The role of lipids in promoting hair growth through HIF-1 signaling pathway by Jieun Seo, Kotone Matsumoto, Ayaka Nanmo, Shan Tu, Do-Won Jeong, Yang-Sook Chun, Lei Yan, Tatsuto Kageyama, Junji Fukuda

“…Lipid supplementation in the culture medium upregulated hair growth-related genes and promoted the proliferation of human dermal papilla cells (DPCs). By using RNA-sequencing analysis and HIF-1α knockdown in DPCs, we found that HIF-1α is a potential candidate that governs lipid-reinforced upregulation of trichogenic genes. …”
Get full text

Synergistic effects of Rhizobium, Bacillus and Arbuscular Mycorrhizal fungi on enhancing cotton growth by Tasleem Sultana, Pavan Kumar Pindi

“…Microbial identification was performed using 16S rRNA gene sequencing. Biochemical evaluations of consortium-inoculated plants included measurements of protein, sugar, proline, and chlorophyll levels, along with IAA quantification. …”
Get full text

A new crustin-like gene from the redclaw crayfish Cherax quadricarinatus and its response to decapod iridescent virus 1 (DIV1) challenge by Xiaoying Hang, Jianbo Zheng, Fei Li

“…Moreover, RNAi-mediated gene silencing of Cqcarc1 could increase the DIV1 copy number compared with the control group, suggesting its involvement in the immune defense against the DIV1 challenge. Furthermore, RNA interference analysis also showed that Cqcarc1 plays positive regulatory roles in the expressions of CqToll and CqCrs during DIV infection. …”
Get full text

Quercetin inhibits the biological activity of endometrial cancer by regulating autophagy: A network pharmacology analysis and cellular experimental validation by Lingchen Yang, Hongwei Ma

“…. + LV-activating transcription factor 5 (ATF5)-RNA interference (RNAi) and Que. + LV-ATF5-RNAi+mTOR agonist. …”
Get full text

Exploring Novel Non-Operative Treatments for Osteoarthritis: An Examination of Innovative Therapies by Piotr Robert Bakuła, Kamila Jałocha, Joanna Zygadło

“…Cutting-edge technologies such as RNA interference, CRISPR/Cas9, and advanced regenerative medicine are also explored for their potential to revolutionize OA management. …”
Get full text

Mediator kinase inhibition suppresses hyperactive interferon signaling in Down syndrome by Kira A Cozzolino, Lynn Sanford, Samuel Hunter, Kayla Molison, Benjamin Erickson, Meaghan CS Courvan, Taylor Jones, Deepa Ajit, Matthew D Galbraith, Joaquín M Espinosa, David Bentley, Mary Ann Allen, Robin D Dowell, Dylan J Taatjes

Get full text

HINT1 suppression protects against age-related cardiac dysfunction by enhancing mitochondrial biogenesis by Michio Sato, Tsuyoshi Kadomatsu, Jun Morinaga, Yuya Kinoshita, Daisuke Torigoe, Haruki Horiguchi, Sumio Ohtsuki, Shuji Yamamura, Ryoko Kusaba, Takanori Yamaguchi, Goro Yoshioka, Kimi Araki, Tomohiko Wakayama, Keishi Miyata, Koichi Node, Yuichi Oike

“…Furthermore, expression of the lncRNA Caren, which inhibits Hint1 mRNA translation, decreased with age in heart, and CR suppressed this effect. …”
Get full text

Activating PKC-ε induces HIV expression with improved tolerability. by Alivelu M Irrinki, Jasmine Kaur, Bally Randhawa, Ryan McFadden, Chelsea Snyder, Hoa Truong, Daniel Soohoo, Eric Hu, Helen Yu, Bernard P Murray, Bing Lu, Dmytro Kornyeyev, Ishak Darryl Irwan, Lan Nguyen, Yu-San Yang, Jean-Philippe Belzile, Uli Schmitz, Todd C Appleby, Brian Schultz, Jay Lalezari, Steven Deeks, Tomas Cihlar, Jeffrey P Murry

“…C-233 increased both supernatant HIV RNA and p24 expression ex vivo after treatment of CD4+ T cells from ART-suppressed people with HIV. …”
Get full text

Integrative analysis of SEPN1 in glioma: Prognostic roles, functional implications, and potential therapeutic interventions. by Zisong Wang, Danwen Wang, Xuanyu Wang, Yihang Xu, Yunhe Yuan, Yuxin Chen, Zhiqiang Li, Xiaoping Liu

“…SEPN1 in glioma was further examined using data from TCGA, CGGA, GEO, and ZN-GC cohorts, along with survival analysis, single-cell RNA sequencing analysis, and enrichment analysis. …”
Get full text

Immunological Approaches and Different Strategies for Vaccine Development Against SARS-COV-2 by Muhammed Babakir-Mina

“…Moreover, there are different strategies that used by researchers and pharmacological companies to develop vaccines including attenuated or killed viruses, RNA of a spike protein, and vector expressing a particular protein of the virus. …”
Get full text

Distinct plasmablast developmental intermediates produce graded expression of IgM secretory transcripts by Evelyn P. Sievert, Marissa C. Franke, Kayla B. Thomas, Yoseop Yoon, Yongsheng Shi, Roger Sciammas

“…This extraordinary capacity requires the upregulation of PC transcriptional determinants that specify PC fate, increase immunoglobulin mRNA synthesis, coordinate alternative 3′ end processing of the heavy chain transcript from the distal to proximal polyadenylation site (PAS), and remodel the secretory pathway. …”
Get full text

Single, but not mixed dietary fibers suppress body weight gain and adiposity in high fat-fed mice by Swang M. Shallangwa, Alexander W. Ross, Peter J. Morgan

“…Plasma levels of the gut hormone PYY were elevated by 10% pectin and FOS, but not 10% mixed fibers, and similarly RNA seq revealed some distinct effects of the 10% single fibers on gut epithelial gene expression. …”
Get full text

Effects of highland barley β-glucan on gut microbiota composition and metabolism in vitro fermentation by Yinchen Ge, Jiaci Liu, Huacheng Tang, Yanqing Zang, Yang Cao

“…Therefore, the effects of HBG on the gut microbiota during fermentation were analyzed by 16 s rRNA sequencing and untargeted metabolomics. The results showed that HBG could enrich microbial diversity, increase the abundance of beneficial bacteria, and inhibit the biology of pathogenic bacteria. …”
Get full text

Evaluation of insertion and deletion polymorphisms of Brazilian Odontoceti by Dafne Adriana Abreu dos Anjos, Anna Luiza dos Santos Donato, Rodrigo Goldenberg-Barbosa, Elizeu Fagundes de Carvalho, Cesar Rogerio Leal do Amaral

“…In this study, we performed an in silico analysis of InDels in 16S rRNA from 27 species of toothed whales, dolphins, and porpoises present in Brazilian waters and recurrently found stranded in the region. …”
Get full text

Molecular genetic methods for intestinal microbiome investigation by O. L. Kardymon, A. V. Kudryavtseva

“…Meanwhile, today, to distinguish species and strains of microorganisms at DNAs or RNA level, standard culture and visual method are combined to molecular biology and genetics methods even more frequently. …”
Get full text

Gemcitabine combined with baicalein exerts antiviral activity against PEDV by inhibiting the entry and replication phases by Yingge Zheng, Yanfei Zhang, Fangying Xiong, Dehua Luo, Yuxiang Wang, Yijia Zhang, Dengguo Wei

“…Porcine epidemic diarrhea virus (PEDV) is a member of the Coronaviridae family, whose genome consists of a single strand of positive-sense RNA and has evolved into multiple epidemic lineages with no available drugs in clinical practice. …”
Get full text

Molecular techniques for cancer diagnostics by Vimal Kishor Singh, Ramesh Chandra

“…Several key findings are being identified to discover and validate such molecular biomarkers for their diagnostic potential at the DNA, RNA, and protein levels. Furthermore, noninvasive imaging technologies and serum biomarkers are promising higher quality outputs in a limited time which could be a useful tool to monitor early responses to the treatment and may be able to design the remedial course. …”
Get full text

Modulatory effects of cinnamomi cortex and its components epicatechin and linalool on skin circadian rhythms by Ji-Young Kim, Juyeon Lee, Soo-Hyeon Lee, Eui-Man Jung, Kyung-Ha Lee

“…Gene expression analysis revealed that CC extract, EC, and LO altered the mRNA and protein levels of clock genes in a time-dependent manner. …”
Get full text

Comparative analysis of microbial contamination in diesel fuels using MALDI-TOF MS by Agnieszka Ludwiczak, Tomasz Zieliński, Ewelina Sibińska, Grażyna Czeszewska-Rosiak, Michał Złoch, Joanna Rudnicka, Andrzej Tretyn, Paweł Pomastowski

“…Detection and characterization of microbiological contamination in fuels were performed with further validation by 16 S rRNA gene sequencing. Microorganisms collected from three types of diesel fuel were cultured, and fuel samples were analyzed. …”
Get full text

Bacteriological valuations of some powdered infant milk and antibiotic resistance estimation by Sameira S. Swilaiman, Lawin A. Omer, Suhaila N. Darogha

“…Method: In a total of 12 samples of commercial dried milk products (infant powdered milk) used by consumers in Erbil state, biochemical and molecular identification were used for identification. A region of 16S rRNA gene were amplified by PCR to allow species identification, and the sensitivity of isolates to eight antibiotics was studied by using standard disc diffusion method Results: Eight samples of infant powdered milk (N = 12) were contaminated with (62.5%) Staphylococcus sp and (37.5%) Lactobacillus sp . …”
Get full text