Biochemical and structural characterization of Rab3GAP reveals insights into Rab18 nucleotide exchange activity by Gage M. J. Fairlie, Kha M. Nguyen, Sung-Eun Nam, Alexandria L. Shaw, Matthew A. H. Parson, Hannah R. Shariati, Xinyin Wang, Meredith L. Jenkins, Michael Gong, John E. Burke, Calvin K. Yip

“…Abstract The heterodimeric Rab3GAP complex is a guanine nucleotide exchange factor (GEF) for the Rab18 GTPase that regulates lipid droplet metabolism, ER-to-Golgi trafficking, secretion, and autophagy. Why both subunits of Rab3GAP are required for Rab18 GEF activity and the molecular basis of how Rab3GAP engages and activates its cognate substrate are unknown. …”
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Asymptomatic cholecystitis and its controversial issues in biliary surgery by Sergey Yurievich Muraviev, Evgeniy Alexandrovich Tarabrin, Alexey Leonidovich Shestakov, Irina Alexandrovna Tarasova, Ivan Alexandrovich Markov, Vadim Sergeevich Razumovsky, Anna Victorovna Ananichuk, Andrey Pavlovich Fabrika, Valeria Alexandrovna Stener, Mehrshad Ebrahimnezhad, Denis Vasilievich Orlushin, Anna Nikolaevna Zavyalova

“…That is why most cases of postcholecystectomy syndrome occur in patients operated on for asymptomatic cholecystitis.The unwillingness to discover the secret of stone formation and asymptomatic cholecystitis in humans when concretions in the gallbladder are detected without reference to surgery, to indicate the trajectory of the examination, leads to a number of tactical errors, preserving the risk of PES, and erasing practical recommendations for the management of such patients. …”
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PhaseSCA: Exploiting Phase-Modulated Emanations in Side Channels by Pierre Ayoub, Aurélien Hernandez, Romain Cayre, Aurélien Francillon, Clémentine Maurice

“…This observation allows us to extract a side-channel leakage that can be exploited to reveal secret cryptographic material. We introduce a technique allowing us to exploit this side-channel in order to perform a full AES key recovery, using cheap and common hardware equipment like a software-defined radio (SDR). …”
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Impact of Probiotics and Prebiotics on Gut Microbiome and Hormonal Regulation by Jelina Basnet, Manar A. Eissa, Licy L. Yanes Cardozo, Damian G. Romero, Samar Rezq

“…These interactions involve the production of metabolites, signaling molecules, and direct communication with endocrine cells, which modulate hormone secretion and activity. As a result, the microbiome can exert neuroendocrine effects and contribute to metabolic regulation, adiposity, and appetite control. …”
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Consortium of <i>Lactobacillus crispatus</i> 2029 and <i>Ligilactobacillus salivarius</i> 7247 Strains Shows In Vitro Bactericidal Effect on <i>Campylobacter jejuni</i> and, in Com... by Vyacheslav M. Abramov, Igor V. Kosarev, Andrey V. Machulin, Evgenia I. Deryusheva, Tatiana V. Priputnevich, Alexander N. Panin, Irina O. Chikileva, Tatiana N. Abashina, Ashot M. Manoyan, Olga E. Ivanova, Tigran T. Papazyan, Ilia N. Nikonov, Nataliya E. Suzina, Vyacheslav G. Melnikov, Valentin S. Khlebnikov, Vadim K. Sakulin, Vladimir A. Samoilenko, Alexey B. Gordeev, Gennady T. Sukhikh, Vladimir N. Uversky, Andrey V. Karlyshev

“…The ability of the LC2029 and LS7247 consortium to promote intestinal homeostasis in vitro was assessed by the effectiveness of controlling CJ-induced TLR4 activation, secretion of pro-inflammatory cytokines, development of intestinal barrier dysfunction, and production of intestinal alkaline phosphatase (IAP). …”
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Lentivirus‐mediated gene therapy for Fabry disease: 5‐year End‐of‐Study results from the Canadian FACTs trial by Aneal Khan, Dwayne L. Barber, William M. McKillop, C. Anthony Rupar, Christiane Auray‐Blais, Graeme Fraser, Daniel H. Fowler, Alexandra Berger, Ronan Foley, Armand Keating, Michael L. West, Jeffrey A. Medin

“…Overexpression of α‐gal A leads to secretion of the hydrolase; which can be taken up and used by uncorrected bystander cells. …”
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Application of lacrimal gland ultrasonography in the evaluation of chronic ocular graft-versus-host-disease by Mingxia Zhong, Siyuan Liu, Jinghan Luo, Qin Zhang, Zhou Yang, Shanshan Zhang

“…While ultrasonography can provide insight into tear secretion, its efficacy in diagnosing oGVHD appears limited.…”
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Antibiofilm Activity of Epinecidin-1 and Its Variants Against Drug-Resistant <i>Candida krusei</i> and <i>Candida tropicalis</i> Isolates from Vaginal Candidiasis Patients by Sivakumar Jeyarajan, Sukumar Ranjith, Raja Veerapandian, Kalimuthusamy Natarajaseenivasan, Prahalathan Chidambaram, Anbarasu Kumarasamy

“…Computational analysis showed that the peptides have a high tendency to interact with <i>Candida</i> spp. cell membrane proteins such as Exo-β-(1,3)-Glucanase, Secreted Aspartic Proteinase (Sap) 1, and N-terminal Domain Adhesin: Als 9-2, thereby preventing biofilm formation. …”
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Diabetes Mellitus, Extreme Insulin Resistance, and Hypothalamic-Pituitary Langerhans Cells Histiocytosis by Mathilde Sollier, Marine Halbron, Jean Donadieu, Ahmed Idbaih, Fleur Cohen Aubart, Corinne Vigouroux, Martine Auclair, Olivier Bourron, Marie Bastin, Géraldine Béra, Philippe Touraine, Jacques Young, Héléna Mosbah, Agnès Hartemann, Fabrizio Andreelli, Chloé Amouyal

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Novel Polymorphism in a Promoter of MBL2 Gene Result in Lower MBL Expression in Chronic Infection Caused by HCV by Paywast Jamal Jalal

“…The Pathogen Recognition Receptors (PRRs) is an active protein in the immune system. The PRRs that secreted in the liver and we addressed were L-ficolin, MBL and H-ficolin. …”
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The structural landscape and diversity of Pyricularia oryzae MAX effectors revisited. by Mounia Lahfa, Philippe Barthe, Karine de Guillen, Stella Cesari, Mouna Raji, Thomas Kroj, Marie Le Naour-Vernet, François Hoh, Pierre Gladieux, Christian Roumestand, Jérôme Gracy, Nathalie Declerck, André Padilla

“…Magnaporthe AVRs and ToxB-like (MAX) effectors constitute a family of secreted virulence proteins in the fungus Pyricularia oryzae (syn. …”
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The manipulation of odor availability of training aids used in detection canine training by Katylynn B. Sloan, Michele N. Maughan, Caitlin E. Sharpes, Robin R. Greubel, Shawna F. Gallegos, Shawna F. Gallegos, Aleksandr E. Miklos, Lindsay D. Waldrop

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Metagenomic Analysis Reveals the Effects of Microplastics on Antibiotic Resistance Genes in Sludge Anaerobic Digestion by Zhonghong Li, Donghai Yuan

“…The results of gene function annotation indicated that exposure to MPs led to an increased the relative abundance of genes related to the production of reactive oxygen species (ROS), alterations in membrane permeability, ATP synthesis, and the secretion of extracellular polymeric substances (EPS). …”
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ANTHROPOCENTRIC INTENTION OF HESYCHAST AND SUFISTIC PRACTICES OF FREEDOM PERSONAL DEVELOPMENT by Yurii Y. Semchuk

“…The author concludes that despite the existence of schools and practices, personal manifestation of union with God through the freedom of own will devoted in listening of spiritual life – own heart, is dominant in Hesychasm and Sufism mystical currents. The main secret of mystics was not a transfer of theoretical knowledge through the generations, but the apparition of truth through his own aspiration to knowledge, in the unbearable austerity initiation experiences obtained enlightenment, happiness deification, the anguish of love. …”
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Anti-Inflammatory and Antimicrobial Actions of Vitamin D in Combating TB/HIV by Anna K. Coussens, Adrian R. Martineau, Robert J. Wilkinson

“…Conversely, vitamin D can act to inhibit expression and secretion of a broad range of inflammatory mediators and matrix degrading enzymes driving immunopathology during active TB and antiretroviral- (ARV-) mediated immune reconstitution inflammatory syndrome (IRIS). …”
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The <i>Pelvicachromis pulcher</i>: A Local Aquarium Species by A.T. Ibim, G.C. Eziefule

“…Their environmental requirements is 24-260C temperature, acidic to neutral (pH 5.6 – 6.2, and soft water (12 – 22 mg/l – 1CaCO3).They are secretive cave spawners, and exhibit vigorous parental care, but easily breed in captivity. …”
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nPPoS: Non-interactive practical proof-of-storage for blockchain by Jun Wook Heo, Gowri Ramachandran, Raja Jurdak

“…Existing proof-of-storage solutions are designed for general-purpose settings where a data owner uses secret information to verify storage, rendering them unsuitable for blockchain where proof-of-storage must be fast, publicly verifiable, and data owner-agnostic. …”
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Les musées amérindiens : des lieux de mémoire ou d’anti-mémoire ? by Gérard Selbach

“…The true spiritual memory cannot be exhibited: it is lived and practiced in secret. Museums are evidence of a secularized world that tends to lose the memory of the past and of the sacred. …”
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Investigation of the relationship between intraocular pressure and ultrasonographic examination of anterior and posterior segment of the eye in dogs by Özgür Erkan, Kurtuluş Parlak, Mustafa Arıcan

“…Schirmer test kit was used to measure the quantitative amount of tear secretion. Tonovet was used for intraocular pressure measurement, direct ophthalmoscopic examination and ultrasonographic examinations were also performed.…”
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Influence of food consumption and packaging on urinary Bisphenol-A level in a sample of Egyptian students by Rania N. Sabry, Rehab S.I. Moustafa, Saneya A. Wahba, Ebtissam M. Salah El-Din, Samia Boseila, Mai M. Youssef, Mones M. Abushady, Jihan Hussein, Dalia Medhat, Safaa M. Morsy, Dina A. Salah

“…Conclusions Food consumption had no obvious effect on BPA levels except for juice consumption which has a significant influence on BPA secretion. Also, food storage and packaging had no significant role in BPA levels.…”
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