The effect of local anaesthetic agents on opioid use and recovery in patients undergoing open heart surgery: a randomized controlled study by Hatice AZİZOĞLU, Mehmet AŞAM, Zeynep GÜRKAN, Yasemin BOZKURT, Canan DEMİR

“…Conclusions In this study, local anesthetic application to the sternotomy incision site and around the chest tubes after open heart surgery was found to reduce postoperative opioid consumption and positively affect recovery. Trial registration Current Controlled Trials NCT06642077 (Retrospectively registered).…”
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Impact on staff of providing non-invasive advanced respiratory support during the COVID-19 pandemic: a qualitative study in an acute hospital by David Wenzel, Christina Faull, Eleanor Wilson, Lucy Bleazard

“…These protective factors may provide modelling for future education and support services to help prevent moral injury or aide in its recovery.Trial registration number Registered on the Open Science Framework, DOI 10.17605/OSF.IO/TB5QJ…”
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Mechanistic insights into PROS1 inhibition of bladder cancer progression and angiogenesis via the AKT/GSK3β/β-catenin pathway by Xin-peng Fan, Ji-rong Wang, Si-yu Chen, Xiao-ran Li, Jin-long Cao, Hua-bin Wang, Li-yun Ding, Tuan-jie Che, Li Yang

“…Next, various functional experiments were performed and the results revealed PROS1 overexpression inhibited the proliferation, cell cycle progression, migration, invasion, and angiogenesis of BLCA. In recovery trials, the AKT activator SC79 offered additional proof that PROS1 may influence BLCA cells via the AKT/GSK3β/β-catenin pathway. …”
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