Red Blood Cell Alloimmunization and Autoimmunization in Blood Transfusion-Dependent Sickle Cell Disease and β-Thalassemia Patients in Al-Ahsa Region, Saudi Arabia by Fahd A. Kuriri, Abdulrahman Ahmed, Fehaid Alanazi, Fahad Alhumud, Mohammed Ageeli Hakami, Osama Atiatalla Babiker Ahmed

“…It is important to determine the rate of alloimmunization and autoimmunization in Al-Ahsa Region, Saudi Arabia, where sickle cell disease (SCD) and thalassemia incidence rates are the highest in Saudi Arabia. …”
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Efficacy and Tolerance of Vascular Electrical Stimulation Therapy in the Management of Vaso-Occlusive Crises in Patients with Sickle Cell Disease: A Phase II Single-Centre Randomized Study in Ivory Coast by Renée-Paule Botti, Sie Saïda Bokoum, Etienne L’Hermite, Dohoma Alexis Silue, Boidy Kouakou, Sarah Anastasie Bognini, Serge Arnaud Agoua, Edgar Mandeng Ma Linwa, Roméo Ayemou, Kouassi Gustave Koffi

“…Vaso-occlusive crisis (VOC) is the primary cause of hospitalization in patients with sickle cell disease. Treatment mainly consists of intravenous morphine or nonsteroidal anti-inflammatory drugs (NSAIDs), which have many dose-related side effects. …”
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A Case Study in Process Improvement to Minimize Delays from Obtaining Blood for Red Cell Exchange for a Patient with Sickle Cell Disease and Multiple Red Blood Cell Alloantibodies by Damodaran Narayanan, Noreen B. Hogan, Karen A. Schaser, Patricia Ruegsegger, William Nicholas Rose

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Amelioration of Sickle Cell Pain after Parathyroidectomy in Two Patients with Concurrent Hyperparathyroidism: An Interesting Finding by John Muthu, Mir Ali

“…Patients with sickle cell disease have high morbidity and healthcare utilization due to repeated painful crises. …”
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Acute Chest Syndrome Progressing to ARDS in a Patient of 25-Week Gestation by Jefferson Chambers, Nichole Smith, Matthew Sehring, Subramanyam Chittivelu

“…Acute chest syndrome is a complication of sickle cell disease and represents the highest cause of mortality in those afflicted with the disorder. …”
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Kidney Transplant in a 26-Year-Old Nigerian Patient with Sickle Cell Nephropathy by U. H. Okafor, C. Wachukwu, P. Emem-Chioma, F. S. Wokoma

“…Sickle cell nephropathy (SCN) is a common complication of sickle cell disease (SCD). It has variable presentation, ranging from hyposthenuria to end-stage renal disease (ESRD). …”
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Assessment of Hemoglobin Variants in Patients Receiving Health Care at the Ho Teaching Hospital: A Three-Year Retrospective Study by Daniel Kpodji Awaitey, Elliot Elikplim Akorsu, Emmanuel Allote Allotey, David Annor Kwasie, Precious Kwablah Kwadzokpui, Philip Apraku Tawiah, Stephen Adomako Amankwah, Albert Abaka-Yawson

“…Data were collected for the period January 2016 to December 2018. Sickle cell disease status was determined using the Hb genotypes from the Hb electrophoresis results. …”
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Sickle Cell Anemia, the First Molecular Disease: Overview of Molecular Etiology, Pathophysiology, and Therapeutic Approaches by Martin H. Steinberg

“…The root cause of sickle cell disease is a single β-globin gene mutation coding for the sickle β-hemoglobin chain. …”
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Genetic Information to Share with Parents when Newborn Screening Reveals the Presence of Sickle Cell Trait by Narcisse Elenga

“…The primary purpose of newborn screening for sickle cell disease is to diagnose the disease before the appearance of symptoms and to initiate early treatment. …”
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HbS-Sicilian (δβ)0-Thalassemia: A Rare Variant of Sickle Cell by Grace Onimoe, Genine Smarzo

“…Sickle cell disease (SCD) is caused by a mutation in the sixth codon of the β-globin gene on chromosome 11, which leads to a single amino acid substitution (glutamine to valine). …”
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Impact of hydroxyurea on clinical and biological parameters of sickle cell anemia in children in Abidjan by MIREILLE YAYO- AYE, Adia Eusèbe Adjambri, Boidy Kouakou, Rebecca N'guessan-Blao, Louis Missa Adjé, Taïratou Kamagaté, Vincent Yapo, Duni Sawadogo

“… Background: The lives of individuals affected by sickle cell disease are marked by painful crises sometimes accompanied by complications. …”
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Prevalence of Priapism and Its Awareness amongst Male Homozygous Sickle Cell Patients in Lagos, Nigeria by Adewumi Adediran, Kikelomo Wright, Akinsegun Akinbami, Adedoyin Dosunmu, Olajumoke Oshinaike, Bodunrin Osikomaiya, Sarah Ajibola, Kamal Ismail, Ebele Uche, Olaitan Ojelabi

“…Impotence and infertility are major problems in male sickle cell disease patients, and priapism has been implicated as a cause of impotence and infertility. …”
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Misdiagnosis: Acute Chest Syndrome That Evolved into Acute Respiratory Distress Syndrome in a Patient without a Documented History of Hemoglobinopathy by Christoph Sossou, Ogechukwu Chika-Nwosuh, Christopher Nnaoma, Jose Bustillo, Asad Chohan, Etinosasere Okundaye, Pratik Patel

“…Acute chest syndrome (ACS) is a feared complication of sickle cell disease. Here is a case of a patient who presented with symptoms suggestive of acute chest syndrome yet had a delayed diagnosis presumably due to the lack of documented history of sickle cell disease of the patient, consequently evolving into acute respiratory distress syndrome (ARDS). …”
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Acute Sickle Hepatic Crisis after Liver Transplantation in a Patient with Hb SC Disease by J. H. Gillis, S. K. Satapathy, L. Parsa, P. B. Sylvestre, N. Dbouk

“…Acute sickle hepatic crisis (ASHC) has been observed in approximately 10% of patients with sickle cell disease. It occurs predominantly in patients with homozygous (Hb SS) sickle cell anemia and to a lesser degree in patients with Hb SC disease, sickle cell trait, and Hb S beta thalassemia. …”
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Sarcomatoid Renal Cell Carcinoma in an Adolescent with Sickle Cell Anaemia by H. R. Ahmad, J. A. Faruk, M. A. Bugaje, A. Solomon, M. O. A. Samaila, R. M. Akuse

“…Malignancies have been reported to occur in people with sickle cell disease. Renal medullary carcinoma (RMC), also tagged seventh sickle cell nephropathy, is an aggressive cancer seen almost exclusively in people with sickle cell disease with more than 160 cases reported worldwide, but only few cases were reported in patients with sickle cell anaemia (HBSS) and from Nigeria. …”
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Therapeutic molecules for multiple human diseases identified from pigeon pea (Cajanus cajan L. Millsp.) through GCâMS and molecular docking by Deepu Mathew, Lidiya John P., Manila T.M., Divyasree P., Sandhya Rajan V.T.K.

“…Keywords: Breast cancer, Drug discovery, Herbal medicine, In silico, Malaria, Measles, Phyto-compounds, Rheumatoid arthritis, Sickle cell disease, Type II diabetes…”
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Musculoskeletal Manifestations of Sickle Cell Anaemia: A Pictorial Review by A. Ganguly, W. Boswell, H. Aniq

“…In this paper we discuss and illustrate the various musculoskeletal manifestations of sickle cell disease focusing primarily on marrow hyperplasia, osteomyelitis and septic arthritis, medullary and epiphyseal bone infarcts, growth defects, and soft tissue changes.…”
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Brodie’s Abscess in a Patient Presenting with Sickle Cell Vasoocclusive Crisis by Onyekachi Henry Ogbonna, Yonette Paul, Hasan Nabhani, Adriana Medina

“…We report a very interesting case of Brodie’s abscess masquerading as sickle cell vasoocclusive crisis in a 20-year-old female with sickle cell disease and review the literature.…”
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Successful Use of Pulmonary Vasodilators in Acute Chest Syndrome Complicated by Persistent Right Ventricular Failure by Jacqueline T. DesJardin, Lucas S. Zier

“…Pulmonary hypertension (PH) is a known consequence of sickle cell disease (SCD) and is associated with increased mortality and more frequent episodes of acute chest syndrome (ACS). …”
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Splenic Anomalies of Shape, Size, and Location: Pictorial Essay by Adalet Elcin Yildiz, Macit Orhan Ariyurek, Musturay Karcaaltincaba

“…Splenosis and small spleen are acquired anomalies which are caused by trauma and sickle cell disease, respectively. These anomalies can be detected easily by using different imaging modalities including ultrasonography, computed tomography, magnetic resonance imaging, and also Tc-99m scintigraphy. …”
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