Awardee Summary of 2023 Taiwan Oncology Society Clinical Research Award Recipient: Persistent Endeavors on Research of Digestive Cancers for Three Decades by Kun-Huei Yeh

“…Conclusion: In the future, our team will make persistent endeavors in research on digestive cancers for immunotherapy and precision medicine to further improve treatment outcomes.…”
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Diversity and inclusion for the All of Us research program: A scoping review. by Brandy M Mapes, Christopher S Foster, Sheila V Kusnoor, Marcia I Epelbaum, Mona AuYoung, Gwynne Jenkins, Maria Lopez-Class, Dara Richardson-Heron, Ahmed Elmi, Karl Surkan, Robert M Cronin, Consuelo H Wilkins, Eliseo J Pérez-Stable, Eric Dishman, Joshua C Denny, Joni L Rutter, All of Us Research Program

“…All of Us aims to address the need for more diversity in research and set the stage for that diversity to be leveraged in precision medicine research to come. This paper describes how the program assessed demographic characteristics of participants who have enrolled in other U.S. biomedical research cohorts to better understand which groups are traditionally represented or underrepresented in biomedical research. …”
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Advances in the application of human-machine collaboration in healthcare: insights from China by Wuzhen Wang, Liangji Liu

“…We use the subject words “Human–machine collaboration” OR “Human-Computer Interaction” OR “HCI” AND “chronic disease” OR “Health management” OR ”Precision medicine “were searched for CNKI, Wanfang Data, VIP, CBM, PubMed, Web of science, Embase, Cochrane Library and other Chinese and English databases to identify all relevant studies and compare their results, and finally include 68 relevant literature articles, we identified the broad application of HCI in five main areas: disease screening and treatment, health management, medical education, traditional medicine, and the integration and processing of medical data. …”
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Molecular pathways in reproductive cancers: a focus on prostate and ovarian cancer by Ayodeji Folorunsho Ajayi, Mega Obukohwo Oyovwi, Oyedayo Phillips Akano, Grace Bosede Akanbi, Florence Bukola Adisa

“…Targeting these pathways with precision medicine approaches holds promise for improving patient outcomes. …”
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Bio-primed machine learning to enhance discovery of relevant biomarkers by David M. Henke, Alexander Renwick, Joseph R. Zoeller, Jitendra K. Meena, Nicholas J. Neill, Elizabeth A. Bowling, Kristen L. Meerbrey, Thomas F. Westbrook, Lukas M. Simon

“…Abstract Precision medicine relies on identifying reliable biomarkers for gene dependencies to tailor individualized therapeutic strategies. …”
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Navigating a challenging path: precision disease treatment with tailored oral nano-armor-probiotics by Anmei Chen, Ying Gong, Shaoquan Wu, Ye Du, Zhijun Liu, Yuhong Jiang, Jiahong Li, Yang-Bao Miao

“…Ultimately, this review aspires to guide the advancement of nano-armored probiotic therapies, driving progress in precision medicine and paving the way for groundbreaking treatment modalities. …”
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Effect of Bacille Calmette–Guérin vaccination on immune responses to SARS‐CoV‐2 and COVID‐19 vaccination by Nicole L Messina, Susie Germano, Amy W Chung, Carolien E van deSandt, Natalie E Stevens, Lilith F Allen, Rhian Bonnici, Julio Croda, Claudio Counoupas, Branka Grubor‐Bauk, Ebene R Haycroft, Katherine Kedzierska, Ellie McDonald, Rebecca McElroy, Mihai G Netea, Boris Novakovic, Kirsten P Perrett, Laure F Pittet, Ruth A Purcell, Kanta Subbarao, James A Triccas, David J Lynn, Nigel Curtis, the BRACE Trial Consortium Group

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Targeting ferroptosis in prostate cancer management: molecular mechanisms, multidisciplinary strategies and translational perspectives by Hubo Yang, Xuefeng Zhang, Zongming Jia, He Wang, Jixiang Wu, Xuedong Wei, Yuhua Huang, Wenying Yan, Yuxin Lin

“…Hence deciphering the role of ferroptosis in carcinogenesis would provide novel insights and strategies for precision medicine and personalized healthcare against PCa. …”
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Characterization of Somatic Mutations in Malaysian Luminal Breast Cancer by Yock Ping Chow, Ryia Illani Mohd Yunos, Isa Mohd Rose, Norlia Abdullah, Rohaizak Muhammad, Shahrun Niza Abdullah Suhaimi, Saladina Jaszle Jasmin, Norshahidah Mahamad Nadzir, Nurul-Syakima Ab Mutalib, Rahman Jamal

“…Therefore, it is clinically important to identify actionable mutated genes or pathways implicated in our local breast cancer patients to establish a more defined framework for precision medicine and clinical trials. In this discovery study, a total of nine pairs of newly diagnosed luminal breast cancer cases (>80% tumour content) and their matched normal samples were subjected to exome sequencing. …”
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Chromatin remodeling (SWI/SNF) complexes, cancer, and response to immunotherapy by Razelle Kurzrock, Shumei Kato, Nithya Krishnamurthy, Scott Lippman

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Immunoinfiltration Analysis of Mitochondrial Damage‐Related Genes in Lung Adenocarcinoma and Construction of a Classification and Prognostic Model Integrated With WGCNA and Machine... by Jirong Zhang, Lin Lin

“…The gene module and models identified have potential applications in LUAD classification and prognosis, offering novel markers for precision medicine. Conclusion This study uncovers the relationship between mitochondrial damage and immune infiltration in LUAD, paving the way for molecular classification, prognosis prediction, and personalized treatment strategies.…”
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Chimerism in Myeloid Malignancies following Stem Cell Transplantation Using FluBu4 with and without Busulfan Pharmacokinetics versus BuCy by Shatha Farhan, Michael Bazydlo, Klodiana Neme, Nancy Mikulandric, Edward Peres, Nalini Janakiraman

“…In the era of precision medicine, the impact of personalized dosing of busulfan is not clear. …”
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The interplay of sex and genotype in disease associations: a comprehensive network analysis in the UK Biobank by Vivek Sriram, Jakob Woerner, Yong-Yeol Ahn, Dokyoon Kim

“…Conclusions Our analysis affirms the presence of GxS interactions in cross-phenotype associations, emphasizing the need to investigate the role of sex in disease onset and its importance in biomedical discovery and precision medicine research.…”
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Fetal-Perinatal Exposure to Bisphenol-A Affects Quality of Spermatozoa in Adulthood Mouse by Teresa Chioccarelli, Francesco Manfrevola, Marina Migliaccio, Lucia Altucci, Veronica Porreca, Silvia Fasano, Gilda Cobellis

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Case report: A case of type 1 diabetes with diabetic ketoacidosis induced by envafolimab treatment in hepatocellular carcinoma by Youjia Li, Kai Qu, Xiuli Li, Xin Yang, Kanghuai Zhang, Jiao Xie

“…Recognizing the limitations of current understanding, there is a clear call for further research, particularly on identifying biomarkers that may predict adverse reactions to immunotherapy, to guide precision medicine and improve patient safety.…”
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Progress in the role of nanoparticles in the diagnosis and treatment of bone and joint tuberculosis by Yitong Ding, Baiyun Li, Yangfei Yi, Can Liu, Jie Wen, Jie Wen, Xiaohong Jian, Yufei Li

“…This review summarizes recent advancements in nanomaterials for diagnosing and treating BJTB and identifies key areas for future research, laying the groundwork for advancing precision medicine and personalized treatments.…”
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Real-world clinical multi-omics analyses reveal bifurcation of ER-independent and ER-dependent drug resistance to CDK4/6 inhibitors by Zhengyan Kan, Ji Wen, Vinicius Bonato, Jennifer Webster, Wenjing Yang, Vladimir Ivanov, Kimberly Hyunjung Kim, Whijae Roh, Chaoting Liu, Xinmeng Jasmine Mu, Jennifer Lapira-Miller, Jon Oyer, Todd VanArsdale, Paul A. Rejto, Jadwiga Bienkowska

“…Abstract To better understand drug resistance mechanisms to CDK4/6 inhibitors and inform precision medicine, we analyze real-world multi-omics data from 400 HR+/HER2- metastatic breast cancer patients treated with CDK4/6 inhibitors plus endocrine therapies, including 200 pre-treatment and 227 post-progression samples. …”
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Comparison of Lung-RADS Version 2022 and British Thoracic Society Guidelines in Classifying Solid Pulmonary Nodules Detected at Lung Cancer Screening CT by Claudiu Avram, Alexandru Ovidiu Mederle, Adelina Mavrea, Paula Irina Barata, Raul Patrascu

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Whole-Genome Duplication and Purifying Selection Contributes to the Functional Redundancy of Auxin Response Factor (ARF) Genes in Foxtail Millet (Setaria italica L.) by You Chen, Bin Liu, Yujun Zhao, Wenzhe Yu, Weina Si

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Advances in Biomedical Missing Data Imputation: A Survey by Miriam Barrabes, Maria Perera, Victor Novelle Moriano, Xavier Giro-I-Nieto, Daniel Mas Montserrat, Alexander G. Ioannidis

“…Ensuring data quality in biomedical sciences is crucial for reliable research outcomes, particularly as precision medicine continues to gain prominence. Missing values compromise data quality and can make it difficult to perform data-based studies. …”
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