Symptom Network and Subgroup Analysis in Patients with Exacerbation of Chronic Obstructive Pulmonary Disease: A Cross-Sectional Study by Yu C, Xu M, Pang X, Zhang Y, Cao X, Xu Y, Huang S, Zhao H, Chen C

“…Chunchun Yu,1 Mengying Xu,1 Xinyue Pang,2 Yuting Zhang,3 Xinmei Cao,2 Yixin Xu,1 Shuai Huang,1 Hongjun Zhao,4 Chengshui Chen1,3,4 1Key Laboratory of Interventional Pulmonology of Zhejiang Province, Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, People’s Republic of China; 2Zhejiang Province, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, People’s Republic of China; 3Cixi Biomedical Research Institute, Wenzhou Medical University, Wenzhou, Zhejiang, 315302, People’s Republic of China; 4Zhejiang Province Engineering Research Center for Endoscope Instruments and Technology Development, Department of Pulmonary and Critical Care Medicine, Quzhou People’s Hospital, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou, 324000, People’s Republic of ChinaCorrespondence: Hongjun Zhao; Chengshui Chen, Zhejiang Province Engineering Research Center for Endoscope Instruments and Technology Development, Department of Pulmonary and Critical Care Medicine, Quzhou People’s Hospital, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou, 324000, People’s Republic of China, Email zhaohongjun@wmu.edu.cn; chenchengshui@wmu.edu.cnPurpose: This study aims to construct a contemporaneous symptom network of inpatients with Exacerbation of Chronic Obstructive Pulmonary Disease (ECOPD) based on the symptom cluster, identify core and bridge symptoms, and patient subgroups with different symptom clusters based on individual differences in the intensity of patient symptom experiences.Patients and Methods: This study used convenience sampling to collect demographic, symptom, auxiliary examination, and prognosis information of 208 inpatients with ECOPD from April 2022 to October 2023. …”
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In-Situ Electrospinning Dressings Loaded with Kaempferol for Reducing MMP9 to Promote Diabetic Ulcer Healing by Li J, Meng H, Guo W, Zhou L, Wu S, Gao G, Liu Q, You D, Qu W

“…Jianwen Li,1,2,* Hongqi Meng,3,* Wenlai Guo,3 Lubin Zhou,4 Siyu Wu,3 Guanghui Gao,4 Quanzhe Liu,3 Di You,5 Wenrui Qu2,3 1Gastroenteric Medicine and Digestive Endoscopy Center, the Second Hospital of Jilin University, Changchun, 130041, People’s Republic of China; 2Joint International Research Laboratory of Ageing Active Strategy and Bionic Health in Northeast Asia of Ministry of Education, Changchun, 130041, People’s Republic of China; 3Department of Hand Surgery, the Second Hospital of Jilin University, Changchun, 130041, People’s Republic of China; 4Polymeric and Soft Materials Laboratory, Advanced Institute of Materials Science, School of Chemical Engineering, Changchun University of Technology, Changchun, 130012, People’s Republic of China; 5Department of Anesthesiology, China-Japan Union Hospital of Jilin University, Changchun, 130012, People’s Republic of China*These authors contributed equally to this workCorrespondence: Di You; Guanghui Gao, Email youdi1118@jlu.edu.cn; ghgao@ccut.edu.cnBackground: Diabetic foot ulcers (DFUs) are often associated with persistent inflammatory response, impaired macrophage polarization, and slow vascular regeneration. …”
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Prognostic significance of neutrophil extracellular trap-related genes in childhood acute lymphoblastic leukemia: insights from multi-omics and in vitro experiment by Cheng Chen, Yu Ma, Yadai Gao, Huiqing Ge, Xiaochun Zhang

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Assessment of Tumor Burden Score as a Feasible and Reliable Tool for Prognosis Prediction for Hepatocellular Carcinoma Undergoing Hepatectomy: A Multicenter, Retrospective Study by Guan R, Zheng Z, Deng M, Mei J, Lin Y

“…Renguo Guan,1– 4,* Zehao Zheng,2– 4,* Min Deng,5,* Jie Mei,2– 4 Ye Lin1 1Department of General Surgery, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, People’s Republic of China; 2Department of Hepatobiliary Oncology, Sun Yat-sen University Cancer Center, Guangzhou, People’s Republic of China; 3State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, People’s Republic of China; 4Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, People’s Republic of China; 5Department of General Surgery, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, People’s Republic of China*These authors contributed equally to this workCorrespondence: Ye Lin, Email linye@gdph.org.cn; Jie Mei, Email meijie@sysucc.org.cnBackground: Maximum diameter and number are the main parameters of tumor burden in hepatocellular carcinoma (HCC). …”
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Increased Co-Expression of PD-L1 and CTLA-4 Predicts Poor Overall Survival in Patients with Acute Myeloid Leukemia Following Allogeneic Hematopoietic Stem Cell Transplantation by Chen C, Qiu K, Chen J, Wang S, Zhang Y, Wang C, Li Y

“…Cunte Chen,1,2,* Kangjie Qiu,2,* Jie Chen,3,* Shunqing Wang,1 Yuping Zhang,1 Caixia Wang,1 Yangqiu Li2 1Department of Hematology, Guangzhou First People’s Hospital, Institute of Blood Transfusion and Hematology, Guangzhou Medical University, Guangzhou, 510180, People’s Republic of China; 2Institute of Hematology, School of Medicine, Key Laboratory for Regenerative Medicine of Ministry of Education, Jinan University, Guangzhou, People’s Republic of China; 3Department of Hematology, First Affiliated Hospital, Jinan University, Guangzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yangqiu Li, Institute of Hematology, School of Medicine, Key Laboratory for Regenerative Medicine of Ministry of Education, Jinan University, Guangzhou, 510632, People’s Republic of China, Email yangqiuli@hotmail.com Caixia Wang, Department of Hematology, Guangzhou First People’s Hospital, Institute of Blood Transfusion and Hematology, Guangzhou Medical University, Guangzhou, 510180, People’s Republic of China, Email wangcx225@163.comPurpose: Our previous study has demonstrated that high expression of immune checkpoints (ICs) was significantly associated with adverse clinical outcomes in patients with acute myeloid leukemia (AML). …”
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The Timing and Spectral Properties of the 2022 Outburst of SGR J1935+2154 Observed with NICER by Fu Yu-Cong, Lin Lin, Ge Ming-Yu, Enoto Teruaki, Hu Chin-Ping, Younes George, Göǧüş Ersin, Malacaria Christian

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Dose-Weighted Network Pharmacology: Evaluating Traditional Chinese Medicine Formulations for Lumbar Disc Herniation by Zhou C, Xiang T, Yu Y, Ma H, Liu C, Yang F, Yang L

“…Changwen Zhou,1 Ting Xiang,2 Yu Yu,3 Hongzhong Ma,1 Ce Liu,1 Feng Yang,1,4,* Lixue Yang1,4,* 1The First Clinical Medical College, Shaanxi University of Chinese Medicine, Shaanxi, People’s Republic of China; 2Rehabilitation Department, Xiang Xi Autonomous Prefecture National Hospital, Hunan, People’s Republic of China; 3Department of Chinese Medicine, Minda Hospital of Hubei Minzu University, Hubei, People’s Republic of China; 4Department of Orthopedic Hospital, The Affiliated Hospital of Shaanxi University of Chinese Medicine, Shaanxi, People’s Republic of China*These authors contributed equally to this workCorrespondence: Lixue Yang; Feng Yang, The First Clinical Medical College, Shaanxi University of Chinese Medicine, Vice No. 2, West Weiyang Road, Qindu District, Shaanxi, 712000, People’s Republic of China, Email ylx18391076233@163.com; yangfengdudu@163.comBackground and Purpose: Lumbar disc herniation (LDH) significantly impacts individuals, particularly those aged 40– 45. …”
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Dynamic Complement Protein Changes in Aqueous Humor and Plasma of Patients With Retinal Vein Occlusion During Ranibizumab Treatment by Guo T, Zhao Y, Liang S, Wang J, Liu H, Zhou Y, Xu H, Chen Z

“…Tingting Guo,1,2,* Yanying Zhao,2,3,* Shengnan Liang,2,3 Jie Wang,2 Hengwei Liu,2 Yufan Zhou,2 Heping Xu,3– 5 Zhongping Chen1– 3,6 1Aier Eye Hospital, Jinan University, Guangzhou, People’s Republic of China; 2Changsha Aier Eye Hospital, Changsha, People’s Republic of China; 3Aier Academy of Ophthalmology, Central South University, Changsha, People’s Republic of China; 4Aier Institute of Optometry and Vision Science, Aier Eye Hospital Group, Changsha, People’s Republic of China; 5The Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen’s University Belfast, Belfast, UK; 6School of Stomatology and Ophthalmology, Xianning Medical College, Xianning, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zhongping Chen; Heping Xu, Email chenzhongping@csu.edu.cn; heping.xu@qub.ac.ukPurpose: To assess dynamic changes of complement protein in aqueous humor (AH) and plasma of retinal vein occlusion (RVO) patients during ranibizumab treatment, and to explore the differential expression of complement proteins in branch retinal vein occlusion (BRVO) and central retinal vein occlusion (CRVO).Patients and Methods: This prospective, consecutive case series study collected AH and plasma samples from 27 RVO patients at baseline, 1 and 2 months after ranibizumab treatment, including 19 BRVO and 8 CRVO patients. …”
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Altered CD73-Adenosine Signaling Linked to Infection in Patients undergoing hemodialysis by Xiang F, Zhang Z, Nie Y, Cao X, Li Y, Chen X, Gong S, Zou J, Teng J, Ding X, Shen B

“…Fangfang Xiang,1– 4,* Zhen Zhang,1,* Yuxin Nie,1 Xuesen Cao,1 Yang Li,1 Xiaohong Chen,1 Shaomin Gong,1 Jianzhou Zou,1 Jie Teng,1 Xiaoqiang Ding,1– 4 Bo Shen1– 4 1Department of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, People’s Republic of China; 2Shanghai Key Laboratory of Renal Disease and Blood Purification, Shanghai, People’s Republic of China; 3Shanghai Medical Center of Kidney, Shanghai, People’s Republic of China; 4Shanghai Institute of Kidney and Dialysis, Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Bo Shen, Department of Nephrology, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, Xuhui District, Shanghai, People’s Republic of China, Email shen.bo@zs-hosptial.sh.cnPurpose: Infection is the most common cause of hospitalization and the second most common cause of mortality among patients undergoing hemodialysis (HD). …”
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Global Research Trends and Focus on the Link Between Heart Failure and NLRP3 Inflammasome: A Bibliometric Analysis From 2010 to 2024 by Lian Y, Zhang H, Xing W, Li S, Lai X, Jia S, Shang J, Liu H

“…YanJie Lian,1,2,* Heyi Zhang,1,2,* Wenlong Xing,1 Sinai Li,3 Xiaolei Lai,1 Sihan Jia,1 JuJu Shang,1 Hongxu Liu1 1Department of Cardiovascular, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, 100010, People’s Republic of China; 2Graduate School of Capital Medical University, Beijing, 100069, People’s Republic of China; 3Beijing Institute of Traditional Chinese Medicine, Beijing, 100010, People’s Republic of China*These authors contributed equally to this workCorrespondence: JuJu Shang, Department of cardiovascular, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, 100010, People’s Republic of China, Email shangjuju@bjzhongyi.com Hongxu Liu, Department of cardiovascular, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, 100010, People’s Republic of China, Email lhx_263.netBackground: Heart failure (HF) is characterized by elevated morbidity, mortality, and rehospitalization frequencies. …”
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Esketamine at a Clinical Dose Attenuates Cerebral Ischemia/Reperfusion Injury by Inhibiting AKT Signaling Pathway to Facilitate Microglia M2 Polarization and Autophagy by Gao Y, Li L, Zhao F, Cheng Y, Jin M, Xue FS

“…Ying Gao,1 Lu Li,1 Fang Zhao,1 Yi Cheng,1 Mu Jin,2 Fu-Shan Xue1,3 1Department of Anesthesiology, Beijing Friendship Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Department of Anesthesiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, People’s Republic of China; 3Department of Anesthesiology, Shengli Clinical Medical College of Fujian Medical University, Fuzhou University Affiliated Provincial Hospital, Fujian Provincial Hospital, Fuzhou, People’s Republic of ChinaCorrespondence: Mu Jin, Department of Anesthesiology, Beijing Anzhen Hospital, Capital Medical University, No. 2 An-Zhen Road, Chao-Yang District, Beijing, 100029, People’s Republic of China, Tel +86-13366600987, Email jinmu0119@hotmail.com Fu-Shan Xue, Department of Anesthesiology, Beijing Friendship Hospital, Capital Medical University, No. 95 Yong-An Road, Xi-Cheng District, Beijing, 100050, People’s Republic of China, Tel +86-13911177655, Fax +86-591-88217841, Email xuefushan@aliyun.com; xuefushan@mail.ccmu.edu.cnPurpose: This study aimed to assess the protective effect of a clinical dose esketamine on cerebral ischemia/reperfusion (I/R) injury and to reveal the potential mechanisms associated with microglial polarization and autophagy.Methods: Experimental cerebral ischemia was induced by middle cerebral artery occlusion (MCAO) in adult rats and simulated by oxygen-glucose deprivation (OGD) in BV-2 microglial cells. …”
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Blood Cell Ratio Combinations for Diagnosing Periprosthetic Joint Infections: A Preliminary Study by Yu Y, Wen Y, Xia J, Dong G, Niu Y

“…Yali Yu,1 Yanan Wen,2 Jiaxuan Xia,3 Guixiang Dong,1 Yanli Niu4 1Department of Clinical Laboratory, Zhengzhou Orthopaedic Hospital, Zhengzhou, People’s Republic of China; 2Department of Blood Transfusion, Huaihe Hospital, Henan University, Kaifeng, People’s Republic of China; 3School of Mathematics and Statistic, Henan University, Kaifeng, People’s Republic of China; 4Laboratory of Cell Signal Transduction, Henan Provincial Engineering Centre for Tumor Molecular Medicine, School of Basic Medical Sciences, Henan University, Kaifeng, People’s Republic of ChinaCorrespondence: Yanli Niu, School of Basic Medical Sciences, Henan University, Kaifeng, People’s Republic of China, Email nyl0925@henu.edu.cnBackground: Periprosthetic joint infection (PJI) is a serious complication following total joint arthroplasty (TJA), which requires prompt and accurate diagnosis for effective management. …”
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Multi-Feature Driver Variable Fusion Downscaling TROPOMI Solar-Induced Chlorophyll Fluorescence Approach by Jinrui Fan, Xiaoping Lu, Guosheng Cai, Zhengfang Lou, Jing Wen

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Neutrophils: From Inflammatory Bowel Disease to Colitis-Associated Colorectal Cancer by Chen T, Liu J, Hang R, Chen Q, Wang D

“…Tianyi Chen,1 Jiachen Liu,2 Ruyi Hang,1 Qian Chen,1 Dong Wang1,3 1Cancer Center, Daping Hospital, Army Medical University, Chongqing, People’s Republic of China; 2Radiology Department, Daping Hospital, Army Medical University, Chongqing, People’s Republic of China; 3Oncology Department of Qianjiang Center Hospital, Chongqing University, Chongqing, People’s Republic of ChinaCorrespondence: Dong Wang, Cancer Center, Daping Hospital, 10 Changjiang Zhi Road, Yuzhong Dist, Chongqing, 400042, People’s Republic of China, Tel +86-23-68757151, Fax +86-23-68894062, Email dongwang64@hotmail.comAbstract: Inflammatory bowel disease (IBD) is a non-specific inflammatory disease of digestive tract, primarily manifesting as ulcerative colitis (UC) and Crohn’s disease (CD). …”
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Influence of Effective Nucleon Mass on Equation of State for Supernova Simulations and Neutron Stars by Shuying Li, Junbo Pang, Hong Shen, Jinniu Hu, Kohsuke Sumiyoshi

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Curcumin inhibits migration and invasion of non-small cell lung cancer cells through up-regulation of miR-206 and suppression of PI3K/AKT/mTOR signaling pathway by Wang Naizhi, Feng Tao, Liu Xiaona, Liu Qin

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CH3OH Thermal Lines Traces 6.7 GHz CH3OH Maser Variation of High-mass Protostar G353.273+0.641 by Shi-Min Song, Xi Chen, Sheng-Yuan Liu, Jun-Ting Liu

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Best Evidence Summary for the Improvement and Management of Disorders of Consciousness in Patients With Severe Brain Injury by Miaoyuan Lin, Qiongna Lu, Sheng Yu, Wenjuan Lin

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The Utilization of Ultrasound-Guided Regional Nerve Blocks in Anesthetic Management for Fracture Surgery by Yi R, Li Z, Yang X, Huang T, Liu H, Zhang J

“…Ruofan Yi,1 Zeng Li,1 Xingjun Yang,2 Ting Huang,1 Hongjun Liu,1 Jun Zhang2 1Department of Anesthesiology, The 955th Hospital of Chinese People’s Liberation Army, Tibet, 854000, People’s Republic of China; 2Department of General Surgery, The 955th Hospital of Chinese People’s Liberation Army, Tibet, 854000, People’s Republic of ChinaCorrespondence: Jun Zhang, Department of General Surgery, The 955th Hospital of Chinese People’s Liberation Army, No. 52, Gadong Street, Karuo District, Chamdo, Tibet, 854000, People’s Republic of China, Tel +86 0895 4820722, Email junzhangyz@outlook.com Hongjun Liu Department of Anesthesiology, The 955th Hospital of Chinese People’s Liberation Army, No. 52, Gadong Street, Karuo District, Chamdo, Tibet, 854000, People’s Republic of China, Tel +86 0895-4820775, Email hongjunliumzk@outlook.comAbstract: Fracture surgeries are frequently accompanied by severe pain, necessitating efficacious pain management strategies to enhance postoperative recovery. …”
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Application of Gastric Tube Decompression for Rapid Tip Positioning in Bedside Blind Insertion of Nasoenteric Tubes by Yang LL, Li DN, Gao P, Zhang H, Wang J

“…Li-Li Yang,1 Di-Na Li,1 Peng Gao,2 Hua Zhang,1 Juan Wang3 1Department of Emergency, China-Japan Friendship Hospital, Beijing, 100029, People’s Republic of China; 2Department of Medical Affairs, China-Japan Friendship Hospital, Beijing, 100029, People’s Republic of China; 3Department of Hepatobiliary Pancreatic Surgery, China-Japan Friendship Hospital, Beijing, 100029, People’s Republic of ChinaCorrespondence: Di-Na Li, Department of Emergency, China-Japan Friendship Hospital, Beijing, 100029, People’s Republic of China, Tel +86 18236933790, Email lidnina_lii@126.comObjective: This study aims to examine the efficacy of gastric tube decompression in rapid tip positioning during bedside blind insertion of nasoenteric tubes.Methods: Between August 2023 and July 2024, patients who were critically ill in the emergency intensive care unit of a tertiary hospital in Beijing who required nasoenteric tube placement were enrolled in this study. …”
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