Sabbarini, Dvir Reif, Kibum Park, Alexander J. McQuown, Anjali R. Nelliat, Charlotte Trejtnar, Volker Dötsch, Eugene I. Shakhnovich, Andrew W. Murray, Vladimir Denic

Get full text

SARS-CoV-2 S-protein expression drives syncytia formation in endothelial cells by Katie V. Tieu, Madaline Espey, Aarthi Narayanan, Rebecca L. Heise, Farhang Alem, Daniel E. Conway

Get full text

PPARD May Play a Protective Role for Major Depressive Disorder by Tao Yang, Juhua Li, Liyuan Li, Xuehua Huang, Jiajun Xu, Xia Huang, Lijuan Huang, Kamil Can Kural

Get full text

Characterizing temporal and global host innate immune responses against SARS-CoV-1 and -2 infection in pathologically relevant human lung epithelial cells. by Vivian Y Tat, Aleksandra K Drelich, Pinghan Huang, Kamil Khanipov, Jason C Hsu, Steven G Widen, Chien-Te Kent Tseng, George Golovko

“…In this study, our objective is to use a systems biology approach to explore the magnitude and scope of innate immune responses triggered by SARS-CoV-1 and -2 infection over time in pathologically relevant human lung epithelial cells (Calu-3/2B4 cells). …”
Get full text

Liver transcriptome analysis reveals PSC-attributed gene set associated with fibrosis progression by Alena Laschtowitz, Eric L. Lindberg, Anna-Maria Liebhoff, Laura Anne Liebig, Christian Casar, Silja Steinmann, Adrien Guillot, Jun Xu, Dorothee Schwinge, Michael Trauner, Ansgar Wilhelm Lohse, Stefan Bonn, Norbert Hübner, Christoph Schramm

Get full text

Targeting protein kinase C-α prolongs survival and restores liver function in sepsis: Evidence from preclinical models by Ling Xiong, Dustin Beyer, Na Liu, Tina Lehmann, Sophie Neugebauer, Sascha Schaeuble, Oliver Sommerfeld, Philipp Ernst, Carl-Magnus Svensson, Sandor Nietzsche, Sebastian Scholl, Tony Bruns, Nikolaus Gaßler, Markus H. Gräler, Marc Thilo Figge, Gianni Panagiotou, Michael Bauer, Adrian T. Press

Get full text

Transcriptional Systems Vaccinology Approaches for Vaccine Adjuvant Profiling by Diogo Pellegrina, Heather L. Wilson, George K. Mutwiri, Mohamed Helmy

“…A comprehensive and efficient way to investigate the molecular mechanism of action for adjuvants is to utilize systems biology approaches such as transcriptomics in so-called “systems vaccinology” analysis. …”
Get full text