Evaluation of the etiological spectrum of obstructive jaundice in patients attending the Al-Azhar Assiut University Hospital Endoscopy Unit in the last five years by Hamdy Mahfouz Moustafa, Ahmed Qasem Mohamed, Ali Sayed Zarea Nouh

“…Background and aim The term ‘cholestasis’ refers to a condition in which the bile flow is reduced, either because of decreased secretion by hepatocytes or because of intrahepatic or extrahepatic bile duct blockage. …”
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Therapeutic tactics in the hypothalamic syndrome of puberty in girls. by T. Borowska-Striuk

“…It was found that the formation and course of HSP in girls during puberty occurs against a background of perinatal hypoxic involvement of the central nervous system, early obesity, viral loads, disorders of menstrual function, increased secretion of prolactin, androgens, cortisol and reduced level of estradiol. …”
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Inhibiting HnRNP L-mediated alternative splicing of EIF4G1 counteracts immune checkpoint blockade resistance in Castration-resistant prostate Cancer by Xumin Zhou, Shilong Cheng, Zhongjie Chen, Jinming Zhang, Jiaqi Wang, Qiang Li, Xumin Zhou

“…Mechanically, HnRNP L enhanced the translation of c-Myc and then promoted CXCL8 secretion via alternative splicing of EIF4G1. In vivo, inhibition of EIF4G1 by the inhibitor, SBI-0640756, attenuated HnRNP l-induced tumor progression and immunosuppressive activity. …”
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Ultrasound-Targeted Microbubble Destruction Improves the Migration and Homing of Mesenchymal Stem Cells after Myocardial Infarction by Upregulating SDF-1/CXCR4: A Pilot Study by Lu Li, Shengzheng Wu, Zheng Liu, Zhongxiong Zhuo, Kaibin Tan, Hongmei Xia, Lisha Zhuo, Xiaojun Deng, Yunhua Gao, Yali Xu

“…The in vitro results demonstrated that UTMD not only led to elevated secretion of SDF-1 but also resulted in an increased proportion of MSCs that expressed surface CXCR4. …”
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Unraveling the immunomodulatory and metabolic effects of bioactive glass S53P4 on macrophages in vitro by Karoliina Kajander, Nicole Nowak, Negin Vaziri, Pekka K. Vallittu, Terhi J. Heino, Jorma A. Määttä

“…Additionally, BG S53P4-exposed macrophages expressed lower mRNA levels of inflammatory cytokines Il6 and Il1b, as well as demonstrated decreased activation of inflammatory interferon regulatory factor (IRF) and NF-κB pathways and nitrogen oxide secretion in response to LPS. These results did not rely on cells being in direct contact with the material as similar effects were observed in the presence of BG S53P4-conditioned medium. …”
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Multifunctional, Novel Formulation for Repairing Photoaged and Sun-Damaged Skin: Insights from In Vitro, Ex Vivo, and In Vivo Studies by María Moneo-Sánchez, Nagore de Pablo, Leire Arana-Pascual, Itziar Beitia, Sandra Benito-Cid, Raúl Pérez-González

“…Results demonstrated that the formulation reduced oxidative stress and suppressed the production of pro-inflammatory cytokines interleukin-6 (IL-6) and interleukin-8 (IL-8), as well as lactate dehydrogenase (LDH) secretion, in a photodamaged skin model, nearly reaching levels observed in undamaged skin. …”
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Hybrid hydrogels containing gradients in gold nanoparticles for localized delivery of mesenchymal stem cells and enhanced nerve tissues remodeling in vivo by Jie Gao, Yiduo Zhou, Gang Xu, Zhongqing Wei, Liucheng Ding, Wei Zhang, Yi Huang

“…Biomaterials that scavenge endogenous ROS and promote GFs secretion might overcome such limitations and thus are being increasingly investigated. …”
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Preparation, characterisation and enhanced fungistatic properties of silicone rubber with different concentrations of CMIT/MIT by Shifang Yang, Zexuan Zhang, Qianpeng Hou, Yunpeng Liu, Chi Gong

“…The accelerated hydrolysis process of polysiloxane, which caused fungi secretion, was proven to be suppressed due to the effects of MIT/CMIT. …”
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Cab45G trafficking through the insulin secretory pathway is altered in human type 2 diabetes by Mark Germanos, Belinda Yau, Matthew Taper, Cara Yeoman, Amy Wilson, Yousun An, Jerome Cattin-Ortolá, Drew Masler, Jason Tong, Sheyda Naghiloo, Elise J Needham, A Gabrielle van der Kraan, Kitty Sun, Thomas Loudovaris, Alexis Diaz-Vegas, Mark Larance, Helen Thomas, Helen von Blume, Peter Thorn, Michael Ailion, Cedric Asensio, Melkam Alamerew Kebede

“…Summary: In type 2 diabetes (T2D), the rate of insulin secretory granule biogenesis can limit insulin secretion from pancreatic β-cells. Using rat insulinoma INS1 β-cells, we show that the soluble Ca2+-binding/trafficking protein, Cab45G, serves as a non-essential chaperone for insulin granule biogenesis. …”
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Assessment of the Quality, Bioactive Compounds, and Antimicrobial Activity of Egyptian, Ethiopian, and Syrian Black Cumin Oils by Adel Gabr Abdel-Razek, Minar Mahmoud M. Hassanein, Shimaa Moawad, Amr Farouk, Ahmed Noah Badr, Mohamed Gamal Shehata, Aleksander Siger, Anna Grygier, Magdalena Rudzińska

“…Ethiopian oil recorded a high antibacterial activity, while Egyptian oil showed a unique antifungal activity against toxigenic fungi. Aflatoxins’ secretion into liquid medium containing NSSO was reduced, especially with Egyptian oil.…”
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Evaluation of exoenzyme profiles of Candida albicans species isolated from females with vaginal candidiasis by Hasti Nouraei, Leila Razeghian Jahromi, Mehdi Ghaderian Jahromi, Kamiar Zomorodian, Keyvan Pakshir

“…Candida albicans is one of the most common causes of vaginitis and commonly affects millions of females with different signs and symptoms. Secretion of exoenzymes from Candida species plays an important role in virulence and pathogenesis. …”
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Design and Performance Evaluation of an Authentic End-to-End Communication Model on Large-Scale Hybrid IPv4-IPv6 Virtual Networks to Detect MITM Attacks by Zeeshan Ashraf, Adnan Sohail, Muddesar Iqbal

“…In an MITM attack, the attacker secretly captures the data, masquerades as the original sender, and sends it toward the receiver. …”
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Specialized nursing intervention on critically ill patient in the prevention of intubation-associated pneumonia: an integrative literature review by Daniela Fradinho Almeida, Maria do Rosário Pinto, Maria Candida Durao, Helga Rafael Henriques, Joana Ferreira Teixeira

“…The results obtained suggest that the nursing interventions identified for the prevention of IAP are elevating the headboard to 30º; washing the teeth, mouth and mucous membranes with a toothbrush and then instilling chlorohexidine 0.12%–0.2% every 8/8 hr; monitoring the cuff pressure of the endotracheal tube (ETT) between 20–30 mm Hg; daily assessment of the need for sedation and ventilatory weaning and the use of ETT with drainage of subglottic secretions. The multimodal nursing interventions identified enable health gains to be made in preventing or reducing IAP. …”
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Pseudomonas syringae lytic transglycosylase HrpH interacts with host ubiquitin ligase ATL2 to modulate plant immunity by Jun-Zhou Li, Yi-Lin Gu, Wei Zhang, Shen Cong, Ruo-Na Wang, Yi-Nan Ma, Ya Jin, Hai-Lei Wei

“…Summary: Pseudomonas syringae deploys a type III secretion system (T3SS) to deliver effector proteins to facilitate infection of plant cells; however, little is known about the direct interactions between T3SS components and plants. …”
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Lung Cyst Hydatid Extracted via Bronchoscopy and the Necessity of Surgery: A Case Report by Oğuz Karcıoğlu, Ayşen Kara, Olcay Kurtulan, Serknan Uysal, Ziya Toros Selçuk

“…We removed the material and purulent secretions covering it and opened the middle lobe bronchus totally. …”
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Adjuvants for Helicobacter pylori vaccines: Outer membrane vesicles provide an alternative strategy by Hanchi Zhang, Zhili Liu, Yi Li, Ziwei Tao, Lu Shen, Yinpan Shang, Xiaotian Huang, Qiong Liu

“…Outer membrane vesicles (OMVs), mainly secreted by gram-negative bacteria, have emerged as promising candidates for H. pylori vaccine adjuvants due to their potential applications. …”
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MicroRNA‐488 inhibits proliferation and glycolysis in human prostate cancer cells by regulating PFKFB3 by Jun Wang, Xiaojuan Li, Zhaoming Xiao, Yu Wang, Yuefu Han, Jun Li, Weian Zhu, Qu Leng, Yuehui Wen, Xinqiao Wen

“…Moreover, CCK‐8, EdU, glucose uptake, and lactate secrete assays revealed that overexpression of miR‐488 in PCa cell lines PC3 and DU145 resulted in inhibition of proliferation and glycolysis. …”
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EZH2 elicits CD8+ T-cell desert in esophageal squamous cell carcinoma via suppressing CXCL9 and dendritic cells by Chun-Yan Zhu, Tian-Tian Zhai, Meng Su, Hong-Chao Pan, Qian Tang, Bao-Hua Huang, Xin-Rui Chi, Nuo Li, Ling-Hui Xie, Si-Qi Qiu, Feng Pan, Guo-Wei Huang

“…Targeted tumor cell-intrinsic EZH2 rewired the transcriptional activation of CXCL9 mediated by NF-κB and concomitantly reinvigorated DC maturation differentiation via inducing the reduction of VEGFC secretion, thereby enhancing the infiltration of cytotoxic CD8+ T cells into TME and inhibiting tumor immune evasion. …”
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<i>Cuphea hookeriana</i>: Phytochemical Profile and the Cosmeceutical and Dermatological Properties of Its Active Fraction from the Whole Plant by Xing Wu, Meng-Fei Wanyan, Bao-Bao Shi, Rong Huang, Hui-Xiang Yang, Xian Wang, Ji-Kai Liu

“…In a model where ultraviolet light promotes the increase in melanin secretion in guinea pig skin tissues, both α-arbutin and the fine active fraction can reduce melanogenesis, and the effect of the fine active fraction is better than that of α-arbutin.…”
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Activated Platelets Induce an Anti-Inflammatory Response of Monocytes/Macrophages through Cross-Regulation of PGE2 and Cytokines by Bona Linke, Yannick Schreiber, Bettina Picard-Willems, Patrick Slattery, Rolf M. Nüsing, Sebastian Harder, Gerd Geisslinger, Klaus Scholich

“…Analyzing cocultures of platelets and murine bone marrow-derived macrophages or human monocytes, we found that collagen-activated platelets release high amounts of prostaglandin E2 (PGE2) that leads to an increased interleukin- (IL-) 10 release and a decreased tumor necrosis factor (TNF) α secretion out of the monocytes or macrophages. Platelet PGE2 mediated the upregulation of IL-10 in both cell types via the PGE2 receptor EP2. …”
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