Hepatic encephalopathy: pathogenesis, clinical presentation, diagnostics, treatment by Ch. S. Pavlov, I. V. Damulin, V. T. Ivashkin

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1+(no)1=3, and more by Carmen García

“…While  an approach to transformational change through paradoxical thinking and the creativity of the absurd is not new, it doesn’t seem to have produced news of difference, since binary thinking seems to persist, with ethical implications for the praxis of systemic therapy and its education and training. Indeed, binary mapping, even when critiqued, tends to reinforce itself, creating a strange loop similar to a Moebius strip. …”
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Molecular docking of ferulic acid, bakuchiol and niazirin on peroxisome proliferator-activated receptor gamma (PPAR-γ) as anti-diabetic agents by Anjar Hermadi Saputro, Riri Fauziyya, Sarmoko, Iwan Syahjoko Saputra

“…The PPAR-gamma protein plays a crucial role in lipid and carbohydrate metabolism, making it a key target for diabetes therapy. …”
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Gastroesophageal reflux disease and functional dyspepsia: clinical efficacy and safety of prokinetic choice by D. I. Trukhan

“…Motility disorder of gastroesophageal zone plays a leading part in pathogenesis of these diseases that assumes application prokinetics as a baseline therapy. …”
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The emerging roles of aberrant alternative splicing in glioma by Reda Ben Mrid, Sara El Guendouzi, Marco Mineo, Rachid El Fatimy

“…Consequently, AS constitutes a key regulatory mechanism that could serve as a target for future therapies. In this review, we explore how AS events, spliceosome components, and their regulatory mechanisms play a critical role in glioma development, highlighting their potential as targets for innovative therapeutic strategies against this challenging cancer.…”
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Inducers of Autophagy and Cell Death: Focus on Copper Metabolism by Weikang Ling, Shuo Li, Yang Zhu, Xin Wang, Dongmei Jiang, Bo Kang

“…Copper is an essential trace element in biological systems, playing a key role in various physiological functions, including redox reactions and energy metabolism. …”
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Common Green Bottle Fly or Sheep Blow Fly Lucilia sericata (Meigen) (Insecta: Diptera: Calliphoridae) by Matthew Anderson, Phillip E. Kaufman

“…Like many of the other blow flies, it plays an important role in forensic, medical, and veterinary science. …”
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Coexistence of giant cell arteritis and subacute thyroiditis: A case report and literature review by Cheng Xu, Yongmei Han

“…We report a rare case of coexisting giant cell arteritis and subacute thyroiditis that were both successfully managed using glucocorticoid therapy. Ultrasound plays a vital role in the diagnosis and treatment of these diseases. …”
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Common Green Bottle Fly or Sheep Blow Fly Lucilia sericata (Meigen) (Insecta: Diptera: Calliphoridae) by Matthew Anderson, Phillip E. Kaufman

“…Like many of the other blow flies, it plays an important role in forensic, medical, and veterinary science. …”
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Genomic characterization of chronic lymphocytic leukemia in patients of African ancestry by Cecilia Bonolo de Campos, Chantal E. McCabe, Laura A. Bruins, Daniel R. O’Brien, Sochilt Brown, Renee C. Tschumper, Cristine Allmer, Yuan Xiao Zhu, Kari G. Rabe, Sameer A. Parikh, Neil E. Kay, Huihuang Yan, James R. Cerhan, John N. Allan, Richard R. Furman, J. Brice Weinberg, Danielle M. Brander, Diane F. Jelinek, Marta Chesi, Susan L. Slager, Esteban Braggio

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Usp11 maintained the survival of marginal zone B cells under ionizing radiation by deubiquitinating DLL1 and JAG2 by Jiaqi Sheng, Depei Wu, Jingzhe Shang, Xiaodan Fu, He Gao, Jianjie Rong, Jun Wang, Jiancheng Hu, Xiaofei Qi

“…Abstract Efficacy of radiation therapy is compromised by hematopoietic and immune impairments, with elusive underlying causes. …”
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The role of natural products targeting macrophage polarization in sepsis-induced lung injury by Yake Li, Sinan Ai, Yuan Li, Wangyu Ye, Rui Li, Xiaolong Xu, Qingquan Liu

“…As a key component of the innate immune system, macrophages play a vital role in SALI, in which a macrophage phenotype imbalance caused by an increase in M1 macrophages or a decrease in M2 macrophages is common. …”
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Is heme biosynthesis influenced the mitochondrial function and cell proliferation in cancer? by Raisa Nauli, Sri Widia A Jusman

“…Protoporphyrin combines with a protein-forming hemoprotein compound that plays an essential role in oxygen-binding and transport as well as in the process of energy production in the mitochondria. …”
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Patients’ preferences on atopic dermatitis skincare and social media use: a qualitative study by Roxana Mazilu, Stefanie Ziehfreund, Stephan Traidl, Alexander Zink

“…Over-the-counter products play a crucial role in AD treatment. The emergence of social media (SM) as a vast information source for skincare and healthy lifestyle has transformed its role from mere entertainment. …”
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Algorithm of management of patients with acute cholestatic hepatitis (Clinical case presentation) by T. A. Deyeva, Ye. N. German, M. V. Mayevskaya, V. T. Ivashkin

“…In the submitted case a main role in recognition of an etiology of liver disease have played by careful taking of past history and analysis of all possible causes of disease, that can be the key point in diagnostic search and choice of patient management tactics.…”
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Network Meta-Analysis of Once Weekly Selinexor-Bortezomib-Dexamethasone in Previously Treated Multiple Myeloma by Michael Dolph, Gabriel Tremblay, Adrienne M Gilligan, Hoyee Leong

“…Thus, network meta-analyses play an important role in allowing health-care decision makers to compare the effectiveness of treatment options. …”
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Patient Experience of Living With Hemophilia A: A Conceptual Model of Humanistic and Symptomatic Experience in Adolescents, Adults, and Children by Zalmai Hakimi, Rakhee Ghelani, Linda Bystrická, Nana Kragh, Patrick Marquis, Jameel Nazir, Nadine McGale

“…Concepts were broadly relevant across all age groups; however, psychological impacts were reported only by adult PwHA, and caregivers reported impacts related to outdoor activities, play, and education. Participants indicated that their ideal treatment would be delivered orally. …”
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Desmoplastic reaction in the microenvironment of head and neck and other solid tumors: the therapeutic barrier by Kohei Okuyama, Maiko Tsuchiya, Kala Chand Debnath, Shajedul Islam, Souichi Yanamoto

“…The tumor microenvironment (TME), particularly the desmoplastic reaction (DR) characterized by stromal fibrosis, plays a crucial role in cancer progression and resistance to therapy. …”
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Unlocking nature’s pharmacy: an in-depth exploration of phytochemicals as potential sources of anti-cancer and anti-inflammatory molecules by Shifana C. Sadiq, Maria Pellissery Joy, Sreekumar U. Aiswarya, Abhishek Ajmani, Chenicheri K. Keerthana, Tennyson P. Rayginia, Noah Isakov, Ruby John Anto

“…Phytochemicals, the bioactive compounds derived from plants, play a significant role in modulating pathways leading to cancer and inflammation, rendering themselves promising candidates for therapeutic interventions. …”
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TOPBP1 as a potential predictive biomarker for enhanced combinatorial efficacy of olaparib and AZD6738 in PDAC by Xiao-Mei Tang, Min-Min Shi, Jia-Cheng Wang, Yi-Jin Gu, Yu-Ting Dai, Qin-Xin Yang, Jia Liu, Ling-Jie Ren, Xin-Yun Liu, Chun Yang, Fang-Fang Ma, Ji-Bing Liu, Hong Yu, Da Fu, Yun-Feng Wang

“…DNA topoisomerase II-binding protein 1 (TOPBP1) plays a supportive role in regulating the DDR pathway, and its overexpression has been linked to the tumorigenesis of various cancers. …”
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