STAT3-Inducible Mouse ESCs: A Model to Study the Role of STAT3 in ESC Maintenance and Lineage Differentiation by Yu Qian Wong, Hongyan Xu, Qiang Wu, Xinyu Liu, Chengchen Lufei, Xiu Qin Xu, Xin-Yuan Fu

“…Therefore, in this study, two inducible STAT3 ESC lines were established, including the STAT3 knockout (InSTAT3 KO) and pSTAT3 overexpressed (InSTAT3 CA) using Tet-on inducible system in which STAT3 expression can be strictly controlled by doxycycline (Dox) stimulation. …”
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The Complex Role of STAT3 in Viral Infections by Suresh V. Kuchipudi

“…Several studies reported differential regulation of STAT3 in a range of viral infections. Interestingly, STAT3 appears to direct seemingly contradictory responses and both pro- and antiviral roles of STAT3 have been described. …”
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STAT3 Genotypic Variant rs744166 and Increased Tyrosine Phosphorylation of STAT3 in IL-23 Responsive Innate Lymphoid Cells during Pathogenesis of Crohn’s Disease by Ying Tang, Sanda A. Tan, Atif Iqbal, Jian Li, Sarah C. Glover

“…Moreover, carriage of STAT3 “A” risk allele exhibited a higher basal level of STAT3 tyrosine phosphorylation, and an increased IL-23 triggered the pSTAT3 level. …”
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Paeoniflorin inhibits the growth of bladder carcinoma via deactivation of STAT3 by Yang Jianhui, Ren Yu, Lou Zhong-Guan, Wan Xue, Weng Guo-Bin, Cen Dong

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IL-6 Inhibition Reduces STAT3 Activation and Enhances the Antitumor Effect of Carboplatin by Zhi-Yong Wang, Jun-Ai Zhang, Xian-Jin Wu, Yan-Fang Liang, Yuan-Bin Lu, Yu-Chi Gao, You-Chao Dai, Shi-Yan Yu, Yan Jia, Xiao-Xia Fu, Xiaoquan Rao, Jun-Fa Xu, Jixin Zhong

“…Enhanced expression of IL-6 and activation of STAT3 were observed in human colorectal carcinoma samples compared to normal colorectal tissue, with higher levels of IL-6/STAT3 in low grade carcinomas. …”
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Role of Stat3 in Skin Carcinogenesis: Insights Gained from Relevant Mouse Models by Everardo Macias, Dharanija Rao, John DiGiovanni

“…Further studies using a transgenic mouse model with a gain of function mutant of Stat3 (Stat3C) expressed in the basal layer of the epidermis revealed a novel role for Stat3 in skin tumor progression. …”
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Tumor-associated neutrophils and macrophages interaction contributes to intrahepatic cholangiocarcinoma progression by activating STAT3 by Jian Zhou, Jia Fan, Zhiqiang Hu, Jia Li, Zhengjun Zhou, Pengcheng Wang, Rongqi Sun, Haoyang Xin, Chubin Luo, Shaolai Zhou

“…Both of those cytokines activated STAT3 signaling in ICC cells. Knockdown of STAT3 abolished the protumor effect of TANs and TAMs on ICC. …”
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Naringenin induces ferroptosis in osteosarcoma cells through the STAT3-MGST2 signaling pathway by Yingang Li, Xizhuang Bai

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Protein tyrosine phosphatase delta is a STAT3-phosphatase and suppressor of metabolic liver disease by Thomas F Baumert, Charlotte Bach, Patrick Pessaux, Catherine Schuster, Frank Jühling, Sarah C Durand, Yujin Hoshida, Fabien Zoulim, Atish Mukherji, Naoto Fujiwara, Marine A Oudot, Armando Andres Roca Suarez, Michel L Tremblay, Barbara Testoni, Joachim Lupberger, Romain Parent, Laurent Mailly, Nassim Dali-Youcef, Emanuele Felli, Maria Saez-Palma, Julien Moehlin, Alessia Virzì, Nicolas Brignon, Eugenie Schaeffer, Romain Martin, Laura Meiss-Heydmann, Zakaria Boulahtouf, Lea Girard, Emma Osswald, Carole Jamey, Daniel Brumaru, Bhuvaneswari Koneru

“…Objective Impaired hepatic expression of protein tyrosine phosphatase delta (PTPRD) is associated with increased STAT3 transcriptional activity and reduced survival from hepatocellular carcinoma in patients with chronic hepatitis C virus infection. …”
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The Link between Type III Reg and STAT3-Associated Cytokines in Inflamed Colonic Tissues by Xin Xu, Hirokazu Fukui, Ying Ran, Xuan Wang, Yoshihito Inoue, Nobuhiko Ebisudani, Heihachiro Nishimura, Toshihiko Tomita, Tadayuki Oshima, Jiro Watari, Hiroshi Kiyama, Hiroto Miwa

“…STAT3 phosphorylation and HIP/PAP expression were significantly enhanced in Caco2 cells upon stimulation with IL-6, IL-17, and IL-22. …”
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Hyper-IgE Syndrome with STAT3 Mutation: A Case Report in Mainland China by Lixin Xie, Xiaoxiang Hu, Yang Li, Weihua Zhang, Liang'an Chen

“…Itis reported that some cases of familial HIES are relative to autosomal dominant or recessive inheritance, but most cases are sporadic, and result from mutations in the human signal transducer and activator of transcription 3 (STAT3) gene. In this paper, we firstly report a young man diagnosed of Hyper-IgE syndrome with STAT3 mutation in Mainland China, and investigate the autosomal dominant trait of his family members.…”
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HOXB8 mediates resistance to cetuximab in colorectal cancer cells through activation of the STAT3 pathway by Yunan Liang, Han Lin, Zongsheng Jiang, Qi Zhao, Ri Cui, Shaotang Li

“…By comparing drug-sensitive cell lines (SW48) with drug-resistant cell lines (HCT116, CACO2), we discovered that HOXB8 was substantially expressed in cetuximab-resistant cell lines, and furthermore, in drug-resistant cell lines (HCT116, CACO2), HOXB8 knockdown increased the cytotoxicity of cetuximab via blocking the signal transducer and activator of transcription 3 (STAT3) signaling pathway. Conversely, the excessive expression of HOXB8 reduced the growth suppression in SW48 cells caused by cetuximab by triggering the STAT3 signaling pathway. …”
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STING agonism overcomes STAT3-mediated immunosuppression and adaptive resistance to PARP inhibition in ovarian cancer by Changli Qian, Gordon J Freeman, Tao Jiang, Ursula Matulonis, Ziying Lin, Hye-Jung Kim, Anniina Färkkilä, Hua Yu, Xin Cheng, Panagiotis A Konstantinopoulos, Antons Martincuks, Joyce F Liu, Qiwei Wang, Liya Ding, Michael J Kearns, Shaozhen Xie, Inga-Maria Launonen, Thomas M Roberts, Jean J Zhao

“…Mechanistically, PARP inhibition elevates the STAT3 signaling pathway in tumor cells, which in turn promotes protumor polarization of TAMs. …”
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The ubiquitin ligase Pellino1 targets STAT3 to regulate macrophage-mediated inflammation and tumor development by Soeun Hwang, Junhee Park, Seo-Young Koo, Si-Yeon Lee, Yunju Jo, Dongryeol Ryu, Heounjeong Go, Chang-Woo Lee

“…Mechanistically, Pellino1 targets STAT3 for lysine 63-mediated ubiquitination, resulting in pathogenic activation of STAT3 signaling. …”
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Overexpression of IL-6 and STAT3 may provide new insights into ovine pulmonary adenocarcinoma development by Corina Toma, Roxana Popa, Lidia Ciobanu, Ioana Baldea, Irina Amorim, Diana Bochynska, Alan Wolfe, Andrada Negoescu, Claudiu Gal, Marian Taulescu

“…Tissue samples were stained with antibodies against IL-6, STAT3, and JSRV-MA. IL-6 and STAT3 were further quantified in both groups using Western Blot (WB). …”
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Annexin A2 Coordinates STAT3 to Regulate the Invasion and Migration of Colorectal Cancer Cells In Vitro by Dianhui Xiu, Lin Liu, Fengli Qiao, Haishan Yang, Lu Cui, Guifeng Liu

“…The present study aimed to reveal the expression of STAT3 and Anxa 2 in CRC specimens and to investigate the effects of STAT3 and Anxa 2 signaling on the proliferation, invasion, and migration in CRC Caco-2 cells. …”
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Free fatty acid receptor 2 promotes cardiomyocyte hypertrophy by activating STAT3 and GATA4 by Hui Gao, Kunming Tian, Xiaojun Feng, Mengqing Yan, Chen Gao, Yisheng Jiang, Chenhao Zhu, Huzhe Zhu, Xueping Liu, Yingfu Peng

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Evidence that a STAT3 Mutation Causing Hyper IgE Syndrome Leads to Repression of Transcriptional Activity by Sameer Bahal, Maha E. Houssen, Ania Manson, Lorena Lorenzo, Mark A. Russell, Noel G. Morgan, Fariba Tahami, Sofia Grigoriadou

“…Genetic analysis identified a missense mutation, N567D, in a conserved region of the linker domain of STAT3. Functional studies in HEK293 cells reveal that this mutation potently inhibits STAT3 activity when compared to the wildtype protein. …”
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Correction: HOXB8 mediates resistance to cetuximab in colorectal cancer cells through activation of the STAT3 pathway by Yunan Liang, Han Lin, Zongsheng Jiang, Qi Zhao, Ri Cui, Shaotang Li

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Endothelial STAT3 Modulates Protective Mechanisms in a Mouse Ischemia-Reperfusion Model of Acute Kidney Injury by Shataakshi Dube, Tejasvi Matam, Jessica Yen, Henry E. Mang, Pierre C. Dagher, Takashi Hato, Timothy A. Sutton

“…STAT3 is a transcriptional regulator that plays an important role in coordinating inflammation and immunity. …”
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