Preclinical development and characterisation of PP353, a formulation of linezolid for intradiscal administration by Graham Hagger, Sarah Guest, Stephen Birchall, Alys Bradley, Charlie Brindley, David Corbett, Paul J. Cummings, Cristina Freire, James Harris, Andrew Wise, Melanie Wood, Lloyd G. Czaplewski

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Preclinical development of an immunoassay for the detection of TREM2: a new biomarker for Alzheimer’s disease by Jie Hu, Huimei Zeng, Jiaqi Lu, Tianpeng Li, Xue Liu, Yang Liu, Weihuan Wen, Weijun Shen, Hongying Chen, Zhicheng Chen

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Preclinical development of an in vivo BCG challenge model for testing candidate TB vaccine efficacy. by Angela M Minassian, Edward O Ronan, Hazel Poyntz, Adrian V S Hill, Helen McShane

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WoE Analysis and Key Risk Factors in Preclinical Development of Medicinal Products: A Review by G. N. Engalycheva, R. D. Syubaev

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Exploring Regulatory Frameworks for Exosome Therapy: Insights and Perspectives by Qiushi Li, Yuxia Li, Jiaqing Shao, Jianhua Sun, Lan Hu, Xia Yun, Chen Liuqing, Likun Gong, Shuxia Wu

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Preclinical Development and Phase I Study of ZSYY001, a Polymeric Micellar Paclitaxel for Advanced Solid Tumor by Ge Gao, Pei Shu, Youzhen Tan, Tongsen Zheng, Wenmao Fan, Luding Lu, Huan Zhou, Zishu Wang, Ling Liu, Zhiqiang Liu, Yongsheng Wang

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O16: Preclinical development of a gene therapy for Ogden syndrome, using new mouse models of the disease by Gholson Lyon, Kathy Snow, Yaned Gaitan, Ethan Saville, Stephen Kneeland, Hye Ri Kang, Steven Gray, Elaine Marchi, Cat Lutz, Steve Murray

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Discovery and preclinical development of a therapeutically active nanobody-based chimeric antigen receptor targeting human CD22 by Scott McComb, Mehdi Arbabi-Ghahroudi, Kevin A. Hay, Brian A. Keller, Sharlene Faulkes, Michael Rutherford, Tina Nguyen, Alex Shepherd, Cunle Wu, Anne Marcil, Annie Aubry, Greg Hussack, Devanand M. Pinto, Shannon Ryan, Shalini Raphael, Henk van Faassen, Ahmed Zafer, Qin Zhu, Susanne Maclean, Anindita Chattopadhyay, Komal Gurnani, Rénald Gilbert, Christine Gadoury, Umar Iqbal, Dorothy Fatehi, Anna Jezierski, Jez Huang, Robert A. Pon, Mhairi Sigrist, Robert A. Holt, Brad H. Nelson, Harold Atkins, Natasha Kekre, Eric Yung, John Webb, Julie S. Nielsen, Risini D. Weeratna

“…This presents a complete report on preclinical development of a novel CD22sdCAR therapeutic.…”
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Preclinical development and clinical safety assessment of a synthetic peptide conjugate enabling endogenous antibody binding to promote innate receptor engagement by Erika A.K. Fletcher, Robert A. Cordfunke, Aikaterini Nasi, Gunilla Törnqvist, Rob R.P.M. Valentijn, Anna Bergqvist, Marita Westhrin, Wenche Rasch, Frida Lindqvist, Inken Dillmann, Martin Lord, Neanke Bouwman, Jacques J. Neefjes, Kees L.M.C. Franken, Stephanie McArdle, Murrium Ahmad, Silvia Johansson, Ferry Ossendorp, Michael Haggman, Maria Lampinen, Gustav Ullenhag, Sam Ladjevardi, Justyna Leja-Jarblad, Wolfgang Lilleby, Jan Wouter Drijfhout, Sara M. Mangsbo

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Early preclinical development of Mycobacterium tuberculosis amino acid biosynthesis pathway inhibitor DRILS-1398 as a potential anti-TB drug by Deepesh Biswas, Rebecca Kristina Edwin, K. Shiva Kumar, Anwar Alam, Dhiraj Kumar, Sandipan Chakraborty, Gopalakrishnan Bulusu, Farhan Jalees Ahmad, Gautham G. Shenoy, Lakshyaveer Singh, Mansi Agarwal, Fouzia Siraj, Srinivas Oruganti, Parimal Misra, Nasreen Zafar Ehtesham, Manojit Pal, Seyed Ehtesham Hasnain

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Preclinical development of ozuriftamab vedotin (BA3021), a novel ROR2-specific conditionally active biologic antibody–drug conjugate by Hwai Wen Chang, Gerhard Frey, Jing Wang, Haizhen Liu, Charles Xing, Jian Chen, William J. Boyle, Jay M. Short

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Izokibep: Preclinical development and first-in-human study of a novel IL-17A neutralizing Affibody molecule in patients with plaque psoriasis by Susanne Klint, Joachim Feldwisch, Lindvi Gudmundsdotter, Karin Dillner Bergstedt, Elin Gunneriusson, Ingmarie Höidén Guthenberg, Anders Wennborg, Andrew C. Nyborg, Amol P. Kamboj, Paul M. Peloso, David Bejker, Fredrik Y. Frejd

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Preclinical development of three novel CARs targeting CD79b for the treatment of non-Hodgkin’s lymphoma and characterization of the loss of the target antigen by Manel Juan, Beatriz Martín-Antonio, Pablo Engel, Narcis Fernandez-Fuentes, Esperanza Esquinas, Alvaro Moreno-Sanz, Victor Sandá, Damian Stodulski-Ciesla, Jennifer Borregón, Virginia Peña-Blanque, Javier Fernández-Calles, Juana Serrano-Lopez, Pilar Llamas-Sillero, Laura Solán-Blanco

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Ucenprubart is an agonistic antibody to CD200R with the potential to treat inflammatory skin disease: preclinical development and a phase 1 clinical study by Anja Koester, Derrick R. Witcher, Mark Lee, Stephen J. Demarest, Scott Potter, Katie Werle, Scott Bauer, Diana Ruiz, Laurent Malherbe, Josh Poorbaugh, Andrew Glasebrook, Christoph Preuss, Gourab Datta, Ziqiao Wang, Jack Knorr, David Manner, Dipak Patel, Carsten Schmitz, Paul Klekotka, Ajay Nirula

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Preclinical development of a replication-competent vesicular stomatitis virus-based Lassa virus vaccine candidate advanced into human clinical trialsResearch in context by Christopher L. Cooper, Gavin Morrow, Maoli Yuan, Thomas S. Postler, Maxwell L. Neal, Robert W. Cross, Courtney Woolsey, Krystle N. Agans, Viktoriya Borisevich, Ryan P. McNamara, Caroline Atyeo, Vicky Roy, Daritza Germosen, Fuxiang Hou, Shui L. Li, Lucia Reiserova, Yesle Choi, Aaron Wilson, Denise Wagner, Olivia Wallace-Selman, Alexei Carpov, Fuqiang Geng, Deborah J. Frederick, Joanne DeStefano, Anne M. Ercolini, Adrian S. Enriquez, Kathryn M. Hastie, Suzane Ramos da Silva, Eddy Sayeed, John W. Coleman, Andrew Kilianski, Galit Alter, Erica Ollmann Saphire, John D. Aitchison, Thomas W. Geisbert, Swati B. Gupta, Mark B. Feinberg, Christopher L. Parks

“…We conducted preclinical development on a promising experimental vaccine that allowed its advancement into human trials. …”
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Preclinical and clinical development of preventive rotavirus vaccines: special considerations by A. S. Korovkin, D. V. Gorenkov, A. A. Soldatov, V. A. Merkulov

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Clinical-grade extracellular vesicles derived from umbilical cord mesenchymal stromal cells: preclinical development and first-in-human intra-articular validation as therapeutics for knee osteoarthritis by Aliosha I. Figueroa-Valdés, Patricia Luz-Crawford, Yeimi Herrera-Luna, Nicolás Georges-Calderón, Cynthia García, Hugo E. Tobar, María Jesús Araya, José Matas, Darío Donoso-Meneses, Catalina de la Fuente, Jimena Cuenca, Eliseo Parra, Fernando Lillo, Cristóbal Varela, María Ignacia Cádiz, Rolando Vernal, Alexander Ortloff, Gino Nardocci, Verónica Castañeda, Catalina Adasme-Vidal, Maximiliano Kunze-Küllmer, Yessia Hidalgo, Francisco Espinoza, Maroun Khoury, Francisca Alcayaga-Miranda

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Assessment of 5-HT7 Receptor Agonists Selectivity Using Nociceptive and Thermoregulation Tests in Knockout versus Wild-Type Mice by Alex Brenchat, Maria Rocasalbas, Daniel Zamanillo, Michel Hamon, José Miguel Vela, Luz Romero

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From data silos to insights: the PRINCE multi-agent knowledge engine for preclinical drug development by Carlos Henrique Vieira-Vieira, Sarang Sanjay Kulkarni, Adam Zalewski, Jobst Löffler, Jonas Münch, Annika Kreuchwig

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Nanoparticle platform preferentially targeting liver sinusoidal endothelial cells induces tolerance in CD4+ T cell-mediated disease models by Shu-Hung Wang, Isabelle Serr, Isabelle Serr, Reinaldo Digigow, Barbara Metzler, Alexey Surnov, Alexey Surnov, Cornelia Gottwick, Muhammad Alsamman, Daria Krzikalla, Markus Heine, Miriam Zahlten, Agata Widera, Disha Mungalpara, Muharrem Şeleci, Marco Fanzutti, Lígia Margarida Marques Mesquita, Anna-Lisa Vocaturo, Johannes Herkel, Johannes Herkel, Antonella Carambia, Christian Schröter, Dikran Sarko, Johannes Pohlner, Carolin Daniel, Carolin Daniel, Carolin Daniel, Cristina de Min, Sabine Fleischer

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