Lidocaine Infusion for the Management of Postoperative Pain and Delirium (LIMPP): protocol for a randomised control trial by Matthias Behrends, Marc Alan Buren, Alekos Theologis, Ariadne Zuraek, Aaron J Clark, Jacqueline M Leung

“…Lidocaine safety will be assessed with daily screening questionnaires and lidocaine plasma levels.Ethics and dissemination This study protocol has been approved by the ethics board at the University of California, San Francisco. The results of this study will be published in a peer-review journal and presented at national conferences as poster or oral presentations. …”
Get full text

Nonclinical immunogenicity risk assessment for knobs-into-holes bispecific IgG1 antibodies by Wen-Ting K. Tsai, Yinyin Li, Zhaojun Yin, Peter Tran, Qui Phung, Zhenru Zhou, Kun Peng, Dan Qin, Sien Tam, Christoph Spiess, Jochen Brumm, Manda Wong, Zhengmao Ye, Patrick Wu, Sivan Cohen, Paul J. Carter

Get full text

More Than Grades: How Students Define Holistic Student Success by Anjali Sundararaman, Kathy Baek, Matthew Gee, Audrey Weber, Monica A. Corzo, Jacob Dinardi, Cara J. Connor, Kathryn Nesbit, Elaine Musselman, Linda M. Platas, Susanna Jones

Get full text

Cartridge-based sequencing for bedaquiline resistance detection from sputum by J.D. Limberis, R.J. Nagel, D. Block, R.E. Colman, A. Nalyvayko, Z. Howard, S. Dewell, S. Chakravorty, J.Z. Metcalfe

Get full text

Modulation of myeloid and T cells in vivo by Bruton’s tyrosine kinase inhibitor ibrutinib in patients with metastatic pancreatic ductal adenocarcinoma by Li Zhang, Matthew Crocker, Lawrence Fong, Lisa M Coussens, Charles D Lopez, Shamilene Sivagnanam, Meenal Sinha, Brandon Chen, Jaqueline Marquez, Alexander Cheung, Whitney Tamaki, Jacob Stultz, Kendra Todd, Courtney Betts, Madeline J Griffith, Isabelle Solman, Eric Liu, Denise Pener, Anne Fahlman, Erin Taber, Kimberly Lerner, Brindha Rajagopalan, Clarisha Ware, Mark Bridge, Johnson Vo, Hannah Dragomanovich, Julie Sudduth-Klinger, Gina Vaccaro, Margaret Tempero

Get full text

Targeted Therapies Compared to Dacarbazine for Treatment of BRAFV600E Metastatic Melanoma: A Cost-Effectiveness Analysis by Vanessa Shih, Renske M. ten Ham, Christine T. Bui, Dan N. Tran, Jie Ting, Leslie Wilson

Get full text

Inadequate Lymph Node Yield: An Inadequate Indication for Adjuvant Chemotherapy in Stage II Colon Cancer by Alan Zambeli-Ljepović, MD, MHS, Daniel Hoffman, MD, Katherine E. Barnes, BS, Fernanda Romero-Hernandez, MD, Amir Ashraf Ganjouei, MD, MPH, Mohamed A. Adam, MD, Ankit Sarin, MD, MHA

Get full text

COVID-19 clinical presentation, management, and epidemiology: a concise compendium by David P. Maison, David P. Maison, Hawi Tasissa, Amelia Deitchman, Michael J. Peluso, Youping Deng, F. DeWolfe Miller, Timothy J. Henrich, Mariana Gerschenson

Get full text

Psychedelics assisting therapy, or therapy assisting psychedelics? The importance of psychotherapy in psychedelic-assisted therapy by Joseph A. Zamaria, Gisele Fernandes-Osterhold, Jonathan Shedler, Rachel Yehuda

Get full text

Person-centred language for describing stratified approaches to TB treatment by M. Nash, A. Deluca, E. Lessem, N. West, L. McKenna, E.V. McConnell, K. Angami, R. Herrera, A. Makone, G.E. Velásquez, R.E. Chaisson, P.P.J. Phillips

Get full text

Delta opioid receptors engage multiple signaling cascades to differentially modulate prefrontal GABA release with input and target specificity by Ryan P.D. Alexander, Kevin J. Bender

Get full text

Nonfluent/Agrammatic PPA with In-Vivo Cortical Amyloidosis and Pick’s Disease Pathology by Francesca Caso, Benno Gesierich, Maya Henry, Manu Sidhu, Amanda LaMarre, Miranda Babiak, Bruce L. Miller, Gil D. Rabinovici, Eric J. Huang, Giuseppe Magnani, Massimo Filippi, Giancarlo Comi, William W. Seeley, Maria Luisa Gorno-Tempini

Get full text

Rapid depletion of “catch-and-release” anti-ASGR1 antibody in vivo by Siva Charan Devanaboyina, Peng Li, Edward L. LaGory, Carrie Poon-Andersen, Kevin D. Cook, Marcus Soto, Zhe Wang, Khue Dang, Craig Uyeda, Ryan B. Case, Veena A. Thomas, Ronya Primack, Manuel Ponce, Mei Di, Brian Ouyang, Joelle Kaner, Sheung Kwan Lam, Mina Mostafavi

Get full text

Acute Bladder Necrosis after Pelvic Arterial Embolization for Pelvic Trauma: Lessons Learned from Two Cases of Immediate Postembolization Bladder Necrosis by Samuel Washington, E. Charles Osterberg, Sean P. Elliott, Adam B. Hittelman, Benjamin N. Breyer

Get full text

A Single Perioperative Injection of Dexamethasone Decreases Nausea, Vomiting, and Pain after Laparoscopic Donor Nephrectomy by Shigeyoshi Yamanaga, Andrew Mark Posselt, Chris Earl Freise, Takaaki Kobayashi, Mehdi Tavakol, Sang-Mo Kang

Get full text

Structure- and machine learning-guided engineering demonstrate that a non-canonical disulfide in an anti-PD-1 rabbit antibody does not impede antibody developability by Wei-Ching Liang, Hongkang Xi, Dawei Sun, Luigi D’Ascenzo, Jonathan Zarzar, Nicole Stephens, Ryan Cook, Yinyin Li, Zhengmao Ye, Marissa Matsumoto, Jian Payandeh, Matthieu Masureel, Yan Wu

Get full text

Advances in the Critical Care Management of Ischemic Stroke by Vineeta Singh, Nancy J. Edwards

Get full text

Real world perspectives on endometriosis disease phenotyping through surgery, omics, health data, and artificial intelligence by Camran R. Nezhat, Tomiko T. Oskotsky, Joshua F. Robinson, Susan J. Fisher, Angie Tsuei, Binya Liu, Juan C. Irwin, Brice Gaudilliere, Marina Sirota, David K. Stevenson, Linda C. Giudice

Get full text

Preference for daily (1HP) vs. weekly (3HP) isoniazid-rifapentine among people living with HIV in Uganda by A. Musinguzi, H. E. Aschmann, J. L. Kadota, J. Nakimuli, F. Welishe, J. Kakeeto, C. Namale, L. Akello, A. Nakitende, C. Berger, A. Katamba, J. Tumuhamye, N. Kiwanuka, D. W. Dowdy, A. Cattamanchi, F. C. Semitala

Get full text

Understanding HIV care providers’ support for tobacco cessation among people living with HIV in Western Kenya: a formative qualitative study by Peter Magati, Maya Vijayaraghavan, Elizabeth A Bukusi, Craig R Cohen, Starley B Shade, Zachary Arochi Kwena, Linet Ongeri, Francesca A Odhiambo, Cirilus O Ogala, Yvonne A Olando, Greshon Rota, Purba Chatterjee, Christine A Osula, Jerry J Nutor, Stella S Bialous

Get full text