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  1. 61

    Individual Differences in Placebo Analgesia: Functional Connectivity and Neural Mechanisms [Letter] by Cao H, Zhang Y, Bai L, Ma X

    Published 2025-02-01
    “…Haixing Cao,* Yujie Zhang,* Lingfeng Bai, Xiang Ma The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiang Ma, The First Affiliated Hospital of Dalian Medical University, 222 Zhongshan Road, Dalian City, Liaoning Province, People’s Republic of China, Email xma9467@vip.sina.com…”
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  2. 62
  3. 63

    The Role of Mature Brain-Derived Neurotrophic Factor and Its Precursor in Predicting Early-Onset Insomnia in Stroke Patients Experiencing Early Neurological Deterioration by Shi G, Yu P, Wang Z, Xu M, Guo M, Wang X, Zhou R

    Published 2025-02-01
    “…Guomei Shi,1,2 Peng Yu,2,3 Ziru Wang,2,4 Mingyang Xu,2,3 Minwang Guo,2,3 Xiaorong Wang,2,3 Rujuan Zhou2,3 1Department of Neurology, Taixing Clinical College of Bengbu Medical College, Taixing, Jiangsu, People’s Republic of China; 2Stroke Center, Taixing People’s Hospital, Taixing, Jiangsu, People’s Republic of China; 3Department of Neurology, Taixing People’s Hospital, Taixing, Jiangsu, People’s Republic of China; 4Department of Rehabilitation, Taixing People’s Hospital, Taixing, Jiangsu, People’s Republic of ChinaCorrespondence: Rujuan Zhou, Taixing People’s Hospital, No. 1 Changzheng Road, Taixing, Jiangsu Province, 225400, People’s Republic of China, Tel +86-13951158499, Email zhourujuan123@163.comBackground: The investigation and management of early-onset insomnia (EOI) in patients undergoing early neurological deterioration (END) appear to be insufficiently prioritized in clinical practice. …”
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  4. 64

    Optimizing Obstructive Sleep Apnea Risk Assessment in Hypertension: Development of a Predictive Nomogram in China by Yang Y, Sun X, Liang J, Liao WF, Ye W, Zheng Z, Du L, Chen M, Zhang Y, Lin W, Huang J, Yao W, Chen R

    Published 2025-02-01
    “…Yitian Yang,1,* Xishi Sun,2,* Jinhua Liang,1,* Wei Feng Liao,1,* Weilong Ye,1 Zhenzhen Zheng,1 Lianfang Du,1 Mingdi Chen,1 Yuan Zhang,3 Wenjia Lin,2 Jinyu Huang,2 Weimin Yao,1 Riken Chen1,4 1The Second Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, 524003, People’s Republic of China; 2Emergency Medicine Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, 524001, People’s Republic of China; 3The First Clinical School of Medicine, Guangdong Medical University, Zhanjiang, Guangdong, 524003, People’s Republic of China; 4State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, 510120, People’s Republic of China*These authors contributed equally to this workCorrespondence: Riken Chen; Weimin Yao, The Second Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, 524003, People’s Republic of China, Tel +13560244631 ; +13822521722, Email chenriken@126.com; 490296443@qq.comPurpose: Obstructive sleep apnea (OSA) is common in patients with hypertension. …”
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  5. 65

    Investigating the Use of Generative Adversarial Networks-Based Deep Learning for Reducing Motion Artifacts in Cardiac Magnetic Resonance by Ma ZP, Zhu YM, Zhang XD, Zhao YX, Zheng W, Yuan SR, Li GY, Zhang TL

    Published 2025-02-01
    “…Ze-Peng Ma,1,2,* Yue-Ming Zhu,3,* Xiao-Dan Zhang,4 Yong-Xia Zhao,1 Wei Zheng,3 Shuang-Rui Yuan,1 Gao-Yang Li,1 Tian-Le Zhang1 1Department of Radiology, Affiliated Hospital of Hebei University/ Clinical Medical College, Hebei University, Baoding, 071000, People’s Republic of China; 2Hebei Key Laboratory of Precise Imaging of inflammation Tumors, Baoding, Hebei Province, 071000, People’s Republic of China; 3College of Electronic and Information Engineering, Hebei University, Baoding, Hebei Province, 071002, People’s Republic of China; 4Department of Ultrasound, Affiliated Hospital of Hebei University, Baoding, Hebei Province, 071000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiao-Dan Zhang, Department of Ultrasound, Affiliated Hospital of Hebei University, No. 212 of Yuhua East Road, Lianchi District, Baoding, 071000, People’s Republic of China, Tel +86 17325535302, Email xiaodanzhangzxd@126.comObjective: To evaluate the effectiveness of deep learning technology based on generative adversarial networks (GANs) in reducing motion artifacts in cardiac magnetic resonance (CMR) cine sequences.Methods: The training and testing datasets consisted of 2000 and 200 pairs of clear and blurry images, respectively, acquired through simulated motion artifacts in CMR cine sequences. …”
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  6. 66

    A Bidirectional Mendelian Randomization Study Investigating the Causal Relationship Between Ankylosing Spondylitis and Chronic Obstructive Pulmonary Disease by Pan D, Dai X, Li P, Xue L

    Published 2025-02-01
    “…Di Pan,1,2 Xiaoling Dai,3 Pan Li,4 Luan Xue1 1Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of China; 2Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China; 3Shanghai Putuo Traditional Chinese Medicine Hospital, Shanghai, People’s Republic of China; 4Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of ChinaCorrespondence: Luan Xue; Xiaoling Dai, Email 610725556@qq.com; 553137182@qq.comBackground: Previous studies have found an association between ankylosing spondylitis (AS) and chronic obstructive pulmonary disease (COPD); however, no research has investigated this relationship using Mendelian randomization (MR).Methods: This study employed a bidirectional two-sample MR approach to assess the causal connection between AS and COPD. …”
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  7. 67

    Acute Necrotizing Fasciitis Caused by Rhizopus Infection in a Patient with Diabetes and Pulmonary Tuberculosis: A Case Report by Huang X, Qiu J, Pan L, Wang C, Tang C

    Published 2025-02-01
    “…Xiaoqing Huang,1 Junke Qiu,1 Lei Pan,1 Caihong Wang,1 Chuanfeng Tang2 1Tuberculosis Intensive Care Unit, Zhejiang Hospital of Integrated Traditional Chinese and Western Medicine, Hangzhou, Zhejiang, People’s Republic of China; 2Emergency Department, Zhejiang Hospital of Integrated Traditional Chinese and Western Medicine, Hangzhou, Zhejiang, Peoples Republic of ChinaCorrespondence: Chuanfeng Tang, Emergency Department, Zhejiang Hospital of Integrated Traditional Chinese and Western Medicine, No. 208 East Huancheng Road, Hangzhou, Zhejiang, 310000, People’s Republic of China, Tel +8615155110013, Email T20237243@163.comBackground: Zygomycosis, also termed mucormycosis, is a rare yet highly fatal fungal infection caused by Mucorales species, notably Rhizopus spp.Case Presentation: This case study details a 72-year-old man with diabetes, pulmonary tuberculosis, and nephrotic syndrome who developed acute necrotizing fasciitis attributable to R. oryzae. …”
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  8. 68

    Nucleic Acid Aptamers for Human Norovirus GII.4 and GII.17 Virus-Like Particles (VLPs) Exhibit Specific Binding and Inhibit VLPs from Entering Cells by Cheng C, Sun M, Li J, Xue Y, Cai X, Liu J, Wang X, Xu S, Xie Y, Zhang J

    Published 2025-02-01
    “…Chao Cheng,1,* Minjia Sun,1– 3,* Jingjing Li,1,* Yitong Xue,1 Xia Cai,4 Jing Liu,1 Xiaolian Wang,5 Shouhong Xu,2 Youhua Xie,1 Junqi Zhang1 1MOE/NHC/CAMS Key Laboratory of Medical Molecular Virology, Shanghai Institute of Infectious Disease and Biosecurity, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, People’s Republic of China; 2Key Laboratory for Advanced Materials and Department of Chemistry, East China University of Science and Technology, Shanghai, 200237, People’s Republic of China; 3Zhejiang CONBA Pharmaceutical Co., Ltd, Hangzhou, 310052, People’s Republic of China; 4Shanghai Medical College, Biosafety Level 3 Laboratory, Fudan University, Shanghai, 200032, People’s Republic of China; 5Department of Pathogeny Microbiology and Preventive Medicine, School of Medicine, Hexi University, Zhangye, 734000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Junqi Zhang, Email junqizhang@fudan.edu.cn; Youhua Xie, Email yhxie@fudan.edu.cnPurpose: Human noroviruses (HuNoVs) are the main cause of non-bacterial acute gastroenteritis. …”
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  9. 69

    Identification of Potential Diagnostic Biomarkers of Carotid Atherosclerosis in Obese Populations by Wu X, Pan J, Pan X, Kang J, Ren J, Huang Y, Gong L, Li Y

    Published 2025-02-01
    “…Xize Wu,1,* Jiaxiang Pan,2,* Xue Pan,1,3,* Jian Kang,1 Jiaqi Ren,1 Yuxi Huang,1 Lihong Gong,2,4 Yue Li2,4 1Graduate School, Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, 110847, People’s Republic of China; 2Department of Cardiology, Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, 110032, People’s Republic of China; 3College of Traditional Chinese Medicine, Dazhou Vocational College of Chinese Medicine, Dazhou, Sichuan, 635000, People’s Republic of China; 4Liaoning Provincial Key Laboratory of TCM Geriatric Cardio-Cerebrovascular Diseases, Shenyang, Liaoning, 110032, People’s Republic of China*These authors contributed equally to this workCorrespondence: Lihong Gong; Yue Li, Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, No. 33, Beiling Street, Huanggu District, Shenyang, Liaoning, 110032, People’s Republic of China, Tel +86 024-82961105, Email Linda1795@sina.com; med_liyue@163.comObjective: This study aimed to investigate the potential mechanisms and biomarkers between Obesity (OB) and carotid atherosclerosis (CAS).Methods: The GSE12828, GSE125771, GSE43292, and GSE100927 datasets were combined and normalized to obtain CAS-related differentially expressed genes (DEGs), and OB-related DEGs were obtained from the GSE151839 dataset and the GeneCards database. …”
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  10. 70

    Blood Lipid Levels and Their Value as Markers of Disease Activity in Severe Ulcerative Colitis by Zhu L, Tian L, Li S, Huo L

    Published 2025-02-01
    “…Lingling Zhu,1– 3 Linglin Tian,3 Suxia Li,1 Lijuan Huo3 1First Clinical Medical College, Shanxi Medical University, Taiyuan, Shanxi, People’s Republic of China; 2Linfen Vocational and Technical College, Linfen, Shanxi, People’s Republic of China; 3Department of Gastroenterology, First Hospital of Shanxi Medical University, Taiyuan, Shanxi, People’s Republic of ChinaCorrespondence: Lijuan Huo, Department of Gastroenterology, First Hospital of Shanxi Medical University, 85 Jiefang South Road, Taiyuan, 030001, Shanxi, People’s Republic of China, Tel +86-13835107953, Email mymail5296@163.comPurpose: There is limited research on the correlation between blood lipid levels and severe ulcerative colitis, and this article helps to reveal the relationship between the two. …”
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  11. 71

    Clinical Characteristics of Inpatients with Diabetic Foot Ulcer Admitted with Non-Ulcer Complaints: A Retrospective Study by Li L, Li Y, Qin S, Zeng J, Ma W, Wei D

    Published 2025-02-01
    “…Lan Li,1,2 Yue Li,2,3 Shuang Qin,2 Jing Zeng,2 Wanxia Ma,2 Dong Wei2 1Medical Examination Center, Chengdu Second People’s Hospital, Chengdu, 610017, People’s Republic of China; 2Department of Endocrinology and Metabolism, Diabetic Foot Care Center, Chengdu Second People’s Hospital, Chengdu, 610017, People’s Republic of China; 3Department of Clinical Medicine, Chengdu Medical College, Chengdu, 610500, People’s Republic of ChinaCorrespondence: Dong Wei, Department of Endocrinology and Metabolism, Diabetic Foot Care Center, The Chengdu Second People’s Hospital, Chengdu, Sichuan, 610017, People’s Republic of China, Tel/Fax +86 02867830801, Email weidong314@126.comBackground: Diabetic foot ulcer (DFU) inpatients admitted with non-ulcer complaints constitute a neglected group that might suffer from more non-standard treatments. …”
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  12. 72

    B Cell Activation, Differentiation, and Their Potential Molecular Mechanisms in Osteoarthritic Synovial Tissue by Lu P, Li Y, Yang S, Yao H, Tu B, Ning R

    Published 2025-02-01
    “…Peizhi Lu,1,2,* Ya Li,1,2,* Shuo Yang,2 Haoyu Yao,2 Bizhi Tu,2 Rende Ning1,2 1Graduate School, Bengbu Medical University, Bengbu, Anhui, People’s Republic of China; 2Department of Orthopedics, the Third Affiliated Hospital of Anhui Medical University, the First People’s Hospital of Hefei, Hefei, Anhui, People’s Republic of China*These authors contributed equally to this workCorrespondence: Bizhi Tu, Department of Orthopedics, the Third Affiliated Hospital of Anhui Medical University, the First People’s Hospital of Hefei, Hefei, Anhui, People’s Republic of China, Tel +86 15357483840, Email 1301535636@qq.com Rende Ning, Graduate School, Bengbu Medical University, Bengbu, Anhui, People’s Republic of China, Tel +86 13956966305, Email nrd1972@outlook.comObjective: The objective of this study was to characterize the activation and differentiation of B cells in the synovium of osteoarthritis (OA) and to explore the underlying molecular mechanisms.Methods: Peripheral blood and synovial samples from OA patients at different stages were collected, and flow cytometry was employed to analyze the activation and differentiation of B cells. …”
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  13. 73
  14. 74

    Golden Tandem of Photothermal Ablation and Simultaneous Anti-Inflammation in One Nanoparticle for Activated Macrophage-Targeted Atherosclerosis Treatment by Lu Y, Wang Y, Li Y, Li Y, Jiang YW, Li J

    Published 2025-02-01
    “…Yuqing Lu,1,* Yan Wang,2,* Yize Li,1,* Yunan Li,1 Yao-Wen Jiang,1,3 Jingjing Li1,3 1School of Medical Imaging, Xuzhou Medical University, Xuzhou, 221004, People’s Republic of China; 2The First Clinical Medical College, Xuzhou Medical University, Xuzhou, 221004, People’s Republic of China; 3Department of Radiology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221006, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yao-Wen Jiang; Jingjing Li, Email jiang@xzhmu.edu.cn; qingchao0124@163.comIntroduction: Photothermal therapy (PTT) is attracting increasing attention in treating atherosclerotic plaques. …”
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  15. 75
  16. 76

    Establishment and Clinical Application of Rh Blood Group Bank in the East China Region by Jin Y, Fu X, Xie S, Liu Z, Xu Z, Wang M, Wang Y, Lu R, Wang L

    Published 2025-02-01
    “…Yiming Jin,1,* Xiaoyan Fu,2,* Shuhong Xie,3 Zhen Liu,1 Zihao Xu,1 Mingyuan Wang,1 Yihan Wang,1 Rong Lu,1 Lingling Wang1 1Department of Blood Screening Test, Suzhou Blood Center, Suzhou, People’s Republic of China; 2Department of Blood Screening Test, Tai Cang Blood Branch Station, Tai Cang, People’s Republic of China; 3Division of Transfusion Medicine, Suzhou Blood Center, Suzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Lingling Wang; Rong Lu, Department of Blood Screening Test, Suzhou Blood Center, Suzhou, People’s Republic of China, Email linglingwang0716@163.com; cv-25a@163.comPurpose: To investigate the expression and distribution of Rh phenotypes (C, c, D, E, e) among voluntary blood donors in a specific region of East China, to establish a regional Rh phenotype database, and to enhance the precision and efficacy of clinical blood transfusions.Patients and Methods: A total of 28979 blood samples were collected from voluntary donors at a central blood station in East China between May 2023 and December 2023. …”
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  17. 77

    GelMA@LNP/AST Promotes eNOS-Dependent Angiogenesis Through Autophagy Activation for the Treatment of Hind Limb Ischemia by Lai L, Wu H, Peng L, Zhang Z, Wu X, Zheng S, Su Z, Chu H

    Published 2025-02-01
    “…Lingzhi Lai,1 Hao Wu,1 Liang Peng,2 Zhen Zhang,3 Xinfan Wu,1 Shuo Zheng,3 Zekang Su,3 Hongxing Chu3 1Maoming People’s Hospital, Maoming, Guangdong, People’s Republic of China; 2The First People’s Hospital of Guiyang, Guiyang, Guizhou, People’s Republic of China; 3Stomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, Guangdong, People’s Republic of ChinaCorrespondence: Hongxing Chu, Stomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, 510280, People’s Republic of China, Tel +86-13533856675, Email chuhongxing22@smu.edu.cnPurpose: Limb ischemia is a refractory disease characterized by insufficient angiogenesis and tissue necrosis. …”
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  18. 78

    Vincristine Regulates C/EBP-β/TGF-β1 to Promote A1 Astrocyte Polarization and Induce Neuropathic Pain by Chen Y, Tang G, Lu J, Tang S, Xiong X, Chen C, Pei L, Shi J

    Published 2025-02-01
    “…Yunfu Chen,1,* Guangling Tang,1,* Jun Lu,1,* Sijie Tang,1 Xinglong Xiong,1 Chao Chen,1 Lijian Pei,2 Jing Shi1 1Department of Anesthesiology, The Affiliated Hospital of Guizhou Medical University, Guizhou, People’s Republic of China; 2Department of Anesthesiology, Peking Union Medical College Hospital, Beijing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jing Shi, Department of Anesthesiology, The Affiliated Hospital of Guizhou Medical University, Guiyang, People’s Republic of China, Tel +86-18685034016, Email shijing81@gmc.edu.cn Lijian Pei, Department of Anesthesiology, Peking Union Medical College Hospital, Beijing, People’s Republic of China, Email hazelbeijing@vip.163.comBackground: The neuropathic pain side induced by Vincristine severely limit its clinical application. …”
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  19. 79

    Serum Ferritin Levels in Pregnancy and Their Association with Gestational Diabetes Mellitus: A Prospective Longitudinal Study by Qin Z, Du Y, Wang Z, Qin X, Wu H, Yu X, Zhao C, Mo L, Huang B

    Published 2025-02-01
    “…Zhenhua Qin,1 Yao Du,1 Zidi Wang,1 Xianfeng Qin,1 Hongchi Wu,1 Xiangyuan Yu,1 Chaochao Zhao,1 Lei Mo,2 Bo Huang1 1Guangxi Key Laboratory of Diabetic Systems Medicine, Guangxi Key Laboratory of Environmental Exposomics and Life-Course Health, Guangxi Health Commission Key Laboratory of Health and Care for Life-Course, School of Public Health, Guilin Medical University, Guilin, Guangxi, People’s Republic of China; 2Department of Obstetrics and Gynecology, the Second Affiliated Hospital of Guilin Medical University, Guilin, Guangxi, People’s Republic of ChinaCorrespondence: Bo Huang, Guangxi Key Laboratory of Diabetic Systems Medicine, Guangxi Key Laboratory of Environmental Exposomics and Life-Course Health, Guangxi Health Commission Key Laboratory of Health and Care for Life-Course, School of Public Health, Guilin Medical University, Guilin, Guangxi, 541199, People’s Republic of China, Tel +86-773-5591452, Email Bo.Huang@glmc.edu.cn Lei Mo, Department of Obstetrics and Gynecology, the Second Affiliated Hospital of Guilin Medical University, Guilin, Guangxi, 541199, People’s Republic of China, Email 50442117@qq.comObjective: Elevated serum ferritin (SF) levels are associated with oxidative stress (OS) and systemic inflammation in various disorders. …”
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  20. 80

    Clinical Features and Prognosis of Double-Positive Anti-MDA5 and Anti-CCP Antibodies in Dermatomyositis: A Retrospective Study by Xu X, Zhu L, Li S, Wang G, Ge Y

    Published 2025-02-01
    “…Xiayu Xu,1 Longyang Zhu,2 Sizhao Li,3 Guochun Wang,3 Yongpeng Ge3 1Department of Rheumatology and Immunology, The Second Affiliated Hospital of Hainan Medical University, Haikou, Hainan Province, People’s Republic of China; 2Peking University, China-Japan Friendship School of Clinical Medicine, Beijing, People’s Republic of China; 3Department of Rheumatology, The Key Laboratory of Myositis, China-Japan Friendship Hospital, Beijing, People’s Republic of ChinaCorrespondence: Yongpeng Ge, Department of Rheumatology, The Key Laboratory of Myositis, China-Japan Friendship Hospital, Beijing, 100029, People’s Republic of China, Email gyp2016@163.comObjective: To investigate the clinical features and prognosis of anti-melanoma differentiation-related gene 5 (MDA5) antibody and anti-cyclic citrullinated peptide (CCP) antibody double-positive dermatomyositis (DM) (MDA5+/CCP+ DM).Methods: A retrospective analysis of 264 consecutive cases of MDA5+ DM hospitalized from March 2018 to March 2022, and patients with anti-CCP antibodies were screened out. …”
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