A novel method for measuring heat injury in leaves provides insights into the sequence of processes of heat injury development by Clara Bertel, Gilbert Neuner

“…Heat injury results from multiple processes and occurs at the molecular level, involving increased membrane fluidity, lipid peroxidation, and protein aggregation and denaturation. Results We have tested whether the DSC method allows the detection of heat-induced denaturation and aggregation of molecules in intact leaves. …”
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An Angelman syndrome substitution in the HECT E3 ubiquitin ligase C-terminal Lobe of E6AP affects protein stability and activity. by Steven A Beasley, Chloe E Kellum, Rachel J Orlomoski, Feston Idrizi, Donald E Spratt

“…Here, we demonstrate that the I827K substitution destabilizes the 3D fold causing protein aggregation of the C-terminal lobe of E6AP using a combination of spectropolarimetry and nuclear magnetic resonance (NMR) spectroscopy. …”
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Low-level overexpression of wild type TDP-43 causes late-onset, progressive neurodegeneration and paralysis in mice. by Chunxing Yang, Tao Qiao, Jia Yu, Hongyan Wang, Yansu Guo, Johnny Salameh, Jake Metterville, Sepideh Parsi, Issa Yusuf, Robert H Brown, Huaibin Cai, Zuoshang Xu

“…Detailed analysis showed ~30% loss of large pyramidal neurons in the layer V motor cortex; in the spinal cord, severe demyelination was accompanied by oligodendrocyte injury, protein aggregation, astrogliosis and microgliosis, and elevation of neuroinflammation. …”
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Pea protein gels crosslinked with transglutaminase with multiple textures for food formulations by Bianca Dimas Rios, Luísa Ozorio, Fabiana Perrechil

“…In all treatments, the microstructure analysis showed that the increase in the enzyme concentration induced greater protein aggregation. Regarding mechanical properties, P1 gels did not fracture, while the P2 ones showed a tendency for Young's Modulus to increase with increasing enzyme concentration and the sample treated with 0.5% (w/w) enzyme was the most deformable. …”
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Loss of FIC-1-mediated AMPylation activates the UPRER and upregulates cytosolic HSP70 chaperones to suppress polyglutamine toxicity. by Kate M Van Pelt, Matthias C Truttmann

“…Targeted regulation of cellular proteostasis machinery represents a promising strategy for the attenuation of pathological protein aggregation. Recent work suggests that the unfolded protein response in the endoplasmic reticulum (UPRER) directly regulates the aggregation and toxicity of expanded polyglutamine (polyQ) proteins. …”
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Improving the water-holding and gelation properties of egg white by glycosylation and alkaline heating by Yang Ye, Xinyue Gou, Guixiang Jia, Jingyu Xiang, Anjiao Li, Yang Wang

“…The degree of crosslinking within the gel was augmented, and SDS-PAGE results corroborated the occurrence of protein aggregation. This study establishes a theoretical foundation for advancing the quality and processing techniques of preserved eggs.…”
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Design of RNAi hairpins for mutation-specific silencing of ataxin-7 and correction of a SCA7 phenotype. by Janine Scholefield, L Jacquie Greenberg, Marc S Weinberg, Patrick B Arbuthnot, Amr Abdelgany, Matthew J A Wood

“…The activity of the most effective short hairpin RNA incorporating the nucleotide mismatch at position 16 was further studied in a heterozygous ataxin-7 disease model, demonstrating significantly reduced levels of toxic mutant ataxin-7 protein with decreased mutant protein aggregation and retention of normal wild-type protein in a non-aggregated diffuse cellular distribution. …”
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Incretin‐Based Therapies in Alzheimer's and Parkinson's Disease: Advancing Neuroprotection With Dual and Triple Agonists—A Review by Ousman Mohammed, Tsehayneh Kelemu

“…Incretin‐based therapies, particularly GLP‐1/GIP receptor agonists, have demonstrated promising effects by addressing several pathological processes, including oxidative stress, inflammation, misfolded protein aggregation, and insulin resistance. Dual agonists like DA‐CH3, DA5‐CH, and DA4‐JC have proven superior in crossing the blood‐brain barrier and offering improved neuroprotection in comparison with conventional GLP‐1 agonists. …”
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Concentration‐Based Analysis of Metal‐Induced Tau Fibrillar versus non‐fibrillar Aggregation: Implications for Neurotoxicity in Alzheimer's Disease by Mahzad Irandoust, Afrooz Anbaraki, Zahra Dindar, Atiyeh Ghasemi, Ali Akbar Saboury, Saeed Rayati, Arefeh Seyedarabi

“…Abstract Tau protein aggregation is the most significant factor in Alzheimer's disease (AD) pathogenesis, and the accumulation of metal ions in the brain is considered a key factor in the development of this disease. …”
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Regulation on Aggregation Behavior and In Vitro Digestibility of Phytic Acid–Whey Protein Isolate Complexes: Effects of Heating, pH and Phytic Acid Levels by Yaqiong Pei, Ziyu Deng, Bin Li

“…In summary, the effect of PA on protein aggregation behavior and digestive characteristics was not simply dependent on its presence but largely on the aggregation degree of PA-WPI induced by heat treatment, pH and PA concentration. …”
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From copper homeostasis to cuproptosis: a new perspective on CNS immune regulation and neurodegenerative diseases by Luhao Li, Liangzhen Lv, Zhaodi Wang, Xianbao Liu, Qingyi Wang, Hui Zhu, Bei Jiang, Yapeng Han, Xue Pan, Xueming Zhou, Li Ren, Zhuo Chang

“…The recently proposed concept of “cuproptosis” has further revealed the unique status of copper in cellular regulation: when copper abnormally accumulates within cells, it can directly bind to the lipoylated proteins of the mitochondrial TCA cycle, triggering protein aggregation and metabolic disorders, ultimately leading to cell death. …”
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SNPs in inflammatory genes CCL11, CCL4 and MEFV in a fibromyalgia family study. by Zhifang Zhang, Jinong Feng, Allen Mao, Keith Le, Deirdre La Placa, Xiwei Wu, Jeffrey Longmate, Claudia Marek, R Paul St Amand, Susan L Neuhausen, John E Shively

“…The variant protein from CCL4 rs1719152 exhibited protein aggregation and a potent down-regulation of its cognate receptor CCR5, a receptor associated with hypotensive effects. …”
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Aging, mortality, and the fast growth trade-off of Schizosaccharomyces pombe. by Hidenori Nakaoka, Yuichi Wakamoto

“…We found that cell deaths were typically preceded by sudden acceleration of protein aggregation; thus, a relatively large amount of protein aggregates existed at the very ends of the dead cell lineages. …”
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Differential unfolded protein response regulation in KRAS silencing sensitive and innately resistant colorectal cancer cells by Flávia Martins, Ana L. Machado, Joana Carvalho, Catarina R. Almeida, Hans C. Beck, Ana S. Carvalho, Vadim Backman, Rune Matthiesen, Sérgia Velho

“…Functional assays validated that the sensitive cell line HCT116 exhibits reduced protein aggregation and lower translational capacity upon KRAS knockdown, consistent with UPR activation. …”
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Effects of Different Heat Treatments on the Structure and Physicochemical Properties of Proteins from Skimmed Camel’s Milk by WANG Tao, WANG Danlin, HE Jing, JI Rimutu

“…Observations by laser scanning confocal microscopy (LSCM) showed that the heat treatment caused protein aggregation, and T3 and T4 resulted in the production of large protein polymers. …”
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EMP1 safeguards hematopoietic stem cells by suppressing sphingolipid metabolism and alleviating endoplasmic reticulum stress by Lei Li, Yufei Lei, Yan Li, Yuxin Xie, Pusheng Hui, Xiaoyan Zang, Weiru Wu, Feng Wu, Jiankun Fan, Jianming Wang, Jieping Chen, Zhe Chen, Yu Hou

“…Emp1 deficiency leads to the accumulation of protein aggregates and elevated ER stress, ultimately resulting in impaired HSC maintenance and self-renewal. …”
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Fragments of viral surface proteins modulate innate immune responses via formyl peptide receptors by Heiko Heilmann, Lukas Busch, Celine Buchmann, Islam Mohamed, Adrian Theiß, Sabryna Junker, Stefan Lohse, Bernd Bufe

“…The physiochemical properties of FPR1 activators correlate with the occurrence of protein aggregation hotspots. Such hotspots are present on various surface proteins of unrelated viruses that can also activate FPRs. …”
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Volatile oil of Acori tatarinowii rhizoma: potential candidate drugs for mitigating dementia by Yifan Bu, Songzhe Li, Ting Ye, Yuqing Wang, Mingrong Song, Jing Chen

“…Furthermore, the study highlights the limitations of existing research and offers insights into future research directions.ResultsThe volatile oil of ATR mitigates dementia through multiple pathways, including reducing abnormal protein aggregation, promoting neurogenesis, inhibiting neuronal apoptosis, regulating neurotransmitters, improving synaptic function, modulating autophagy, countering cellular stress, reducing neuroinflammation, and alleviating vascular risk factors.ConclusionThe multi-pathway pharmacological effects of the volatile oil of ATR are well-aligned with the complex mechanisms of dementia progression, highlighting its significant therapeutic potential for anti-dementia applications. …”
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Biosynthesis and potential uses of silver nanoparticles with Hericium erinaceus extracts by Luis Jorge Gutiérrez-Barrera, Mario Antonio Reyna-Mata, Dulce Viridiana Melo-Máximo, Ana Laura Torres-Huerta, Aurora Antonio-Pérez

“…Accordingly, Hee-AgNPs showed a tendency to disintegrate synthetic protein aggregates, which are related to amyloid fibers. …”
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Associations of Environmental Exposure to Arsenic, Manganese, Lead, and Cadmium with Alzheimer’s Disease: A Review of Recent Evidence from Mechanistic Studies by Giasuddin Ahmed, Md. Shiblur Rahaman, Enrique Perez, Khalid M. Khan

“…Environmental exposure to these heavy metals induces a wide range of pathological processes that intersect with well-known mechanisms leading to AD, such as oxidative stress, mitochondrial dysfunction, protein aggregation, neuroinflammation, autophagy dysfunction, and tau hyperphosphorylation. …”
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