YAP/TAZ-Hippo pathway mediates the tumorigenesis of various cancers through post-translational modification represented by ubiquitination by Fangshi Xu, Zongyu Li, Hao Guan, Jiancang Ma

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Case Report: Dangerous liaisons between splenectomy and eltrombopag-induced chronic thromboembolic pulmonary hypertension in patients with immune thrombocytopenia: report of two ca... by Roberto Castelli, Enrico Atzori, Alessandro Palmerio Delitala, Salvatore Antonio Masala, Valentina Micheluzzi, Enrico Ponti, Enrico Ponti, Giuseppe Sanna, Dante Castro, Antonio Gidaro, Mattia Donadoni, Roberto Manetti, Pierluigi Merella, Nicia Isabella Profili, Andrea Maria D'Armini, Gavino Casu, Gavino Casu

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LncRNA PVT1 links estrogen receptor alpha and the polycomb repressive complex 2 in suppression of pro-apoptotic genes in hormone-responsive breast cancer by Viola Melone, Domenico Palumbo, Luigi Palo, Noemi Brusco, Annamaria Salvati, Antonietta Tarallo, Giorgio Giurato, Francesca Rizzo, Giovanni Nassa, Alessandro Weisz, Roberta Tarallo

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Single-cell transcriptomes of dissecting the intra-tumoral heterogeneity of breast cancer microenvironment by Peixian Chen, Kaifeng Liang, Xiaofan Mao, Qiuyuan Wu, Zhiyan Chen, Yabin Jin, Kairong Lin, Tiancheng He, Shuqing Yang, Huiqi Huang, Guolin Ye, Juntao Gao, Dan Zhou, Zhihao Zeng

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SPC25 upregulates CCND1 to promote the progression of esophageal squamous cell carcinoma by inhibiting MDM2-mediated E2F1 ubiquitination by Haoyao Jiang, Xiangfeng Jin, Haiyong Gu, Bin Li, Zhigang Li, Yifeng Sun

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Correction: Identification and validation of neutrophils-related subtypes and prognosis model in triple negative breast cancer by Shanqi Li, Yuzhou Qian, Wanchen Xie, Xinyu Li, Jiaying Wei, Long Wang, Guosheng Ren, Xuedong Yin

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CytoSorb hemoadsorption of apixaban during cardio-pulmonary bypass for heart transplantation by Anouk Frering, MD, Antoine Abi Lutfallah, MD, Aude Carillion, MD, PhD, Daniel Wendt, MD, Pascal Leprince, MD, PhD, Adrien Bougle, MD, PhD, Guillaume Lebreton, MD, PhD

“…Background: Heart transplantation is an emergency surgery requiring cardio-pulmonary bypass (CPB) and its timing is unpredictable. …”
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Distal Femoral Replacement With a Metaphyseal Sleeve: Outcomes and Risk Factors for Subsidence by David Alexander George, MBChB, BMedSc, FRCS (Tr & Orth), Christopher Lee Buckle, MBBS, BSc, MSc (Oxon), FRCS (Tr & Orth), Abtin Alvand, BSc (Hons), MBBS, DPhil (PhD), FRCS (Tr & Orth), William Jackson, MBBS, BSc, FRCS (Tr & Orth), Adrian Taylor, MBBS, FRCS (Orth), Ben Kendrick, DPhil (PhD), FRCS (Tr & Orth)

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Microfluidic Flow Promotes a Steatotic Phenotype in Induced Pluripotent Stem Cell–Derived Hepatocytes that is Influenced by Disease State of the Donor by Ekta Minocha, Linan Jiang, Ashwani Kumar Gupta, Richard M. Green, Yitshak Zohar, Jason A. Wertheim

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The South African Prostate Cancer Screening Guidelines by J John, A Adam, L Kaestner, P Spies, S Mutambirwa, J Lazarus

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Intuitive stent simulation with internal cavity airway models created by a consumer-grade three-dimensional printer: A case series by Naoya Kitamura, Toshihiro Ojima, Yoshifumi Shimada, Keitaro Tanabe, Ryo Yokoyama, Naru Kitade, Koichiro Shimoyama, Tomoshi Tsuchiya

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Comprehensive genomic and transcriptomic profiling of pulmonary nodules in synchronous multiple primary lung cancer by Xingsheng Liu, Kun Qian, Lei Su, Xiaoru Tian, Xin Zhao, Tengteng Wang, Li Han, Zhenzhen Li, Peilong Zhang, Ruotian Wang, Baodong Liu, Yuanbo Li, Xiaogang Tan, Yi Zhang

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Helicobacter pylori SlyD stabilizes TPT1 via hnRNPK and enhances OCT1-mediated CDX2 transcriptional activation to drive gastric intestinal metaplasia by Shuwen Zheng, Yingying Wang, Chuxuan Ni, Rui Guo, Xunan Qiu, Jijun Chen, Lu Wang, Xiaohu Sun, Moye Chen, Yunen Liu, Yuan Yuan, Yuehua Gong

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CD109, a master regulator of inflammatory responses by Adel Batal, Adel Batal, Setareh Garousi, Setareh Garousi, Kenneth W. Finnson, Kenneth W. Finnson, Anie Philip, Anie Philip

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THE EFFECT OF TRANEXAMIC ACID INJECTION ON HEMOGLOBIN LEVEL, ALBUMIN LEVEL, AND PAIN ON PATIENT RECEIVING TOTAL KNEE REPLACEMENT by Dwikora Novembri Utomo, Teddy Heri Wardhana, Ahmad Hannan Amrullah, Hamzah Hamzah

“…Total Knee Replacement (TKR) surgery procedure is at risk of massive bleeding. …”
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Return to sport and patient satisfaction after arthroscopic Bankart repair: a single-institution experience by Yeow Boon Tan, Ken Lee Puah, Roland Weng Wah Chong, Kee Leong Ong, Yi-Jia Lim, Dave Yee Han Lee

“…Mean follow-up was 4.4 ± 1.3 (3.0–9.0) years and 2.5 ± 3.0 (0.1–15.4) years elapsed from first dislocation to surgery. 41 (50.0%) patients played overhead or contact sports and 44 (53.7%) played competitive sports before injury; 8 (9.8%) patients reported recurrence of dislocation, which was significantly associated with playing competitive sports before injury (p <0.039), 5 (6.1%) underwent revision surgery and 22 (26.8%) reported residual instability after surgery. 49 (59.8%) patients returned to playing sports, 75 (91.5%) were satisfied with their surgery and 79 (96.3%) were willing to undergo the surgery again. 74 (90.2%) patients had two-year good/excellent OSIS, which was significantly associated with playing competitive sports before injury (p = 0.039), self-reported stability after surgery (p = 0.017), satisfaction with surgery (p = 0.018) and willingness to undergo surgery again (p = 0.024). …”
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Successful Surgical Treatment of “Complex” Abdominal Echinococcosis by A. B. Goncharov, Yu. A. Stepanova, V. S. Shirokov, I. A. Turchenko, Yu. A. Kovalenko, D. V. Kalinin, B. N. Gurmikov, A. V. Zhao

“…Pericystectomy was carried out according to the technique of the National Medical Research Center of Surgery named after A. Vishnevsky.Conclusion. Due to the peculiarities of the course of helminthiasis and the pronounced variability of the lesion, it is extremely difficult to develop universal and effective treatment algorithms. …”
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Integrating manual annotation with deep transfer learning and radiomics for vertebral fracture analysis by Jing Wang, Zhirui Dong, Huanxin He, Zhiyang Gao, Yukai Huang, Guangcheng Yuan, Libo Jiang, Mingdong Zhao

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TIM‐4 increases the proportion of CD4+CD25+FOXP3+ regulatory T cells in the pancreatic ductal adenocarcinoma microenvironment by inhibiting IL‐6 secretion by Ziyao Wang, Zerong Xie, Yu Mou, Ruiman Geng, Chen Chen, Nengwen Ke

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Case study: An unusual and fatal injury: stab wound of a bovine aortic arch anomaly by Sergio AM Vieira, Ryan J Keet, Jacobus D Winter, Sharon R Čačala, George V Oosthuizen

“…Such an injury is challenging, especially in a “crashing” patient in whom emergency surgery is undertaken. When this scenario is coupled with an aortic arch abnormality, it may be infinitely more difficult to deal with, and the injury may prove non-salvageable. …”
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