PD-1 is conserved from sharks to humans: new insights into PD-1, PD-L1, PD-L2, and SHP-2 evolution by Ryohei Kondo, Kohei Kondo, Kei Nabeshima, Akihiko Nishikimi, Yasumasa Ishida, Toshiaki Shigeoka, Johannes M. Dijkstra

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Tyrosine phosphatase SHP2 promoted the progression of CRC via modulating the PI3K/BRD4/TFEB signaling induced ferroptosis by Jian Chen, Wei Li, Cheng Zhang, Dihao Wen, Cheng Jiao

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Targeting SHP2 with Natural Products: Exploring Saponin-Based Allosteric Inhibitors and Their Therapeutic Potential by Dong-Oh Moon

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Design, synthesis and biological evaluation of novel triazoloquinazolinone and imidazoquinazolinone derivatives as allosteric inhibitors of SHP2 phosphatase by Wenjun Ye, Ye Liu, Qian Ren, Tianhui Liao, Yumei Chen, Dongmei Chen, Sisi Wang, Lihong Yao, Yihe Jia, Chunshen Zhao, Zhixu Zhou

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SHP2 inhibition and adjuvant therapy synergistically target KIT‐mutant GISTs via ERK1/2‐regulated GSK3β/cyclin D1 pathway by Chunxiao He, Jiaying Yu, Shuang Mao, Shaohua Yang, Xianming Jiang, Lei Huang, Mingzhe Li, Yulong He, Xinhua Zhang, Xi Xiang

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Deciphering the structural and dynamic effects of SHP2-E76 mutations: mechanistic insights into oncogenic activation by Humaira Rafiq, Lu Han, Ashfaq Ur Rehman, Pei He, Ali Saber Abdelhameed, Eman S. G. Hassan, Hongxia Fu, Abdul Wadood, Junjian Hu

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Tyrosine phosphatase Shp2 accelerated the progression of dilated cardiomyopathy via upregulating NF-κB/Src/FAK signaling induced ROS and mitophagy by Jingxia Hao, Hua Wang, Bo Li, Jingshi Chen, Wenlu Wang, Yingxue Wang, Yingqian Zhang

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Targeting the SHP2 phosphatase promotes vascular damage and inhibition of tumor growth by Yuyi Wang, Ombretta Salvucci, Hidetaka Ohnuki, Andy D Tran, Taekyu Ha, Jing‐Xin Feng, Michael DiPrima, Hyeongil Kwak, Dunrui Wang, Yanlin Yu, Michael Kruhlak, Giovanna Tosato

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KRASG12C‐inhibitor‐based combination therapies for pancreatic cancer: insights from drug screening by Constanza Tapia Contreras, Jonas Dominik Falke, Dana‐Magdalena Seifert, Carolin Schneider, Lukas Krauß, Xin Fang, Denise Müller, Engin Demirdizen, Melanie Spitzner, Tiago De Oliveira, Christian Schneeweis, Jochen Gaedcke, Silke Kaulfuß, Kimia Mirzakhani, Bernd Wollnik, Karly Conrads, Tim Beißbarth, Gabriela Salinas, Jonas Hügel, Nils Beyer, Sophia Rheinländer, Ulrich Sax, Matthias Wirth, Lena‐Christin Conradi, Maximilian Reichert, Volker Ellenrieder, Philipp Ströbel, Michael Ghadimi, Marian Grade, Dieter Saur, Elisabeth Hessmann, Günter Schneider

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Siglec6 CAR T cells suppressed progression of AML via inhibiting Siglec6 and SHP2 induced Src and ERK signaling activation by Qian Li, Li Lin, Shuang Gao, Lin Chen, Zhiying Zhang, Jing Ma, Su Liu, Zeng Cao, Haifeng Zhao, Yafei Wang

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Shc1 cooperates with Frs2 and Shp2 to recruit Grb2 in FGF-induced lens development by Qian Wang, Hongge Li, Yingyu Mao, Ankur Garg, Eun Sil Park, Yihua Wu, Alyssa Chow, John Peregrin, Xin Zhang

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Down-regulation of SHP2 promotes neutrophil autophagy and inhibits neutrophil extracellular trap formation to alleviate asthma through the ERK5 pathway by Dandan Shi, Jian Huang, Jie Wu

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SFX-01 is therapeutic against myeloproliferative disorders caused by activating mutations in Shp2 by Hyun-Ju Cho, Joy Smith, Christopher H Switzer, Eleni Louka, Rebecca L Charles, Oleksandra Prysyazhna, Ewald Schroder, Mariana Fernandez-Caggiano, Daniel Simoes de Jesus, Seda Eminaga, Xiaoke Yin, Xiaoping Yang, Steven Lynham, Manuel Mayr, Valle Morales, Katiuscia Bianchi, Vinothini Rajeeve, Pedro R Cutillas, Adam J Mead, Philip Eaton

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SHP2 inhibition by SHP099 attenuates IL-6–driven osteoclastogenesis in growth plate injury by Qin Zhang, Qin Zhang, Ning Li, Ning Li, Zhen-Zhen Dai, Xiao-Man Liu, Jing Ding, Lin Sha, Hai Li

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SHP2 inhibitor specifically suppresses the stemness of KRAS-mutant non-small cell lung cancer cells by Lei Jiang, Weiping Xu, Yi Chen, Yue Zhang

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Progranulin sustains STAT3 hyper‐activation and oncogenic function in colorectal cancer cells by Federica Laudisi, Fabio Cherubini, Antonio Di Grazia, Vincenzo Dinallo, Davide Di Fusco, Eleonora Franzè, Angela Ortenzi, Illari Salvatori, Silvia Scaricamazza, Ivan Monteleone, Naoya Sakamoto, Giovanni Monteleone, Carmine Stolfi

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SHP2 promotes the epithelial-mesenchymal transition in triple negative breast cancer cells by regulating β-catenin by Shihan Qian, Jingjing Zhu, Qing Han, Huang Cheng, Huaibin Zhou

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KSHV reprograms host RNA splicing via FAM50A to activate STAT3 and drive oncogenic cellular transformation by Shenyu Sun, Ling Ding, Karla Paniagua, Xian Wang, Yufei Huang, Mario A. Flores, Shou-Jiang Gao

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PD-L1 monoclonal antibody alleviated MI injury of left ventricular function via modulating CD47/SHP2/SIRPα/SYK/FcγR signalings in tumor associated macrophages by Deyou Kong, Yongzhen Chen, Yajuan Yin, Zhikun Liu, Fang Yang, Xiaohong Li, Dongxing Shen, Jun Zhang

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