RevCAR-mediated T-cell response against PD-L1-expressing cells turns suppression into activation by Eugenia Crespo, Liliana R. Loureiro, Antonia Stammberger, Lydia Hoffmann, Nicole Berndt, Anja Hoffmann, Claudia Dagostino, Karla E. G. Soto, Luise Rupp, Claudia Arndt, Martin Schneider, Claudia R. Ball, Michael Bachmann, Marc Schmitz, Anja Feldmann

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Effect of arm-ergometry versus treadmill supervised exercise on health-related quality of life and mental health in patients with peripheral artery disease: secondary outcomes from... by Sandra Magalhães, Mário Santos, Sofia Viamonte, Fernando Ribeiro, Joana Martins, Cristine Schmidt, Henrique Cyrne-Carvalho

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Structured reporting of neuroendocrine tumors in PET/CT using [18F]SiTATE - impact on interdisciplinary communication by Anna Hinterberger, Lukas Trupka, Sophia Kortbein, Ricarda Ebner, Nicola Fink, Matthias F. Froelich, Dominik Nörenberg, Carmen Wängler, Björn Wängler, Ralf Schirrmacher, Adrien Holzgreve, Matthias Brendel, Stefanie Corradini, Christoph Auernhammer, Johannes Rübenthaler, Freba Grawe

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Comparison of the efficacy of the modified S-P approach and the Ganz method for surgical hip dislocation in Pipkin I fractures: an early follow-up study by Hanwen Zhang, Wei Deng, Shengtao Wang, Yong Yin

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Exploiting somatic oncogenic driver alterations in a patient with Li-Fraumeni syndrome– paving the path towards precision medicine: a case report by Carolin Seeling, Sonja Dahlum, Ralf Marienfeld, Vera Jan, Brigitte Rack, Uwe Gerstenmaier, Ambros J. Beer, Regine Mayer-Steinacker, Wolfgang Thaiss, Thomas F. E. Barth, Thomas Seufferlein, Nadine T. Gaisa, Stephan Stilgenbauer, Wolfgang Janni, Reiner Siebert, Hartmut Döhner, Verena I. Gaidzik

“…Case presentation We present the case of a woman with breast cancer and subsequent osteosarcoma, both treated with surgery and chemotherapy. Constitutional genetic germline testing identified a pathogenic TP53 variant in line with the clinical features of Li-Fraumeni syndrome. …”
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Adverse health effects after breast cancer up to 14 years after diagnosis by Marianne J. Heins, Kelly M. de Ligt, Janneke Verloop, Sabine Siesling, Joke C. Korevaar, Annette Berendsen, Daan Brandenbarg, Anneriet Dassen, Agnes Jager, Jacqueline Hugtenburg, Gerda van der Weele

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Elastosonographic Evaluation of Endometrium in Postmenopausal Bleeding by İsmail Burak Gültekin, Orhan Altınboğa, Serap Gültekin, Elif Akkaş Yılmaz, Gökşen İnanç İmamoğlu, Afra Alkan, Tuncay Küçüközkan

“…All patients with a history of previous uterine surgery (including myomectomy) and/or endometrial interventions such as endometrial ablation, polyp removal, hysteroscopic interventions (except solely diagnostic procedures) and endometrial sampling within one year were excluded from the study because of the possibility of endometrial changes that may interfere with elastosonographic starin ratios. …”
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Cochlear implantation in vestibular schwannoma: A game changer? A narrative review by Luis Lassaletta, Miryam Calvino, Isabel Sánchez-Cuadrado, José Manuel Morales-Puebla, Javier Gavilán

“…On the other hand, there is growing evidence in favor of the 'wait and see' approach as opposed to surgery or irradiation for most small VS. The aim of this paper is to discuss the current role of CIs in patients with VS, addressing the most controversial topics such as the variability of outcomes, the emerging clinical scenarios, the lack of consistent prognostic factors, and the need for an intraoperative tool to aid decision-making in challenging cases. …”
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Identification of a distinctive immunogenomic gene signature in stage-matched colorectal cancer by Pankaj Ahluwalia, Ashis K. Mondal, Ashutosh Vashisht, Harmanpreet Singh, Ahmet Alptekin, Kalyani Ballur, Nivin Omar, Meenakshi Ahluwalia, Kimya Jones, Amanda Barrett, Vamsi Kota, Ravindra Kolhe

“…Despite advances in diagnosis and treatment, including surgery, chemotherapy, and immunotherapy, accurate clinical markers are still lacking. …”
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Age- and Sex-Specific Risks of Major Cardiovascular Complications and All-Cause Mortality Following Elective Hip and Knee Arthroplasty in the Netherlands: A Dutch Hospital Data Reg... by Mark J.R. Smeets, MD, Maaike G.J. Gademan, PhD, Rob G.H.H. Nelissen, MD, PhD, Suzanne C. Cannegieter, MD, PhD, Banne Nemeth, MD, PhD

“…Overall risks for venous thromboembolism, arterial thromboembolism, bleeding, and all-cause mortality were estimated at 30 and 90 days following surgery. Time trends were assessed by plotting 90-day risks by year. …”
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Tracheostomy-related indications, early complications and their predictors among patients in low resource settings: a prospective cohort study in the pre-COVID-19 era by Nyanzi, Daniel J., Daniel, Atwine, Kamoga, Ronald, Birungi, Caroline, Nansubuga, Caroline A., Nyaiteera, Victoria, Nakku, Doreen

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Dual Role of α-MSH in Colitis Progression: Mediating Neutrophil Differentiation via Bone Marrow by Liao X, Liu H, Li Y, Zhang W, Dai Q, Wei H, Zhou J, Xie X, Zhou H

“…Xiping Liao,1,2 Hengqian Liu,3 Yuanyuan Li,1,4 Wei Zhang,1 Qian Dai,1 Haoqi Wei,5 Jianyun Zhou,1 Xia Xie,2 Hongli Zhou1 1Clinical Medical Research Center, The Second Affiliated Hospital, Army Medical University, Chongqing, People’s Republic of China; 2Department of Gastroenterology, The Second Affiliated Hospital, Army Medical University, Chongqing, People’s Republic of China; 3School of Medicine, Chongqing University, Chongqing, People’s Republic of China; 4Hematopoietic Acute Radiation Syndrome Medical and Pharmaceutical Basic Research Innovation Center, Ministry of Education of the People’s Republic of China, Chongqing, People’s Republic of China; 5Department of General Surgery, The PLA 77th Group Army Hospital, Leshan City, People’s Republic of ChinaCorrespondence: Xia Xie, Department of Gastroenterology, The Second Affiliated Hospital, Army Medical University, No. 83 Xinqiao Main Street, Shapingba District, Chongqing, 400037, People’s Republic of China, Email xiexia0128@tmmu.edu.cn Hongli Zhou, Clinical Medical Research Center, The Second Affiliated Hospital, Army Medical University, No. 83 Xinqiao Main Street, Shapingba District, Chongqing, 400037, People’s Republic of China, Email zhouhongli@tmmu.edu.cnBackground: Inflammatory bowel disease (IBD) comprises a group of autoimmune disorders characterized by chronicity and resistance to cure, with an unknown etiology. …”
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Ilaser Submucous Destruction in the Treatment of Hemorrhoids by S. A. Frolov, D. V. Vyshegorodtsev, A. M. Kuzminov, Yu. L. Trubacheva, V. Yu. Korolik, I. S. Bogormistrov, I. A. Mukhin, A. N. Ryndin, A. A. Anarbaeva

“…In all patients, by day 7 after surgery, the pain syndrome in 43 patients (75.4 %) corresponded to 0 points according to VAS. …”
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Medicinal plants with neuroprotective potential in East African countries: A systematic review by Ibe Michael Usman, Ekom Monday Etukudo, Elna Owembabazi, Wusa Makena, Augustine Oviosun, Makeri Danladi, Vivian Ojiakor, Patrick Maduabuchi Aja, Emeka Anyanwu, Yanurkis Duranones Rosales, Mario Edgar Fernandez Diaz, Josiah Ifie, Ismahil Adekunle Adeniyi, Ilemobayo Victor Fasogbon, Victor Bassey Archibong

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Methylprednisolone substituted lipid nanoparticles deliver C3 transferase mRNA for combined treatment of spinal cord injury by Haoru Dong, Zongxing He, Shiyi Cai, Haiqiang Ma, Lili Su, Jianfeng Li, Huiying Yang, Rong Xie

“…The novel formulation, MP-LNP-C3, is designed for direct administration to the injury site during decompression surgery, offering a targeted therapeutic modality for SCI. …”
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Phthalate exposure induces microRNA-5010/Nrf2-EGR1/GDF15 signaling expression in prostate cancer by Yuh-Shyan Tsai, Yeong-Chin Jou, Ian Seng Cheong, Hsiu-Ting Tung, Lin-Nei Hsu, Hsin-Tzu Tsai, Tzong-Shin Tzai

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Platelet-derived HMGB1 induces NETosis, exacerbating brain damage in the photothrombotic stroke model by Sang-A. Oh, Song-I. Seol, Dashdulam Davaanyam, Seung-Woo Kim, Ja-Kyeong Lee

“…Importantly, BBCA administration, both 30 min before and 4 h after PTS surgery, significantly reduced infarct volumes at 24 h and improved neurological outcomes. …”
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Recommendations of the Russian Gastroenterological Association in Diagnosis and Treatment of Gastroesophageal Reflux Disease by V. T. Ivashkin, I. V. Maev, A. S. Trukhmanov, T. L. Lapina, O. A. Storonova, O. V. Zayratyants, O. B. Dronova, Yu. A. Kucheryavyy, S. S. Pirogov, R. G. Sayfutdinov, Yu. P. Uspenskiy, A. A. Sheptulin, D. N. Andreev, D. E. Rumyantseva

“…Prokinetics can be used in combination with PPIs for their properties to recover normal functionality of esophagus through affecting pathogenetic mechanisms of GERD.Complicated patients (repeated bleedings, peptic esophageal strictures) are recommended anti-reflux surgery with prior examination of esophageal functionality using pH-impedance and high-resolution manometry.Conclusion. …”
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Ultrasonographic Assessment of Intima-Media Thickness (IMT), as a Surrogate of Future Atherosclerosis and Cardiac Diseases in Patients with Hashimoto’s Thyroiditis and Concomitant... by Maryam Alaei, Mohamad Ghazanfari Hashemi, Seyedeh Nooshin Miratashi Yazdi, Mohammad Ali Kaviani, Ali Asadifar, Sahand Adib Moradi, Khazar Adibmoradi Langaroudi, Helia Helali, Mina Mahboudi, Aynaz Gerami

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Association of walking cadence to changes in knee pain and physical function: The multicenter osteoarthritis study by Khara A. James, Tuhina Neogi, David T. Felson, Patrick Corrigan, Cara L. Lewis, Irene S. Davis, Kathryn L. Bacon, James C. Torner, Cora E. Lewis, Michael C. Nevitt, Joshua J. Stefanik

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