Treatment of Decompensated Alcoholic Liver Disease by John Menachery, Ajay Duseja

“…Pentoxifylline, a tumor necrosis factor alpha (TNFα) suppressor, and infliximab, an anti-TNFα mouse/human chimeric antibody, has been extensively studied in patients with alcoholic hepatitis. …”
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Biomarkers for Risk Stratification of Neoplastic Progression in Barrett Esophagus by Marjon Kerkhof, Johannes G. Kusters, Herman van Dekken, Ernst J. Kuipers, Peter D. Siersema

“…In this review, we will summarize the most promising tissue biomarkers, i.e. proliferation/cell cycle proteins, tumor suppressor genes, adhesion molecules, DNA ploidy status and inflammation associated markers, that can be used for risk stratification in BE, and discuss their respective clinical application.…”
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KLF4: a multifunctional nexus connecting tumor progression and immune regulation by Yunjie Ju, Wen Xiao, Bryan James Mathis, Ying Shi

“…KLF4 plays a promoter role in tumorigenesis and development, or tumor suppressor as a context-dependent anti- and pro-inflammatory factor. …”
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Application of Bionanomaterials in Tumor Immune Microenvironment Therapy by Jiawei Wang, Yan Bao, Yandan Yao

“…In this review, we will summarize the most current researches on bionanomaterials for targeted regulation of tumor-associated macrophages, myeloid-derived suppressor cells, dendritic cells, T lymphocyte cells, and cancer-associated fibroblasts and summarize the prospects and challenges of cell-targeted therapy and clinical translational potential in a tumor immune microenvironment in cancer treatment.…”
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PPARγ and PPARδ as Modulators of Neoplasia and Cell Fate by Robert I. Glazer, Hongyan Yuan, Zhihui Xie, Yuzhi Yin

“…There is now emerging evidence that PPARs regulate tumor suppressor genes and developmental pathways associated with transformation and cell fate determination. …”
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Autophagy in brain tumors: molecular mechanisms, challenges, and therapeutic opportunities by Jiarui Zhang, Jinan Zhang, Chen Yang

“…The discussion would focus on the molecular pathways that control autophagy in brain tumors, and its dual role as a tumor suppressor and a supporter of tumor survival. Autophagy can control the advancement of different types of brain tumors like glioblastoma, glioma, and ependymoma, demonstrating its potential for treatment. …”
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Annotation of Genes Having Candidate Somatic Mutations in Acute Myeloid Leukemia with Whole-Exome Sequencing Using Concept Lattice Analysis by Kye Hwa Lee, Jae Hyeun Lim, Ju Han Kim

“…In cancer genome studies, the annotation of newly detected oncogene/tumor suppressor gene candidates is a challenging process. …”
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Suppression of the Oncogenic Transcription Factor FOXM1 by Proteasome Inhibitors by Andrei L. Gartel

“…We also determined that FOXM1 is negatively regulated by the tumor suppressor p53. We identified the thiazole antibiotics Siomycin A and thiostrepton as inhibitors of transcriptional activity and FOXM1 expression via proteasome inhibition. …”
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Altered Expression of Cellular Bcl-2 in the Progression of Hamster Cholangiocarcinogenesis by Byung-suk Jeon, Byung-IL Yoon

“…Bcl-2 is an intracytoplasmic and membrane-associated apoptosis suppressor, and its overexpression is closely associated with survival of malignant tumors, in particular their aggressive behavior and poor prognosis. …”
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Finding the Correct Partner: The Meiotic Courtship by Tomás Naranjo

“…Pairing seems to arise as a balance between promoter and suppressor pairing genes. Some fungi, plants and animals, use mechanisms based on recombinational interactions. …”
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MiRNAs as major players in brain health and disease: current knowledge and future perspectives by Sarika V. Kapplingattu, Sujata Bhattacharya, Yogita K. Adlakha

“…Several reports show downregulation of miR-135 in glioblastoma, indicating its tumor suppressor role in the pathogenesis of brain tumors. …”
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FBXW7 metabolic reprogramming inhibits the development of colon cancer by down-regulating the activity of arginine/mToR pathways. by Qing Li, Yan Li, Tong Zhou, Yong Zhang, Huiyu Li, Fajia Yuan, Yanghui Bi

“…FBXW7 is a tumor suppressor gene that regulates metabolism and is associated with the onset and progression of colorectal cancer (CRC)), however, the precise mechanism whereby FBXW7 participates in the metabolic reprogramming of CRC remains unclear. …”
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NF-κB signaling and the tumor microenvironment in osteosarcoma: implications for immune evasion and therapeutic resistance by Shaoyan Shi, Xuehai Ou, Chao Liu, Rui Li, Qianjin Zheng, Leiming Hu

“…This research aimed to explore how NF-κB influences the recruitment and polarization of tumor-associated macrophages and myeloid-derived suppressor cells, both of which contribute to immunosuppression. …”
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Genetic Alterations in Presumptive Precursor Lesions of Breast Carcinomas by Michaela Aubele, Martin Werner, Heinz Höfler

“…An expression of mutant p53 tumor suppressor gene as well as expression of cyclin D1 was identified in DCIS. …”
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miR-149 Inhibits Non-Small-Cell Lung Cancer Cells EMT by Targeting FOXM1 by Yang Ke, Weiyong Zhao, Jie Xiong, Rubo Cao

“…Our work suggested that miR-149 might be an EMT suppressor in NSCLC cells.…”
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Potential Use of Bisphosphonates in Invasive Extramammary Paget’s Disease: An Immunohistochemical Investigation by Taku Fujimura, Sadanori Furudate, Yumi Kambayashi, Setsuya Aiba

“…Among them, the abrogation of immunosuppressive cells, myeloid derived suppressor cells (MDSC), by BPs might be one of the optimal methods to induce an antitumor immune response both locally and at sites remote from the tumor. …”
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Extracellular HMGB1 blockade inhibits tumor growth through profoundly remodeling immune microenvironment and enhances checkpoint inhibitor-based immunotherapy by Coraline Radermecker, Pascale Hubert, Patrick Roncarati, Stephanie Demoulin, Charlotte Pilard, Marie Ancion, Celia Reynders, Thomas Lerho, Diane Bruyere, Alizee Lebeau, Margot Meunier, Marie-Julie Nokin, Elodie Hendrick, Olivier Peulen, Philippe Delvenne, Michael Herfs

“…Indeed, without affecting the global number of (CD45+) immune cells, drastic reductions of monocytic/granulocytic myeloid-derived suppressor cells (MDSC) and regulatory T lymphocytes, a higher M1/M2 ratio of macrophages as well as an increased activation of both DC and pDC were continually observed following HMGB1 inhibition. …”
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PPARγ as a Novel Therapeutic Target in Lung Cancer by Aravind T. Reddy, Sowmya P. Lakshmi, Raju C. Reddy

“…Its involvement in adipocyte differentiation and glucose and lipid homeostasis is well-recognized, but accumulating evidence now suggests that PPARγ may also function as a tumor suppressor, inhibiting development of primary tumors and metastases in lung cancer and other malignancies. …”
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SOCS1, a Negative Regulator of Cytokine Signals and TLR Responses, in Human Liver Diseases by Minoru Fujimoto, Tetsuji Naka

“…Recent lines of evidence indicate that the suppressor of cytokine signaling (SOCS) family proteins, originally identified as negative-feedback regulators in cytokine signaling, are involved in the regulation of TLR-mediated immune responses. …”
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A Pleural Solitary Fibrous Tumor, Multiple Gastrointestinal Stromal Tumors, Moyamoya Disease, and Hyperparathyroidism in a Patient Associated with NF1 by Yoko Yamamoto, Ken Kodama, Shigekazu Yokoyama, Masashi Takeda, Shintaro Michishita

“…Neurofibromatosis type 1 (NF1), also called von Recklinghausen’s disease, is a multisystemic disease caused by an alteration of the NF1 gene, a tumor suppressor located on the long arm of chromosome 17 (17q11.2). …”
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