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    GPX3 as a Novel and Potential Therapeutic Target in the Shared Molecular Mechanisms of Traumatic Brain Injury and Parkinson’s Disease by Wang Y, Fang J, Yuan Q, Yu J, Hu J

    Published 2025-02-01
    “…Yue Wang,1– 5 Jiang Fang,1– 5 Qiang Yuan,1– 5 Jian Yu,1– 5 Jin Hu1– 5 1Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200040, People’s Republic of China; 2National Center for Neurological Disorders, Huashan Hospital, Fudan University, Shanghai, 200040, People’s Republic of China; 3Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Huashan Hospital, Fudan University, Shanghai, 200040, People’s Republic of China; 4Neurosurgical Institute of Fudan University, Huashan Hospital, Fudan University, Shanghai, 200040, People’s Republic of China; 5Shanghai Clinical Medical Center of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200040, People’s Republic of ChinaCorrespondence: Jian Yu; Jin Hu, Department of Neurosurgery, Huashan Hospital, Fudan University, 12 Wulumuqi Zhong Road, Shanghai, 200040, People’s Republic of China, Tel +86 21 52889999, Email hujin@fudan.edu.cn; lance2000@hotmail.comBackground: Traumatic brain injury (TBI) is a prevalent neurological disorder associated with significant public health burdens and long-term risks, including neurodegenerative diseases such as Parkinson’s disease (PD). …”
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    Acid-Unlocked Two-Layer Ca-Loaded Nanoplatform to Interfere With Mitochondria for Synergistic Tumor Therapy by Zheng Y, Williams GR, Hu R, Tong S, Xu J, Wang T, Zhang Y, Wu J, Li F, Cai Y, Zhu LM

    Published 2025-02-01
    “…Yilu Zheng,1 Gareth R Williams,2 Ran Hu,1 Sen Tong,3 Jianxiang Xu,1 Tong Wang,1 Yanyan Zhang,1 Junzi Wu,3 Fan Li,4 Yingyu Cai,4 Li-Min Zhu1 1College of Biological Science and Medical Engineering, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, Donghua University, Shanghai, 201620, People’s Republic of China; 2UCL School of Pharmacy, University College London, London, WC1N 1AX, UK; 3The Key Laboratory of Microcosmic Syndrome Differentiation, Education Department of Yunnan, Yunnan University of Chinese Medicine, Kunming, 650500, People’s Republic of China; 4Department of Ultrasound, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, People’s Republic of ChinaCorrespondence: Yingyu Cai, Department of Ultrasound, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, People’s Republic of China, Email yingyu.cai@shgh.cn Li-Min Zhu, College of Biological Science and Medical Engineering, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, Donghua University, Shanghai, 201620, People’s Republic of China, Email lzhu@dhu.edu.cnBackground: The development of selective formulations able to target and kill tumor cells without the application of external energy has shown great promise for anti-tumor therapy.Methods: Here, we report a “nanobomb” that explosively increases Ca content within cells. …”
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